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BMC Medical Genomics, ISSN 1755-8794, 07/2019, Volume 12, Issue 1
Patient-derived xenograft (PDX) models are in vivo models of human cancer that have been used for translational cancer research and therapy selection for... 
Care and treatment | Rats as laboratory animals | Xenotransplantation | Genetic aspects | Research | Health aspects | Cancer
Journal Article
Cancer Research, ISSN 0008-5472, 04/2013, Volume 73, Issue 8 Supplement, pp. 2001 - 2001
Journal Article
Cancer Research, ISSN 0008-5472, 04/2012, Volume 72, Issue 8 Supplement, pp. 4947 - 4947
Journal Article
Nature Medicine, ISSN 1078-8956, 04/2012, Volume 18, Issue 4, pp. 521 - 528
Tyrosine kinase inhibitors (TKIs) elicit high response rates among individuals with kinase-driven malignancies, including chronic myeloid leukemia (CML) and... 
CHRONIC MYELOGENOUS LEUKEMIA | MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | GEFITINIB | BIOCHEMISTRY & MOLECULAR BIOLOGY | EYE DISEASES | CHRONIC MYELOID-LEUKEMIA | CELL BIOLOGY | CELL LUNG-CANCER | FACTOR RECEPTOR EGFR | GROWTH | ACTIVATING MUTATIONS | MUTANT EGFR | Enzyme-Linked Immunosorbent Assay - methods | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Follow-Up Studies | Apoptosis - drug effects | Humans | Middle Aged | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Male | BH3 Interacting Domain Death Agonist Protein - genetics | Dose-Response Relationship, Drug | Protein Isoforms - metabolism | Transfection | Bcl-2-Like Protein 11 | Statistics, Nonparametric | Aged, 80 and over | Apoptosis Regulatory Proteins - genetics | Adult | Female | Gene Expression Regulation, Neoplastic - drug effects | Lung Neoplasms - genetics | Annexins - metabolism | Carcinoma, Non-Small-Cell Lung - genetics | Membrane Proteins - genetics | Gene Frequency | Exons - genetics | Genotype | Proto-Oncogene Proteins - genetics | International Cooperation | Drug Resistance, Neoplasm - genetics | Cell Line, Tumor | Polymorphism, Genetic - genetics | Aged | Protein Kinase Inhibitors - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy | Cohort Studies | Drug Resistance, Neoplasm - drug effects | Protein Isoforms - genetics | RNA, Small Interfering - metabolism | Sequence Deletion - genetics | Antimitotic agents | Physiological aspects | Protein tyrosine kinase | Dosage and administration | Genetic aspects | Research | Antineoplastic agents | Tumor proteins | Genetic polymorphisms | Inhibitor drugs | Mutation | Kinases | Gene expression | Apoptosis | Polymorphism
Journal Article
CrystEngComm, ISSN 1466-8033, 01/2011, Volume 13, Issue 6, pp. 2006 - 2014
The desired bioavailability and the method of drug administration and delivery can require stringent control on the crystal size distribution. Optimal control... 
Crystallizers | Size distribution | Nucleation | Simulation | Crystallization | Crystals | Strategy | Supersaturation
Journal Article
Genome Research, ISSN 1088-9051, 01/2011, Volume 21, Issue 5, pp. 676 - 687
Using a long-span, paired-end deep sequencing strategy, we have comprehensively identified cancer genome rearrangements in eight breast cancer genomes. Herein,... 
Journal Article
Cancer Research, ISSN 0008-5472, 07/2017, Volume 77, Issue 13 Supplement, pp. 3842 - 3842
Journal Article
Cell Reports, ISSN 2211-1247, 07/2015, Volume 12, Issue 2, pp. 272 - 285
Journal Article
Crystal Growth and Design, ISSN 1528-7483, 01/2009, Volume 9, Issue 1, pp. 182 - 191
This paper presents a thorough simulation and experimental evaluation of the concentration control approach for batch and semibatch crystallization. The... 
PHARMACEUTICAL CRYSTALLIZATION | MATERIALS SCIENCE, MULTIDISCIPLINARY | DIRECT DESIGN | PROCESS ANALYTICAL TECHNOLOGY | PARACETAMOL | CRYSTALLOGRAPHY | INDUSTRIAL CRYSTALLIZATION | CHEMISTRY, MULTIDISCIPLINARY | SUPERSATURATION CONTROL | ATR-FTIR SPECTROSCOPY | OPTIMIZATION | SEEDED BATCH CRYSTALLIZATION | ANTI-SOLVENT
Journal Article
Industrial and Engineering Chemistry Research, ISSN 0888-5885, 02/2008, Volume 47, Issue 4, pp. 1245 - 1252
A new approach for the estimation of kinetic parameters of crystallization from data obtained during the determination of metastable zone width is presented.... 
ENGINEERING, CHEMICAL | CONTROL TRAJECTORIES | MODEL IDENTIFICATION | BATCH PROCESSES | SPECTROSCOPY | LASER BACKSCATTERING | PHARMACEUTICAL CRYSTALLIZATION | FBRM | OPTIMIZATION | NUCLEATION
Journal Article
Crystal Growth and Design, ISSN 1528-7483, 01/2009, Volume 9, Issue 1, pp. 156 - 164
Computational fluid dynamics (CFD), micromixing modeling, and the population balance equation (PBE) are coupled to simulate the crystal size distribution in a... 
TRANSFORMATION | L-HISTIDINE | SOLVENT COMPOSITION | SCALE-UP | MANUFACTURE | MATERIALS SCIENCE, MULTIDISCIPLINARY | CRYSTALLOGRAPHY | ANTISOLVENT CRYSTALLIZATION | POLYMORPHS | CHEMISTRY, MULTIDISCIPLINARY | CALCIUM-OXALATE | NANOPARTICLE PRECIPITATION | TECHNOLOGY
Journal Article
CrystEngComm, ISSN 1466-8033, 03/2011, Volume 13, Issue 6, pp. 2006 - 2014
The desired bioavailability and the method of drug administration and delivery can require stringent control on the crystal size distribution. Optimal control... 
FINE CHEMICALS | BATCH-COOLING CRYSTALLIZATION | LASER BACKSCATTERING | ATR-FTIR SPECTROSCOPY | PHARMACEUTICAL CRYSTALLIZATION | PRODUCT QUALITY | DIRECT DESIGN | CRYSTALLOGRAPHY | ANTISOLVENT CRYSTALLIZATION | CHEMISTRY, MULTIDISCIPLINARY | SUPERCRITICAL ANTISOLVENT | POTASSIUM-SULFATE
Journal Article
Journal Article
AIChE Journal, ISSN 0001-1541, 10/2007, Volume 53, Issue 10, pp. 2643 - 2650
Journal Article
Journal Article
Crystal Growth and Design, ISSN 1528-7483, 06/2006, Volume 6, Issue 6, pp. 1291 - 1303
Journal Article
Journal Article
Crystal Growth and Design, ISSN 1528-7483, 04/2006, Volume 6, Issue 4, pp. 892 - 898
Recent advances in in situ measurement technology and automation of batch crystallizers have enabled the development of batch crystallization recipes in which... 
ACETONE-WATER MIXTURES | BATCH CRYSTALLIZATION | MATERIALS SCIENCE, MULTIDISCIPLINARY | SIZE | PARACETAMOL | COOLING CRYSTALLIZATION | CRYSTALLOGRAPHY | CHEMISTRY, MULTIDISCIPLINARY | CHEMOMETRICS | LASER BACKSCATTERING | ATR-FTIR SPECTROSCOPY | CONCENTRATION PREDICTION | OPTIMIZATION
Journal Article
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