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Hepatology, ISSN 0270-9139, 10/2013, Volume 58, Issue 4, p. 1413
  Hepatitis induced by concanavalin A (Con A) in mice is well known to be a T-lymphocyte-mediated injury. It has been reported that T helper (Th)1 and Th2... 
Lymphocytes | Liver | Rodents | Hepatology
Journal Article
by Estrada Gil, Karol and Styrkarsdottir, Unnur and Evangelou, Evangelos and Hsu, Yi-Hsiang and Duncan, Emma and Ntzani, Evangelia and Oei, Ling and Albagha, Omar M and Amin, Najaf and Kemp, John and Koller, Daniel and Li, Guo and Liu, Ching-Ti and Minster, Ryan and Moayyeri, Alireza and Vandenput, Liesbeth and Willner, Dana and Xiao, Su-Mei and Yerges-Armstrong, Laura and Zheng, Hou-Feng and Alonso, Nerea and Eriksson, Joel and Kammerer, Candace and Kaptoge, Stephen and Leo, Paul and Thorleifsson, Gudmar and Wilson, Scott and Wilson, James and Aalto, Ville and Alen, Theo and Aragaki, Aaron and Aspelund, Thor and Center, Jacqueline and Dailiana, Zoe and Duggan, C and Garcia, Melissa and Garcia-Giralt, Natàlia and Giroux, Sylvie and Hallmans, Göran and Hocking, Lynne and Husted, Lise Bjerre and Jameson, Karen and Khusainova, Rita and Kim, Ghi Su and Kooperberg, Charles and Koromila, Theodora and Kruk, Marcin and Laaksonen, Marika and LaCroix, Anea and Lee, Seung and Leung, Ping and Lewis, Joshua and Masi, Laura and Mencej-Beac, Simona and Nguyen, Tuan and Nogues, Xavier and Patel, Millan and Prezelj, Janez and Rose, Lynda and Scollen, Serena and Siggeirsdottir, Kristin and Smith, G.D and Svensson, Olle and Trompet, Stella and Trummer, Olivia and Schoor, Natasja and Woo, Margaret M and Zhu, Kun and Balcells, Susana and Brandi, M.L and Buckley, Brendan M and Cheng, Sulin and Christiansen, C and Cooper, Charles and Dedoussis, George and Ford, Ian and Frost, Morten and Goltzman, David and González-Macías, Jesús and Kähönen, Mika and Karlsson, Magnus and Khusnutdinova, Elza and Koh, Jung-Min and Kollia, Panagoula and Langdahl, Bente and Leslie, William and Lips, Paul and Ljunggren, Östen and Lorenc, Roman and Marc, Janja and Mellström, Dan and Obermayer-Pietsch, Barbara and Olmos, David and Pettersson-Kymmer, Ulrika and Reid, David and Riancho, José and Ridker, Paul and Rousseau, Francois and Lagboom, P Eline and Tang, Nelson L and ... and Medicinska fakulteten and Umeå universitet and Institutionen för folkhälsa och klinisk medicin and Institutionen för farmakologi och klinisk neurovetenskap and Klinisk farmakologi and Näringsforskning and Institutionen för kirurgisk och perioperativ vetenskap
Nature Genetics, ISSN 1061-4036, 05/2012, Volume 44, Issue 5, pp. 491 - 501
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 10/2012, Volume 70, Issue 4, p. 513
  Elucidating the metabolic profile of anticancer agent panobinostat is essential during drug development. Disposition, metabolism, and excretion profiles were... 
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 10/2012, Volume 70, Issue 4, pp. 513 - 522
Purpose: Elucidating the metabolic profile of anticancer agent panobinostat is essential during drug development. Disposition, metabolism, and excretion... 
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2015, Volume 10, Issue 7, pp. e0132771 - e0132771
Journal Article
by Wyss, Annah B and Sofer, Tamar and Lee, Mi Kyeong and Terzikhan, Natalie and Nguyen, Jennifer N and Lahousse, Lies and Latourelle, Jeanne C and Smith, Albert Vernon and Bartz, Traci M and Feitosa, Mary F and Gao, Wei and Ahluwalia, Tarunveer S and Tang, Wenbo and Oldmeadow, Christopher and Duan, Qing and de Jong, Kim and Wojczynski, Mary K and Wang, Xin-Qun and Noordam, Raymond and Hartwig, Fernando Pires and Jackson, Victoria E and Wang, Tianyuan and Obeidat, Ma’en and Hobbs, Brian D and Huan, Tianxiao and Gui, Hongsheng and Parker, Margaret M and Hu, Donglei and Mogil, Lauren S and Kichaev, Gleb and Jin, Jianping and Graff, Mariaelisa and Harris, Tamara B and Kalhan, Ravi and Heckbert, Susan R and Paternoster, Lavinia and Burkart, Kristin M and Liu, Yongmei and Holliday, Elizabeth G and Wilson, James G and Vonk, Judith M and Sanders, Jason L and Barr, R. Graham and de Mutsert, Renée and Menezes, Ana Maria Baptista and Adams, Hieab H. H and van den Berge, Maarten and Joehanes, Roby and Levin, Albert M and Liberto, Jennifer and Launer, Lenore J and Morrison, Alanna C and Sitlani, Colleen M and Celedón, Juan C and Kritchevsky, Stephen B and Scott, Rodney J and Christensen, Kaare and Rotter, Jerome I and Bonten, Tobias N and Wehrmeister, Fernando César and Bossé, Yohan and Xiao, Shujie and Oh, Sam and Franceschini, Nora and Brody, Jennifer A and Kaplan, Robert C and Lohman, Kurt and McEvoy, Mark and Province, Michael A and Rosendaal, Frits R and Taylor, Kent D and Nickle, David C and Williams, L. Keoki and Burchard, Esteban G and Wheeler, Heather E and Sin, Don D and Gudnason, Vilmundur and North, Kari E and Fornage, Myriam and Psaty, Bruce M and Myers, Richard H and O’Connor, George and Hansen, Torben and Laurie, Cathy C and Cassano, Patricia A and Sung, Joohon and Kim, Woo Jin and Attia, John R and Lange, Leslie and Boezen, H. Marike and Thyagarajan, Bharat and Rich, Stephen S and Mook-Kanamori, Dennis O and Horta, Bernardo Lessa and Uitterlinden, André G and Im, Hae Kyung and Cho, Michael H and Brusselle, Guy G and Gharib, Sina A and Dupuis, Josée and ...
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 2976 - 15
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 07/2016, Volume 194, Issue 1, pp. 48 - 57
Journal Article
Investigational New Drugs, ISSN 0167-6997, 8/2013, Volume 31, Issue 4, pp. 974 - 985
Purpose Panobinostat, a pan-deacetylase inhibitor, is a promising anti-cancer agent that increases acetylation of proteins associated with growth and survival... 
Panobinostat | Medicine & Public Health | DAC | Oncology | Pharmacology/Toxicology | DACi | Cancer | CRITERIA | ACETYLATION | T-CELL LYMPHOMA | HISTONE-DEACETYLASE INHIBITORS | ONCOLOGY | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA | CLINICAL-TRIALS | LBH589 | PHARMACOLOGY & PHARMACY | Demography | Humans | Hydroxamic Acids - adverse effects | Middle Aged | Histone Deacetylase Inhibitors - administration & dosage | Male | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Indoles - administration & dosage | Dose-Response Relationship, Drug | Histone Deacetylase Inhibitors - pharmacokinetics | Lymphoma - drug therapy | Antineoplastic Agents - adverse effects | Hydroxamic Acids - administration & dosage | Female | Antineoplastic Agents - pharmacokinetics | Acetylation | Treatment Outcome | Hydroxamic Acids - pharmacokinetics | Administration, Intravenous | Maximum Tolerated Dose | Indoles - adverse effects | Hydroxamic Acids - therapeutic use | Indoles - pharmacokinetics | Indoles - therapeutic use | Aged | Histone Deacetylase Inhibitors - therapeutic use | Histone Deacetylase Inhibitors - adverse effects | Antimitotic agents | Complications and side effects | Dosage and administration | Lymphomas | Research | Antineoplastic agents | Drug therapy | Tumors | Studies | Cancer therapies | Patients | Pharmaceutical sciences | Index Medicus
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 5/2010, Volume 66, Issue 1, pp. 181 - 189
Histone deacetylase inhibitors have demonstrated anticancer activity against a range of tumors. We aimed to define the maximum tolerated dose, toxicity,... 
Panobinostat | Histone deacetylase inhibitor | Medicine & Public Health | Docetaxel | Oncology | Cancer Research | Castration-resistant | Pharmacology/Toxicology | Prostate cancer | ANDROGEN RECEPTOR | SUBEROYLANILIDE HYDROXAMIC ACID | REPRODUCIBILITY | CIRCULATING TUMOR-CELLS | ONCOLOGY | RECOMMENDATIONS | CLINICAL-TRIALS | END-POINTS | MALIGNANCIES | PHARMACOLOGY & PHARMACY | PET | Humans | Hydroxamic Acids - adverse effects | Middle Aged | Histone Deacetylase Inhibitors - administration & dosage | Drug Resistance, Neoplasm | Male | Positron-Emission Tomography | Histone Deacetylase Inhibitors - pharmacokinetics | Neoplasm Metastasis | Aged, 80 and over | Hydroxamic Acids - administration & dosage | Prostate-Specific Antigen - drug effects | Prostatic Neoplasms - diagnostic imaging | Indoles | Prostatic Neoplasms - drug therapy | Prostatic Neoplasms - pathology | Neoplastic Cells, Circulating - drug effects | Administration, Oral | Treatment Outcome | Prostate-Specific Antigen - blood | Histones - blood | Hydroxamic Acids - pharmacokinetics | Taxoids - administration & dosage | Acetylation - drug effects | Maximum Tolerated Dose | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Fluorodeoxyglucose F18 | Aged | Histone Deacetylase Inhibitors - adverse effects | Medical colleges | Antigens | Care and treatment | Oncology, Experimental | Research | DNA binding proteins | Antineoplastic agents | Antimitotic agents | Cancer patients | Histones | Injuries | Tumors | Cancer | Index Medicus
Journal Article