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Journal of Neurochemistry, ISSN 0022-3042, 06/2005, Volume 93, Issue 6, pp. 1412 - 1421
Brain‐derived neurotrophic factor (BDNF) is critical for the function and survival of neurons that degenerate in the late stage of Alzheimer's disease (AD).... 
precursor form of brain‐derived neurotrophic factor | mild cognitive impairment | parietal cortex | neurotrophin | western blotting | brain‐derived neurotrophic factor | Neurotrophin | Brain-derived neurotrophic factor | Precursor form of brain-derived neurotrophic factor | Mild cognitive impairment | Western blotting | Parietal cortex | precursor form of brain-derived neurotrophic factor | SENILE DEMENTIA | NUCLEUS BASALIS NEURONS | MESSENGER-RNA EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOPAMINERGIC-NEURONS | NEUROSCIENCES | NERVE GROWTH-FACTOR | CHOLINERGIC HYPOTHESIS | CORTICAL-NEURONS | brain-derived neurotrophic factor | LONG-TERM POTENTIATION | Neurons - pathology | Humans | Nerve Degeneration - physiopathology | Cognition Disorders - metabolism | Male | Parietal Lobe - metabolism | Parietal Lobe - physiopathology | Nerve Degeneration - metabolism | Aged, 80 and over | Female | Brain-Derived Neurotrophic Factor - metabolism | Neurons - metabolism | Alzheimer Disease - psychology | Cell Survival - physiology | Cognition Disorders - psychology | Biomarkers - metabolism | Alzheimer Disease - physiopathology | Cognition Disorders - physiopathology | Disease Progression | Nerve Degeneration - pathology | Parietal Lobe - pathology | Protein Precursors - metabolism | Down-Regulation - physiology | Neuropsychological Tests | Cell Death - physiology | Alzheimer Disease - metabolism | Aged | Proteins | Brain | Neurology | Nervous system | Cognition & reasoning | Alzheimers disease
Journal Article
Neuron, ISSN 0896-6273, 12/2010, Volume 68, Issue 5, pp. 857 - 864
Journal Article
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, ISSN 2167-8421, 07/2019, Volume 20, Issue 5-6, pp. 303 - 309
Successful treatment of neurodegenerative disease may hinge on early therapeutic intervention. This requires an understanding of early/pre-symptomatic disease,... 
Pre-symptomatic | pre-manifest | prodromal | biomarkers
Journal Article
Journal of Neurology, Neurosurgery & Psychiatry, ISSN 0022-3050, 06/2016, Volume 87, Issue 6, pp. 580 - 588
ObjectiveTo discern presymptomatic changes in brain structure or function using advanced MRI in carriers of mutations predisposing to amyotrophic lateral... 
SURFACE-BASED ANALYSIS | SURGERY | ACCURATE | PSYCHIATRY | MODEL | CLINICAL NEUROLOGY | BIOMARKERS | DIFFUSION TENSOR | ROBUST | MUTATION | SEGMENTATION | BRAIN | ONSET | Brain - diagnostic imaging | Amyotrophic Lateral Sclerosis - physiopathology | Corpus Callosum - physiopathology | Humans | Middle Aged | Gyrus Cinguli - diagnostic imaging | Image Interpretation, Computer-Assisted | Male | Parietal Lobe - physiopathology | Cerebral Cortex - physiopathology | Cone-Beam Computed Tomography | Young Adult | Pyramidal Tracts - physiopathology | Cerebellum - diagnostic imaging | Adult | Female | C9orf72 Protein | Nerve Net - physiopathology | Amyotrophic Lateral Sclerosis - diagnostic imaging | Genetic Predisposition to Disease - genetics | Nerve Net - diagnostic imaging | Amyotrophic Lateral Sclerosis - genetics | Brain - physiopathology | Frontal Lobe - physiopathology | Cerebellum - physiopathology | Cerebral Cortex - diagnostic imaging | Proteins - genetics | Corpus Callosum - diagnostic imaging | Frontal Lobe - diagnostic imaging | Magnetic Resonance Imaging | Pyramidal Tracts - diagnostic imaging | Diffusion Magnetic Resonance Imaging | Parietal Lobe - diagnostic imaging | Superoxide Dismutase-1 - genetics | Gyrus Cinguli - physiopathology | Aged | Genetic Carrier Screening | Cohort Studies | Brain | Care and treatment | Usage | Magnetic resonance imaging | Gene mutations | Amyotrophic lateral sclerosis | Research | Neurodegeneration | 1506 | Clinical Medicine | Neurology | Neurologi | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 04/2006, Volume 97, Issue 2, pp. 475 - 487
Dysfunction of cholinergic basal forebrain (CBF) neurons of the nucleus basalis (NB) is a cardinal feature of Alzheimer's disease (AD) and correlates with... 
microarray | trkA | mild cognitive impairment | RNA amplification | neurotrophin | nucleus basalis | Neurotrophin | Nucleus basalis | Microarray | Mild cognitive impairment | Humans | Cognition Disorders - metabolism | Male | Receptors, Nerve Growth Factor - metabolism | RNA, Messenger - metabolism | Choline O-Acetyltransferase - metabolism | Mental Status Schedule - statistics & numerical data | Alzheimer Disease - pathology | Reverse Transcriptase Polymerase Chain Reaction - methods | Aged, 80 and over | Female | Neurons - metabolism | In Situ Hybridization - methods | Prosencephalon - pathology | Severity of Illness Index | Oligonucleotide Array Sequence Analysis - methods | Cognition Disorders - pathology | Gene Expression Regulation - physiology | Nerve Tissue Proteins - genetics | Disease Progression | Receptors, Nerve Growth Factor - genetics | Immunohistochemistry - methods | Nerve Tissue Proteins - metabolism | Receptor, trkA - metabolism | Alzheimer Disease - metabolism | Receptor, trkA - genetics | Aged | Alzheimer Disease - genetics | Postmortem Changes | Cohort Studies | Neurosciences | Alzheimers disease | Gene expression | Neurons | Cell survival | Neurodegenerative diseases | Cognitive ability | Nerve growth factor | Forebrain (basal) | Neurotrophin receptors | Polymerase chain reaction | DNA microarrays | Cerebral blood flow | Degeneration | TrkA receptors | TrkB receptors | Alzheimer's disease
Journal Article
Journal Article
by Nicolas, Aude and Kenna, Kevin P and Kenna, Aoife and Kenna, Kevin and Kenna, Brendan J and Renton, Alan E and Ticozzi, Nicola and Faghri, Faraz and Chia, Ruth and Dominov, Janice A and Nalls, Mike A and Keagle, Pamela and Rivera, Alberto M and van Rheenen, Wouter and Murphy, Natalie A and van Vugt, Joke and van Vugt, Joke J.F.A and Geiger, Joshua T and Van der Spek, Rick A and Pliner, Hannah A and Shankaracharya and Smith, Bradley N and Marangi, Giuseppe and Topp, Simon D and Abramzon, Yevgeniya and Gkazi, Athina Soragia and Eicher, John D and Logullo, Francesco O and Simone, Isabella and Simone, Isabella L and Logroscino, Giancarlo and Salvi, Fabrizio and Bartolomei, Ilaria and Borghero, Giuseppe and Murru, Maria Rita and Costantino, Emanuela and Pani, Carla and Puddu, Roberta and Caredda, Carla and Piras, Valeria and Tranquilli, Stefania and Cuccu, Stefania and Corongiu, Daniela and Melis, Maurizio and Milia, Antonio and Marrosu, Francesco and Marrosu, Maria Giovanna and Floris, Gianluca and Cannas, Antonino and Capasso, Margherita and Caponnetto, Claudia and Mancardi, Gianluigi and Origone, Paola and Mandich, Paola and Conforti, Francesca L and Cavallaro, Sebastiano and Mora, Gabriele and Mora, Jesús S and Marinou, Kalliopi and Sideri, Riccardo and Penco, Silvana and Mosca, Lorena and Lunetta, Christian and Pinter, Giuseppe Lauria and Corbo, Massimo and Riva, Nilo and Carrera, Paola and Volanti, Paolo and Mandrioli, Jessica and Fini, Nicola and Fasano, Antonio and Tremolizzo, Lucio and Arosio, Alessandro and Ferrarese, Carlo and Trojsi, Francesca and Tedeschi, Gioacchino and Monsurrò, Maria Rosaria and Piccirillo, Giovanni and Femiano, Cinzia and Ticca, Anna and Ortu, Enzo and La Bella, Vincenzo and Spataro, Rossella and Colletti, Tiziana and Sabatelli, Mario and Zollino, Marcella and Conte, Amelia and Luigetti, Marco and Lattante, Serena and Santarelli, Marialuisa and Petrucci, Antonio and Pugliatti, Maura and Pirisi, Angelo and Parish, Leslie D and Occhineri, Patrizia and Giannini, Fabio and Battistini, Stefania and Ricci, Claudia and Benigni, Michele and Cau, Tea B and ... and Genomic Translation ALS Care GTAC and ALS Sequencing Consortium and Clinical Res ALS Related Disorders and NYGC ALS Consortium and ITALSGEN Consortium and SLAGEN Consortium and French ALS Consortium and Project MinE ALS Sequencing Consor and Answer ALS Fdn and Project MinE ALS Sequencing Consortium and Genomic Translation for ALS Care (GTAC) Consortium and Answer ALS Foundation and Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe) Consortium and Medicinska fakulteten and Institutionen för farmakologi och klinisk neurovetenskap and Umeå universitet
Neuron, ISSN 0896-6273, 03/2018, Volume 97, Issue 6, pp. 1268 - 1283.e6
Journal Article