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2008, ISBN 9780521860338, xii, 324
Obesity is one of the prime contributors to ill health in modern society, affecting around 20–25% of the population. It can cause or exacerbate a variety of... 
Pathophysiology | Obesity | Etiology | Biology, life sciences | Obesity - Etiology
Book
Nature, ISSN 0028-0836, 02/2017, Volume 542, Issue 7641, pp. 299 - 300
We now know that biological signalling networks that respond to nutrients and hormones modulate lifespan in a highly evolutionarily conserved manner2. The... 
Aging | Enzymes | Kinases | Metabolism | Rodents
Journal Article
Current Topics in Microbiology and Immunology, ISSN 0070-217X, 2010, Volume 346, Issue 1, pp. 115 - 141
The Insulin Receptor/PI 3-kinase (INSR/PI3K) signalling pathway is a key regulator of cell and organismal metabolism. Phosphoinositides generated by PI... 
Animals | Islets of Langerhans - physiology | Humans | PTEN Phosphohydrolase - physiology | Insulin Resistance | Phosphatidylinositol 3-Kinases - physiology | Signal Transduction - physiology | Phosphatidylinositols - physiology | Receptor, Insulin - physiology
Journal Article
Philosophical Transactions of the Royal Society of London, Series B: Biological Sciences, ISSN 0962-8436, 01/2011, Volume 366, Issue 1561, pp. 99 - 107
Over the last two centuries, there has been a significant increase in average lifespan expectancy in the developed world. One unambiguous clinical implication... 
Journal Article
Philosophical Transactions: Biological Sciences, ISSN 0962-8436, 1/2011, Volume 366, Issue 1561, pp. 99 - 107
Journal Article
Science, ISSN 0036-8075, 10/2009, Volume 326, Issue 5949, pp. 140 - 144
Journal Article
ISSN 2212-8778, 2018
Objective: Imprinted genes are crucial for the growth and development of fetal and juvenile mammals. Altered imprinted gene dosage causes a variety of human... 
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 08/2013, Volume 123, Issue 8, pp. 3539 - 3551
Journal Article
Cell reports, 10/2018, Volume 25, Issue 2, p. 278
Leptin acts on hypothalamic pro-opiomelanocortin (POMC) neurons to regulate glucose homeostasis, but the precise mechanisms remain unclear. Here, we... 
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 2011, Volume 51, pp. S78 - S79
Journal Article