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Nature Structural and Molecular Biology, ISSN 1545-9993, 09/2011, Volume 18, Issue 9, pp. 990 - 998
Journal Article
Molecular Cell, ISSN 1097-2765, 03/2015, Volume 57, Issue 6, pp. 1074 - 1087
The eIF4E-binding proteins (4E-BPs) represent a diverse class of translation inhibitors that are often deregulated in cancer cells. 4E-BPs inhibit translation... 
STRUCTURAL INSIGHTS | COMPLEX | MECHANISM | PHOSPHORYLATION | MESSENGER-RNA CAP | BIOCHEMISTRY & MOLECULAR BIOLOGY | FACTOR 4E | INITIATION-FACTOR EIF4E | REPRESSOR 4E-BP2 | 4E-BINDING PROTEIN | REVEALS | CELL BIOLOGY | Adaptor Proteins, Signal Transducing - chemistry | Phosphorylation | Humans | Eukaryotic Initiation Factor-4E - metabolism | Crystallography, X-Ray | Intracellular Signaling Peptides and Proteins - metabolism | Eukaryotic Initiation Factor-4G - metabolism | Drosophila Proteins - metabolism | Phosphoproteins - metabolism | Phosphoproteins - chemistry | Peptide Initiation Factors - chemistry | Molecular Mimicry | Carrier Proteins - chemistry | Binding Sites | Intracellular Signaling Peptides and Proteins - genetics | Binding, Competitive | Recombinant Proteins - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Drosophila Proteins - chemistry | Amino Acid Motifs | Peptide Initiation Factors - metabolism | Carrier Proteins - genetics | Peptide Initiation Factors - genetics | Eukaryotic Initiation Factor-4E - chemistry | Animals | Carrier Proteins - metabolism | Intracellular Signaling Peptides and Proteins - chemistry | Protein Conformation | Eukaryotic Initiation Factor-4G - chemistry | Drosophila Proteins - genetics | Adaptor Proteins, Signal Transducing - metabolism | Binding proteins | Protein binding | Developmental biology | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 11/2016, Volume 64, Issue 3, pp. 467 - 479
Eukaryotic initiation factor 4G (eIF4G) plays a central role in translation initiation through its interactions with the cap-binding protein eIF4E. This... 
translational inhibitors | translation initiation | translational regulation | protein-protein interaction | eIF4F | 4E-BP | BIPARTITE | DOMAIN | DISSOCIATING EIF4G | MECHANISM | REPRESSION | CAP-DEPENDENT TRANSLATION | MESSENGER-RNA CAP | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING PROTEIN EIF4E | MOTIF | CELL BIOLOGY | Humans | Eukaryotic Initiation Factor-4E - metabolism | Crystallography, X-Ray | Peptide Chain Initiation, Translational | Eukaryotic Initiation Factor-4G - metabolism | Drosophila melanogaster - genetics | Drosophila melanogaster - metabolism | Thermodynamics | Cloning, Molecular | Escherichia coli - metabolism | Protein Interaction Domains and Motifs | Binding Sites | Eukaryotic Initiation Factor-4E - genetics | Recombinant Proteins - metabolism | Amino Acid Sequence | Protein Conformation, alpha-Helical | Gene Expression | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Sequence Homology, Amino Acid | Eukaryotic Initiation Factor-4E - chemistry | Sequence Alignment | Animals | Protein Conformation, beta-Strand | Escherichia coli - genetics | Protein Binding | Eukaryotic Initiation Factor-4G - chemistry | Eukaryotic Initiation Factor-4G - genetics | Kinetics | Mutation | Developmental biology | Analysis | Crystals | Binding proteins | Structure | Genetic translation | Protein binding | Index Medicus
Journal Article
Nucleic acids research, ISSN 0305-1048, 07/2019
XRN1 is the major cytoplasmic exoribonuclease in eukaryotes, which degrades deadenylated and decapped mRNAs in the last step of the 5'-3' mRNA decay pathway.... 
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