Journal of Molecular Medicine, ISSN 0946-2716, 03/2015, Volume 93, Issue 4, pp. 383 - 394
The NO/cGMP pathway plays an important role in many physiological functions and pathophysiological conditions. In the last few years, several genetic and...
Nitrate-nitrite-NO pathway | Coronary artery disease (CAD) | Soluble guanylyl cyclase (sGC) | l-arginine-NOS pathway | Myocardial infarction (MI) | Nitric oxide (NO)/cyclic guanosine-3′,5′-monophosphate (cGMP) pathway | Nitric oxide synthases (NOS) | Phosphodiesterase 5 (PDE5) | MEDICINE, RESEARCH & EXPERIMENTAL | Nitric oxide (NO)/cyclic guanosine-3 ',5 '-monophosphate (cGMP) pathway | PULMONARY-HYPERTENSION | NITRIC-OXIDE SYNTHASE | GENE POLYMORPHISMS | BLOOD-PRESSURE | SOLUBLE GUANYLYL CYCLASE | CYCLIC-GMP | GENETICS & HEREDITY | L-arginine-NOS pathway | MOLECULAR-CLONING | ISCHEMIA-REPERFUSION | CORONARY-ARTERY-DISEASE | ERECTILE DYSFUNCTION | Myocardial Infarction - genetics | Signal Transduction | Humans | Guanylate Cyclase - metabolism | Soluble Guanylyl Cyclase | Receptors, Cytoplasmic and Nuclear - genetics | Myocardial Infarction - metabolism | Nitric Oxide Synthase Type III - genetics | Polymorphism, Genetic | Animals | Myocardial Infarction - drug therapy | Cyclic GMP - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 5 - genetics | Guanylate Cyclase - genetics | Mutation | Nitric Oxide Synthase Type III - metabolism | Nitric Oxide - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 5 - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism | Care and treatment | Nitric oxide | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Heart attack | Risk factors
Nitrate-nitrite-NO pathway | Coronary artery disease (CAD) | Soluble guanylyl cyclase (sGC) | l-arginine-NOS pathway | Myocardial infarction (MI) | Nitric oxide (NO)/cyclic guanosine-3′,5′-monophosphate (cGMP) pathway | Nitric oxide synthases (NOS) | Phosphodiesterase 5 (PDE5) | MEDICINE, RESEARCH & EXPERIMENTAL | Nitric oxide (NO)/cyclic guanosine-3 ',5 '-monophosphate (cGMP) pathway | PULMONARY-HYPERTENSION | NITRIC-OXIDE SYNTHASE | GENE POLYMORPHISMS | BLOOD-PRESSURE | SOLUBLE GUANYLYL CYCLASE | CYCLIC-GMP | GENETICS & HEREDITY | L-arginine-NOS pathway | MOLECULAR-CLONING | ISCHEMIA-REPERFUSION | CORONARY-ARTERY-DISEASE | ERECTILE DYSFUNCTION | Myocardial Infarction - genetics | Signal Transduction | Humans | Guanylate Cyclase - metabolism | Soluble Guanylyl Cyclase | Receptors, Cytoplasmic and Nuclear - genetics | Myocardial Infarction - metabolism | Nitric Oxide Synthase Type III - genetics | Polymorphism, Genetic | Animals | Myocardial Infarction - drug therapy | Cyclic GMP - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 5 - genetics | Guanylate Cyclase - genetics | Mutation | Nitric Oxide Synthase Type III - metabolism | Nitric Oxide - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 5 - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism | Care and treatment | Nitric oxide | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Heart attack | Risk factors
Journal Article
Nitric Oxide, ISSN 1089-8603, 06/2018, Volume 76, pp. 105 - 112
In the past ten years, several chromosomal loci have been identified by genome-wide association studies to influence the risk of coronary artery disease (CAD)...
PHOSPHODIESTERASE TYPE 3A | SOLUBLE GUANYLYL CYCLASE | SMOOTH-MUSCLE | MYOCARDIAL-INFARCTION | BLOOD-PRESSURE LOCI | PLATELET-AGGREGATION | NITRIC-OXIDE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROMOTER REGION | CORONARY-ARTERY-DISEASE | GENOME-WIDE ASSOCIATION | CELL BIOLOGY
PHOSPHODIESTERASE TYPE 3A | SOLUBLE GUANYLYL CYCLASE | SMOOTH-MUSCLE | MYOCARDIAL-INFARCTION | BLOOD-PRESSURE LOCI | PLATELET-AGGREGATION | NITRIC-OXIDE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROMOTER REGION | CORONARY-ARTERY-DISEASE | GENOME-WIDE ASSOCIATION | CELL BIOLOGY
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 05/2018, Volume 38, Issue Suppl_1
Journal Article
Basic Research in Cardiology, ISSN 0300-8428, 7/2016, Volume 111, Issue 4, pp. 1 - 13
Stimulators of the soluble guanylyl cyclase (sGC) are emerging therapeutic agents in cardiovascular diseases. Genetic alterations of the GUCY1A3 gene, which...
Myocardial infarction | Pharmacogenetics | Medicine & Public Health | Cardiology | Coronary artery disease | Soluble guanylyl cyclase | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCARDIAL-INFARCTION | RISK | ACTIVATORS | NITRIC-OXIDE RECEPTOR | RIOCIGUAT | CARDIOVASCULAR-DISEASE | HYPERTENSION | CORONARY-ARTERY-DISEASE | GENOME-WIDE ASSOCIATION | Coronary heart disease | Nitric oxide | Atherosclerosis
Myocardial infarction | Pharmacogenetics | Medicine & Public Health | Cardiology | Coronary artery disease | Soluble guanylyl cyclase | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCARDIAL-INFARCTION | RISK | ACTIVATORS | NITRIC-OXIDE RECEPTOR | RIOCIGUAT | CARDIOVASCULAR-DISEASE | HYPERTENSION | CORONARY-ARTERY-DISEASE | GENOME-WIDE ASSOCIATION | Coronary heart disease | Nitric oxide | Atherosclerosis
Journal Article
Circulation Journal, ISSN 1346-9843, 2015, Volume 79, Issue 3, pp. 463 - 469
Soluble guanylyl cyclase (sGC) is the physiological receptor for nitric oxide (NO) and NO-releasing drugs, and is a key enzyme in several cardiovascular...
Cardiovascular disease | Molecular variants | Soluble guanylyl cyclase (sGC) | Nitric oxide (NO) | Cyclic guanosine-3’,5’-monophosphate (cGMP) | ASSOCIATION ANALYSIS | CARDIAC & CARDIOVASCULAR SYSTEMS | NITRIC-OXIDE SYNTHASE | CRYSTAL-STRUCTURE | SUSCEPTIBILITY LOCI | Cyclic guanosine-3 ',5 '-monophosphate (cGMP) | CYCLIC-GMP | CATALYTIC DOMAINS | SMOOTH-MUSCLE RELAXATION | HEME-BINDING | CORONARY-ARTERY-DISEASE | BETA SUBUNIT | Humans | Guanylate Cyclase - metabolism | Soluble Guanylyl Cyclase | Receptors, Cytoplasmic and Nuclear - genetics | Cardiovascular Diseases - enzymology | Cardiovascular Diseases - pathology | Cardiovascular Diseases - genetics | Cyclic GMP-Dependent Protein Kinases - metabolism | Cyclic GMP-Dependent Protein Kinases - genetics | Animals | Cyclic GMP - metabolism | Nitric Oxide - genetics | Cyclic GMP - genetics | Guanylate Cyclase - genetics | Nitric Oxide - metabolism | Ion Channel Gating | Receptors, Cytoplasmic and Nuclear - metabolism
Cardiovascular disease | Molecular variants | Soluble guanylyl cyclase (sGC) | Nitric oxide (NO) | Cyclic guanosine-3’,5’-monophosphate (cGMP) | ASSOCIATION ANALYSIS | CARDIAC & CARDIOVASCULAR SYSTEMS | NITRIC-OXIDE SYNTHASE | CRYSTAL-STRUCTURE | SUSCEPTIBILITY LOCI | Cyclic guanosine-3 ',5 '-monophosphate (cGMP) | CYCLIC-GMP | CATALYTIC DOMAINS | SMOOTH-MUSCLE RELAXATION | HEME-BINDING | CORONARY-ARTERY-DISEASE | BETA SUBUNIT | Humans | Guanylate Cyclase - metabolism | Soluble Guanylyl Cyclase | Receptors, Cytoplasmic and Nuclear - genetics | Cardiovascular Diseases - enzymology | Cardiovascular Diseases - pathology | Cardiovascular Diseases - genetics | Cyclic GMP-Dependent Protein Kinases - metabolism | Cyclic GMP-Dependent Protein Kinases - genetics | Animals | Cyclic GMP - metabolism | Nitric Oxide - genetics | Cyclic GMP - genetics | Guanylate Cyclase - genetics | Nitric Oxide - metabolism | Ion Channel Gating | Receptors, Cytoplasmic and Nuclear - metabolism
Journal Article
Circulation, ISSN 0009-7322, 11/2015, Volume 132, Issue Suppl_3 Suppl 3, pp. A15483 - A15483
IntroductionMyocardial infarction (MI) is the main complication of coronary artery disease (CAD). Recently, a locus tagging the GUCY1A3 gene has been shown to...
Journal Article
Circulation, ISSN 0009-7322, 11/2015, Volume 132, Issue 19
Journal Article
Circulation, ISSN 0009-7322, 08/2017, Volume 136, Issue 5, pp. 476 - 489
BACKGROUND:A chromosomal locus at 4q32.1 has been genome-wide significantly associated with coronary artery disease risk. The locus encompasses GUCY1A3, which...
Myocardial infarction | Genome-wide association studies | Nitric oxide | Soluble guanylyl cyclase | Genetics | Genotype | Coronary artery disease | coronary artery disease | CORNEAL-DYSTROPHY | nitric oxide | ASSOCIATION ANALYSIS | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCARDIAL-INFARCTION | myocardial infarction | ATHEROSCLEROSIS | genotype | genetics | soluble guanylyl cyclase | UCSC | PERIPHERAL VASCULAR DISEASE | MUTATIONS | HYPERTENSION | genome-wide association studies | GENOME BROWSER | Muscle, Smooth, Vascular - metabolism | Soluble Guanylyl Cyclase - metabolism | Humans | Zinc Finger E-box-Binding Homeobox 1 - antagonists & inhibitors | Risk | Genetic Loci | Nitroprusside - pharmacology | RNA, Messenger - metabolism | Zinc Finger E-box-Binding Homeobox 1 - genetics | Zinc Finger E-box-Binding Homeobox 1 - metabolism | Soluble Guanylyl Cyclase - genetics | RNA Interference | Coronary Artery Disease - pathology | HEK293 Cells | Platelet Aggregation - drug effects | Muscle, Smooth, Vascular - drug effects | Sildenafil Citrate - pharmacology | Cell Line | Promoter Regions, Genetic | Transcription Factors - genetics | Muscle, Smooth, Vascular - cytology | Transcription Factors - metabolism | Cell Movement - drug effects | Homozygote | Cyclic GMP - metabolism | Blood Platelets - metabolism | Alleles | Coronary Artery Disease - genetics | Polymorphism, Single Nucleotide | Nitric Oxide - metabolism | RNA, Small Interfering - metabolism | Research | Gene expression | Coronary heart disease | Risk factors | Atherosclerosis | GWAS | human
Myocardial infarction | Genome-wide association studies | Nitric oxide | Soluble guanylyl cyclase | Genetics | Genotype | Coronary artery disease | coronary artery disease | CORNEAL-DYSTROPHY | nitric oxide | ASSOCIATION ANALYSIS | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCARDIAL-INFARCTION | myocardial infarction | ATHEROSCLEROSIS | genotype | genetics | soluble guanylyl cyclase | UCSC | PERIPHERAL VASCULAR DISEASE | MUTATIONS | HYPERTENSION | genome-wide association studies | GENOME BROWSER | Muscle, Smooth, Vascular - metabolism | Soluble Guanylyl Cyclase - metabolism | Humans | Zinc Finger E-box-Binding Homeobox 1 - antagonists & inhibitors | Risk | Genetic Loci | Nitroprusside - pharmacology | RNA, Messenger - metabolism | Zinc Finger E-box-Binding Homeobox 1 - genetics | Zinc Finger E-box-Binding Homeobox 1 - metabolism | Soluble Guanylyl Cyclase - genetics | RNA Interference | Coronary Artery Disease - pathology | HEK293 Cells | Platelet Aggregation - drug effects | Muscle, Smooth, Vascular - drug effects | Sildenafil Citrate - pharmacology | Cell Line | Promoter Regions, Genetic | Transcription Factors - genetics | Muscle, Smooth, Vascular - cytology | Transcription Factors - metabolism | Cell Movement - drug effects | Homozygote | Cyclic GMP - metabolism | Blood Platelets - metabolism | Alleles | Coronary Artery Disease - genetics | Polymorphism, Single Nucleotide | Nitric Oxide - metabolism | RNA, Small Interfering - metabolism | Research | Gene expression | Coronary heart disease | Risk factors | Atherosclerosis | GWAS | human
Journal Article
Circulation Journal, ISSN 1346-9843, 2015
Soluble guanylyl cyclase (sGC) is the physiological receptor for nitric oxide (NO) and NO-releasing drugs, and is a key enzyme in several cardiovascular...
Molecular variants | Soluble guanylyl cyclase (sGC) | Cardiovascular disease | Nitric oxide (NO) | Cyclic guanosine-3’,5’-monophosphate (cGMP)
Molecular variants | Soluble guanylyl cyclase (sGC) | Cardiovascular disease | Nitric oxide (NO) | Cyclic guanosine-3’,5’-monophosphate (cGMP)
Journal Article
Nitric Oxide, ISSN 1089-8603, 04/2017, Volume 64, pp. 7 - 15
Beetroot has a high concentration of inorganic nitrate, which can serially reduced to form nitrite and nitric oxide (NO) after oral ingestion. Increased renal...
Beetroot | Dietary nitrate | Cardiovascular disease | Renal resistive index | Chronic kidney disease | Blood pressure | VIVO ISCHEMIA-REPERFUSION | ISCHEMIA/REPERFUSION INJURY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CORONARY HEART-DISEASE | HYPERTENSIVE PATIENTS | CELL BIOLOGY | ALL-CAUSE | IN-VIVO | NITRIC-OXIDE | CARDIOVASCULAR-DISEASE | VEGETABLE INTAKE | INORGANIC NITRATE | Kidney - drug effects | Plant Extracts - pharmacology | Humans | Nitrates - pharmacology | Male | Beta vulgaris | Renal Insufficiency, Chronic - metabolism | Kidney - metabolism | Pilot Projects | Female | Aged | Blood Pressure - drug effects | Dietary Supplements | Hypertension | Medical research | Ultrasound imaging | Mortality | Diabetic nephropathies | Dietary supplements | Development and progression | Diagnostic imaging | Diet therapy | Chronic kidney failure | Nitric oxide | Medicine, Experimental
Beetroot | Dietary nitrate | Cardiovascular disease | Renal resistive index | Chronic kidney disease | Blood pressure | VIVO ISCHEMIA-REPERFUSION | ISCHEMIA/REPERFUSION INJURY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CORONARY HEART-DISEASE | HYPERTENSIVE PATIENTS | CELL BIOLOGY | ALL-CAUSE | IN-VIVO | NITRIC-OXIDE | CARDIOVASCULAR-DISEASE | VEGETABLE INTAKE | INORGANIC NITRATE | Kidney - drug effects | Plant Extracts - pharmacology | Humans | Nitrates - pharmacology | Male | Beta vulgaris | Renal Insufficiency, Chronic - metabolism | Kidney - metabolism | Pilot Projects | Female | Aged | Blood Pressure - drug effects | Dietary Supplements | Hypertension | Medical research | Ultrasound imaging | Mortality | Diabetic nephropathies | Dietary supplements | Development and progression | Diagnostic imaging | Diet therapy | Chronic kidney failure | Nitric oxide | Medicine, Experimental
Journal Article
Forensic Science International: Genetics, ISSN 1872-4973, 2014, Volume 12, Issue 100, pp. 12 - 23
Abstract In a worldwide collaborative effort, 19,630 Y-chromosomes were sampled from 129 different populations in 51 countries. These chromosomes were typed...
Pathology | Gene diversity | Discriminatory power | Database | Population structure | AMOVA | Haplotypes | Forensic Genetics | Chromosomes, Human, Y | Humans | Microsatellite Repeats | Alleles | SYSTEM | POPULATION | RECOMBINATION | EVENTS | MEDICINE, LEGAL | AZFA REGION | MARKERS | DELETION | ALLELE FREQUENCIES | SEQUENCE | GENETICS & HEREDITY | Index Medicus
Pathology | Gene diversity | Discriminatory power | Database | Population structure | AMOVA | Haplotypes | Forensic Genetics | Chromosomes, Human, Y | Humans | Microsatellite Repeats | Alleles | SYSTEM | POPULATION | RECOMBINATION | EVENTS | MEDICINE, LEGAL | AZFA REGION | MARKERS | DELETION | ALLELE FREQUENCIES | SEQUENCE | GENETICS & HEREDITY | Index Medicus
Journal Article
Cardiovascular Research, ISSN 0008-6363, 08/2019, Volume 115, Issue 10, pp. 1512 - 1518
Abstract Aim A common genetic variant at the GUCY1A3 coronary artery disease locus has been shown to influence platelet aggregation. The risk of ischaemic...
Genome-wide association studies | CARDIAC & CARDIOVASCULAR SYSTEMS | TICAGRELOR | Genetic variation | PLATELET-AGGREGATION | On-aspirin platelet reactivity | Platelet aggregation | Stent thrombosis | ASPIRIN | CLOPIDOGREL | INHIBITION | NITRIC-OXIDE | CGMP | Kardiologi | Clinical Medicine | Cardiac and Cardiovascular Systems | Medical and Health Sciences | Medicin och hälsovetenskap | Klinisk medicin
Genome-wide association studies | CARDIAC & CARDIOVASCULAR SYSTEMS | TICAGRELOR | Genetic variation | PLATELET-AGGREGATION | On-aspirin platelet reactivity | Platelet aggregation | Stent thrombosis | ASPIRIN | CLOPIDOGREL | INHIBITION | NITRIC-OXIDE | CGMP | Kardiologi | Clinical Medicine | Cardiac and Cardiovascular Systems | Medical and Health Sciences | Medicin och hälsovetenskap | Klinisk medicin
Journal Article
BMC Pharmacology and Toxicology, ISSN 2050-6511, 12/2015, Volume 16, Issue S1
Journal Article
BMC Pharmacology and Toxicology, 10/2017, Volume 18, Issue S1, pp. 1 - 35
Journal Article
BMC Pharmacology and Toxicology, ISSN 2050-6511, 12/2015, Volume 16, Issue S1
Journal Article
Basic research in cardiology, 07/2016, Volume 111, Issue 4, p. 51
Stimulators of the soluble guanylyl cyclase (sGC) are emerging therapeutic agents in cardiovascular diseases. Genetic alterations of the GUCY1A3 gene, which...
Genetic Predisposition to Disease - genetics | Immunoprecipitation | Soluble Guanylyl Cyclase - metabolism | Humans | Middle Aged | Immunoblotting | Mutation, Missense | Young Adult | Animals | Soluble Guanylyl Cyclase - genetics | Radioimmunoassay | Coronary Artery Disease - genetics | Cyclic GMP - genetics | HEK293 Cells | Polymerase Chain Reaction | Adult | Mice | Polymorphism, Single Nucleotide | Pyridines - pharmacology | Cyclic GMP - biosynthesis | Pyrazoles - pharmacology
Genetic Predisposition to Disease - genetics | Immunoprecipitation | Soluble Guanylyl Cyclase - metabolism | Humans | Middle Aged | Immunoblotting | Mutation, Missense | Young Adult | Animals | Soluble Guanylyl Cyclase - genetics | Radioimmunoassay | Coronary Artery Disease - genetics | Cyclic GMP - genetics | HEK293 Cells | Polymerase Chain Reaction | Adult | Mice | Polymorphism, Single Nucleotide | Pyridines - pharmacology | Cyclic GMP - biosynthesis | Pyrazoles - pharmacology
Journal Article
BMC pharmacology & toxicology, ISSN 2050-6511, 10/2017, Volume 18, Issue Suppl 1, p. 64
Journal Article