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1. Full Text Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases
by Xu, Yan-hui and Xu, Wei and Yang, Chen and Yang, Ying and Yang, Hui and Liu, Li-xia and Liu, Ying and Liu, Jing and Wang, Bin and Wang, Ping and Wang, Pu and Kim, Se-Hee and Ito, Shinsuke and Xiao, Meng-Tao and Jiang, Wen-qing and Zhang, Yi and Zhang, Jin-ye and Frye, Stephen and Lei, Qun-ying and Guan, Kun-Liang and Zhao, Shi-min and Xiong, Yue
Cancer Cell, ISSN 1535-6108, 2011, Volume 19, Issue 1, pp. 17 - 30
and mutations occur frequently in gliomas and acute myeloid leukemia, leading to simultaneous loss and gain of activities in the production of α-ketoglutarate... 
BREAST-CANCER | TRANSCRIPTIONAL ACTIVITY | IDH2 MUTATIONS | ONCOLOGY | PROLYL HYDROXYLATION | INTEGRATED GENOMIC ANALYSIS | 2-OXOGLUTARATE OXYGENASES | ACUTE MYELOID-LEUKEMIA | HIF-ALPHA | HISTONE DEMETHYLATION | FAMILY | CELL BIOLOGY | Dioxygenases - metabolism | Histone Demethylases - antagonists & inhibitors | Gene Expression - genetics | Caenorhabditis elegans Proteins - chemistry | Humans | Ketoglutaric Acids - chemistry | Glioma - genetics | F-Box Proteins | Oxidoreductases, N-Demethylating - antagonists & inhibitors | Ketoglutaric Acids - pharmacology | Cytosine - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Glutarates - chemistry | Oxidoreductases, N-Demethylating - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Glioma - enzymology | Endostatins - metabolism | Models, Molecular | Isocitrate Dehydrogenase - genetics | Histone Demethylases - metabolism | Dioxygenases - antagonists & inhibitors | Amino Acid Substitution - physiology | Procollagen-Proline Dioxygenase - genetics | Cell Line, Tumor | Isocitrate Dehydrogenase - metabolism | Glutarates - pharmacology | Histones - metabolism | Jumonji Domain-Containing Histone Demethylases - metabolism | Caenorhabditis elegans - enzymology | Cytosine - analogs & derivatives | Gene Expression - drug effects | Caenorhabditis elegans Proteins - metabolism | Isocitrate Dehydrogenase - antagonists & inhibitors | Glioma - metabolism | Procollagen-Proline Dioxygenase - metabolism | DNA-Binding Proteins - metabolism | Mixed Function Oxygenases | Biocatalysis - drug effects | Jumonji Domain-Containing Histone Demethylases - antagonists & inhibitors | Jumonji Domain-Containing Histone Demethylases - chemistry | Procollagen-Proline Dioxygenase - antagonists & inhibitors | Ketoglutaric Acids - metabolism | Oxalates - pharmacology | Binding, Competitive | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Catalytic Domain | Proto-Oncogene Proteins - genetics | Hypoxia-Inducible Factor-Proline Dioxygenases | DNA-Binding Proteins - genetics | Homeodomain Proteins - genetics | Animals | 5-Methylcytosine - metabolism | Caenorhabditis elegans Proteins - antagonists & inhibitors | Glutarates - metabolism
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2. Full Text In VivoPharmacokinetic and Pharmacodynamic Profiles of Antofloxacin against Klebsiella pneumoniae in a Neutropenic Murine Lung Infection Model
by Zhou, Yu-Feng and Tao, Meng-Ting and Huo, Wei and Liao, Xiao-Ping and Sun, Jian and Liu, Ya-Hong
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 05/2017, Volume 61, Issue 5
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3. Full Text MicroRNA-143 promotes apoptosis of osteosarcoma cells by caspase-3 activation via targeting Bcl-2
by Li, Wei-hua and Wu, Hao-jie and Li, Yu-xia and Pan, Hua-gang and Meng, Tao and Wang, Xiao
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 2016, Volume 80, pp. 8 - 15
Abstract Osteosarcoma is the most common malignant bone tumor. In recent years, although a lot of research in the mechanism of osteosarcoma development and... 
Internal Medicine | Medical Education | 143 | Bcl-2 | Osteosarcoma | MiR | Apoptosis | MIGRATION | SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | BECLIN 1 | CANCER CELLS | P53 | LUNG-CANCER | INVASION | PHARMACOLOGY & PHARMACY | MiR-143 | Cell Proliferation | Osteosarcoma - enzymology | Humans | Caspase 3 - metabolism | Gene Expression Regulation, Neoplastic | Apoptosis - genetics | MicroRNAs - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Neoplasm Metastasis | Animals | Mice, Nude | Base Sequence | Cell Line, Tumor | Mice, Inbred BALB C | MicroRNAs - genetics | Enzyme Activation | Osteosarcoma - genetics | Osteosarcoma - pathology | MicroRNA | Analysis | Development and progression | Antisense RNA | Metastasis | Gene expression | Prostate cancer
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4. Full Text Involvement of angiotensin-(1–7) in the neuroprotection of captopril against focal cerebral ischemia
by Tao, Meng-Xing and Xue, Xiao and Gao, Li and Lu, Jun-Ling and Zhou, Jun-Shan and Jiang, Teng and Zhang, Ying-Dong
Neuroscience Letters, ISSN 0304-3940, 11/2018, Volume 687, pp. 16 - 21
Accumulating evidence suggests that brain angiotensin-converting enzyme (ACE)/angiotensin II/angiotensin II type I receptor axis is activated and thus... 
ACE2 | Neuroprotection | Ischemic stroke | Captopril | Ang-(1–7) | PULMONARY | SYSTEM | CONVERTING ENZYME | RATS | NEUROSCIENCES | STROKE | INHIBITION | PATHWAY | Ang-(1-7) | BRAIN | AXIS | Stroke (Disease) | Prevention | Enzymes | Evaluation | Medical colleges | Cerebral ischemia | Neurons | Analysis | Angiotensin
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5. Full Text Plasmon-driven reaction controlled by the number of graphene layers and localized surface plasmon distribution during optical excitation
by Dai, Zhi-Gao and Xiao, Xiang-Heng and Wu, Wei and Zhang, Yu-Peng and Liao, Lei and Guo, Shi-Shang and Ying, Jian-Jian and Shan, Chong-Xin and Sun, Meng-Tao and Jiang, Chang-Zhong
Light: Science and Applications, ISSN 2047-7538, 10/2015, Volume 4, Issue 10, pp. e342 - e342
Graphene-plasmonic hybrid platforms have attracted an enormous amount of interest in surface-enhanced Raman scattering (SERS); however, the mechanism of... 
Plasmon-driven reaction | Graphene | SERS | Graphene-mediated SERS | ENHANCED RAMAN-SPECTROSCOPY | GOLD | NANOSTRUCTURES | graphene | PLATFORM | SUBSTRATE | plasmon-driven reaction | OPTICS | PHOTODETECTION | METAL NANOPARTICLES | SCATTERING | graphene-mediated SERS | Catalysts | Raman scattering | Mathematical analysis | Chemical reactions | Plasmons | Nanostructure | Catalysis
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6. Full Text Increased activity of colistin in combination with amikacin against Escherichia coli co-producing NDM-5 and MCR-1
by Zhou, Yu-Feng and Tao, Meng-Ting and Feng, Youjun and Yang, Run-Shi and Liao, Xiao-Ping and Liu, Ya-Hong and Sun, Jian
Journal of Antimicrobial Chemotherapy, ISSN 0305-7453, 2017, Volume 72, Issue 6, pp. 1723 - 1730
Objectives: Colistin and carbapenem are two lines of last-resort antibiotics against lethal infections caused by MDR Gram-negative pathogens. The emergence of... 
COMPANION ANIMALS | INFECTIOUS DISEASES | MICROBIOLOGY | SYNERGISTIC ACTIVITY | LUNG INFECTION | CARBAPENEM-RESISTANT ENTEROBACTERIACEAE | ACINETOBACTER-BAUMANNII | IN-VITRO | BETA-LACTAMASE | ST648 ISOLATE | PSEUDOMONAS-AERUGINOSA | PHARMACOLOGY & PHARMACY | KLEBSIELLA-PNEUMONIAE | Escherichia coli Infections - drug therapy | Escherichia coli - enzymology | Escherichia coli - drug effects | Colistin - administration & dosage | Escherichia coli Infections - microbiology | Amikacin - pharmacology | beta-Lactamases - biosynthesis | Drug Synergism | Microbial Sensitivity Tests | Anti-Bacterial Agents - therapeutic use | Amikacin - administration & dosage | Amikacin - therapeutic use | Animals | Colistin - pharmacology | Drug Resistance, Multiple, Bacterial | Escherichia coli Proteins - biosynthesis | Colistin - therapeutic use | Anti-Bacterial Agents - pharmacology | Mice | Drug Therapy, Combination | Anti-Bacterial Agents - administration & dosage
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7. Full Text Degradation of endogenous proteins and generation of a null-like phenotype in zebrafish using Trim-Away technology
by Chen, Xiao and Liu, Mi and Lou, Hongyan and Lu, Yiyi and Zhou, Meng-Tao and Ou, Rongying and Xu, Yunsheng and Tang, Kai-Fu
Genome Biology, ISSN 1474-7596, 01/2019, Volume 20, Issue 1, pp. 19 - 6
Trim-Away is a recent technique to rapidly deplete a protein from any cell type. Guided by antibodies, TRIM21 selects proteins for destruction. However, the... 
Trim-away | Knockdown | Protein degradation | TRIM21 | ANTIBODIES | RNA HELICASE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | KIT | GENETICS & HEREDITY | DBP5 | GENOME | Biotechnology - methods | Animals | Animals, Genetically Modified | Proteolysis | Embryo, Nonmammalian - metabolism | Zebrafish | Ribonucleoproteins - metabolism | Proteins | Immunoglobulins | Embryogenesis | Phenotypes | Morphology | Genomes | Gene expression | Embryos | Defects
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8. Full Text Stroke Detector and Structure Based Models for Character Recognition: A Comparative Study
by Cun-Zhao Shi and Song Gao and Meng-Tao Liu and Cheng-Zuo Qi and Chun-Heng Wang and Bai-Hua Xiao
IEEE Transactions on Image Processing, ISSN 1057-7149, 12/2015, Volume 24, Issue 12, pp. 4952 - 4964
Characters, which are man-made symbols composed of strokes arranged in a certain structure, could provide semantic information and play an indispensable role... 
Deformable models | Training | spatiality embedded codeword | Thyristors | Text recognition | part-based model | Detectors | stroke detector | Feature extraction | tree-structure | Character recognition | structure | REPRESENTATION | HISTOGRAM | TEXT | COOCCURRENCE | COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE | ENGINEERING, ELECTRICAL & ELECTRONIC | SCENE IMAGES | EXTRACTION | Datasets | OCR
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9. Full Text Fabrication of a Au nanoporous film by self-organization of networked ultrathin nanowires and its application as a surface-enhanced raman scattering substrate for single-molecule detection
by Liu, Rui and Liu, Jing-Fu and Zhou, Xiao-Xia and Sun, Meng-Tao and Jiang, Gui-Bin
Analytical Chemistry, ISSN 0003-2700, 12/2011, Volume 83, Issue 23, pp. 9131 - 9137
Due to its demonstrated usefulness in fields such as trace analysis, biodiagnosis, and in vivo study, surface-enhanced Raman scattering (SERS) has received... 
CHEMISTRY, ANALYTICAL | SPECTROSCOPY | ASSEMBLIES | SERS | GOLD-FILMS | NANOSHELLS | OPTICAL-PROPERTIES | ELECTRODES | NANOSTRUCTURES | LOW-TEMPERATURE | SILVER NANOPARTICLES | Thin films | Gold | Usage | Innovations | Research | Dielectric films | Raman spectroscopy | Nanoparticles | Analytical chemistry | Molecules | Scattering
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10. Full Text Resveratrol possesses protective effects in a pristane-induced lupus mouse model
by Wang, Zhuo-Long and Luo, Xiao-Fang and Li, Meng-Tao and Xu, Dong and Zhou, Shuang and Chen, Hou-Zao and Gao, Na and Chen, Zhen and Zhang, Ling-Ling and Zeng, Xiao-Feng
PLoS ONE, ISSN 1932-6203, 12/2014, Volume 9, Issue 12, p. e114792
Background: Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease characterized by the production of autoantibodies. To date, no therapy has... 
AUTOANTIBODIES | CELLS | KAPPA-B ACTIVATION | INDUCED APOPTOSIS | MULTIDISCIPLINARY SCIENCES | MECHANISMS | DIFFERENTIATION | LEUKEMIA | ERYTHEMATOSUS | BALB/C MICE | LYMPHOCYTES | Inflammation - chemically induced | Stilbenes - administration & dosage | Antigens, CD - biosynthesis | Apoptosis - drug effects | Humans | Terpenes - toxicity | Lectins, C-Type - biosynthesis | CD4-Positive T-Lymphocytes - immunology | Inflammation - drug therapy | Lupus Erythematosus, Systemic - drug therapy | Lupus Erythematosus, Systemic - immunology | B-Lymphocytes - pathology | Sirtuin 1 - deficiency | Receptors, Transferrin - biosynthesis | Inflammation - immunology | Gene Expression Regulation - drug effects | B-Lymphocytes - drug effects | Animals | B-Lymphocytes - immunology | Sirtuin 1 - immunology | Antigens, CD19 - metabolism | Lupus Erythematosus, Systemic - chemically induced | Mice | Antigens, Differentiation, T-Lymphocyte - biosynthesis | CD4-Positive T-Lymphocytes - drug effects | Lupus | Autoimmunity | Autoantibodies | Systemic lupus erythematosus | Analysis | Immunoglobulin G | Resveratrol | B cells | T cells | Cell proliferation | Glomerulonephritis | Flow cytometry | Lymphocytes T | CD69 antigen | Lymphocytes | Spleen | CD19 antigen | Kidneys | Immunomodulation | Pristane | SIRT1 protein | CD4 antigen | Cytometry | Chronic conditions | Lymphocytes B | γ-Interferon | Autoimmune diseases | Proteinuria | Apoptosis
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11. Full Text In vivo bioluminescent monitoring of therapeutic efficacy and pharmacodynamic target assessment of antofloxacin against Escherichia coli in a neutropenic murine thigh infection model
by Zhou, Yu-Feng and Tao, Meng-Ting and He, Yu-Zhang and Sun, Jian and Liu, Ya-Hong and Liao, Xiao-Ping
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 01/2018, Volume 62, Issue 1
Antimicrobial resistance among uropathogens has increased the rates of infection-related morbidity and mortality. Antofloxacin is a novel fluoroquinolone with... 
Antofloxacin | Bioluminescence | PK/PD | Escherichia coli | Murine thigh infection | MICROBIOLOGY | antofloxacin | GRAM-NEGATIVE BACTERIA | LEVOFLOXACIN 500 MG | STREPTOCOCCUS-PNEUMONIAE | NBTI 5463 | II TOPOISOMERASE INHIBITOR | bioluminescence | PHARMACOLOGY & PHARMACY | ACUTE UNCOMPLICATED PYELONEPHRITIS | STAPHYLOCOCCUS-AUREUS | HEALTHY-VOLUNTEERS | FLUOROQUINOLONE | murine thigh infection | RESPIRATORY-TRACT INFECTIONS
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12. Full Text Reduced pulmonary function and increased pro-inflammatory cytokines in nanoscale carbon black-exposed workers
by Zhang, Rong and Dai, Yufei and Zhang, Xiao and Niu, Yong and Meng, Tao and Li, Yuanyuan and Duan, Huawei and Bin, Ping and Ye, Meng and Jia, Xiaowei and Shen, Meili and Yu, Shanfa and Yang, Xiaofa and Gao, Weimin and Zheng, Yuxin
Particle and Fibre Toxicology, ISSN 1743-8977, 12/2014, Volume 11, Issue 1, pp. 73 - 73
Background: Although major concerns exist regarding the potential consequences of human exposures to nanoscale carbon black (CB) particles, limited human... 
Nanoparticles | Pro-inflammatory cytokines | Carbon black | Pulmonary function | Occupational exposure | MORTALITY | SURFACE-AREA | PARTICLES | SUBCHRONIC INHALATION | RATS | INHALATION EXPOSURE | RESPONSES | TOXICOLOGY | RESPIRATORY HEALTH | LUNG INFLAMMATION | Pneumonia - physiopathology | Respiratory Mucosa - drug effects | Air Pollutants, Occupational - toxicity | Humans | Middle Aged | Pneumonia - pathology | Soot - toxicity | Male | Polyacetylenes - chemical synthesis | Occupational Diseases - physiopathology | Pneumonia - chemically induced | China | Inhalation Exposure - adverse effects | Lung - ultrastructure | Adult | Occupational Diseases - pathology | Respiratory Mucosa - physiopathology | Lung - metabolism | Cytokines - blood | Occupational Diseases - metabolism | Soot - chemistry | Cytokines - metabolism | Occupational Exposure - adverse effects | Lung - physiopathology | Chemical Industry - manpower | Random Allocation | Air Pollutants, Occupational - chemistry | Respiratory Mucosa - ultrastructure | Particle Size | Occupational Diseases - chemically induced | Animals | Lung - drug effects | Toxicity Tests, Subacute | Atmosphere Exposure Chambers | Product Packaging - manpower | Mice, Inbred BALB C | Respiratory Mucosa - metabolism | Pneumonia - metabolism | Air Pollution, Indoor - adverse effects | Soot - administration & dosage | Occupational health and safety | Pulmonary function tests | Inflammation | Workers | Outdoor air quality | Scanning electron microscopy | Toxicology | Transmission electron microscopy | Mortality | Lung cancer | Air pollution | Occupational health | Organic chemicals | Variance analysis | Disease control | Lungs | Cytokines | Exposure | Mice | Nanostructure | Deposition | Index Medicus
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13. Full Text The Influence of Temperature on Mode I Fracture Toughness and Fracture Characteristics of Sandstone
by Feng, Gan and Kang, Yong and Meng, Tao and Hu, Yao-qing and Li, Xiao-hong
Rock Mechanics and Rock Engineering, ISSN 0723-2632, 8/2017, Volume 50, Issue 8, pp. 2007 - 2019
This study investigated the influence of temperature on the mode I fracture toughness of sandstone using semicircular bend specimens. Fracture characteristics... 
Earth Sciences | Fracture analysis | Civil Engineering | Semicircular bend | Fracture crack shape | Geophysics/Geodesy | Sandstone | Fracture toughness | STRAIN-RATE | PRESSURE | GEOSCIENCES, MULTIDISCIPLINARY | ROCK | THERMAL-TREATMENT | TENSILE-STRENGTH | ENGINEERING, GEOLOGICAL | Electron microscopy | Analysis | Mutual coupling | Scanning electron microscopy | Transgranular fracture | Heat treatment | Fracture mechanics | Stability | Temperature gradients | Stability analysis | Stone | Cracking (fracturing) | Temperature gradient | Fragmentation | Toughness | Temperature effects | Sedimentary rocks | Mechanics | Heat treating | Fracturing | Low temperature
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14. Full Text Thermo-responsive gating membranes with controllable length and density of poly( N-isopropylacrylamide) chains grafted by ATRP method
by Li, Peng-Fei and Xie, Rui and Jiang, Jun-Chao and Meng, Tao and Yang, Lihua and Yang, Mei and Ju, Xiao-Jie and Chu, Liang-Yin
Journal of Membrane Science, ISSN 0376-7388, 2009, Volume 337, Issue 1, pp. 310 - 317
A series of thermo-responsive gating membranes with controllable length and density of grafted polymer chains are prepared by grafting poly(... 
Diffusional permeability | Gating membranes | Graft polymerization | Atom-transfer radical polymerization (ATRP) | Thermo-response | POLY N-ISOPROPYLACRYLAMIDE | TRACK-ETCHED MEMBRANES | POLYMER SCIENCE | POROUS MEMBRANES | TRANSFER RADICAL POLYMERIZATION | CELL-CULTURE MEMBRANES | CORE-SHELL MICROCAPSULES | FUNCTIONALIZATION | ENGINEERING, CHEMICAL | TEMPERATURE | BRUSHES | THERMOSENSITIVE MEMBRANES | Polymerization | Permeability | Analysis | Methods | Monomers | Aluminum oxide
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