Nature, ISSN 0028-0836, 08/2017, Volume 548, Issue 7668, pp. 413 - 419
Genome editing has potential for the targeted correction of germline mutations. Here we describe the correction of the heterozygous MYBPC3 mutation in human...
PRIMATE EMBRYOS | HUMAN-CELLS | DNA | ZYGOTES | MULTIDISCIPLINARY SCIENCES | MOUSE | DIGENOME-SEQ | RNA-GUIDED ENDONUCLEASES | CRISPR-CAS9 | CAS9 | NUCLEASES | Gene Targeting | Embryo, Mammalian - pathology | Recombinational DNA Repair - genetics | Humans | Blastocyst - metabolism | Zygote - metabolism | Templates, Genetic | Male | Blastocyst - pathology | Mutation - genetics | DNA Breaks, Double-Stranded | Genetic Complementation Test | Embryo, Mammalian - metabolism | Zygote - pathology | Carrier Proteins - genetics | Homozygote | Cell Division | S Phase | Alleles | Adult | Heterozygote | Mosaicism | Clustered Regularly Interspaced Short Palindromic Repeats - genetics | Gene Editing - methods | Care and treatment | Gene targeting | Gene mutations | Genetic aspects | Genetic engineering | Human embryo | Methods | Heart failure | CRISPR | Cardiomyopathy | Therapeutic applications | Genomics | Homology | Genomes | Double-strand break repair | Embryos | DNA repair | Genetic screening | Proteins | Point mutation | Cell cycle | Mutation | Gene therapy | Deoxyribonucleic acid--DNA
PRIMATE EMBRYOS | HUMAN-CELLS | DNA | ZYGOTES | MULTIDISCIPLINARY SCIENCES | MOUSE | DIGENOME-SEQ | RNA-GUIDED ENDONUCLEASES | CRISPR-CAS9 | CAS9 | NUCLEASES | Gene Targeting | Embryo, Mammalian - pathology | Recombinational DNA Repair - genetics | Humans | Blastocyst - metabolism | Zygote - metabolism | Templates, Genetic | Male | Blastocyst - pathology | Mutation - genetics | DNA Breaks, Double-Stranded | Genetic Complementation Test | Embryo, Mammalian - metabolism | Zygote - pathology | Carrier Proteins - genetics | Homozygote | Cell Division | S Phase | Alleles | Adult | Heterozygote | Mosaicism | Clustered Regularly Interspaced Short Palindromic Repeats - genetics | Gene Editing - methods | Care and treatment | Gene targeting | Gene mutations | Genetic aspects | Genetic engineering | Human embryo | Methods | Heart failure | CRISPR | Cardiomyopathy | Therapeutic applications | Genomics | Homology | Genomes | Double-strand break repair | Embryos | DNA repair | Genetic screening | Proteins | Point mutation | Cell cycle | Mutation | Gene therapy | Deoxyribonucleic acid--DNA
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2011, Volume 108, Issue 43, pp. 17720 - 17725
The global distribution of soil animals and the relationship of below-ground biodiversity to above-ground biodiversity are not well understood. We examined...
Soil fauna | Animals | Forest steppe soils | Soil science | Soil nematodes | Biodiversity | Geodetic position | Grassland soils | Forest soils | Soil ecology | Endemism | Cosmopolitan species | BIODIVERSITY | PLANT | PINE FOREST | FOOD-WEB | GRASSLAND | MULTIDISCIPLINARY SCIENCES | TERRESTRIAL ECOSYSTEMS | DECOMPOSITION | PATTERNS | endemism | ORGANISMS | cosmopolitan species | FAUNA | Demography | Species Specificity | Nitrogen - analysis | RNA, Ribosomal, 18S - genetics | Computational Biology | Metagenomics - methods | Invertebrates - genetics | Molecular Sequence Data | DNA Primers - genetics | Sequence Analysis, DNA | Base Sequence | Soil | Hydrogen-Ion Concentration | Environmental aspects | Research | Subterranean organisms | Molecular biology | Burrowing animals | Biological diversity | Biological Sciences
Soil fauna | Animals | Forest steppe soils | Soil science | Soil nematodes | Biodiversity | Geodetic position | Grassland soils | Forest soils | Soil ecology | Endemism | Cosmopolitan species | BIODIVERSITY | PLANT | PINE FOREST | FOOD-WEB | GRASSLAND | MULTIDISCIPLINARY SCIENCES | TERRESTRIAL ECOSYSTEMS | DECOMPOSITION | PATTERNS | endemism | ORGANISMS | cosmopolitan species | FAUNA | Demography | Species Specificity | Nitrogen - analysis | RNA, Ribosomal, 18S - genetics | Computational Biology | Metagenomics - methods | Invertebrates - genetics | Molecular Sequence Data | DNA Primers - genetics | Sequence Analysis, DNA | Base Sequence | Soil | Hydrogen-Ion Concentration | Environmental aspects | Research | Subterranean organisms | Molecular biology | Burrowing animals | Biological diversity | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2011, Volume 108, Issue 43, p. 17720
The global distribution of soil animals and the relationship of below-ground biodiversity to above-ground biodiversity are not well understood. We examined...
Soils | Molecular structure | Taxonomy | Gene expression | Biological diversity
Soils | Molecular structure | Taxonomy | Gene expression | Biological diversity
Journal Article
SIAM JOURNAL ON APPLIED DYNAMICAL SYSTEMS, ISSN 1536-0040, 2013, Volume 12, Issue 4, pp. 1722 - 1762
National boundaries have never prevented infectious diseases from reaching distant territories; however, the speed at which an infectious agent can spread...
influenza modeling | MATHEMATICS, APPLIED | VIRUS | PANDEMIC INFLUENZA | STABILITY | EQUATIONS | transportation model | MODEL | PHYSICS, MATHEMATICAL | epidemic spread | differential equations | TRANSMISSION | TRANSPORT-RELATED INFECTION | DISEASE | INFLUENZA-A H1N1
influenza modeling | MATHEMATICS, APPLIED | VIRUS | PANDEMIC INFLUENZA | STABILITY | EQUATIONS | transportation model | MODEL | PHYSICS, MATHEMATICAL | epidemic spread | differential equations | TRANSMISSION | TRANSPORT-RELATED INFECTION | DISEASE | INFLUENZA-A H1N1
Journal Article
Global Ecology and Biogeography, ISSN 1466-822X, 09/2014, Volume 23, Issue 9, pp. 968 - 978
Aim To conduct the first global‐scale investigation of soil nematode assemblages using a standardized approach to quantify how environmental and climatic...
soil fauna | family richness | biogeography | nematoda | macroecology | Biodiversity | distribution | Family richness | Soil fauna | Distribution | Macroecology | Biogeography | Nematoda | GRASSLAND | DISTURBANCE | COMMUNITY STRUCTURE | EXTRACTION | GEOGRAPHY, PHYSICAL | SPECIES RICHNESS | ECOLOGY | DIVERSITY | GENERA | Soil moisture | Ecosystems | Environmental aspects | Family | Soil structure | Climatic changes | Deserts | Rain and rainfall
soil fauna | family richness | biogeography | nematoda | macroecology | Biodiversity | distribution | Family richness | Soil fauna | Distribution | Macroecology | Biogeography | Nematoda | GRASSLAND | DISTURBANCE | COMMUNITY STRUCTURE | EXTRACTION | GEOGRAPHY, PHYSICAL | SPECIES RICHNESS | ECOLOGY | DIVERSITY | GENERA | Soil moisture | Ecosystems | Environmental aspects | Family | Soil structure | Climatic changes | Deserts | Rain and rainfall
Journal Article
Genes and Development, ISSN 0890-9369, 2014, Volume 28, Issue 10, pp. 1085 - 1100
Glioblastomas are the most prevalent and lethal primary brain tumor and are comprised of hierarchies with self-renewing cancer stem cells (CSCs) at the apex....
BMP antagonists | Bone morphogenetic proteins (BMPs) | Cancer stem cells | Gremlin1 | Glioblastoma | Stem cell hierarchies | BMP | BONE MORPHOGENETIC PROTEIN | MAINTAINS TUMORIGENICITY | RECURRENT GLIOBLASTOMA | DNA-DAMAGE | SELF-RENEWAL | PROLIFERATION | DEVELOPMENTAL BIOLOGY | ANTAGONIST GREMLIN-1 | CELL BIOLOGY | glioblastoma | stem cell hierarchies | GROWTH | GENETICS & HEREDITY | cancer stem cells | BRAIN | bone morphogenetic proteins (BMPs) | Cell Cycle - genetics | Cell Proliferation | Signal Transduction | Humans | Gene Expression Regulation, Neoplastic | Intercellular Signaling Peptides and Proteins - genetics | Gene Knockdown Techniques | Glioma - metabolism | Glioma - genetics | Intercellular Signaling Peptides and Proteins - metabolism | Animals | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Heterografts | Neoplastic Stem Cells - metabolism | Bone Morphogenetic Protein 2 - metabolism | Glioma - pathology | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Neoplastic Stem Cells - pathology | Mice | Intercellular Signaling Peptides and Proteins - secretion | Research | Genetic transcription | Gene expression | Gliomas | Stem cells | Research Paper
BMP antagonists | Bone morphogenetic proteins (BMPs) | Cancer stem cells | Gremlin1 | Glioblastoma | Stem cell hierarchies | BMP | BONE MORPHOGENETIC PROTEIN | MAINTAINS TUMORIGENICITY | RECURRENT GLIOBLASTOMA | DNA-DAMAGE | SELF-RENEWAL | PROLIFERATION | DEVELOPMENTAL BIOLOGY | ANTAGONIST GREMLIN-1 | CELL BIOLOGY | glioblastoma | stem cell hierarchies | GROWTH | GENETICS & HEREDITY | cancer stem cells | BRAIN | bone morphogenetic proteins (BMPs) | Cell Cycle - genetics | Cell Proliferation | Signal Transduction | Humans | Gene Expression Regulation, Neoplastic | Intercellular Signaling Peptides and Proteins - genetics | Gene Knockdown Techniques | Glioma - metabolism | Glioma - genetics | Intercellular Signaling Peptides and Proteins - metabolism | Animals | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Heterografts | Neoplastic Stem Cells - metabolism | Bone Morphogenetic Protein 2 - metabolism | Glioma - pathology | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Neoplastic Stem Cells - pathology | Mice | Intercellular Signaling Peptides and Proteins - secretion | Research | Genetic transcription | Gene expression | Gliomas | Stem cells | Research Paper
Journal Article
Nature Methods, ISSN 1548-7091, 05/2018, Volume 15, Issue 5, pp. 394 - 394
Journal Article
Nature, ISSN 0028-0836, 08/2018, Volume 560, Issue 7717, pp. E10 - E23
Journal Article
Cell Stem Cell, ISSN 1934-5909, 01/2017, Volume 20, Issue 1, pp. 112 - 119
Oocyte defects lie at the heart of some forms of infertility and could potentially be addressed therapeutically by alternative routes for oocyte formation....
polar body nuclear transfer | meiosis | reconstructed human oocytes | mitochondrial replacement therapy | infertility treatment | haploid | METHYLATION | MITOCHONDRIAL REPLACEMENT | THERAPY | ABNORMALITIES | EMBRYONIC STEM-CELLS | PLURIPOTENT CELLS | FERTILITY | AGE | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Genomic Instability | Human Embryonic Stem Cells - metabolism | Oocytes - metabolism | Epigenesis, Genetic | Humans | Blastocyst - metabolism | Embryonic Development - genetics | Male | DNA Methylation - genetics | Gene Expression Profiling | Nuclear Transfer Techniques | Spermatozoa - metabolism | Fertilization in Vitro | Polar Bodies - metabolism | Sequence Analysis, RNA | Spindle Apparatus - metabolism | Metaphase | Ploidies | Adult | Female | Transcription, Genetic | Genome, Human
polar body nuclear transfer | meiosis | reconstructed human oocytes | mitochondrial replacement therapy | infertility treatment | haploid | METHYLATION | MITOCHONDRIAL REPLACEMENT | THERAPY | ABNORMALITIES | EMBRYONIC STEM-CELLS | PLURIPOTENT CELLS | FERTILITY | AGE | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Genomic Instability | Human Embryonic Stem Cells - metabolism | Oocytes - metabolism | Epigenesis, Genetic | Humans | Blastocyst - metabolism | Embryonic Development - genetics | Male | DNA Methylation - genetics | Gene Expression Profiling | Nuclear Transfer Techniques | Spermatozoa - metabolism | Fertilization in Vitro | Polar Bodies - metabolism | Sequence Analysis, RNA | Spindle Apparatus - metabolism | Metaphase | Ploidies | Adult | Female | Transcription, Genetic | Genome, Human
Journal Article
Nature, ISSN 0028-0836, 08/2018, Volume 560, Issue 7717, pp. E10 - 2
[...]we asked whether DNA proofreading and mismatch repair mechanisms involved in HDR could also contribute to the conversion of neighbouring neutral paternal...
CRISPR | Stem cells | Genomes | Mutation | Gene expression | Deoxyribonucleic acid--DNA
CRISPR | Stem cells | Genomes | Mutation | Gene expression | Deoxyribonucleic acid--DNA
Journal Article
Global Ecology and Biogeography, ISSN 1466-822X, 09/2014, Volume 23, Issue 9, pp. 968 - 978
Journal Article
Journal of Reproductive Medicine for the Obstetrician and Gynecologist, ISSN 0024-7758, 02/2008, Volume 53, Issue 2, pp. 141 - 144
BACKGROUND: Mature, benign cystic teratomas of the ovary are common in reproductive-age women, but they are very rarely associated with androgen production and...
Postmenopause | Testosterone | Hyperandrogenism | Cystic | Teratoma | Mature | testosterone | hyperandrogenism | mature | TUMORS | OBSTETRICS & GYNECOLOGY | NEOPLASTIC OVARIES | WOMEN | ANDROGEN | ESTROGEN | postmenopause | SECRETION | teratoma | cystic | Diagnosis, Differential | Teratoma - pathology | Humans | Middle Aged | Ovarian Neoplasms - pathology | Female | Ovarian Neoplasms - complications | Hyperandrogenism - etiology | Teratoma - complications
Postmenopause | Testosterone | Hyperandrogenism | Cystic | Teratoma | Mature | testosterone | hyperandrogenism | mature | TUMORS | OBSTETRICS & GYNECOLOGY | NEOPLASTIC OVARIES | WOMEN | ANDROGEN | ESTROGEN | postmenopause | SECRETION | teratoma | cystic | Diagnosis, Differential | Teratoma - pathology | Humans | Middle Aged | Ovarian Neoplasms - pathology | Female | Ovarian Neoplasms - complications | Hyperandrogenism - etiology | Teratoma - complications
Journal Article
13.
Glioma cancer stem cells secrete Gremlinl to promote their maintenance within the tumor hierarchy
Genes & Development, ISSN 0890-9369, 05/2014, Volume 28, Issue 10, pp. 1085 - 1100
Glioblastomas are the most prevalent and lethal primary brain tumor and are comprised of hierarchies with self-renewing cancer stem cells (CSCs) at the apex....
Journal Article
Proceedings of the National Academy of Sciences, USA, ISSN 0027-8424, 10/2011, Volume 108, Issue 43, pp. 17720 - 17725
The global distribution of soil animals and the relationship of below-ground biodiversity to above-ground biodiversity are not well understood. We examined...
Community structure | Grasslands | Litter | environmental factors | arthropods | Soil | taxonomy | Biological diversity
Community structure | Grasslands | Litter | environmental factors | arthropods | Soil | taxonomy | Biological diversity
Journal Article
Soil Biology and Biochemistry, ISSN 0038-0717, 2009, Volume 41, Issue 4, pp. 849 - 857
A major problem facing ecologists is obtaining a complete picture of the highly complex soil community. While DNA-based methods are routinely used to assess...
Community structure | Phylogenetic analysis | Soil | DNA sequence | Biodiversity | Morphological analysis | SPECIES-DIVERSITY | SEQUENCES | IDENTIFICATION | TAXONOMY | SOIL SCIENCE | EXTRACTION | MICROBIAL COMMUNITIES | DNA | NEMATODES | CULTIVATION | Ecology | Universities and colleges | Ecosystems | Analysis | Biological diversity
Community structure | Phylogenetic analysis | Soil | DNA sequence | Biodiversity | Morphological analysis | SPECIES-DIVERSITY | SEQUENCES | IDENTIFICATION | TAXONOMY | SOIL SCIENCE | EXTRACTION | MICROBIAL COMMUNITIES | DNA | NEMATODES | CULTIVATION | Ecology | Universities and colleges | Ecosystems | Analysis | Biological diversity
Journal Article
Fertility and Sterility, ISSN 0015-0282, 2011, Volume 95, Issue 8, pp. 2778 - 2780
We evaluated the rate of blastocyst development in day 3 embryos with appropriate cellular division and investigated whether maternal age modified the effect...
Internal Medicine | Obstetrics and Gynecology | blastocyst | Embryo fragmentation | in vitro fertilization | age | in vitro fertilization | FERTILIZATION | BLASTOMERES | PREGNANCY | OBSTETRICS & GYNECOLOGY | MATERNAL AGE | IN-VITRO | IMPACT | REPRODUCTIVE BIOLOGY | MORPHOLOGY | Risk Assessment | Humans | Risk Factors | Cleavage Stage, Ovum - pathology | Blastocyst - pathology | Embryo Culture Techniques | Embryonic Development | Chi-Square Distribution | Young Adult | Fertilization in Vitro | Maternal Age | Time Factors | Adult | Female | Ohio | Retrospective Studies | Embryonic development | Embryo
Internal Medicine | Obstetrics and Gynecology | blastocyst | Embryo fragmentation | in vitro fertilization | age | in vitro fertilization | FERTILIZATION | BLASTOMERES | PREGNANCY | OBSTETRICS & GYNECOLOGY | MATERNAL AGE | IN-VITRO | IMPACT | REPRODUCTIVE BIOLOGY | MORPHOLOGY | Risk Assessment | Humans | Risk Factors | Cleavage Stage, Ovum - pathology | Blastocyst - pathology | Embryo Culture Techniques | Embryonic Development | Chi-Square Distribution | Young Adult | Fertilization in Vitro | Maternal Age | Time Factors | Adult | Female | Ohio | Retrospective Studies | Embryonic development | Embryo
Journal Article
IOP Conference Series: Earth and Environmental Science, ISSN 1755-1315, 02/2009, Volume 6, Issue 30, pp. 302036 - 1
This article was submitted without an abstract, please refer to the full-text PDF file.
Journal Article
Gastroenterology, ISSN 0016-5085, 04/2017, Volume 152, Issue 5, pp. S884 - S884
Journal Article
Gastroenterology, ISSN 0016-5085, 04/2017, Volume 152, Issue 5, pp. S880 - S880
Journal Article
Gastroenterology, ISSN 0016-5085, 2017, Volume 152, Issue 5, pp. S884 - S884
Journal Article
No results were found for your search.
Cannot display more than 1000 results, please narrow the terms of your search.