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1. Full Text Temporomandibular joint arthritis in juvenile idiopathic arthritis: prevalence, clinical and radiological signs, and relation to dentofacial morphology
by An D Billiau and Yuqian Hu and An Verdonck and Carine Carels and Carine Wouters
The Journal of Rheumatology, ISSN 0315-162X, 09/2007, Volume 34, Issue 9, pp. 1925 - 1933
OBJECTIVE: To perform a prospective, comprehensive, clinical, and radiological evaluation of temporomandibular joint (TMJ) involvement and its influence on... 
Temporomandibular joint | Dentofacial growth | Juvenile idiopathic arthritis | RHEUMATOID-ARTHRITIS | CRITERIA | FORM | INVOLVEMENT | CLASSIFICATION | DISORDERS | DENTAL OCCLUSION | RHEUMATOLOGY | juvenile idiopathic arthritis | CHILDREN | FACIAL MORPHOLOGY | temporomandibular joint | dentofacial growth | MANDIBULAR GROWTH | Maxillofacial Development | Prevalence | Prospective Studies | Belgium - epidemiology | Humans | Child, Preschool | Infant | Male | Temporomandibular Joint Disorders - diagnostic imaging | Temporomandibular Joint - pathology | Temporomandibular Joint Disorders - complications | Radiography | Mandibular Condyle - pathology | Adolescent | Arthritis, Juvenile - complications | Adult | Arthritis, Juvenile - diagnostic imaging | Female | Temporomandibular Joint Disorders - epidemiology | Arthritis, Juvenile - epidemiology | Child | Cohort Studies
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2. Full Text Prednisone versus prednisone plus ciclosporin versus prednisone plus methotrexate in new-onset juvenile dermatomyositis: a randomised trial
by Ruperto, Nicolino, Dr and Pistorio, Angela, MD and Oliveira, Sheila, MD and Zulian, Francesco, MD and Cuttica, Ruben, MD and Ravelli, Angelo, MD and Fischbach, Michel, MD and Magnusson, Bo, MD and Sterba, Gary, MD and Avcin, Tadej, MD and Brochard, Karine, MD and Corona, Fabrizia, MD and Dressler, Frank, MD and Gerloni, Valeria, MD and Apaz, Maria T, MD and Bracaglia, Claudia, MD and Cespedes-Cruz, Adriana, MD and Cimaz, Rolando, MD and Couillault, Gerard, MD and Joos, Rik, MD and Quartier, Pierre, MD and Russo, Ricardo, MD and Tardieu, Marc, MD and Wulffraat, Nico, MD and Bica, Blanca, MD and Dolezalova, Pavla, MD and Ferriani, Virginia, MD and Flato, Berit, MD and Bernard-Medina, Ana G, MD and Herlin, Troels, MD and Trachana, Maria, MD and Meini, Antonella, MD and Allain-Launay, Emma, MD and Pilkington, Clarissa, MD and Vargova, Veronika, MD and Wouters, Carine, MD and Angioloni, Simona, BSA and Martini, Alberto, MD and Paediat Rheumatology Int Trials and Paediatric Rheumatology International Trials Organisation (PRINTO)
The Lancet, ISSN 0140-6736, 2016, Volume 387, Issue 10019, pp. 671 - 678
Summary Background Most data for treatment of dermatomyositis and juvenile dermatomyositis are from anecdotal, non-randomised case series. We aimed to compare,... 
Internal Medicine | CRITERIA | MEDICINE, GENERAL & INTERNAL | SYSTEMIC-LUPUS-ERYTHEMATOSUS | MULTICENTER | THERAPY | EFFICACY | INTRAVENOUS IMMUNOGLOBULIN | POLYMYOSITIS | IDIOPATHIC INFLAMMATORY MYOPATHIES | DAMAGE INDEXES | VALIDATED DISEASE-ACTIVITY | Prednisone - administration & dosage | Prednisone - adverse effects | Drug Administration Schedule | Dermatologic Agents - administration & dosage | Humans | Kaplan-Meier Estimate | Child, Preschool | Male | Treatment Outcome | Dermatologic Agents - adverse effects | Methotrexate - adverse effects | Anti-Inflammatory Agents - adverse effects | Analysis of Variance | Dermatomyositis - drug therapy | Cyclosporine - adverse effects | Adolescent | Cyclosporine - administration & dosage | Anti-Inflammatory Agents - administration & dosage | Female | Methotrexate - administration & dosage | Drug Therapy, Combination | Child | Prednisone | Corticosteroids | Cyclosporine | Methotrexate | Dermatomyositis | Steroids | Clinical trials | Skin diseases | Drug therapy | Drug dosages | Patients | Children & youth
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3. Full Text Hematopoietic stem cell transplantation rescues the immunologic phenotype and prevents vasculopathy in patients with adenosine deaminase 2 deficiency
by Van Eyck, Lien, MD and Hershfield, Michael S., MD and Pombal, Diana, MSc and Kelly, Susan J., PhD and Ganson, Nancy J., PhD and Moens, Leen, PhD and Frans, Glynis, MPharm and Schaballie, Heidi, MD and De Hertogh, Gert, MD, PhD and Dooley, James, MSc and Bossuyt, Xavier, MD, PhD and Wouters, Carine, MD, PhD and Liston, Adrian, PhD and Meyts, Isabelle, MD, PhD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2014, Volume 135, Issue 1, pp. 283 - 287.e5
  Despite the addition of mycophenolate mofetil, sirolimus, tacrolimus, cyclosporine, and mercaptopurine, the cytopenia and lymphoproliferation persisted.... 
Allergy and Immunology | ALLERGY | MACROPHAGES | IMMUNOLOGY | Agammaglobulinemia - immunology | Agammaglobulinemia - genetics | Adenosine Deaminase - genetics | Agammaglobulinemia - therapy | Humans | Intercellular Signaling Peptides and Proteins - genetics | Child, Preschool | Hematopoietic Stem Cell Transplantation | Severe Combined Immunodeficiency - therapy | Infant | Male | Severe Combined Immunodeficiency - immunology | Intercellular Signaling Peptides and Proteins - blood | Adenosine Deaminase - blood | Severe Combined Immunodeficiency - genetics | Phenotype | Agammaglobulinemia - blood | Interleukin-6 - blood | Severe Combined Immunodeficiency - blood | Lymphocyte Count | Intercellular Signaling Peptides and Proteins - deficiency | Mutation | Adenosine Deaminase - deficiency | Adenosine Deaminase - immunology | Genetic aspects | Transplantation | Hospitals | Hematopoietic stem cells | Stem cells | Bone marrow | Lymphocytes | Medical treatment | Immune system | Letter to the Editor
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4. Full Text Disease-associated mutations identify a novel region in human STING necessary for the control of type I interferon signaling
by Melki, Isabelle, MD and Rose, Yoann, BSc and Uggenti, Carolina, PhD and Van Eyck, Lien, MD and Frémond, Marie-Louise, MD and Kitabayashi, Naoki, BSc and Rice, Gillian I., PhD and Jenkinson, Emma M., PhD and Boulai, Anaïs, BSc and Jeremiah, Nadia, PhD and Gattorno, Marco, MD and Volpi, Sefano, MD, PhD and Sacco, Olivero, MD and Terheggen-Lagro, Suzanne W.J., MD and Tiddens, Harm A.W.M., MD, PhD and Meyts, Isabelle, MD, PhD and Morren, Marie-Anne, MD and De Haes, Petra, MD, PhD and Wouters, Carine, MD, PhD and Legius, Eric, MD, PhD and Corveleyn, Anniek, PhD and Rieux-Laucat, Frederic, PhD and Bodemer, Christine, MD, PhD and Callebaut, Isabelle, PhD and Rodero, Mathieu P., PhD and Crow, Yanick J., MD, PhD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 140, Issue 2, pp. 543 - 552.e5
Background Gain-of-function mutations in transmembrane protein 173 (TMEM173) encoding stimulator of interferon genes (STING) underlie a recently described type... 
Allergy and Immunology | type I interferonopathy | Stimulator of interferon genes (STING) | TMEM173 | interferon | STING-associated vasculopathy with onset in infancy | FUSION | ALLERGY | PHOSPHORYLATION | TRIGGER | ADAPTER | IMMUNOLOGY | TMEM173 interferon | REVEALS | Signal Transduction | Membrane Proteins - genetics | Humans | Male | STAT1 Transcription Factor - metabolism | Adolescent | HEK293 Cells | Inflammation - genetics | Interferon Type I - genetics | Interferon Type I - metabolism | Adult | Female | Mutation | Child | Amino Acid Substitution | Autoimmunity | Genetic aspects | Interferon | Hospitals | Biological response modifiers | Analysis | RNA viruses | Membrane fusion | Phosphorylation | Disease | Lung diseases | Amino acids | Viruses | Kinases | Ribonucleic acid--RNA | Patients | Proteins | Pathology | Cytometry | Vascular diseases | Mutagenesis | Genetic analysis | Janus kinase | Skin diseases | Lesions | Deoxyribonucleic acid--DNA | Structural analysis
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5. Full Text Randomized Trial of Tocilizumab in Systemic Juvenile Idiopathic Arthritis
by De Benedetti, Fabrizio and Brunner, Hermine I and Ruperto, Nicolino and Kenwright, Andrew and Wright, Stephen and Calvo, Inmaculada and Cuttica, Ruben and Ravelli, Angelo and Schneider, Rayfel and Woo, Patricia and Wouters, Carine and Xavier, Ricardo and Zemel, Lawrence and Baildam, Eileen and Burgos-Vargas, Ruben and Dolezalova, Pavla and Garay, Stella M and Merino, Rosa and Joos, Rik and Grom, Alexei and Wulffraat, Nico and Zuber, Zbigniew and Zulian, Francesco and Lovell, Daniel and Martini, Alberto and PRCSG and PRINTO
The New England Journal of Medicine, ISSN 0028-4793, 12/2012, Volume 367, Issue 25, pp. 2385 - 2395
In a randomized trial involving children with severe systemic juvenile idiopathic arthritis, the anti–interleukin-6 receptor antibody tocilizumab was effective... 
RHEUMATOID-ARTHRITIS | MEDICINE, GENERAL & INTERNAL | RECEPTOR ANTAGONIST ANAKINRA | SAFETY | DISEASE | DOUBLE-BLIND | PRELIMINARY DEFINITION | CHRONIC INFLAMMATION | INTERLEUKIN-6 | ETANERCEPT | CHILDREN | Antibodies, Monoclonal, Humanized - adverse effects | Glucocorticoids - therapeutic use | Antibodies, Monoclonal, Humanized - therapeutic use | Double-Blind Method | Humans | Child, Preschool | Male | Receptors, Interleukin-6 - antagonists & inhibitors | Methotrexate - therapeutic use | Arthritis, Juvenile - blood | Infection - chemically induced | Arthritis, Juvenile - drug therapy | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Adolescent | Female | Transaminases - blood | Drug Therapy, Combination | Neutropenia - chemically induced | Child | Drugs | Dose-response relationship (Biochemistry) | Product/Service Evaluations | Drug therapy | Juvenile arthritis | Clinical trials | Pediatrics | Data processing | Statistical analysis | Cytokines | Rheumatology | Index Medicus | Abridged Index Medicus
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6. Full Text The cellular composition of the human immune system is shaped by age and cohabitation
by Carr, Edward J and Dooley, James and Garcia-Perez, Josselyn E and Lagou, Vasiliki and Lee, James C and Wouters, Carine and Meyts, Isabelle and Goris, An and Boeckxstaens, Guy and Linterman, Michelle A and Liston, Adrian
Nature Immunology, ISSN 1529-2908, 04/2016, Volume 17, Issue 4, pp. 461 - 468
Detailed population-level description of the human immune system has recently become achievable. We used a 'systems-level' approach to establish a resource of... 
RESPONSES | INFLAMMATION | SMOOTH-MUSCLE-CELLS | INFLUENZA VACCINATION | MICROBIOTA | IMMUNOLOGY | CONCORDANCE | THYMIC INVOLUTION | T-CELLS | ADULT | ADIPOSE-TISSUE | Residence Characteristics | Age Factors | Humans | Middle Aged | Child, Preschool | Homeostasis - immunology | Male | Environmental Exposure | Immune System - cytology | Leukocytes - immunology | Young Adult | Aging - immunology | Influenza Vaccines - immunology | Systems Analysis | Adolescent | Aged, 80 and over | Adult | Antigens - immunology | Environment | Female | Aged | Child | Medical research | Environmental health | Physiological aspects | Medicine, Experimental | Cellular signal transduction | Research | Observations | Immune system
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7. Full Text International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study
by Pagès, Franck and Mlecnik, Bernhard and Marliot, Florence and Bindea, Gabriela and Ou, Fang-Shu and Bifulco, Carlo and Lugli, Alessandro and Zlobec, Inti and Rau, Tilman T and Berger, Martin D and Berger, Anne and Nagtegaal, Iris D and Vink-Börger, Elisa and Hartmann, Arndt and Geppert, Carol and Kolwelter, Julie and Merkel, Susanne and Grützmann, Robert and Van den Eynde, Marc and Jouret-Mourin, Anne and Kartheuser, Alex and Léonard, Daniel and Remue, Christophe and Wang, Julia Y and Wang, Yili and Bavi, Prashant and Roehrl, Michael H A and Ohashi, Pamela S and Nguyen, Linh T and Han, SeongJun and MacGregor, Heather L and Hafezi-Bakhtiari, Sara and Wouters, Bradly G and Masucci, Giuseppe V and Andersson, Emilia K and Zavadova, Eva and Vocka, Michal and Spacek, Jan and Petruzelka, Lubos and Konopasek, Bohuslav and Dundr, Pavel and Skalova, Helena and Nemejcova, Kristyna and Botti, Gerardo and Tatangelo, Fabiana and Delrio, Paolo and Ciliberto, Gennaro and Maio, Michele and Laghi, Luigi and Grizzi, Fabio and Fredriksen, Tessa and Buttard, Bénédicte and Angelova, Mihaela and Vasaturo, Angela and Maby, Pauline and Church, Sarah E and Angell, Helen K and Lafontaine, Lucie and Bruni, Daniela and El Sissy, Carine and Haicheur, Nacilla and Kirilovsky, Amos and Lagorce, Christine and Meyers, Jeffrey P and Paustian, Christopher and Feng, Zipei and Ballesteros-Merino, Carmen and Dijkstra, Jeroen and van de Water, Carlijn and van Lent-van Vliet, Shannon and Knijn, Nikki and Mușină, Ana-Maria and Scripcariu, Dragos-Viorel and Popivanova, Boryana and Xu, Mingli and Fujita, Tomonobu and Hazama, Shoichi and Suzuki, Nobuaki and Nagano, Hiroaki and Okuno, Kiyotaka and Torigoe, Toshihiko and Sato, Noriyuki and Furuhata, Tomohisa and Takemasa, Ichiro and Itoh, Kyogo and Patel, Jayendrakumar B and Patel, Prabhu S and Vora, Hemangini H and Shah, Birva and Rajvik, Kruti N and Pandya, Shashank J and Shukla, Shilin N and Zhang, Guanjun and Kawakami, Yutaka and Marincola, Francesco M and Ascierto, Paolo A and Sargent, Daniel J and Fox, Bernard A and Galon, Jérôme
The Lancet, ISSN 0140-6736, 05/2018, Volume 391, Issue 10135, pp. 2128 - 2139
The estimation of risk of recurrence for patients with colon carcinoma must be improved. A robust immune score quantification is needed to introduce immune... 
SURVIVAL | MEDICINE, GENERAL & INTERNAL | IMPACT | IMMUNE CELLS | METASTASIS | IMMUNOTHERAPY | COLORECTAL-CANCER | MICROSATELLITE INSTABILITY | IMMUNOSURVEILLANCE | TUMORS | INFILTRATION | Reproducibility of Results | Colonic Neoplasms - classification | Prognosis | Humans | Middle Aged | Colonic Neoplasms - diagnosis | Proportional Hazards Models | Male | Neoplasm Recurrence, Local - etiology | Lymphocytes, Tumor-Infiltrating | Colonic Neoplasms - immunology | Adult | Female | Aged | Neoplasm Staging | Colon cancer | Research | Analysis | Oncology, Experimental | Cancer | Immunohistochemistry | CD8 antigen | Colorectal cancer | Cytotoxicity | Lymphocytes T | Statistical methods | Microsatellite instability | Assaying | Paraffin | Multivariate analysis | Consortia | Training | Immunology | Lymphocytes | Risk assessment | Surgery | Immunotherapy | Classification | Mathematical models | Colon | Medical research | Stability | Statistical analysis | Microsatellites | Invasiveness | Health risks | CD3 antigen | Gene expression | Patients | Reproducibility | Medical prognosis | Quality control | Tumors
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8. Full Text Condylar asymmetry in children with juvenile idiopathic arthritis assessed by cone-beam computed tomography
by Huntjens, Elisabeth and Kiss, Gabriel and Wouters, Carine and Carels, Carine
The European Journal of Orthodontics, ISSN 0141-5387, 12/2008, Volume 30, Issue 6, pp. 545 - 551
The purpose of this study was to determine the degree of condylar asymmetry in children with juvenile idiopathic arthritis (JIA) using cone-beam computed... 
Facial Asymmetry - pathology | Humans | Image Interpretation, Computer-Assisted - methods | Organ Size | Male | Facial Asymmetry - complications | Functional Laterality | Anatomy, Cross-Sectional | Cone-Beam Computed Tomography | Mandibular Condyle - pathology | Adolescent | Arthritis, Juvenile - complications | Female | Child | Arthritis, Juvenile - pathology
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9. Full Text Two Randomized Trials of Canakinumab in Systemic Juvenile Idiopathic Arthritis
by Ruperto, Nicolino and Brunner, Hermine I and Quartier, Pierre and Constantin, Tamás and Wulffraat, Nico and Horneff, Gerd and Brik, Riva and McCann, Liza and Kasapcopur, Ozgur and Rutkowska-Sak, Lidia and Schneider, Rayfel and Berkun, Yackov and Calvo, Inmaculada and Erguven, Muferet and Goffin, Laurence and Hofer, Michael and Kallinich, Tilmann and Oliveira, Sheila K and Uziel, Yosef and Viola, Stefania and Nistala, Kiran and Wouters, Carine and Cimaz, Rolando and Ferrandiz, Manuel A and Flato, Berit and Gamir, Maria Luz and Kone-Paut, Isabelle and Grom, Alexei and Magnusson, Bo and Ozen, Seza and Sztajnbok, Flavio and Lheritier, Karine and Abrams, Ken and Kim, Dennis and Martini, Alberto and Lovell, Daniel J and PRCSG and PRINTO
The New England Journal of Medicine, ISSN 0028-4793, 12/2012, Volume 367, Issue 25, pp. 2396 - 2406
In two placebo-controlled trials, canakinumab, an anti-interleukin-1β monoclonal antibody, achieved a response, prevented flares, and allowed glucocorticoid... 
RHEUMATOID-ARTHRITIS | MEDICINE, GENERAL & INTERNAL | RECEPTOR ANTAGONIST ANAKINRA | EFFICACY | PERIODIC SYNDROME | DISEASE | DOUBLE-BLIND | PRELIMINARY DEFINITION | CLASSIFICATION | SELECT CATEGORIES | CHILDREN | Glucocorticoids - therapeutic use | Double-Blind Method | Humans | Antibodies, Monoclonal - adverse effects | Kaplan-Meier Estimate | Child, Preschool | Antibodies, Monoclonal - therapeutic use | Male | Thrombocytopenia - chemically induced | Methotrexate - therapeutic use | Infection - chemically induced | Arthritis, Juvenile - drug therapy | Macrophage Activation Syndrome - etiology | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Adolescent | Arthritis, Juvenile - complications | Female | Drug Therapy, Combination | Neutropenia - chemically induced | Child | Interleukin-1beta - antagonists & inhibitors | Drugs | Dose-response relationship (Biochemistry) | Product/Service Evaluations | Drug therapy | Juvenile arthritis | Pediatrics | Cytokines | Fever | Rheumatology | Index Medicus | Abridged Index Medicus
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10. Full Text IL-2 consumption by highly activated CD8 T cells induces regulatory T-cell dysfunction in patients with hemophagocytic lymphohistiocytosis
by Humblet-Baron, Stéphanie, MD, PhD and Franckaert, Dean, MSc and Dooley, James, MSc and Bornschein, Simon, MSc and Cauwe, Bénédicte, PhD and Schönefeldt, Susann, MSc and Bossuyt, Xavier, MD, PhD and Matthys, Patrick, PhD and Baron, Frédéric, MD, PhD and Wouters, Carine, MD, PhD and Liston, Adrian, PhD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 138, Issue 1, pp. 200 - 209.e8
Background Hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory condition driven by excessive CD8+ T-cell activation. HLH occurs as both acquired... 
Allergy and Immunology | familial hemophagocytic lymphohistiocytosis | perforin | IL-2 | immune homeostasis | lymphocytic choriomeningitis virus | Regulatory T cells | INTERLEUKIN-2 | HLH | TOLERANCE | MCL-1 | SUBSETS | IMMUNOLOGY | PATHOGENESIS | ALLERGY | EXPANSION | INFECTION | Interleukin-2 - metabolism | T-Lymphocytes, Regulatory - metabolism | Perforin - genetics | Immunomodulation | Lymphohistiocytosis, Hemophagocytic - drug therapy | Humans | Homeostasis | Lymphocytic Choriomeningitis - immunology | Mice, Knockout | T-Lymphocytes, Regulatory - immunology | Lymphocytic Choriomeningitis - metabolism | Lymphocyte Activation - immunology | Animals | Lymphohistiocytosis, Hemophagocytic - metabolism | CD8-Positive T-Lymphocytes - metabolism | Lymphocyte Count | Lymphocytic choriomeningitis virus - physiology | Mice | CD8-Positive T-Lymphocytes - immunology | Lymphohistiocytosis, Hemophagocytic - genetics | Lymphohistiocytosis, Hemophagocytic - immunology | Disease Models, Animal | T cells | Analysis | Cells | Antigens | Disease | Cytokines | Pathogenesis | Colleges & universities | Nervous system | Cytotoxicity | T cell receptors | Infections | Inflammation | Lymphocytes | Mutation | Viral infections
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11. Full Text Brief Report: IFIH1 Mutation Causes Systemic Lupus Erythematosus With Selective IgA Deficiency
by Van Eyck, Lien and De Somer, Lien and Pombal, Diana and Bornschein, Simon and Frans, Glynis and Humblet‐Baron, Stéphanie and Moens, Leen and de Zegher, Francis and Bossuyt, Xavier and Wouters, Carine and Liston, Adrian
Arthritis & Rheumatology, ISSN 2326-5191, 06/2015, Volume 67, Issue 6, pp. 1592 - 1597
Objective To identify the underlying genetic defect in a 16‐year‐old girl with severe early‐onset and refractory systemic lupus erythematosus (SLE), IgA... 
DEAD-box RNA Helicases - genetics | Lupus Erythematosus, Systemic - complications | IgA Deficiency - genetics | Humans | Lupus Erythematosus, Systemic - genetics | Adolescent | Female | IgA Deficiency - complications | Sequence Analysis, DNA | Interferon-Induced Helicase, IFIH1
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12. Full Text Hemophagocytic lymphohistiocytosis (HLH): A heterogeneous spectrum of cytokine-driven immune disorders
by Brisse, Ellen and Wouters, Carine H and Matthys, Patrick
Cytokine and Growth Factor Reviews, ISSN 1359-6101, 2014, Volume 26, Issue 3, pp. 263 - 280
Highlights • HLH comprises a broad spectrum of disorders that all present with a cytokine storm. • Diverse animal models of HLH have enhanced our understanding... 
Advanced Basic Science | Hemophagocytic lymphohistiocytosis | Therapy | Animal models | Cytokine storm | Macrophage activation syndrome | NATURAL-KILLER-CELLS | MURINE CYTOMEGALOVIRUS-INFECTION | DENDRITIC CELLS | TRYPANOSOMA-CONGOLENSE | BIOCHEMISTRY & MOLECULAR BIOLOGY | LINKED LYMPHOPROLIFERATIVE DISEASE | CD8(+) T-CELLS | HERMANSKY-PUDLAK-SYNDROME | CELL BIOLOGY | INTERFERON-GAMMA | EPSTEIN-BARR-VIRUS | Cytokines | Analysis
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