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Proceedings of the National Academy of Sciences, USA, ISSN 0027-8424, 03/2015, Volume 112, Issue 11, pp. 3344 - 3344
Aberrant cleavage of amyloid precursor protein (APP) by gamma -secretase contributes to the development of Alzheimer's disease. More than 200 disease-derived... 
Journal Article
细胞研究:英文版, ISSN 1001-0602, 2017, Volume 27, Issue 4, pp. 540 - 558
ExtraceUular signals have been shown to impact on alternative pre-mRNA splicing; however, the molecular mech- anisms and biological significance of... 
Journal Article
Journal Article
Chemical Science, ISSN 2041-6520, 07/2015, Volume 6, Issue 10, pp. 5400 - 5408
Bromodomain-containing protein 4 (BRD4) has recently emerged as an attractive epigenetic target for anticancer therapy. In this study, an iridium(III) complex... 
DRUG | CHROMATIN | TARGETS | CELL-CYCLE | BROMODOMAIN | CANCER | EXPRESSION | CHEMISTRY, MULTIDISCIPLINARY | METAL-COMPLEXES | DISCOVERY | RUTHENIUM(III) COMPLEXES | Proteins | Inhibitors | Chips | Histones | Coordination compounds | Scaffolds | Anticancer properties | Cancer
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2012, Volume 109, Issue 38, pp. 15461 - 15466
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2013, Volume 110, Issue 47, pp. 18750 - 18750
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 04/2017, Volume 8, Issue 1, p. 14929
Mammalian shelterin proteins POT1 and TPP1 form a stable heterodimer that protects chromosome ends and regulates telomerase-mediated telomere extension.... 
SYSTEM | HUMAN-CHROMOSOMES | COMPLEX | PROTECTION | SPECIFICITY | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | TELOMERE PROTEIN TPP1 | DYSFUNCTION | END-BINDING-PROTEIN | PREDISPOSE
Journal Article
PLoS Genetics, ISSN 1553-7390, 02/2013, Volume 9, Issue 2, p. e1003277
Journal Article
Cell Metabolism, ISSN 1550-4131, 05/2012, Volume 15, Issue 5, pp. 739 - 751
Journal Article