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ACS Medicinal Chemistry Letters, ISSN 1948-5875, 03/2011, Volume 2, Issue 3, pp. 224 - 229
The iminothiazolidinone BMS-858 (2) was identified as a specific inhibitor of HCV replication in a genotype 1b replicon assay via a high-throughput screening... 
stilbene | iminothiazolidinone | HCV NS5A inhibitor | POTENT | DOMAIN | CHEMISTRY, MEDICINAL | PROTEIN | HEPATITIS-C | DERIVATIVES
Journal Article
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 08/2016, Volume 44, Issue 8, pp. 1332 - 1340
During a medicinal chemistry campaign to identify inhibitors of the hepatitis C virus nonstructural protein 5B (RNA-dependent RNA polymerase), a... 
NONNUCLEOSIDE INHIBITORS | VIRUS POLYMERASE | POTENT | DEPENDENT RNA-POLYMERASE | CRYSTAL-STRUCTURE | BIOSYNTHESIS | PHOSPHOLIPIDS | PHARMACOLOGY & PHARMACY | PHOSPHATIDYLCHOLINE | RECEPTOR ANTAGONIST | DISCOVERY
Journal Article
Journal of Molecular Catalysis. B, Enzymatic, ISSN 1381-1177, 07/2015, Volume 117, pp. 45 - 53
•Enzymatic oxidations of betulinic and betulonic acids.•Biotransformations with two bacteria and two fungi were studied.•Several di-, tri-, tetrahydroxy and... 
Enzymatic oxidation | Microbial transformation | Enzymatic hydroxylation | Betulinic acid | Betulonic acid | BIOTRANSFORMATION | PRODUCTS | CHEMISTRY, PHYSICAL | TRITERPENES | DERIVATIVES
Journal Article
Journal Article
Journal Article
Food and Chemical Toxicology, ISSN 0278-6915, 09/2019, Volume 131, p. 110585
Monacolin K (MK) is the principal active substance in Monascus-fermentation products (e.g. red yeast rice). MK is effective in reducing cholesterol levels in... 
Lovastatin | Monacolin K | Bioactivity | Red yeast rice | Monascus | Statins | APOPTOSIS | CELLS | HYPOCHOLESTEROLEMIC AGENT | FOOD SCIENCE & TECHNOLOGY | SCHIZOPHRENIA | INTOLERANT | INHIBITION | MOLD-RICE | TOXICOLOGY
Journal Article
Magnetic resonance in chemistry : MRC, ISSN 0749-1581, 06/2007, Volume 45, Issue 6, p. 447
We report here the observation of O-H...N hydrogen-bond (1h)J(N,OH) scalar coupling in a biologically active natural product. The intramolecular hydrogen bond... 
Hydrogen Bonding | Magnetic Resonance Spectroscopy | Nitrogen - chemistry | Peptides - chemistry | Molecular Conformation | Oxygen - chemistry | Models, Molecular | Molecular Structure | Hydrogen - chemistry | Nitrogen Isotopes
Journal Article
Journal Article
Journal Article
Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 04/2011, Volume 21, Issue 8, pp. 2484 - 2488
A series of N-fluoroalkyl-8-(6-methoxy-2-methylpyridin-3-yl)-2,7-dimethyl-N-al k ylpyrazolo[1,5-a][1,3,5]triazin-4-amines were prepared and evaluated as... 
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2011, Volume 21, Issue 8, pp. 2484 - 2488
A series of N-(3-fluoroalkyl)-8-(6-methoxy-2-methylpyridin-3-yl)-2,7-dimethyl- N-alkylpyrazolo[1,5- a][1,3,5]triazin-4-amines were prepared and evaluated as... 
Imaging agents | Depression | Corticotropin-releasing factor | Anxiety | Positron emission tomography
Journal Article
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