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Journal of Clinical Investigation, ISSN 0021-9738, 05/2015, Volume 125, Issue 5, pp. 1913 - 1913
In this paper, the authors developed a murine model in which a constitutively active Gq alpha subunit is specifically expressed in podocytes and examined the... 
Journal Article
Science, ISSN 0036-8075, 6/2005, Volume 308, Issue 5729, pp. 1801 - 1804
Focal and segmental glomerulosclerosis (FSGS) is a kidney disorder of unknown etiology, and up to 20% of patients on dialysis have been diagnosed with it. Here... 
Receptors | Kidneys | Messenger RNA | Focal segmental glomerulosclerosis | Calcium | HEK293 cells | Cell lines | Reports | Kidney cells | Kidney diseases | Genetic mutation | INSERTION | PROTEIN | SLIT DIAPHRAGM | NEPHRIN | MULTIDISCIPLINARY SCIENCES | GENETIC-HETEROGENEITY | PODOCIN | NEPHROTIC SYNDROME | EXPRESSION | ALPHA-ACTININ-4 | GLOMERULAR-DISEASE | Haplotypes | Uridine Triphosphate - metabolism | Calcium Channels - metabolism | Calcium - metabolism | Exons | Glomerulosclerosis, Focal Segmental - genetics | Humans | Male | Mutation, Missense | Sodium - metabolism | Kidney - metabolism | Receptor, Angiotensin, Type 1 - genetics | Transfection | Kidney Glomerulus - metabolism | Female | Cell Membrane - metabolism | GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism | Kidney Tubules - metabolism | Calcium Channels - genetics | Calcium Signaling | Cell Line | Angiotensin II - pharmacology | TRPC6 Cation Channel | Angiotensin II - metabolism | TRPC Cation Channels | Uridine Triphosphate - pharmacology | Chromosomes, Human, Pair 11 - genetics | Sequence Analysis, DNA | Carbachol - pharmacology | Patch-Clamp Techniques | Pedigree | Calcium Channels - chemistry | Receptor, Angiotensin, Type 1 - metabolism | Amino Acid Substitution | Glomerulonephritis | Case studies | Research | Analysis | Heredity | Mutation | Chromosomes | Genes
Journal Article
Journal Article
Journal of the American Society of Nephrology, ISSN 1046-6673, 06/2008, Volume 19, Issue 6, pp. 1071 - 1075
FSGS is a pathologic lesion that frequently causes the nephrotic syndrome and ensuing renal failure. The cause remains unknown in the majority of individuals;... 
TRPC6 | CHANNEL | FOCAL-SEGMENTAL GLOMERULOSCLEROSIS | PDZ-DOMAIN PROTEIN | UROLOGY & NEPHROLOGY | GENETIC-HETEROGENEITY | RENAL-DISEASE | MUTATIONS | NEPHROTIC SYNDROME | PODOCYTE | ASSOCIATION | TRPC6 Cation Channel | Pedigree | Glomerulosclerosis, Focal Segmental - genetics | Humans | Awards and Prizes | Mutation | TRPC Cation Channels - genetics
Journal Article
Kidney International, ISSN 0085-2538, 12/2014, Volume 86, Issue 6, pp. 1253 - 1259
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 05/2015, Volume 125, Issue 5, pp. 1913 - 1926
Familial forms of focal segmental glomerulosclerosis (FSGS) have been linked to gain-of-function mutations in the gene encoding the transient receptor... 
MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | CHANNEL | KINASE | GENE-EXPRESSION | CALCINEURIN | DIABETIC-NEPHROPATHY | MECHANISMS | NEPHROTIC SYNDROME | INHIBITOR | PODOCYTE | Glomerulosclerosis, Focal Segmental - genetics | Humans | TRPC Cation Channels - deficiency | Diabetes Mellitus, Type 1 - complications | Recombinant Fusion Proteins - metabolism | Puromycin Aminonucleoside - toxicity | Mice, Mutant Strains | Gene Deletion | HEK293 Cells | Tacrolimus - pharmacology | Glomerulosclerosis, Focal Segmental - chemically induced | Kidney Tubules - pathology | TRPC Cation Channels - genetics | Genes, Reporter | GTP-Binding Protein alpha Subunits, Gq-G11 - genetics | Diabetic Nephropathies - pathology | Podocytes - metabolism | Signal Transduction | TRPC Cation Channels - biosynthesis | Diabetic Nephropathies - metabolism | NFATC Transcription Factors - metabolism | Diabetes Mellitus, Type 1 - genetics | Diabetic Nephropathies - genetics | Mice, Transgenic | GTP-Binding Protein alpha Subunits, Gq-G11 - physiology | Kidney Glomerulus - pathology | Point Mutation | Animals | Albuminuria - chemically induced | Mice | TRPC Cation Channels - physiology | Calcineurin - metabolism | Glomerulosclerosis, Focal Segmental - pathology | Glomerulonephritis | Genetic aspects | Research | Gene mutations | Health aspects | Risk factors | Studies | Urine | Variables | Disease | Pathogenesis | Rodents | Software | Histology | Mutation | Laboratory animals | Nephrology
Journal Article
Journal of the American Society of Nephrology : JASN, ISSN 1046-6673, 09/2014, Volume 25, Issue 9, pp. 1991 - 2002
Journal Article
Journal of the American Society of Nephrology, ISSN 1046-6673, 07/2015, Volume 26, Issue 7, pp. 1701 - 1710
Journal Article
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Journal Article
BBA - Molecular Basis of Disease, ISSN 0925-4439, 2007, Volume 1772, Issue 8, pp. 859 - 868
Journal Article