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1. Full Text Comment on: New onset of lupus nephritis in two patients with SLE shortly after initiation of treatment with belimumab
by Witte, Torsten
Seminars in Arthritis and Rheumatism, ISSN 0049-0172, 10/2017, Volume 47, Issue 2, pp. e11 - e11
Antibodies, Monoclonal, Humanized | Cognition | Immunosuppressive Agents | Lupus Nephritis | Humans | Lupus Erythematosus, Systemic | Lupus | Care and treatment | Kidney diseases
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2. Full Text Sjogren's syndrome/Sjogren-Syndrom
by Witte, Torsten
Zeitschrift fur Rheumatologie, ISSN 0340-1855, 08/2019, Volume 78, Issue 6, p. 511
Das primare Sjogren-Syndrom ist mit einer Pravalenz zwischen 1:100 und 1:1000 die haufigste Kollagenose. Dennoch ist die Erkrankung wegen der uberwiegend... 
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3. Full Text Sjögren-Syndrom
by Witte, Torsten
Zeitschrift für Rheumatologie, ISSN 0340-1855, 8/2019, Volume 78, Issue 6, pp. 511 - 517
Das primäre Sjögren-Syndrom ist mit einer Prävalenz zwischen 1:100 und 1:1000 die häufigste Kollagenose. Dennoch ist die Erkrankung wegen der überwiegend... 
Connective tissue diseases | Rheumatology | Internal Medicine | Laboratory Medicine | Review | SS-A-Antikörper | SSA antibodies | Medicine/Public Health, general | Immunology | Treatment | Medicine & Public Health | Therapie | Orthopedics | Outcome | Kollagenosen
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4. Full Text JAK-Inhibitoren in der Rheumatologie
by Witte, Torsten
DMW - Deutsche Medizinische Wochenschrift, ISSN 0012-0472, 06/2019, Volume 144, Issue 11, pp. 748 - 752
„Was ist neu?“ Wirkmechanismen der JAK-Inhibitoren  JAK-Inhibitoren wirken intrazellulär und hemmen im Gegensatz zu den Biologika viele Zytokine.... 
Klinischer Fortschritt
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5. Full Text Sjögren-Syndrom: früher diagnostizieren, wirksam behandeln
by Witte, Torsten
DMW - Deutsche Medizinische Wochenschrift, ISSN 0012-0472, 12/2018, Volume 143, Issue 24, pp. 1778 - 1782
Was ist neu? Therapiestudien  Fortschritte im Verständnis der Pathophysiologie des primären Sjögren-Syndroms und die Erarbeitung von Aktivitätscores führten... 
Klinischer Fortschritt
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6. Full Text Sjögren's Syndrome: Early diagnosis and effective treatment
by Witte, Torsten
Deutsche Medizinische Wochenschrift, ISSN 0012-0472, 2018, Volume 143, Issue 24, pp. 1778 - 1782
Sjögren's syndrome | therapy | classification criteria
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7. Full Text Was ist gesichert in der Therapie der rheumatoiden Arthritis?
by Witte, Torsten
Der Internist, ISSN 0020-9554, 12/2018, Volume 59, Issue 12, pp. 1249 - 1254
Die rheumatoide Arthritis (RA) ist mit einer Prävalenz von ca. 1 % die wichtigste chronisch-entzündliche Gelenkerkrankung. Unbehandelt führt sie zu... 
Nephrology | Disease modifying antirheumatic drugs | Early diagnosis | Disease progression | General Practice / Family Medicine | Biologika | Internal Medicine | Früherkennung | Krankheitsprogression | Medicine & Public Health | JAK-Inhibitoren | Hepatology | Biologics | Gastroenterology | Cardiology | JAK inhibitors
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8. Full Text What is certain in the treatment of rheumatoid arthritis?/Was ist gesichert in der Therapie der rheumatoiden Arthritis?
by Witte, Torsten
Der Internist, ISSN 0020-9554, 12/2018, Volume 59, Issue 12, p. 1249
Die rheumatoide Arthritis (RA) ist mit einer Pravalenz von ca. 1a[macron]% die wichtigste chronisch-entzundliche Gelenkerkrankung. Unbehandelt fuhrt sie zu... 
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9. Full Text What is certain in the treatment of rheumatoid arthritis?
by Witte, Torsten
Internist, ISSN 0020-9554, 12/2018, Volume 59, Issue 12, pp. 1249 - 1254
Disease modifying antirheumatic drugs | Early diagnosis | Biologics | Disease progression | JAK inhibitors
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10. Full Text Sjogren's syndrome
by Witte, T
ZEITSCHRIFT FUR RHEUMATOLOGIE, ISSN 0340-1855, 08/2019, Volume 78, Issue 6, pp. 511 - 517
The prevalence of primary Sjogren's syndrome (pSS) is between 1:100 and 1:1000 and it is therefore the most common connective tissue disease. Nevertheless, it... 
SALIVARY-GLAND BIOPSY | DIAGNOSIS | Connective tissue diseases | DRY MOUTH | AMERICAN-COLLEGE | CONSENSUS | DATA-DRIVEN | Review | RHEUMATOLOGY | SSA antibodies | Treatment | Outcome | DOUBLE-BLIND | ULTRASONOGRAPHY | CLASSIFICATION CRITERIA | TREATMENT GUIDELINES
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11. Full Text Methotrexate as combination partner of TNF inhibitors and tocilizumab. What is reasonable from an immunological viewpoint?
by Witte, Torsten
Clinical Rheumatology, ISSN 0770-3198, 03/2015, Volume 34, Issue 4, pp. 629 - 634
The goal of therapy of rheumatoid arthritis is to achieve a remission or at least low disease activity. TNF inhibitors induce high remission rates only in... 
Rheumatoid arthritis (RA) | Specialty fields | Immunology | Cytokines and inflammatory mediators | Rheumatic diseases | Tissues or models | RHEUMATOID-ARTHRITIS | CELLS | MODIFYING ANTIRHEUMATIC DRUGS | CLINICAL-TRIAL | RECEPTOR | RHEUMATOLOGY | INTERLEUKIN-6 | INFLIXIMAB THERAPY | DOUBLE-BLIND | NECROSIS FACTOR THERAPY | EXPRESSION | Cell Proliferation | RANK Ligand - metabolism | Antirheumatic Agents - administration & dosage | Humans | Gene Expression Regulation | Joints - pathology | Vascular Endothelial Growth Factor A - metabolism | Cell Adhesion | Monocytes - drug effects | Inflammation - metabolism | Antibodies, Monoclonal, Humanized - administration & dosage | Immune System | Arthritis, Rheumatoid - drug therapy | Dendritic Cells - drug effects | Methotrexate - administration & dosage | Dendritic Cells - cytology | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Cell Movement | Rheumatoid factor | Dendritic cells | Methotrexate | Tumor necrosis factor | Review
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12. Full Text Impact of sleep disordered breathing on short-term post-operative outcome after elective coronary artery bypass graft surgery: A prospective observational study
by Rupprecht, Sven and Schultze, Torsten and Nachtmann, Andreas and Julian Rastan, Ardawan and Doenst, Torsten and Schwab, Matthias and Witte, Otto W and Rohe, Sebastian and Zwacka, Isabelle and Hoyer, Heike
European Respiratory Journal, ISSN 0903-1936, 04/2017, Volume 49, Issue 4, pp. 1601486 - 1601486
Sleep disordered breathing (SDB) is common in patients with coronary disease, but its impact on post-operative recovery after coronary artery bypass graft... 
MORTALITY | APNEA SYNDROME | METAANALYSIS | EVENTS | RESPIRATORY SYSTEM | HEART-FAILURE | FOLLOW-UP | RISK | POSITIVE AIRWAY PRESSURE | DYSFUNCTION | ACCURACY | Coronary Artery Disease - surgery | Prospective Studies | Sleep Apnea Syndromes - epidemiology | Hospital Mortality | Humans | Middle Aged | Logistic Models | Male | Treatment Outcome | Postoperative Complications - epidemiology | Coronary Artery Disease - mortality | Germany - epidemiology | Coronary Artery Bypass - adverse effects | Coronary Artery Bypass - mortality | Time Factors | Female | Aged | Sleep | Kidneys | Heart surgery | Mortality | Coronary vessels | Surgery | Coronary artery | Renal failure | Sepsis | Respiration | Heart diseases | Morbidity
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13. Full Text Clinical picture and treatment of 2212 patients with common variable immunodeficiency
by Gathmann, Benjamin, MA and Mahlaoui, Nizar, MD, MSc, MPH and Gérard, Laurence, MD and Oksenhendler, Eric, MD and Warnatz, Klaus, MD and Schulze, Ilka, MD and Kindle, Gerhard, MD and Kuijpers, Taco W., MD and van Beem, Rachel T., PhD and Guzman, David, Lic and Workman, Sarita, RN, MSc and Soler-Palacín, Pere, MD, PhD and De Gracia, Javier, MD, PhD and Witte, Torsten, MD and Schmidt, Reinhold E., MD and Litzman, Jiri, MD and Hlavackova, Eva, MD and Thon, Vojtech, MD, PhD and Borte, Michael, MD, PhD and Borte, Stephan, MD and Kumararatne, Dinakantha, MD and Feighery, Conleth, MD and Longhurst, Hilary, FRCP, PhD and Helbert, Matthew, MD and Szaflarska, Anna, MD and Sediva, Anna, MD and Belohradsky, Bernd H., MD and Jones, Alison, MRCP, PhD and Baumann, Ulrich, MD, PhD and Meyts, Isabelle, MD, PhD and Kutukculer, Necil, MD and Wågström, Per, MD and Galal, Nermeen Mouftah, MD and Roesler, Joachim, MD and Farmaki, Evangelia, MD, PhD and Zinovieva, Natalia, MD and Ciznar, Peter, MD, PhD and Papadopoulou-Alataki, Efimia, MD, PhD and Bienemann, Kirsten, MD and Velbri, Sirje, MD, PhD and Panahloo, Zoya, MD and Grimbacher, Bodo, MD and CEREDIH and Dutch WID and European Soc Immunodeficiencies and European Society for Immunodeficiencies Registry Working Party
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2014, Volume 134, Issue 1, pp. 116 - 126.e11
Background Common variable immunodeficiency (CVID) is an antibody deficiency with an equal sex distribution and a high variability in clinical presentation.... 
Allergy and Immunology | patient self-reported outcomes | treatment | Common variable immunodeficiency | primary antibody deficiency | autoimmunity | enteropathy | immunoglobulin replacement | quality of life | lymphadenopathy | granulomas | INFECTIONS | PHENOTYPES | IMMUNOLOGY | DEFICIENCY | IGM | TRIAL | B-CELL | ALLERGY | HYPOGAMMAGLOBULINEMIA | INTRAVENOUS IMMUNOGLOBULIN | DISEASE | Autoimmunity | Common Variable Immunodeficiency - immunology | Common Variable Immunodeficiency - drug therapy | Humans | Child, Preschool | Lymphoproliferative Disorders - complications | Male | Lymphoproliferative Disorders - immunology | Splenomegaly - pathology | Bronchiectasis - pathology | Common Variable Immunodeficiency - mortality | Pneumonia - mortality | Pneumonia - immunology | Adult | Female | Retrospective Studies | Child | Europe | Delayed Diagnosis | Common Variable Immunodeficiency - complications | Lymphoproliferative Disorders - mortality | Pneumonia - drug therapy | Immunoglobulins, Intravenous - therapeutic use | Adolescent | Age of Onset | Survival Analysis | Pneumonia - complications | Lymphoproliferative Disorders - drug therapy | Immunological deficiency syndromes | Care and treatment | Health aspects | Respiratory tract diseases | Studies | Pneumonia | Meningitis | Lymphomas | Multivariate analysis | Patients | Age | Data bases
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14. Full Text Sensitivity and Specificity of Autoantibodies Against CD74 in Nonradiographic Axial Spondyloarthritis
by Riechers, Elke and Baerlecken, Niklas and Baraliakos, Xenofon and Achilles‐Mehr Bakhsh, Katrin and Aries, Peer and Bannert, Bettina and Becker, Klaus and Brandt‐Jürgens, Jan and Braun, Jürgen and Ehrenstein, Boris and Euler, Hans‐Hartwig and Fleck, Martin and Hein, Reinhard and Karberg, Kirsten and Köhler, Lars and Matthias, Torsten and Max, Regina and Melzer, Adelheid and Meyer‐Olson, Dirk and Rech, Jürgen and Rockwitz, Karin and Rudwaleit, Martin and Schmidt, Reinhold E and Schweikhard, Eva and Sieper, Joachim and Stille, Carsten and Hinüber, Ulrich and Wagener, Peter and Weidemann, Heike‐Franziska and Zinke, Silke and Witte, Torsten
Arthritis & Rheumatology, ISSN 2326-5191, 05/2019, Volume 71, Issue 5, pp. 729 - 735
Objective Autoantibodies against CD74 (anti‐CD74) are associated with ankylosing spondylitis (AS). The present multicenter study, the International... 
CRITERIA | CLASSIFICATION | ANKYLOSING-SPONDYLITIS | RHEUMATOLOGY | INFLAMMATORY BACK-PAIN | HIGH PREVALENCE | Back pain | Chiropractic medicine | Autoantibodies | Identification methods | Immunoglobulin G | Rheumatic diseases | Arthritis | Inflammation | Joint diseases | Immunoglobulin A | Blood donors | Inflammatory diseases | Spondylitis | Sensitivity | Pain | Magnetic resonance imaging | Genotyping | Diagnostic software | Histocompatibility antigen HLA | Diagnostic systems | Ankylosing spondylitis
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15. Full Text Association of the LILRA3 deletion with B-NHL and functional characterization of the immunostimulatory molecule
by Low, Hui Zhi and Reuter, Sandra and Topperwien, Michael and Dankenbrink, Nadine and Peest, Dietrich and Kabalak, Gamze and Stripecke, Renata and Schmidt, Reinhold E and Matthias, Torsten and Witte, Torsten
PLoS ONE, ISSN 1932-6203, 12/2013, Volume 8, Issue 12, p. e81360
LILRA3 is the sole soluble member of the LILR family. Previous studies from our group had shown that a 6.7 kb genetic deletion of LILRA3 is associated with MS... 
COMPLEX | CYTOKINE PRODUCTION | MULTIDISCIPLINARY SCIENCES | IMMUNOGLOBULIN | NON-HODGKIN-LYMPHOMA | INHIBITORY RECEPTOR | LEUKOCYTE RECEPTOR CLUSTER | CLASS-I MOLECULES | MYELOID CELLS | TRANSCRIPT-2 | FAMILY | Recombinant Proteins - metabolism | Humans | Fluorescent Dyes - metabolism | Male | Monocytes - metabolism | Tritium | Fluoresceins | Lymphoma, B-Cell - genetics | Lymphocyte Activation - immunology | Gene Deletion | Succinimides | Adjuvants, Immunologic - metabolism | Lymphoma, B-Cell - immunology | Adjuvants, Immunologic - genetics | Female | CD8-Positive T-Lymphocytes - immunology | Receptors, Immunologic - genetics | B-Lymphocytes - metabolism | Germany | Receptors, Immunologic - metabolism | Killer cells | Disease susceptibility | Genetic aspects | T cells | Risk factors | Blood donors | Cell proliferation | Sjogren's syndrome | Disease | CD8 antigen | Oncology | Lymphocytes T | Gene deletion | Medical schools | Interleukin 6 | Proteins | Immunology | Clonal deletion | Deletion | Interleukin 8 | Recombinant | Immune system | Antigens | Cytomegalovirus | Immunoglobulins | Immune response | Immunostimulation | Cytokines | Hematology | Dendritic cells | Incubation | Secretion | Rheumatology | Patients | Monocytes | Lymphocytes B | Interleukin 10 | Stem cells | Lymphomas
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16. Full Text IgG4-related sialadenitis: IgG4 is helpful, but biopsies are still crucial
by Witte, Torsten and Schulze-Koops, Hendrik
Arthritis Research and Therapy, ISSN 1478-6354, 12/2015, Volume 17, Issue 1, p. 368
IgG4-related disease is rare, but a frequent differential diagnosis for malignant and for autoimmune diseases. Li and colleagues report the largest cohort of... 
Diagnosis, Differential | Immunoglobulin G - blood | Biopsy | Humans | Sialadenitis - blood | Biomarkers - blood | Sialadenitis - diagnosis | Complications and side effects | Care and treatment | Usage | Immunoglobulin G | Pancreatitis | Development and progression | Influence | Research | Health aspects
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17. Full Text What is certain in the treatment of rheumatoid arthritis?
by Witte, T
INTERNIST, ISSN 0020-9554, 12/2018, Volume 59, Issue 12, pp. 1249 - 1254
Rheumatoid arthritis (RA) is the most important chronic inflammatory joint disease with a prevalence of 1%. When untreated the disease leads to joint... 
MEDICINE, GENERAL & INTERNAL | Early diagnosis | Disease modifying antirheumatic drugs | Biologics | Disease progression | JAK inhibitors | DISEASE-ACTIVITY | Arthritis, Rheumatoid - drug therapy | Humans | Germany | Antirheumatic Agents - therapeutic use | Biological Products - therapeutic use
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18. Full Text Antifodrin Antibodies
by Witte, Torsten
2014, 5
Autoimmunity | Autoantibodies | Systemic lupus erythematosus | Antibodies | Calcium binding proteins
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19. Full Text Leukocyte immunoglobulin-like receptors as new players in autoimmunity
by Thomas, Rachel and Matthias, Torsten and Witte, Torsten
Clinical Reviews in Allergy and Immunology, ISSN 1080-0549, 04/2010, Volume 38, Issue 2-3, pp. 159 - 162
Leukocyte immunoglobulin-like receptors (LILR) are a family of at least 13 receptors mainly expressed on lymphoid and myelomonocytic cells. They are involved... 
Autoimmunity | Immunoglobulin-like transcripts | Leukocyte immunoglobulin-like receptors | ILT2 | DENDRITIC CELLS | IMMUNOLOGY | HLA-G | CANCER | T-CELL RESPONSES | ALLERGY | CLASS-I | INHIBITORY RECEPTOR | ASSOCIATION | EXPRESSION | ANTIGEN | Humans | Autoimmune Diseases - immunology | Autoimmunity - genetics | Antigen Presentation - genetics | Antigen Presentation - immunology | Autoimmune Diseases - genetics | Lymphocyte Activation - genetics | Lymphocyte Activation - immunology | Animals | Autoimmunity - immunology | Myeloid Cells - immunology | Receptors, Immunologic - immunology | Receptors, Immunologic - genetics | Immunoglobulins | Systemic lupus erythematosus | T cells | Reviews | Immunoregulation | Data processing | Immunoglobulin-like receptors | Lymphocytes T | Leukocytes | Autoimmune diseases | Gene polymorphism | Immune system
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20. Full Text IgM Antibodies Against dsDNA in SLE
by Witte, Torsten
Clinical Reviews in Allergy & Immunology, ISSN 1080-0549, 6/2008, Volume 34, Issue 3, pp. 345 - 347
IgG antibodies against dsDNA are involved in the pathogenesis of systemic lupus erythematosus (SLE) glomerulonephritis. In contrast, glomerulonephritis is rare... 
Allergology | Glomerulonephritis | Immunology | Medicine & Public Health | Internal Medicine | SLE | Protective antibodies | IgM | dsDNA | AUTOANTIBODIES | SYSTEMIC-LUPUS-ERYTHEMATOSUS | COMPLEXES | REACTIVITY | protective antibodies | IMMUNOLOGY | DOUBLE-STRANDED DNA | ANTI-DNA ANTIBODIES | ALLERGY | ANTINUCLEOSOME ANTIBODIES | DISEASE | NEPHRITIS | glomerulonephritis | CLINICAL-SIGNIFICANCE | DNA - immunology | Immunoglobulin G - blood | Antibodies, Antinuclear - immunology | Humans | Antibodies, Monoclonal - therapeutic use | Lupus Nephritis - immunology | Immunoglobulin M - immunology | Immunoglobulin M - therapeutic use | Animals | Immunoglobulin M - blood | Immunoglobulin G - immunology | Antibodies, Antinuclear - blood | Lupus Erythematosus, Systemic - immunology | Lupus Erythematosus, Systemic - prevention & control | Mice | Antigen-Antibody Complex - immunology | Antibodies, Monoclonal - immunology | Lupus Nephritis - prevention & control | Lupus | Autoimmune diseases
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