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1. Full Text Thematic review series: Recent advances in the treatment of lysosomal storage diseases: Lysosomal exocytosis and lipid storage disorders
by Samie, Mohammad Ali and Xu, Haoxing
Journal of Lipid Research, ISSN 0022-2275, 2014, Volume 55, Issue 6, pp. 995 - 1009
Transient receptor potential mucolipin 1 | Calcium | Lysosomal storage disease | Transcription factor EB
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2. Full Text A painful TRP to lysosomes
by Gu, Mingxue and Xu, Haoxing
The Journal of Cell Biology, ISSN 0021-9525, 11/2016, Volume 215, Issue 3, p. 309
The ion channel TRPA1 detects noxious stimuli at the plasma membrane of neurons and elicits pain and inflammation. In this issue, Shang et al. (2016. J. Cell... 
Lysosomes | Health aspects | Cell membranes
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3. Full Text Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB
by Medina, Diego L and Di Paola, Simone and Peluso, Ivana and Armani, Andrea and De Stefani, Diego and Venditti, Rossella and Montefusco, Sandro and Scotto-Rosato, Anna and Prezioso, Carolina and Forrester, Alison and Settembre, Carmine and Wang, Wuyang and Gao, Qiong and Xu, Haoxing and Sandri, Marco and Rizzuto, Rosario and De Matteis, Maria Antonietta and Ballabio, Andrea
Nature Cell Biology, ISSN 1465-7392, 03/2015, Volume 17, Issue 3, pp. 288 - 299
The view of the lysosome as the terminal end of cellular catabolic pathways has been challenged by recent studies showing a central role of this organelle in... 
TRANSCRIPTION FACTORS | SKELETAL-MUSCLE | MENDELIAN-INHERITANCE | TRP CHANNEL | MUCOLIPIDOSIS TYPE-IV | AMINO-ACIDS | GENE-EXPRESSION | ACIDIC ORGANELLES | ENDOPLASMIC-RETICULUM | CELLULAR CLEARANCE | CELL BIOLOGY | Phosphorylation | Humans | Gene Expression Regulation | Protein Transport | Animals | Calcineurin - genetics | Lysosomes - metabolism | Transient Receptor Potential Channels - genetics | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | Cell Line, Tumor | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Fibroblasts - cytology | Mice | Autophagy - genetics | Transient Receptor Potential Channels - metabolism | Calcineurin - metabolism | Calcium Signaling | Fibroblasts - metabolism | Autophagy (Cytology) | Transcription factors | Cellular signal transduction | Genetic aspects | Properties | Calcium ions | Index Medicus
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4. Full Text PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome
by Dong, Xian-Ping and Shen, Dongbiao and Wang, Xiang and Dawson, Taylor and Li, Xinran and Zhang, Qi and Cheng, Xiping and Zhang, Yanling and Weisman, Lois S and Delling, Markus and Xu, Haoxing
Nature Communications, ISSN 2041-1723, 2010, Volume 1, Issue 4, p. 38
Membrane fusion and fission events in intracellular trafficking are controlled by both intraluminal Ca2+ release and phosphoinositide (PIP) signalling.... 
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5. Full Text A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation
by Li, Xinran and Rydzewski, Nicholas and Hider, Ahmad and Zhang, Xiaoli and Yang, Junsheng and Wang, Wuyang and Gao, Qiong and Cheng, Xiping and Xu, Haoxing
Nature Cell Biology, ISSN 1465-7392, 03/2016, Volume 18, Issue 4, pp. 404 - 417
To mediate the degradation of biomacromolecules, lysosomes must traffic towards cargo-carrying vesicles for subsequent membrane fusion or fission. Mutations of... 
MUCOLIPIDOSIS | TRANSPORT | RAB7 | KINESIN | CHOLESTEROL | TRP CHANNEL | PROTEIN RILP | MEMBRANE | TRAFFICKING | CA2+ CHANNEL | CELL BIOLOGY | Phosphatidylinositol Phosphates - metabolism | Fluorescence Recovery After Photobleaching | Calcium - metabolism | Humans | Cercopithecus aethiops | Molecular Sequence Data | rab GTP-Binding Proteins - genetics | Autophagy | Lysosomes - metabolism | Base Sequence | HEK293 Cells | Apoptosis Regulatory Proteins - genetics | Transient Receptor Potential Channels - metabolism | Calcium-Binding Proteins - metabolism | Dyneins - metabolism | rab GTP-Binding Proteins - metabolism | Cell Line | Signal Transduction | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Animals | Models, Biological | Transient Receptor Potential Channels - genetics | Adaptor Proteins, Signal Transducing - genetics | Luminescent Proteins - genetics | HeLa Cells | Mutation | Adaptor Proteins, Signal Transducing - metabolism | COS Cells | Microscopy, Fluorescence | Calcium-Binding Proteins - genetics | Luminescent Proteins - metabolism | Motility | Lysosomes | Ion transport | Genetic aspects | Properties | Observations | Cells | Index Medicus | TRPML1 | dynein | lysosome reformation | PI(3,5)P2 | ALG-2 | nutrient starvation | cholesterol | phosphoinositide | membrane trafficking
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6. Full Text Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels
by Clapham, David E and Jun, Janice C and Xu, Haoxing and Delling, Markus
Nature Neuroscience, ISSN 1097-6256, 05/2006, Volume 9, Issue 5, pp. 628 - 635
Carvacrol, eugenol and thymol are major components of plants such as oregano, savory, clove and thyme. When applied to the tongue, these flavors elicit a warm... 
CELLS | HEAT | GATED ION-CHANNEL | 2-AMINOETHOXYDIPHENYL BORATE | THERMOSENSATION | STIMULI | RECEPTOR | KERATINOCYTES | MECHANISMS | CURRENTS | NEUROSCIENCES | Enzyme-Linked Immunosorbent Assay - methods | Skin - cytology | Epithelial Cells - metabolism | Gene Expression - drug effects | Epithelial Cells - drug effects | Humans | Membrane Potentials - radiation effects | Patch-Clamp Techniques - methods | Dose-Response Relationship, Drug | Monoterpenes - pharmacology | Transfection - methods | Tongue - cytology | Indoles | TRPC Cation Channels - genetics | In Situ Hybridization - methods | Animals, Newborn | Membrane Potentials - drug effects | Green Fluorescent Proteins - metabolism | Interleukin-1 - metabolism | Cells, Cultured | Rats | Eugenol - pharmacology | Membrane Potentials - physiology | Rats, Sprague-Dawley | Animals | Thymol - pharmacology | Nasal Mucosa - cytology | TRPC Cation Channels - metabolism | Mice | Physiological aspects | Neural stimulation | Genetic aspects | Ion channels | Research | Capsaicin | Index Medicus
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7. Full Text The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel
by Kurz, Tino and Wang, Fudi and Dong, Xian-Ping and Xu, Haoxing and Cheng, Xiping and Delling, Markus and Mills, Eric and Institutionen för medicin och hälsa and Farmakologi and Linköpings universitet and Hälsouniversitetet
Nature, ISSN 0028-0836, 10/2008, Volume 455, Issue 7215, pp. 992 - 996
TRPML1 (mucolipin 1, also known as MCOLN1) is predicted to be an intracellular late endosomal and lysosomal ion channel protein that belongs to the mucolipin... 
METABOLISM | PATHWAY | MULTIDISCIPLINARY SCIENCES | DISEASE | MEMBRANE-PROTEIN | MICE | MUTATIONS | SKIN | RECEPTOR POTENTIAL CHANNEL | Protons | Cell Line | TRPM Cation Channels - deficiency | Humans | Cell Membrane Permeability | Fluorescence | Transient Receptor Potential Channels | Iron - metabolism | Endosomes - metabolism | Iron - analysis | Animals | Lysosomes - metabolism | Transfection | Mucolipidoses - metabolism | Fibroblasts | TRPM Cation Channels - genetics | Ion Transport | Mice | TRPM Cation Channels - metabolism | Physiological aspects | Genetic aspects | Ion channels | Research | Mucolipidoses | Proteins | Permeability | Mutation | Patients | Cells | Index Medicus | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
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8. Full Text MCOLN1 is a ROS sensor in lysosomes that regulates autophagy
by Zhang, Xiaoli and Cheng, Xiping and Yu, Lu and Yang, Junsheng and Calvo, Raul and Patnaik, Samarjit and Hu, Xin and Gao, Qiong and Yang, Meimei and Lawas, Maria and Delling, Markus and Marugan, Juan and Ferrer, Marc and Xu, Haoxing
Nature Communications, ISSN 2041-1723, 06/2016, Volume 7, Issue 1, pp. 12109 - 12109
Cellular stresses trigger autophagy to remove damaged macromolecules and organelles. Lysosomes 'host' multiple stress-sensing mechanisms that trigger the... 
OXIDATIVE STRESS | BIOGENESIS | MULTIDISCIPLINARY SCIENCES | CALCIUM | DISEASE | MITOCHONDRIA | SENSITIZE | TFEB | TRAFFICKING | QUALITY-CONTROL | ION CHANNELS | Reactive Oxygen Species - metabolism | Calcium - metabolism | Microtubule-Associated Proteins - metabolism | Humans | Cercopithecus aethiops | Mitochondria - metabolism | Autophagy | Organelle Biogenesis | Patch-Clamp Techniques | Animals | Lysosomes - metabolism | HEK293 Cells | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Mice | HeLa Cells | Transient Receptor Potential Channels - metabolism | COS Cells | Index Medicus
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9. Full Text Structure of mammalian endolysosomal TRPML1 channel in nanodiscs
by Chen, Qingfeng and She, Ji and Zeng, Weizhong and Guo, Jiangtao and Xu, Haoxing and Bai, Xiao-Chen and Jiang, Youxing
Nature, ISSN 0028-0836, 10/2017, Volume 550, Issue 7676, pp. 415 - 418
Transient receptor potential mucolipin 1 (TRPML1) is a cation channel located within endosomal and lysosomal membranes. Ubiquitously expressed in mammalian... 
CATION CHANNELS | SYSTEM | PROTEIN | MULTIDISCIPLINARY SCIENCES | MUTATION | LEADS | DEAFNESS | RELEASE | IDENTIFICATION | MUCOLIPIN-1 | Physiological aspects | Ion channels | Cell membranes | Structure | Mammals | Membranes | Channel gating | Lipids | Selectivity | pH effects | Crystallography | Luminance distribution | Phosphatidylinositol | Mucolipidosis | Transient receptor potential proteins | Divalent cations | Mutagenesis | Microscopy | Calcium conductance | Ligands | Cations | Conductance | Mutation | Embedded structures | Binding sites | Index Medicus
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10. Full Text Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells
by Sun, Yubing and Yong, Koh Meng Aw and Villa-Diaz, Luis G and Zhang, Xiaoli and Chen, Weiqiang and Philson, Renee and Weng, Shinuo and Xu, Haoxing and Krebsbach, Paul H and Fu, Jianping
Nature Materials, ISSN 1476-1122, 2014, Volume 13, Issue 6, pp. 599 - 604
Our understanding of the intrinsic mechanosensitive properties of human pluripotent stem cells (hPSCs), in particular the effects that the physical... 
PHYSICS, CONDENSED MATTER | PHYSICS, APPLIED | PROTEIN | ACTIN | MATERIALS SCIENCE, MULTIDISCIPLINARY | CHEMISTRY, PHYSICAL | SELF-RENEWAL | SPECIFICATION | ELASTICITY | INHIBITION | PATHWAY | GENERATION | MOTONEURONS | MECHANOTRANSDUCTION | Phosphorylation | Pluripotent Stem Cells - cytology | Humans | Cells, Cultured | Nuclear Proteins - metabolism | Transcription Factors - genetics | Actomyosin - metabolism | Motor Neurons - metabolism | Pluripotent Stem Cells - metabolism | Transcription Factors - metabolism | Mechanotransduction, Cellular | Motor Neurons - cytology | Cytoskeleton - metabolism | Cell Differentiation | Nuclear Proteins - genetics | Smad Proteins - metabolism | Protein-Serine-Threonine Kinases - metabolism | Arrays | Neurons | Neural networks | Stem cells | Index Medicus | Human | Motors | Rigidity | Differentiation | Culture
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11. Full Text Phosphoinositide isoforms determine compartment-specific ion channel activity
by Xiaoli Zhang and Xinran Li and Haoxing Xu
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 07/2012, Volume 109, Issue 28, pp. 11384 - 11389
Phosphoinositides serve as address labels for recruiting peripheral cytoplasmic proteins to specific subcellular compartments, and as endogenous factors for... 
Mucolipin | TRP channel | ACTIVATION | PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE | mucolipin | MULTIDISCIPLINARY SCIENCES | TRP CHANNELS | RELEASE | K+ CHANNEL | PROTEINS | RECEPTOR POTENTIAL CHANNEL | PIP2 | MUCOLIPIN-1 | Phosphatidylinositols - chemistry | Humans | Cercopithecus aethiops | Exocytosis | Phosphatidylinositol Phosphates - chemistry | Animals | Electrophysiology - methods | Lysosomes - metabolism | Cell-Free System | Ion Channels - metabolism | Models, Biological | Mucolipidoses - metabolism | Protein Isoforms | HEK293 Cells | Cell Membrane - metabolism | Ion Transport | Transient Receptor Potential Channels - metabolism | COS Cells | Phosphatidylinositol 4,5-Diphosphate - chemistry | Physiological aspects | Phosphoinositides | Ion channels | Phosphatases | Research | Proteins | Lipids | Amino acids | Membranes | Cytoplasm | Index Medicus | Biological Sciences
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12. Full Text Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release
by Shen, Dongbiao and Wang, Xiang and Li, Xinran and Zhang, Xiaoli and Yao, Zepeng and Dibble, Shannon and Dong, Xian-Ping and Yu, Ting and Lieberman, Andrew P and Showalter, Hollis D and Xu, Haoxing
Nature Communications, ISSN 2041-1723, 2012, Volume 3, Issue 1, pp. 731 - 731
Lysosomal lipid accumulation, defects in membrane trafficking and altered Ca2+ homoeostasis are common features in many lysosomal storage diseases. Mucolipin... 
TRANSPORT | CHOLESTEROL | MUCOLIPIDOSIS TYPE-IV | MULTIDISCIPLINARY SCIENCES | DISEASE | MEMBRANE-PROTEIN | DEGRADATION | MUTATIONS | ACID SPHINGOMYELINASE | IDENTIFICATION | Cricetinae | Sphingomyelins - metabolism | Calcium - metabolism | Humans | Cercopithecus aethiops | Niemann-Pick Diseases - metabolism | Cholesterol - metabolism | TRPC Cation Channels - antagonists & inhibitors | Quinolines - pharmacology | Mice, Knockout | Protein Transport | Phthalimides - pharmacology | Macrophages - metabolism | Patch-Clamp Techniques | Animals | Lysosomes - metabolism | Sphingomyelin Phosphodiesterase - metabolism | TRPC Cation Channels - metabolism | Mice | Mice, Inbred BALB C | Transient Receptor Potential Channels - metabolism | COS Cells | Index Medicus
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13. Full Text The channel kinase, TRPM7, is required for early embryonic development
by Jie Jin and Long-Jun Wu and Janice Jun and Xiping Cheng and Haoxing Xu and Nancy C. Andrews and David E. Clapham
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 01/2012, Volume 109, Issue 5, pp. E225 - E233
Global disruption of transient receptor potential-melastatin-like 7 ( Trpm7 ) in mice results in embryonic lethality before embryonic day 7. Using... 
Melanocytes | Gastrulation | Magnesium | Chanzyme | TRPM6 | chanzyme | SURVIVAL | melanocytes | PROTEIN | MULTIDISCIPLINARY SCIENCES | CRE | NICHE | magnesium | EXPRESSION | gastrulation | Nerve Tissue Proteins - physiology | Nestin | Animals | Pluripotent Stem Cells - cytology | Embryonic Development - physiology | Intermediate Filament Proteins - physiology | Female | Male | Mice, Transgenic | Cell Differentiation | Mice | TRPM Cation Channels - physiology | Tissue | Kinases | Neurons | Rodents | Stem cells | Index Medicus | Biological Sciences | PNAS Plus
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