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heme (7) 7
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lipid-peroxidation (7) 7
nitric oxide (7) 7
proteins (7) 7
research article (7) 7
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anti-inflammatory agents - pharmacology (6) 6
arsenic (6) 6
biochemistry (6) 6
cells, cultured (6) 6
dose-response relationship, drug (6) 6
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expression (6) 6
flavones - pharmacology (6) 6
gene expression - drug effects (6) 6
heme oxygenase-1 - genetics (6) 6
hep g2 cells (6) 6
integrative & complementary medicine (6) 6
kinases (6) 6
lipoproteins, ldl - metabolism (6) 6
luteolin (6) 6
luteolin - pharmacology (6) 6
map kinase signaling system - drug effects (6) 6
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lipid peroxidation - drug effects (5) 5
low density lipoproteins (5) 5
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neurites - metabolism (5) 5
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1. Full Text A study of energy literacy among nursing students to examine implications on energy conservation efforts in Taiwan
by Lee, Lung-Sheng and Lee, Yi-Fang and Wu, Ming-Jiuan and Pan, Ying-Ju
Energy Policy, ISSN 0301-4215, 12/2019, Volume 135, p. 111005
Nurses' energy literacy should be developed during schooling to ensure their involvement in sustainable healthcare. In this study, we explored nursing... 
Energy conservation behavior | Nursing education | Energy literacy | Energy affect | Energy knowledge
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2. Full Text Anti-inflammatory Activity of 8‑Hydroxydaidzein in LPS-Stimulated BV2 Microglial Cells via Activation of Nrf2-Antioxidant and Attenuation of Akt/NF-κB-Inflammatory Signaling Pathways, as Well As Inhibition of COX‑2 Activity
by Wu, Pei-Shan and Ding, Hsiou-Yu and Yen, Jui-Hung and Chen, Shu-Fen and Lee, Kuan-Han and Wu, Ming-Jiuan
Journal of Agricultural and Food Chemistry, ISSN 0021-8561, 06/2018, Volume 66, Issue 23, pp. 5790 - 5801
It was demonstrated that isoflavones can cross the blood–brain barrier, making them desirable candidate agents for the prevention of neurological symptoms.... 
NF-κB | 8-hydroxydaidzein | Akt | COX-2 | Nrf2
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3. Full Text Arsenic modulates heme oxygenase-1, interleukin-6, and vascular endothelial growth factor expression in endothelial cells: Roles of ROS, NF -kB, and MAPK pathways
by Wang, Lisu and Kou, Mei-Chun and Weng, Ching-Yi and Hu, Ling-Wei and Wang, Ying-Jan and Wu, Ming-Jiuan
Archives of Toxicology, ISSN 0340-5761, 06/2012, Volume 86, Issue 6, pp. 879 - 896
Arsenic | VEGF | HO-1 | MAPK | IL-6 | A-Lipoic acid
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4. Full Text Nobiletin Down-Regulates c‑KIT Gene Expression and Exerts Antileukemic Effects on Human Acute Myeloid Leukemia Cells
by Chen, Pei-Yi and Chen, Yu-Ting and Gao, Wan-Yun and Wu, Ming-Jiuan and Yen, Jui-Hung
Journal of Agricultural and Food Chemistry, ISSN 0021-8561, 12/2018, Volume 66, Issue 51, pp. 13423 - 13434
Nobiletin, a dietary citrus flavonoid, has been reported to possess several biological activities such as antioxidant, anti-inflammatory, and anticancer... 
AML | cytarabine | nobiletin | flavonoid | c-KIT | APOPTOSIS | PROGNOSTIC IMPACT | PROFILES | FOOD SCIENCE & TECHNOLOGY | PROLIFERATION | CITRUS FLAVONOIDS | RESISTANT | ENHANCEMENT | AGRICULTURE, MULTIDISCIPLINARY | 5-DEMETHYLNOBILETIN | MUTATIONS | CHEMISTRY, APPLIED | BINDING
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5. Full Text α-Lipoic acid inhibits liver fibrosis through the attenuation of ROS-triggered signaling in hepatic stellate cells activated by PDGF and TGF-β
by Foo, Ning-Ping and Lin, Shu-Huei and Lee, Yu-Hsuan and Wu, Ming-Jiuan and Wang, Ying-Jan
Toxicology, ISSN 0300-483X, 2011, Volume 282, Issue 1, pp. 39 - 46
Abstract Reactive oxygen species (ROS) have been implicated in hepatic stellate cell activation and liver fibrosis. We previously reported that α -lipoic acid... 
Emergency | α-Lipoic acid | Reactive oxygen species | Liver fibrosis | Hepatic stellate cell | Dihydrolipoic acid | OXIDATIVE STRESS | INJURY | FACTOR-KAPPA-B | MECHANISMS | TUMOR PROMOTION | THIOACETAMIDE RAT MODEL | AMELIORATES DEVELOPMENT | CIRRHOSIS | GROWTH-FACTORS | PROTEIN-KINASE PATHWAYS | PHARMACOLOGY & PHARMACY | TOXICOLOGY | alpha-Lipoic acid | Reactive Oxygen Species - metabolism | Rats, Wistar | Hepatic Stellate Cells - metabolism | Male | RNA, Messenger - metabolism | Liver - drug effects | Cytokines - toxicity | Liver Cirrhosis - metabolism | Hepatic Stellate Cells - drug effects | Biomarkers - metabolism | Cell Line | Platelet-Derived Growth Factor - toxicity | Liver Cirrhosis - prevention & control | Proto-Oncogene Proteins c-sis | Liver - metabolism | Rats | Thioctic Acid - pharmacology | Liver Cirrhosis - blood | Antioxidants - pharmacology | Biomarkers - blood | Transforming Growth Factor beta - toxicity | Gene Expression Regulation - drug effects | Antioxidants - therapeutic use | Animals | MAP Kinase Signaling System - drug effects | Liver Cirrhosis - pathology | Recombinant Proteins - toxicity | Thioctic Acid - analogs & derivatives | Cell Proliferation - drug effects | Oxidative Stress - drug effects | Thioctic Acid - therapeutic use | Platelet-derived growth factor | Actin | Emergency medicine | Liver | Fibrosis | Aspartate | Muscle proteins | Transforming growth factors | Liver cirrhosis | Protein kinases | Index Medicus
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6. Full Text Curcumin enhances cell‐surface LDLR level and promotes LDL uptake through downregulation of PCSK9 gene expression in HepG2 cells
by Tai, Mi‐Hsueh and Chen, Po‐Kong and Chen, Pei‐Yi and Wu, Ming‐Jiuan and Ho, Chi‐Tang and Yen, Jui‐Hung
Molecular Nutrition & Food Research, ISSN 1613-4125, 11/2014, Volume 58, Issue 11, pp. 2133 - 2145
Scope Curcumin has been demonstrated as having numerous desirable characteristics, such as antioxidant, anti‐inflammatory, and antiatherogenic activities. We... 
HNF‐1α | PCSK9 | Curcumin | Hypercholesterolemia | LDLR | HNF-1α | AUTOSOMAL-DOMINANT HYPERCHOLESTEROLEMIA | FOOD SCIENCE & TECHNOLOGY | RECEPTOR EXPRESSION | CHEMOPREVENTIVE AGENT CURCUMIN | TARGET GENES | HNF-1 alpha | LIVER-REGENERATION | HIGH-RISK | ENDOPLASMIC-RETICULUM | HEME OXYGENASE-1 | HUMAN HEPATOCELLULAR-CARCINOMA | CORONARY-HEART-DISEASE | Hepatocyte Nuclear Factor 1-alpha - genetics | Curcumin - chemistry | Humans | Gene Expression Regulation, Neoplastic | Hepatocytes - metabolism | Hepatocyte Nuclear Factor 1-alpha - metabolism | RNA, Messenger - metabolism | Hypercholesterolemia - drug therapy | Proprotein Convertases - genetics | Serine Endopeptidases - genetics | Transcription, Genetic | Cell Membrane - metabolism | Cell Membrane - drug effects | Hepatocytes - drug effects | Receptors, LDL - genetics | Proprotein Convertases - metabolism | RNA, Messenger - genetics | Curcumin - pharmacology | Receptors, LDL - metabolism | Down-Regulation - drug effects | Hep G2 Cells | Drug Synergism | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Cholesterol, LDL - metabolism | Serine Endopeptidases - metabolism | Proprotein Convertase 9 | Antioxidants | RNA | Low density lipoproteins | Genes | Genetic aspects | Gene expression | Statins
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7. Full Text Distinctive Antioxidant and Antiinflammatory Effects of Flavonols
by Wang, Lisu and Tu, Yi-Chen and Lian, Tzi-Wei and Hung, Jing-Ting and Yen, Jui-Hung and Wu, Ming-Jiuan
Journal of Agricultural and Food Chemistry, ISSN 0021-8561, 12/2006, Volume 54, Issue 26, pp. 9798 - 9804
The antioxidant and antiinflammatory effects of flavonols have been suggested to be structure-related. Results revealed that selected flavonols, including... 
Fisetin | NF-κB | Antioxidant | Kaempferol | Anti-inflammatory | Quercetin | antioxidant | PLANT FLAVONOIDS | CHEMILUMINESCENCE | MACROPHAGES | FOOD SCIENCE & TECHNOLOGY | inflammatory | TRANSCRIPTION | fisetin | KAPPA-B | anti | FREE-RADICALS | NF-kappa B | INHIBITION | DISEASES | kaempferol | SCAVENGING ACTIVITY | AGRICULTURE, MULTIDISCIPLINARY | quercetin | CHEMISTRY, APPLIED | Free Radical Scavengers - pharmacology | Cell Line | Gene Expression - drug effects | Reactive Oxygen Species - blood | Anti-Inflammatory Agents - pharmacology | Humans | Neutrophils - drug effects | Structure-Activity Relationship | Antioxidants - pharmacology | Flavonols - chemistry | Dinoprostone - metabolism | Macrophages - metabolism | Animals | Nitric Oxide Synthase Type II - genetics | Quercetin - pharmacology | NF-kappa B - physiology | Macrophages - drug effects | Flavonoids - pharmacology | Kaempferols - pharmacology | Mice | Flavonols - pharmacology | Nitric Oxide - metabolism | Neutrophils - metabolism
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8. Full Text Solasodine inhibits invasion of human lung cancer cell through downregulation of miR-21 and MMPs expression
by Shen, Kun-Hung and Hung, Jui-Hsiang and Chang, Chia-Wei and Weng, Yu-Ting and Wu, Ming-Jiuan and Chen, Pin-Shern
Chemico-Biological Interactions, ISSN 0009-2797, 04/2017, Volume 268, pp. 129 - 135
Solasodine, a naturally occurring aglycone of glycoalkaloid in eggplant ( ), was found to inhibit proliferation in various tumor cells. However, the effect of... 
Matrix metalloproteinase | MicroRNA-21 | Cell invasion | Solasodine | Lung cancer | CARCINOMA-CELLS | MIGRATION | SIGNALING PATHWAYS | METASTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROLIFERATION | MATRIX METALLOPROTEINASES | COLORECTAL-CANCER | PHARMACOLOGY & PHARMACY | TOXICOLOGY | RECK | PROGRESSION | Lung Neoplasms - drug therapy | Matrix Metalloproteinases - genetics | Phosphorylation | Humans | MicroRNAs - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Proto-Oncogene Proteins c-akt - genetics | Tissue Inhibitor of Metalloproteinase-2 - genetics | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Tissue Inhibitor of Metalloproteinase-2 - metabolism | Matrix Metalloproteinase 9 - metabolism | Neoplasm Metastasis | Basigin - genetics | Matrix Metalloproteinase 9 - genetics | Antineoplastic Agents - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | A549 Cells | Matrix Metalloproteinase 2 - metabolism | Neoplasm Invasiveness | Down-Regulation | Solanaceous Alkaloids - pharmacology | GPI-Linked Proteins - metabolism | Phosphatidylinositol 3-Kinases - genetics | Matrix Metalloproteinase 2 - genetics | Tissue Inhibitor of Metalloproteinase-1 - genetics | Basigin - metabolism | MicroRNAs - genetics | Matrix Metalloproteinases - metabolism | GPI-Linked Proteins - genetics | Cysteine | Metastasis | RNA | Health aspects | MicroRNA | Index Medicus
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9. Full Text Xanthohumol Suppresses NPC1L1 Gene Expression through Downregulation of HNF-4 alpha( )and Inhibits Cholesterol Uptake in Caco-2 Cells
by Thang, SK and Chen, PY and Gao, WY and Wu, MJ and Pan, MH and Yen, JH
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, ISSN 0021-8561, 10/2019, Volume 67, Issue 40, pp. 11119 - 11128
Xanthohumol (Xan) is a prenylated chalcone mainly found in hops; it has been demonstrated to function against hypercholesterolemia, hyperlipidemia, and... 
HNF-4 alpha | PICK C1-LIKE 1 | LIPID-METABOLISM | PROTEIN | ANGIOGENESIS | SAFETY | FOOD SCIENCE & TECHNOLOGY | STEROL | statin | cholesterol absorption | NPC1L1 | GLUCOSE | LINE | AGRICULTURE, MULTIDISCIPLINARY | ABSORPTION | CHEMISTRY, APPLIED | xanthohumol
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10. Full Text Xanthohumol Suppresses Mylip/Idol Gene Expression and Modulates LDLR Abundance and Activity in HepG2 Cells
by Chen, Shih-Fen and Chen, Pei-Yi and Hsu, Hao-Jen and Wu, Ming-Jiuan and Yen, Jui-Hung
Journal of Agricultural and Food Chemistry, ISSN 0021-8561, 09/2017, Volume 65, Issue 36, pp. 7908 - 7918
Xanthohumol, a prenylated flavonoid found in hops (Humulus lupulus L.), exhibits multiple biological activities such as antiatherosclerosis and hypolipidemic... 
LXRα | simvastatin | Mylip/Idol | LDLR | xanthohumol | FAMILIAL HYPERCHOLESTEROLEMIA | NUCLEAR RECEPTORS | FOOD SCIENCE & TECHNOLOGY | LXR | LOW-DENSITY-LIPOPROTEIN | TANDEM MASS-SPECTROMETRY | INDUCIBLE DEGRADER | HOPS HUMULUS-LUPULUS | AGRICULTURE, MULTIDISCIPLINARY | LXR alpha | IDOL | CHOLESTEROL HOMEOSTASIS | CHEMISTRY, APPLIED | LIVER-X-RECEPTOR | Receptors, LDL - genetics | Plant Extracts - pharmacology | Humans | Propiophenones - pharmacology | Ubiquitin-Protein Ligases - metabolism | Receptors, LDL - metabolism | Flavonoids - pharmacology | Down-Regulation - drug effects | Humulus - chemistry | Ubiquitin-Protein Ligases - genetics | Hep G2 Cells
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11. Full Text Curcuminoids Promote Neurite Outgrowth in PC12 Cells through MAPK/ERK- and PKC-Dependent Pathways
by Liao, Kuo-Kai and Wu, Ming-Jiuan and Chen, Pei-Yi and Huang, Szu-Wei and Chiu, Shu-Jun and Ho, Chi-Tang and Yen, Jui-Hung
Journal of Agricultural and Food Chemistry, ISSN 0021-8561, 01/2012, Volume 60, Issue 1, pp. 433 - 443
Curcuminoids, the predominant polyphenolic compounds in the rhizome of Curcuma longa Linn., consist of curcumin, demethoxycurcumin (DMC), and... 
PKC | ERK1/2 | curcuminoids | CREB | neurite outgrowth | PC12 cells | FOOD SCIENCE & TECHNOLOGY | NEURONAL DIFFERENTIATION | FLAVONOIDS | BIOAVAILABILITY | AGENT | GAP-43 GENE-EXPRESSION | GROWTH | AGRICULTURE, MULTIDISCIPLINARY | NEUROTROPHINS | CHEMISTRY, APPLIED | Protein Kinase C - genetics | Plant Extracts - pharmacology | Neurites - enzymology | Curcumin - pharmacology | Rats | Neurons - cytology | Neurites - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | PC12 Cells | Animals | MAP Kinase Signaling System - drug effects | Protein Kinase C - metabolism | Neurons - enzymology | Neurogenesis - drug effects | Neurons - drug effects | Neurites - drug effects | Curcuma - chemistry
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12. Full Text Luteolin and apigenin attenuate 4-hydroxy- 2-nonenal-mediated cell death through modulation of UPR, Nrf2-ARE and MAPK pathways in PC12 cells
by Wu, Pei-Shan and Yen, Jui-Hung and Kou, Mei-Chun and Wu, Ming-Jiuan
PLoS ONE, ISSN 1932-6203, 06/2015, Volume 10, Issue 6, p. e0130599
Luteolin and apigenin are dietary flavones and exhibit a broad spectrum of biological activities including antioxidant, anti-inflammatory, anti-cancer and... 
GLUTAMATE CYSTEINE LIGASE | OXIDATIVE STRESS | HEME OXYGENASE-1 EXPRESSION | LIPID-PEROXIDATION PRODUCT | CYSTINE/GLUTAMATE ANTIPORTER | PROTEIN-KINASE | ER STRESS | MULTIDISCIPLINARY SCIENCES | ACTIVATE AUTOPHAGY | FACTOR-KAPPA-B | ENDOPLASMIC-RETICULUM STRESS | Unfolded Protein Response - drug effects | PC12 Cells - cytology | Reactive Oxygen Species - metabolism | Caspase 3 - metabolism | Rats | Antioxidants - pharmacology | Aldehydes - metabolism | Luteolin - pharmacology | Gene Expression Regulation - drug effects | PC12 Cells - drug effects | Animals | MAP Kinase Signaling System - drug effects | Neuroprotective Agents - pharmacology | Signal Transduction - drug effects | PC12 Cells - metabolism | NF-E2-Related Factor 2 - metabolism | Cell Death - drug effects | Lipid Peroxidation | Apigenin - pharmacology | Antioxidants | Nervous system diseases | Flavonoids | Flavones | Cell death | Bioflavonoids | Lipid peroxidation | Development and progression | Biochemistry | Oxidative stress | Biotechnology | Neuroprotection | Cell culture | Reactive oxygen species | Transcription factors | Phosphorylation | Traumatic brain injury | Toxicity | Homeostasis | Cytotoxicity | Activation | Kinases | Caspase-3 | Anticancer properties | Proteins | Biological effects | Pathways | Protein folding | Rodents | Peroxidation | Enzymes | Neurodegenerative diseases | Poly(ADP-ribose) polymerase | Caspase | MAP kinase | Inflammation | Gene expression | Poly(ADP-ribose) Polymerase 1 | Brain research | Diet | Pharmacy | Pheochromocytoma cells | Endoplasmic reticulum | Viability | Cellular stress response | Apoptosis | Cancer
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13. Full Text Lipid peroxidation end product 4-hydroxy-trans-2-nonenal triggers unfolded protein response and heme oxygenase-1 expression in PC12 cells: Roles of ROS and MAPK pathways
by Lin, Meng-Han and Yen, Jui-Hung and Weng, Ching-Yi and Wang, Lisu and Ha, Choi-Lan and Wu, Ming-Jiuan
Toxicology, ISSN 0300-483X, 2013, Volume 315, Issue 1, pp. 24 - 37
Abstract This study investigates the roles of ROS overproduction and MAPK signaling pathways in the induction of unfolded protein response (UPR) and the... 
Emergency | ER stress | HO-1 | 4-HNE | p38 MAPK | Unfolded protein response | P38 MAPK | OXIDATIVE STRESS | PHYSIOLOGICAL ROLES | MURINE MACROPHAGES | NRF2 TRANSCRIPTION FACTOR | ENDOPLASMIC-RETICULUM STRESS | NEURODEGENERATIVE DISEASES | CELLULAR-RESPONSES | NF-E2-RELATED FACTOR-2 | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | TOXICOLOGY | Heme Oxygenase-1 - metabolism | Reactive Oxygen Species - metabolism | Calcium - metabolism | Caspase 3 - metabolism | Gene Expression Regulation | Rats | Imidazoles - pharmacology | Resting Phase, Cell Cycle | Aldehydes - metabolism | PC12 Cells | Aldehydes - administration & dosage | Heme Oxygenase-1 - genetics | Animals | G1 Phase Cell Cycle Checkpoints | Signal Transduction - physiology | Pyridines - pharmacology | p38 Mitogen-Activated Protein Kinases - metabolism | Apoptosis - physiology | Lipid Peroxidation | Unfolded Protein Response - physiology | Endoplasmic Reticulum Stress - physiology | Lipid peroxidation | Drugstores | Enzymes | Superoxide | Heme | Index Medicus
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14. Full Text Cleome rutidosperma and euphorbia thymifolia suppress inflammatory response via upregulation of phase II enzymes and modulation of NF-κB and JNK activation in LPS-stimulated BV2 microglia
by Ding, Hsiou-Yu and Wu, Pei-Shan and Wu, Ming-Jiuan
International Journal of Molecular Sciences, ISSN 1661-6596, 09/2016, Volume 17, Issue 9, pp. 1420 - 1420
Cleome rutidosperma DC. and Euphorbia thymifolia L. are herbal medicines used in traditional Indian and Chinese medicine to treat various illnesses. Reports... 
Cleome rutidosperma | Microglial cells | Euphorbia thymifolia | NF-κB | HO-1 | JNK | Tumor Necrosis Factor-alpha - metabolism | Cell Line | Cell Survival - drug effects | Microglia - metabolism | Plant Extracts - chemistry | Microglia - drug effects | Anti-Inflammatory Agents - pharmacology | Plant Extracts - pharmacology | Nitrites - metabolism | JNK Mitogen-Activated Protein Kinases - metabolism | NF-kappa B - metabolism | Euphorbia - chemistry | Animals | Anti-Inflammatory Agents - chemistry | Lipopolysaccharides - pharmacology | Mice | Interleukin-6 - metabolism | Cleome - chemistry | microglial cells
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15. Full Text Fisetin protects PC12 cells from tunicamycin-mediated cell death via reactive oxygen species scavenging and modulation of Nrf2-driven gene expression, SIRT1 and MAPK signaling in PC12 cells
by Yen, Jui-Hung and Wu, Pei-Shan and Chen, Shu-Fen and Wu, Ming-Jiuan
International Journal of Molecular Sciences, ISSN 1661-6596, 04/2017, Volume 18, Issue 4, pp. 852 - 852
Background: Fisetin (3,7,3',4'-tetrahydroxyflavone) is a dietary flavonol and exhibits antioxidant, anti-inflammatory, and neuroprotective activities. However,... 
Fisetin | HO-1 | p38 MAPK | SIRT1 | Tunicamycin | PATHWAYS | APOPTOSIS | OXIDATIVE STRESS | ACTIVATION | FLAVONOID FISETIN | ER STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | fisetin | NRF2 TRANSCRIPTION FACTOR | ENDOPLASMIC-RETICULUM STRESS | AUTOPHAGY | CHEMISTRY, MULTIDISCIPLINARY | HEME OXYGENASE-1 | tunicamycin | Sirtuin 1 - metabolism | Reactive Oxygen Species - metabolism | Endoplasmic Reticulum Stress - drug effects | Apoptosis - drug effects | Oxidative Stress - genetics | Rats | Antioxidants - pharmacology | Endoplasmic Reticulum Stress - genetics | PC12 Cells | Sirtuin 1 - genetics | Autophagy - drug effects | Gene Expression Regulation - drug effects | Animals | MAP Kinase Signaling System - drug effects | Signal Transduction - drug effects | NF-E2-Related Factor 2 - metabolism | Flavonoids - pharmacology | Neuroprotection | Cysteine | Transcription factors | Phosphorylation | Toxicity | Cytotoxicity | Homology | CCAAT/enhancer-binding protein | Kinases | Western blotting | Cystine | Proteins | Signal transduction | Pathways | Heme | NRF2 protein | Stresses | Enzymes | Oxygen | Scavenging | Extracellular signal-regulated kinase | MAP kinase | JNK protein | Inflammation | Gene expression | Studies | Polymerase chain reaction | Oxygenase | Inhibitors | Cellular biology | Protein kinase | Cell death | Glutamic acid transporter | Viability | Endoplasmic reticulum | Transporter | Phagocytosis | CHOP protein | Cellular stress response | Apoptosis | Cancer
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