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JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 03/2009, Volume 52, Issue 6, pp. 1522 - 1524
In this communication, we report the discovery of IS (apremilast), a novel potent and orally active phosphodiesterase 4 (PDE4) and tumor necrosis factor-alpha... 
OBSTRUCTIVE PULMONARY-DISEASE | CHEMISTRY, MEDICINAL | ANALOGS | PDE4 INHIBITION | ASTHMA | ROFLUMILAST | PSORIASIS
Journal Article
Journal of Immunology, ISSN 0022-1767, 07/1999, Volume 163, Issue 1, pp. 380 - 386
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2008, Volume 51, Issue 20, pp. 6271 - 6279
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2012, Volume 7, Issue 7, pp. e42124 - e42124
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 1999, Volume 9, Issue 11, pp. 1625 - 1630
Thalidomide, (1), is a known inhibitor of TNF-α release in LPS stimulated human PBMC. Herein we describe the TNF-α inhibitory activity of amino substituted... 
Thalidomide - analogs & derivatives | Thalidomide - chemical synthesis | Models, Chemical | U937 Cells | Humans | Blood - drug effects | Inhibitory Concentration 50 | Structure-Activity Relationship | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Index Medicus | AIDS/HIV
Journal Article
Neonatology, ISSN 1661-7800, 11/2017, Volume 112, Issue 4, pp. I - IV
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2010, Volume 53, Issue 17, pp. 6398 - 6411
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2010, Volume 20, Issue 5, pp. 1680 - 1684
A novel class of pyrazolopyridazine p38α mitogen-activated protein kinase (MAPK) inhibitors is disclosed. A structure activity relationship (SAR) investigation... 
MAP kinase | Pyrazolopyridazine | p38 | TNF | RHEUMATOID-ARTHRITIS | HALIDES | CHEMISTRY, MEDICINAL | DISEASES | ROLES | CHEMISTRY, ORGANIC | DISCOVERY | P38 MAP KINASE
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2008, Volume 51, Issue 20, pp. 6280 - 6292
The p38 mitogen-activated protein kinase (MAPK) is a central signaling molecule in many proinflammatory pathways, regulating the cellular response to a... 
RHEUMATOID-ARTHRITIS | TUMOR-NECROSIS-FACTOR | CYTOKINES | 1,2-BENZISOTHIAZOLES | DOMAIN | CHEMISTRY, MEDICINAL | 7-SUBSTITUTED BENZOTHIOPHENES | DERIVATIVES | PSORIASIS | P38 MAP KINASE | PREDICTION
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2009, Volume 19, Issue 16, pp. 4724 - 4728
A novel class of fused pyrazole-derived inhibitors of p38α mitogen-activated protein kinase (MAPK) is disclosed. These inhibitors were evaluated for their... 
MAP kinase | Pyrazolopyridinone | p38 | TNF | RHEUMATOID-ARTHRITIS | HALIDES | CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC | IDENTIFICATION | DISCOVERY | P38 MAP KINASE | DISEASES | ROLES | AGENTS | SCAFFOLD
Journal Article
Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 03/2010, Volume 20, Issue 5, pp. 1680 - 1684
A novel class of pyrazolopyridazine p38a mitogen-activated protein kinase (MAPK) inhibitors is disclosed. A structure activity relationship (SAR) investigation... 
Journal Article
Journal Article
by Klionsky, Daniel J and Abdelmohsen, Kotb and Abe, Akihisa and Abedin, Md Joynal and Abeliovich, Hagai and Acevedo Arozena, Abraham and Adachi, Hiroaki and Adams, Christopher M and Adams, Peter D and Adeli, Khosrow and Adhihetty, Peter J and Adler, Sharon G and Agam, Galila and Agarwal, Rajesh and Aghi, Manish K and Agnello, Maria and Agostinis, Patrizia and Aguilar, Patricia V and Aguirre-Ghiso, Julio and Airoldi, Edoardo M and Ait-Si-Ali, Slimane and Akematsu, Takahiko and Akporiaye, Emmanuel T and Al-Rubeai, Mohamed and Albaiceta, Guillermo M and Albanese, Chris and Albani, Diego and Albert, Matthew L and Aldudo, Jesus and Algül, Hana and Alirezaei, Mehrdad and Alloza, Iraide and Almasan, Alexandru and Almonte-Beceril, Maylin and Alnemri, Emad S and Alonso, Covadonga and Altan-Bonnet, Nihal and Altieri, Dario C and Alvarez, Silvia and Alvarez-Erviti, Lydia and Alves, Sandro and Amadoro, Giuseppina and Amano, Atsuo and Amantini, Consuelo and Ambrosio, Santiago and Amelio, Ivano and Amer, Amal O and Amessou, Mohamed and Amon, Angelika and An, Zhenyi and Anania, Frank A and Andersen, Stig U and Andley, Usha P and Andreadi, Catherine K and Andrieu-Abadie, Nathalie and Anel, Alberto and Ann, David K and Anoopkumar-Dukie, Shailendra and Antonioli, Manuela and Aoki, Hiroshi and Apostolova, Nadezda and Aquila, Saveria and Aquilano, Katia and Araki, Koichi and Arama, Eli and Aranda, Agustin and Araya, Jun and Arcaro, Alexandre and Arias, Esperanza and Arimoto, Hirokazu and Ariosa, Aileen R and Armstrong, Jane L and Arnould, Thierry and Arsov, Ivica and Asanuma, Katsuhiko and Askanas, Valerie and Asselin, Eric and Atarashi, Ryuichiro and Atherton, Sally S and Atkin, Julie D and Attardi, Laura D and Auberger, Patrick and Auburger, Georg and Aurelian, Laure and Autelli, Riccardo and Avagliano, Laura and Avantaggiati, Maria Laura and Avrahami, Limor and Awale, Suresh and Azad, Neelam and Bachetti, Tiziana and Backer, Jonathan M and Bae, Dong-Hun and Bae, Jae-sung and Bae, Ok-Nam and Bae, Soo Han and Baehrecke, Eric H and Baek, Seung-Hoon and Baghdiguian, Stephen and Bagniewska-Zadworna, Agnieszka and ... and Medicinska fakulteten and Region Östergötland and Linköpings universitet and Institutionen för klinisk och experimentell medicin and Diagnostikcentrum and Klinisk patologi och klinisk genetik and Institutionen för medicin och hälsa and Avdelningen för läkemedelsforskning and Avdelningen för cellbiologi
Autophagy, ISSN 1554-8627, 01/2016, Volume 12, Issue 1, pp. 1 - 222
Journal Article