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Journal of Molecular Medicine, ISSN 0946-2716, 03/2015, Volume 93, Issue 4, pp. 383 - 394
The NO/cGMP pathway plays an important role in many physiological functions and pathophysiological conditions. In the last few years, several genetic and... 
Nitrate-nitrite-NO pathway | Coronary artery disease (CAD) | Soluble guanylyl cyclase (sGC) | l-arginine-NOS pathway | Myocardial infarction (MI) | Nitric oxide (NO)/cyclic guanosine-3′,5′-monophosphate (cGMP) pathway | Nitric oxide synthases (NOS) | Phosphodiesterase 5 (PDE5) | MEDICINE, RESEARCH & EXPERIMENTAL | Nitric oxide (NO)/cyclic guanosine-3 ',5 '-monophosphate (cGMP) pathway | PULMONARY-HYPERTENSION | NITRIC-OXIDE SYNTHASE | GENE POLYMORPHISMS | BLOOD-PRESSURE | SOLUBLE GUANYLYL CYCLASE | CYCLIC-GMP | GENETICS & HEREDITY | L-arginine-NOS pathway | MOLECULAR-CLONING | ISCHEMIA-REPERFUSION | CORONARY-ARTERY-DISEASE | ERECTILE DYSFUNCTION | Myocardial Infarction - genetics | Signal Transduction | Humans | Guanylate Cyclase - metabolism | Soluble Guanylyl Cyclase | Receptors, Cytoplasmic and Nuclear - genetics | Myocardial Infarction - metabolism | Nitric Oxide Synthase Type III - genetics | Polymorphism, Genetic | Animals | Myocardial Infarction - drug therapy | Cyclic GMP - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 5 - genetics | Guanylate Cyclase - genetics | Mutation | Nitric Oxide Synthase Type III - metabolism | Nitric Oxide - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 5 - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism | Care and treatment | Nitric oxide | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Heart attack | Risk factors
Journal Article
Nitric Oxide, ISSN 1089-8603, 06/2018, Volume 76, pp. 105 - 112
In the past ten years, several chromosomal loci have been identified by genome-wide association studies to influence the risk of coronary artery disease (CAD)... 
PHOSPHODIESTERASE TYPE 3A | SOLUBLE GUANYLYL CYCLASE | SMOOTH-MUSCLE | MYOCARDIAL-INFARCTION | BLOOD-PRESSURE LOCI | PLATELET-AGGREGATION | NITRIC-OXIDE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROMOTER REGION | CORONARY-ARTERY-DISEASE | GENOME-WIDE ASSOCIATION | CELL BIOLOGY
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 05/2018, Volume 38, Issue Suppl_1
Journal Article
Circulation, ISSN 0009-7322, 11/2015, Volume 132, Issue Suppl_3 Suppl 3, pp. A15483 - A15483
IntroductionMyocardial infarction (MI) is the main complication of coronary artery disease (CAD). Recently, a locus tagging the GUCY1A3 gene has been shown to... 
Journal Article
Circulation, ISSN 0009-7322, 08/2017, Volume 136, Issue 5, pp. 476 - 489
BACKGROUND:A chromosomal locus at 4q32.1 has been genome-wide significantly associated with coronary artery disease risk. The locus encompasses GUCY1A3, which... 
Myocardial infarction | Genome-wide association studies | Nitric oxide | Soluble guanylyl cyclase | Genetics | Genotype | Coronary artery disease | coronary artery disease | CORNEAL-DYSTROPHY | nitric oxide | ASSOCIATION ANALYSIS | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCARDIAL-INFARCTION | myocardial infarction | ATHEROSCLEROSIS | genotype | genetics | soluble guanylyl cyclase | UCSC | PERIPHERAL VASCULAR DISEASE | MUTATIONS | HYPERTENSION | genome-wide association studies | GENOME BROWSER | Muscle, Smooth, Vascular - metabolism | Soluble Guanylyl Cyclase - metabolism | Humans | Zinc Finger E-box-Binding Homeobox 1 - antagonists & inhibitors | Risk | Genetic Loci | Nitroprusside - pharmacology | RNA, Messenger - metabolism | Zinc Finger E-box-Binding Homeobox 1 - genetics | Zinc Finger E-box-Binding Homeobox 1 - metabolism | Soluble Guanylyl Cyclase - genetics | RNA Interference | Coronary Artery Disease - pathology | HEK293 Cells | Platelet Aggregation - drug effects | Muscle, Smooth, Vascular - drug effects | Sildenafil Citrate - pharmacology | Cell Line | Promoter Regions, Genetic | Transcription Factors - genetics | Muscle, Smooth, Vascular - cytology | Transcription Factors - metabolism | Cell Movement - drug effects | Homozygote | Cyclic GMP - metabolism | Blood Platelets - metabolism | Alleles | Coronary Artery Disease - genetics | Polymorphism, Single Nucleotide | Nitric Oxide - metabolism | RNA, Small Interfering - metabolism | Research | Gene expression | Coronary heart disease | Risk factors | Atherosclerosis | GWAS | human
Journal Article
Circulation Journal, ISSN 1346-9843, 2015
Soluble guanylyl cyclase (sGC) is the physiological receptor for nitric oxide (NO) and NO-releasing drugs, and is a key enzyme in several cardiovascular... 
Molecular variants | Soluble guanylyl cyclase (sGC) | Cardiovascular disease | Nitric oxide (NO) | Cyclic guanosine-3’,5’-monophosphate (cGMP)
Journal Article
Journal Article
by Purps, Josephine and Siegert, Sabine and Willuweit, Sascha and Nagy, Marion and Alves, Cíntia and Salazar, Renato and Angustia, Sheila M.T and Santos, Lorna H and Anslinger, Katja and Bayer, Birgit and Ayub, Qasim and Wei, Wei and Xue, Yali and Tyler-Smith, Chris and Bafalluy, Miriam Baeta and Martínez-Jarreta, Begoña and Egyed, Balazs and Balitzki, Beate and Tschumi, Sibylle and Ballard, David and Court, Denise Syndercombe and Barrantes, Xinia and Bäßler, Gerhard and Wiest, Tina and Berger, Burkhard and Niederstätter, Harald and Parson, Walther and Davis, Carey and Budowle, Bruce and Burri, Helen and Borer, Urs and Koller, Christoph and Carvalho, Elizeu F and Domingues, Patricia M and Chamoun, Wafaa Takash and Coble, Michael D and Hill, Carolyn R and Corach, Daniel and Caputo, Mariela and D’Amato, Maria E and Davison, Sean and Decorte, Ronny and Larmuseau, Maarten H.D and Ottoni, Claudio and Rickards, Olga and Lu, Di and Jiang, Chengtao and Dobosz, Tadeusz and Jonkisz, Anna and Frank, William E and Furac, Ivana and Gehrig, Christian and Castella, Vincent and Grskovic, Branka and Haas, Cordula and Wobst, Jana and Hadzic, Gavrilo and Drobnic, Katja and Honda, Katsuya and Hou, Yiping and Zhou, Di and Li, Yan and Hu, Shengping and Chen, Shenglan and Immel, Uta-Dorothee and Lessig, Rüdiger and Jakovski, Zlatko and Ilievska, Tanja and Klann, Anja E and García, Cristina Cano and de Knijff, Peter and Kraaijenbrink, Thirsa and Kondili, Aikaterini and Miniati, Penelope and Vouropoulou, Maria and Kovacevic, Lejla and Marjanovic, Damir and Lindner, Iris and Mansour, Issam and Al-Azem, Mouayyad and Andari, Ansar El and Marino, Miguel and Furfuro, Sandra and Locarno, Laura and Martín, Pablo and Luque, Gracia M and Alonso, Antonio and Miranda, Luís Souto and Moreira, Helena and Mizuno, Natsuko and Iwashima, Yasuki and Neto, Rodrigo S. Moura and Nogueira, Tatiana L.S and Silva, Rosane and Nastainczyk-Wulf, Marina and Edelmann, Jeanett and Kohl, Michael and Nie, Shengjie and Wang, Xianping and Cheng, Baowen and ...
Forensic Science International: Genetics, ISSN 1872-4973, 2014, Volume 12, Issue 100, pp. 12 - 23
Abstract In a worldwide collaborative effort, 19,630 Y-chromosomes were sampled from 129 different populations in 51 countries. These chromosomes were typed... 
Pathology | Gene diversity | Discriminatory power | Database | Population structure | AMOVA | Haplotypes | Forensic Genetics | Chromosomes, Human, Y | Humans | Microsatellite Repeats | Alleles | SYSTEM | POPULATION | RECOMBINATION | EVENTS | MEDICINE, LEGAL | AZFA REGION | MARKERS | DELETION | ALLELE FREQUENCIES | SEQUENCE | GENETICS & HEREDITY | Index Medicus
Journal Article
Cardiovascular Research, ISSN 0008-6363, 08/2019, Volume 115, Issue 10, pp. 1512 - 1518
Journal Article
BMC Pharmacology and Toxicology, ISSN 2050-6511, 12/2015, Volume 16, Issue S1
Journal Article
by G. Todd Milne and on behalf of the Ironwood team and Peter Sandner and Kathleen A. Lincoln and Paul C. Harrison and Hongxing Chen and Hong Wang and Holly Clifford and Hu Sheng Qian and Diane Wong and Chris Sarko and Ryan Fryer and Jeremy Richman and Glenn A. Reinhart and Carine M. Boustany and Steven S. Pullen and Henriette Andresen and Lise Román Moltzau and Alessandro Cataliotti and Finn Olav Levy and Robert Lukowski and Sandra Frankenreiter and Andreas Friebe and Timothy Calamaras and Robert Baumgartner and Angela McLaughlin and Mark Aronovitz and Wendy Baur and Guang-Rong Wang and Navin Kapur and Richard Karas and Robert Blanton and Stefan Hell and Scott A. Waldman and Jieru E. Lin and Francheska Colon-Gonzalez and Gilbert W. Kim and Erik S. Blomain and Dante Merlino and Adam Snook and Jeanette Erdmann and Jana Wobst and Thorsten Kessler and Heribert Schunkert and Ulrich Walter and Oliver Pagel and Elena Walter and Stepan Gambaryan and Albert Smolenski and Kerstin Jurk and Rene Zahedi and James R. Klinger and Raymond L. Benza and Paul A. Corris and David Langleben and Robert Naeije and Gérald Simonneau and Christian Meier and Pablo Colorado and Mi Kyung Chang and Dennis Busse and Marius M. Hoeper and Jaime L. Masferrer and Sarah Jacobson and Guang Liu and Renee Sarno and Sylvie Bernier and Ping Zhang and G. Todd Milne and Roger Flores-Costa and Mark Currie and Katherine Hall and Dorit Möhrle and Katrin Reimann and Steffen Wolter and Markus Wolters and Evanthia Mergia and Nicole Eichert and Hyun-Soon Geisler and Peter Ruth and Andreas Friebe and Robert Feil and Ulrike Zimmermann and Doris Koesling and Marlies Knipper and Lukas Rüttiger and Yasutake Tanaka and Atsuko Okamoto and Takashi Nojiri and Motofumi Kumazoe and Takeshi Tokudome and Koichi Miura and Jun Hino and Hiroshi Hosoda and Mikiya Miyazato and Kenji Kangawa and Vikas Kapil and Amrita Ahluwalia and Nazareno Paolocci and Philip Eaton and ...
BMC Pharmacology and Toxicology, 10/2017, Volume 18, Issue S1, pp. 1 - 35
Journal Article
by Todd Milne, G and Sandner, Peter and Lincoln, Kathleen A and Harrison, Paul C and Chen, Hongxing and Wang, Hong and Clifford, Holly and Qian, Hu Sheng and Wong, Diane and Sarko, Chris and Fryer, Ryan and Richman, Jeremy and Reinhart, Glenn A and Boustany, Carine M and Pullen, Steven S and Andresen, Henriette and Moltzau, Lise Román and Cataliotti, Alessandro and Levy, Finn Olav and Lukowski, Robert and Frankenreiter, Sandra and Friebe, Andreas and Calamaras, Timothy and Baumgartner, Robert and McLaughlin, Angela and Aronovitz, Mark and Baur, Wendy and Wang, Guang-Rong and Kapur, Navin and Karas, Richard and Blanton, Robert and Hell, Stefan and Waldman, Scott A and Lin, Jieru E and Colon-Gonzalez, Francheska and Kim, Gilbert W and Blomain, Erik S and Merlino, Dante and Snook, Adam and Erdmann, Jeanette and Wobst, Jana and Kessler, Thorsten and Schunkert, Heribert and Walter, Ulrich and Pagel, Oliver and Walter, Elena and Gambaryan, Stepan and Smolenski, Albert and Jurk, Kerstin and Zahedi, Rene and Klinger, James R and Benza, Raymond L and Corris, Paul A and Langleben, David and Naeije, Robert and Simonneau, Gérald and Meier, Christian and Colorado, Pablo and Chang, Mi Kyung and Busse, Dennis and Hoeper, Marius M and Masferrer, Jaime L and Jacobson, Sarah and Liu, Guang and Sarno, Renee and Bernier, Sylvie and Zhang, Ping and Flores-Costa, Roger and Currie, Mark and Hall, Katherine and Möhrle, Dorit and Reimann, Katrin and Wolter, Steffen and Wolters, Markus and Mergia, Evanthia and Eichert, Nicole and Geisler, Hyun-Soon and Ruth, Peter and Feil, Robert and Zimmermann, Ulrike and Koesling, Doris and Knipper, Marlies and Rüttiger, Lukas and Tanaka, Yasutake and Okamoto, Atsuko and Nojiri, Takashi and Kumazoe, Motofumi and Tokudome, Takeshi and Miura, Koichi and Hino, Jun and Hosoda, Hiroshi and Miyazato, Mikiya and Kangawa, Kenji and Kapil, Vikas and Ahluwalia, Amrita and Paolocci, Nazareno and Eaton, Philip and Campbell, James C and Henning, Philipp and Franz, Eugen and ... and on behalf of the Ironwood team and RD-CURE consortium
BMC pharmacology & toxicology, ISSN 2050-6511, 10/2017, Volume 18, Issue Suppl 1, p. 64
Journal Article