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Investigational New Drugs, ISSN 0167-6997, 10/2014, Volume 32, Issue 5, pp. 825 - 837
The G1 restriction point is critical for regulating the cell cycle and is controlled by the Rb pathway (CDK4/6-cyclin D1-Rb-p16/ink4a). This pathway is... 
Medicine & Public Health | Cell cycle | Oncology | In vivo antitumor activity | Pharmacology/Toxicology | Combination therapy | LY2835219 | Kinase inhibitor | CDK4/6 inhibitor | Cdk4/6 inhibitor | LUNG | HUMAN BREAST | PHOSPHORYLATION | CANCER | DEPENDENT KINASE 4/6 | CONSTITUTIVELY ACTIVATED FLT3 | ONCOLOGY | BRAIN METASTASES | RESTRICTION POINT | TUMOR-SUPPRESSOR | PHARMACOLOGY & PHARMACY | EXPRESSION | Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Neoplasms - metabolism | Humans | Deoxycytidine - pharmacology | Antineoplastic Agents - therapeutic use | Deoxycytidine - therapeutic use | Aminopyridines - therapeutic use | Female | Antineoplastic Agents - pharmacology | Phosphorylation - drug effects | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Drug Therapy, Combination | Benzimidazoles - therapeutic use | Retinoblastoma Protein - metabolism | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Tumor Burden - drug effects | Protein Kinase Inhibitors - therapeutic use | Aminopyridines - pharmacology | Retinoblastoma Protein - antagonists & inhibitors | Cell Line, Tumor | Benzimidazoles - pharmacology | Mice | Protein Kinase Inhibitors - pharmacology | G1 Phase Cell Cycle Checkpoints - drug effects | Neoplasms - pathology | Deoxycytidine - analogs & derivatives | Dosage and administration | Research | Gemcitabine | Studies | Protein expression | Inhibitor drugs | Kinases | Cancer therapies | Analysis | CDK4 | Preclinical Studies | 6 inhibitor
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 09/2015, Volume 43, Issue 9, pp. 1360 - 1371
Effective treatments for primary brain tumors and brain metastases represent a major unmet medical need. Targeting the CDK4/CDK6-cyclin D1-Rb-p16/ink4a pathway... 
BREAST-CANCER | DRUG-DELIVERY | TRANSPORTERS | BARRIER | METASTASES | RESTRICTION POINT | PHARMACOLOGY & PHARMACY | BLOOD-BRAIN | DEPENDENT KINASES | CANCER RESISTANCE PROTEIN | P-GLYCOPROTEIN | Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Piperazines - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Brain Neoplasms - pathology | Male | Aminopyridines - therapeutic use | Benzimidazoles - administration & dosage | Dacarbazine - analogs & derivatives | Madin Darby Canine Kidney Cells | Female | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Benzimidazoles - therapeutic use | Pyridines - therapeutic use | Aminopyridines - administration & dosage | Dacarbazine - administration & dosage | Pyridines - administration & dosage | Rats | Piperazines - therapeutic use | Brain Neoplasms - drug therapy | Piperazines - pharmacology | Brain - drug effects | Xenograft Model Antitumor Assays | Protein Kinase Inhibitors - administration & dosage | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Aminopyridines - pharmacology | Glioblastoma - pathology | Dogs | Benzimidazoles - pharmacology | Mice | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Glioblastoma - drug therapy
Journal Article
BRITISH JOURNAL OF PHARMACOLOGY, ISSN 0007-1188, 01/2019, Volume 176, Issue 1, pp. 110 - 126
Background and Purpose Experimental Approach We aimed to identify and develop novel, selective muscarinic M-1 receptor agonists as potential therapeutic agents... 
DONEPEZIL | ACTIVATION | INHIBITION | CONCISE GUIDE | MEMORY | ALZHEIMERS-DISEASE | PHARMACOLOGY & PHARMACY | LONG-TERM POTENTIATION | ALLOSTERIC MODULATION | ACETYLCHOLINE-RECEPTOR | METHYL-D-ASPARTATE
Journal Article
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2007, Volume 17, Issue 6, pp. 1765 - 1768
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 1995, Volume 5, Issue 23, pp. 2783 - 2788
A new series of naphtho[1,2-b]pyran-3-carbonitriles with enhanced stability under acid conditions has been synthesised and examined for antiproliferative and... 
Journal Article
Biochemical Society Transactions, ISSN 0300-5127, 1997, Volume 25, Issue 4, p. S656
Journal Article
Biochemical Society Transactions, ISSN 0300-5127, 11/1997, Volume 25, Issue 4, pp. S655 - S655
Journal Article
Journal of Pharmacological Methods, ISSN 0160-5402, 1985, Volume 13, Issue 3, pp. 241 - 248
An improved technique for perfused lung preparations adapted for absorption studies with organic aerosols is described. The model developed by Niemeier and... 
Pulmonary function | Perfused lung | Computerized respiratory measurement | Rabbits | Perfusion - instrumentation | Tidal Volume | Lung - physiology | Aerosols - metabolism | Carbon Dioxide - blood | Oxygen - blood | Absorption | Animals | Models, Biological | Anesthesia | In Vitro Techniques | Respiration | Hydrogen-Ion Concentration
Journal Article
PLoS Genetics, ISSN 1553-7390, 04/2017, Volume 13, Issue 4, p. e1006744
Degeneration and loss of lower motor neurons is the major pathological hallmark of spinal muscular atrophy (SMA), resulting from low levels of... 
UBIQUITIN HOMEOSTASIS | MESSENGER-RNA | MITOCHONDRIAL BIOGENESIS | NEUROLOGICAL DYSFUNCTION | MOUSE MODEL | GENETICS & HEREDITY | SELECTIVE VULNERABILITY | SMN PROTEIN | CHRONIC HEMOLYTIC-ANEMIA | NEUROMUSCULAR-JUNCTIONS | NEURODEGENERATIVE DISEASES | Spinal Cord - metabolism | Spinal Cord - growth & development | Humans | Muscle, Skeletal - metabolism | Prazosin - analogs & derivatives | Prazosin - administration & dosage | Muscular Atrophy, Spinal - genetics | Gene Expression Regulation, Developmental | Spinal Cord - pathology | Adenosine Triphosphate - metabolism | Survival of Motor Neuron 1 Protein - genetics | Phosphoglycerate Kinase - antagonists & inhibitors | Muscular Atrophy, Spinal - physiopathology | Motor Neurons - drug effects | Phosphoglycerate Kinase - genetics | Disease Models, Animal | Muscular Atrophy, Spinal - metabolism | Disease Susceptibility | Axons - metabolism | Mitochondria - metabolism | Survival of Motor Neuron 1 Protein - metabolism | Zebrafish - growth & development | Zebrafish - genetics | Motor Neurons - metabolism | Animals | Energy Metabolism | Axons - pathology | Mice | Muscle, Skeletal - pathology | Zebra fish | Physiological aspects | Development and progression | Models | Genetic aspects | Research | Gene expression | Spinal muscular atrophy | Motor neurons | Neurosciences | Cell survival | SMN protein | Muscles | Zebrafish | Amyotrophic lateral sclerosis | Vulnerability | Phosphoglycerate kinase | Motor task performance | Skeletal muscle | Disease resistance | Mitochondria | Rodents | Phosphoglycerate kinase 1 | Degeneration
Journal Article
Journal Article
Journal Article