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Angewandte Chemie International Edition, ISSN 1433-7851, 08/2018, Volume 57, Issue 35, pp. 11359 - 11364
Functional metagenomics has opened new opportunities for enzyme discovery. To exploit the full potential of this new tool, the design of selective screens is... 
hydrolases | self-immolative linkers | enzyme discovery | functional metagenomics | high-throughput screening | UNSATURATED GLUCURONYL HYDROLASE | THIOGLYCOSIDES | ACID | REAGENTS | HYDROLYSIS | CHEMISTRY, MULTIDISCIPLINARY | CARBAMATE | SUBSTRATE | PURIFICATION | BETA-GLUCURONIDASE | DERIVATIVES | Enzymes | Screening | Aromatic compounds | Glycosidases | Substrates
Journal Article
Biochemistry, ISSN 0006-2960, 09/2018, Volume 57, Issue 37, pp. 5384 - 5387
Journal Article
Protein Science, ISSN 0961-8368, 08/2017, Volume 26, Issue 8, pp. 1555 - 1563
Journal Article
Carbohydrate Research, ISSN 0008-6215, 09/2018, Volume 467, pp. 33 - 44
Azide- and amine-substituted sugars can be useful tools in the probing of biological systems as well as in the assembly of libraries of derivatives using click... 
IN-VITRO | MIMETICS | ACID | SELECTIVE BENZOYLATION | ENZYMES | BIOCHEMISTRY & MOLECULAR BIOLOGY | GLYCANS | CHEMISTRY, ORGANIC | CHEMISTRY, APPLIED | PROBES | Enzymes | Polysaccharides | Libraries | Amines | Fluorides | Galactose
Journal Article
by Newton-Cheh, Christopher and Johnson, Toby and Gateva, Vesela and Tobin, Martin D and Bochud, Murielle and Coin, Lachlan and Najjar, Samer S and Zhao, Jing Hua and Heath, Simon C and Eyheramendy, Susana and Papadakis, Konstantinos and Voight, Benjamin F and Scott, Laura J and Zhang, Feng and Farrall, Martin and Tanaka, Toshiko and Wallace, Chris and Chambers, John C and Khaw, Kay-Tee and Nilsson, Peter and van der Harst, Pim and Polidoro, Silvia and Grobbee, Diederick E and Onland-Moret, N. Charlotte and Bots, Michiel L and Wain, Louise V and Elliott, Katherine S and Teumer, Alexander and Luan, Jian'an and Lucas, Gavin and Kuusisto, Johanna and Burton, Paul R and Hadley, David and McArdle, Wendy L and Brown, Morris and Dominiczak, Anna and Newhouse, Stephen J and Samani, Nilesh J and Webster, John and Zeggini, Eleftheria and Beckmann, Jacques S and Bergmann, Sven and Lim, Noha and Song, Kijoung and Vollenweider, Peter and Waeber, Gerard and Waterworth, Dawn M and Yuan, Xin and Groop, Leif and Orho-Melander, Marju and Allione, Alessana and Di Gregorio, Alessana and Guarrera, Simonetta and Panico, Salvatore and Ricceri, Fulvio and Romanazzi, Valeria and Sacerdote, Carlotta and Vineis, Paolo and Barroso, Ines and Sandhu, Manjinder S and Luben, Robert N and Crawford, Gabriel J and Jousilahti, Pekka and Perola, Markus and Boehnke, Michael and Bonnycastle, Lori L and Collins, Francis S and Jackson, Anne U and Mohlke, Karen L and Stringham, Heather M and Valle, Timo T and Willer, Cristen J and Bergman, Richard N and Morken, Mario A and Doering, Angela and Gieger, Christian and Illig, Thomas and Meitinger, Thomas and Org, Elin and Pfeufer, Arne and Wichmann, H. Erich and Kathiresan, Sekar and Marrugat, Jaume and O'Donnell, Christopher J and Schwartz, Stephen M and Siscovick, David S and Subirana, Isaac and Freimer, Nelson B and Hartikainen, Anna-Liisa and McCarthy, Mark I and O'Reilly, Paul F and Peltonen, Leena and Pouta, Anneli and de Jong, Paul E and Snieder, Harold and van Gilst, Wiek H and Clarke, Robert and Goel, Anuj and Hamsten, Anders and Peden, John F and ... and Wellcome Trust Case Control Consor and Wellcome Trust Case Control Consortium and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Molekylär medicin and Uppsala universitet and Institutionen för medicinska vetenskaper
Nature Genetics, ISSN 1061-4036, 06/2009, Volume 41, Issue 6, pp. 666 - 676
Journal Article
Analytical Chemistry, ISSN 0003-2700, 09/2016, Volume 88, Issue 17, p. 8587
  In vitro compartmentalization-based fluorescence-activated cell sorting (IVC-FACS) is a powerful screening tool for directed evolution of enzymes. However,... 
Proteins | Enzymes | Genotype & phenotype | Fluorescence | Cells
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 12/2012, Volume 8, Issue 12, pp. 952 - 953
  Post-translational modication of proteins by N-acetylglucosamine (O-GlcNAc) is carried out by a single glycosyltransferase, OGT. Two independent groups have... 
SUBSTRATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSFERASE | Diphosphates - metabolism | Nucleotides - metabolism | Humans | N-Acetylglucosaminyltransferases - metabolism | Proteins | Enzymes | Eukaryotes | Catalysis | Peptides | Sugar
Journal Article
by Burton, Paul R and Clayton, David G and Cardon, Lon R and Craddock, Nick and Deloukas, Panos and Duncanson, Audrey and Kwiatkowski, Dominic P and McCarthy, Mark I and Ouwehand, Willem H and Samani, Nilesh J and Todd, John A and Donnelly, Peter and Barrett, Jeffrey C and Davison, Dan and Easton, Doug and Evans, David and Leung, Hin-Tak and Marchini, Jonathan L and Morris, Andrew P and Spencer, Chris C. A and Tobin, Martin D and Attwood, Antony P and Boorman, James P and Cant, Barbara and Everson, Ursula and Hussey, Judith M and Jolley, Jennifer D and Knight, Alexandra S and Koch, Kerstin and Meech, Elizabeth and Nutland, Sarah and Prowse, Christopher V and Stevens, Helen E and Taylor, Niall C and Walters, Graham R and Walker, Neil M and Watkins, Nicholas A and Winzer, Thilo and Jones, Richard W and McArdle, Wendy L and Ring, Susan M and Strachan, David P and Pembrey, Marcus and Breen, Gerome and St. Clair, David and Caesar, Sian and Gordon-Smith, Katherine and Jones, Lisa and Fraser, Christine and Green, Elaine K and Grozeva, Detelina and Hamshere, Marian L and Holmans, Peter A and Jones, Ian R and Kirov, George and Moskvina, Valentina and Nikolov, Ivan and O'Donovan, Michael C and Owen, Michael J and Collier, David A and Elkin, Amanda and Farmer, Anne and Williamson, Richard and McGuffin, Peter and Young, Allan H and Ferrier, I. Nicol and Ball, Stephen G and Balmforth, Anthony J and Barrett, Jennifer H and Bishop, D. Timothy and Iles, Mark M and Maqbool, Azhar and Yuldasheva, Nadira and Hall, Alistair S and Braund, Peter S and Dixon, Richard J and Mangino, Massimo and Stevens, Suzanne and Thompson, John R and Bredin, Francesca and Tremelling, Mark and Parkes, Miles and Drummond, Hazel and Lees, Charles W and Nimmo, Elaine R and Satsangi, Jack and Fisher, Sheila A and Forbes, Alastair and Lewis, Cathryn M and Onnie, Clive M and Prescott, Natalie J and Sanderson, Jeremy and Mathew, Christopher G and Barbour, Jamie and Mohiuddin, M. Khalid and Todhunter, Catherine E and Mansfield, John C and Ahmad, Tariq and Cummings, Fraser R and Jewell, Derek P and ... and Breast Canc Susceptib Collaborat and Wellcome Trust Case Control Cons and Biol RA Genet & Genom Study and Wellcome Trust Case Control Consortium and The Wellcome Trust Case Control Consortium
Nature, ISSN 0028-0836, 06/2007, Volume 447, Issue 7145, pp. 661 - 678
Journal Article