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1. Full Text Oral fingolimod in primary progressive multiple sclerosis (INFORMS): a phase 3, randomised, double-blind, placebo-controlled trial
by Lublin, Fred, Prof and Miller, David H, Prof and Freedman, Mark S, Prof and Cree, Bruce A C, Prof and Wolinsky, Jerry S, Prof and Weiner, Howard, Prof and Lubetzki, Catherine, Prof and Hartung, Hans-Peter, Prof and Montalban, Xavier, Prof and Uitdehaag, Bernard M J, Prof and Merschhemke, Martin, MD and Li, Bingbing, PhD and Putzki, Norman, MD and Liu, Fonda C, PharmD and Häring, Dieter A, PhD and Kappos, Ludwig, Prof and INFORMS study investigators and INFORMS Study Investigators
The Lancet (British edition), ISSN 0140-6736, 03/2016, Volume 387, Issue 10023, pp. 1075 - 1084
Internal Medicine | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Double-Blind Method | Administration, Oral | Humans | Middle Aged | Male | Treatment Outcome | Disease Progression | Dose-Response Relationship, Drug | Young Adult | Adolescent | Adult | Female | Aged | Multiple Sclerosis, Chronic Progressive - drug therapy | Immunosuppressive Agents - administration & dosage | Fingolimod Hydrochloride - administration & dosage | Phosphates | Clinical trials | Medical colleges | Multiple sclerosis | Research institutes | Sphingosine | Studies | Drug therapy | Neurodegeneration | Clinical outcomes | Index Medicus | Abridged Index Medicus
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2. Full Text Ocrelizumab versus Placebo in Primary Progressive Multiple Sclerosis
by Montalban, Xavier and Hauser, Stephen L and Kappos, Ludwig and Arnold, Douglas L and Bar-Or, Amit and Comi, Giancarlo and de Seze, Jérôme and Giovannoni, Gavin and Hartung, Hans-Peter and Hemmer, Bernhard and Lublin, Fred and Rammohan, Kottil W and Selmaj, Krzysztof and Traboulsee, Anthony and Sauter, Annette and Masterman, Donna and Fontoura, Paulo and Belachew, Shibeshih and Garren, Hideki and Mairon, Nicole and Chin, Peter and Wolinsky, Jerry S and ORATORIO Clinical Investigators
The New England journal of medicine, ISSN 0028-4793, 01/2017, Volume 376, Issue 3, pp. 209 - 220
CD20 | MULTICENTER TRIAL | DEMYELINATION | DOUBLE-BLIND | CANCER-RISK | ANTIBODY | PATHOLOGY | DAMAGE | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Antibodies, Monoclonal, Humanized - adverse effects | Brain - diagnostic imaging | Antibodies, Monoclonal, Humanized - therapeutic use | Antigens, CD20 | Double-Blind Method | Multiple Sclerosis, Chronic Progressive - immunology | T-Lymphocytes | Humans | Middle Aged | Male | Disease Progression | Young Adult | Magnetic Resonance Imaging | B-Lymphocytes - immunology | Adolescent | Infusions, Intravenous - adverse effects | Intention to Treat Analysis | Lymphocyte Count | Adult | Female | Multiple Sclerosis, Chronic Progressive - drug therapy | Neuroimaging | Multiple sclerosis | Intravenous administration | Pathogenesis | Clinical trials | Patients | Placebo effect | Magnetic resonance imaging | Lymphocytes B | Lymphocytes | Immunotherapy | Immunopathogenesis | Monoclonal antibodies | CD20 antigen | Respiratory tract diseases | Index Medicus | Abridged Index Medicus | Life Sciences | Human health and pathology
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3. Full Text Oral teriflunomide for patients with relapsing multiple sclerosis (TOWER): a randomised, double-blind, placebo-controlled, phase 3 trial
by Confavreux, Christian, Prof and O'Connor, Paul, Prof and Comi, Giancarlo, Prof and Freedman, Mark S, Prof and Miller, Aaron E, Prof and Olsson, Tomas P, Prof and Wolinsky, Jerry S, Prof and Bagulho, Teresa, MD and Delhay, Jean-Luc, MD and Dukovic, Deborah, MS and Truffinet, Philippe, MD and Kappos, Ludwig, Prof and for the TOWER Trial Group and TOWER Trial Grp and TOWER Trial Group
Lancet neurology, ISSN 1474-4422, 2014, Volume 13, Issue 3, pp. 247 - 256
Neurology | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Double-Blind Method | Administration, Oral | Multiple Sclerosis, Relapsing-Remitting - drug therapy | Humans | Middle Aged | Male | Treatment Outcome | Multiple Sclerosis, Relapsing-Remitting - diagnosis | Toluidines - administration & dosage | Multiple Sclerosis, Relapsing-Remitting - epidemiology | Adult | Female | Crotonates - administration & dosage | Clinical trials | Medical colleges | Multiple sclerosis | Care and treatment | Voice recognition | Patient safety | Disease | Drug therapy | Drug dosages | Index Medicus | Medicin och hälsovetenskap
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4. Full Text Disability outcome measures in multiple sclerosis clinical trials: current status and future prospects
by Cohen, Jeffrey A, Prof and Reingold, Stephen C, PhD and Polman, Chris H, Prof and Wolinsky, Jerry S, Prof and for the International Advisory Committee on Clinical Trials in Multiple Sclerosis and Int Advisory Comm Clinical Trial and International Advisory Committee on Clinical Trials in Multiple Sclerosis
Lancet neurology, ISSN 1474-4422, 2012, Volume 11, Issue 5, pp. 467 - 476
Neurology | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Disability Evaluation | Retina - drug effects | Multiple Sclerosis - diagnosis | Tomography, Optical Coherence | Humans | Disease Progression | Randomized Controlled Trials as Topic | Brain - drug effects | Magnetic Resonance Imaging | Activities of Daily Living - classification | Neurologic Examination | Biomarkers | Brain - pathology | Retina - pathology | Multiple Sclerosis - drug therapy | Measurement | Clinical trials | Multiple sclerosis | Data processing | biomarkers | Quality of life | Index Medicus
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5. Full Text Patient selection for trials
by Wolinsky, Jerry S
Multiple sclerosis, ISSN 1352-4585, 10/2017, Volume 23, Issue 12, pp. 1636 - 1641
progression | phenotypes | outcomes research | primary progressive multiple sclerosis | efficacy | Trial design | Neuroprotective Agents - therapeutic use | Clinical Trials as Topic | Multiple Sclerosis, Chronic Progressive - drug therapy | Humans | Patient Selection | Clinical trials | Neuroprotection | Multiple sclerosis | Index Medicus
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6. Full Text Oral teriflunomide for patients with a first clinical episode suggestive of multiple sclerosis (TOPIC): a randomised, double-blind, placebo-controlled, phase 3 trial
by Miller, Aaron E, Prof and Wolinsky, Jerry S, Prof and Kappos, Ludwig, MD and Comi, Giancarlo, Prof and Freedman, Mark S, Prof and Olsson, Tomas P, Prof and Bauer, Deborah, MS and Benamor, Myriam, MD and Truffinet, Philippe, MD and O'Connor, Paul W, Prof and for the TOPIC Study Group and TOPIC Study Grp and TOPIC Study Group
Lancet neurology, ISSN 1474-4422, 2014, Volume 13, Issue 10, pp. 977 - 986
Neurology | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Humans | Middle Aged | Male | Alanine Transaminase - blood | Toluidines - administration & dosage | Dose-Response Relationship, Drug | Young Adult | Endpoint Determination | Adult | Female | Crotonates - administration & dosage | Toluidines - therapeutic use | Double-Blind Method | Immunologic Factors - administration & dosage | Proportional Hazards Models | Treatment Outcome | Toluidines - adverse effects | Magnetic Resonance Imaging | Crotonates - therapeutic use | Aspartate Aminotransferases - blood | Adolescent | Immunologic Factors - adverse effects | Crotonates - adverse effects | Immunologic Factors - therapeutic use | Multiple Sclerosis - drug therapy | Clinical trials | Medical colleges | Multiple sclerosis | Care and treatment | Spinal cord | Disease | Drug therapy | Patients | Index Medicus | Medicin och hälsovetenskap
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7. Full Text Ocrelizumab versus Interferon Beta-1a in Relapsing Multiple Sclerosis
by Hauser, Stephen L and Bar-Or, Amit and Comi, Giancarlo and Giovannoni, Gavin and Hartung, Hans-Peter and Hemmer, Bernhard and Lublin, Fred and Montalban, Xavier and Rammohan, Kottil W and Selmaj, Krzysztof and Traboulsee, Anthony and Wolinsky, Jerry S and Arnold, Douglas L and Klingelschmitt, Gaelle and Masterman, Donna and Fontoura, Paulo and Belachew, Shibeshih and Chin, Peter and Mairon, Nicole and Garren, Hideki and Kappos, Ludwig and OPERA I OPERA II Clinical and OPERA I and OPERA II Clinical Investigators
The New England journal of medicine, ISSN 0028-4793, 01/2017, Volume 376, Issue 3, pp. 221 - 234
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Antibodies, Monoclonal, Humanized - adverse effects | Recurrence | Brain - diagnostic imaging | Antibodies, Monoclonal, Humanized - therapeutic use | Antigens, CD20 | Multiple Sclerosis, Relapsing-Remitting - drug therapy | Humans | Middle Aged | Male | Disease Progression | Interferon-beta - therapeutic use | Magnetic Resonance Imaging | B-Lymphocytes - immunology | Interferon-beta - adverse effects | Multiple Sclerosis, Relapsing-Remitting - diagnostic imaging | Infusions, Intravenous - adverse effects | Adult | Female | Immunologic Factors - adverse effects | Immunologic Factors - therapeutic use | Multiple sclerosis | Intravenous administration | Lymphocytes B | Lymphocytes | β-Interferon | Immunotherapy | Clinical trials | Monoclonal antibodies | CD20 antigen | Gadolinium | Cognition | Interferon | Index Medicus | Abridged Index Medicus | Medicin och hälsovetenskap
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8. Full Text Diagnostic Criteria for Multiple Sclerosis: 2010 Revisions to the McDonald Criteria
by Polman, C.H and Reingold, S.C and Banwell, B and Clanet, M and Cohen, J.A and Filippi, M and Fujihara, K and Havrdova, E and Hutchinson, M and Kappos, L and Lublin, F.D and Montalban, X and O'Connor, P and Sandberg-Wollheim, M and Thompson, A.J and Waubant, E and Weinshenker, B and Wolinsky, J.S
Annals of neurology, ISSN 0364-5134, 2011, Volume 69, Issue 2, pp. 292 - 302
Neurosciences | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Neurology | Biological and medical sciences | Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis | Medical sciences | Magnetic Resonance Imaging | Multiple Sclerosis - diagnosis | Early Diagnosis | Humans | Sensitivity and Specificity | Revisions | Multiple sclerosis | Older people | Index Medicus | Rapid Communication | Neurologi | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
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