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Journal of Clinical Investigation, ISSN 0021-9738, 05/2016, Volume 126, Issue 5, pp. 1679 - 1690
Hemodynamic shear forces are intimately linked with cardiac development, during which trabeculae form a network of branching outgrowths from the myocardium.... 
MEDICINE, RESEARCH & EXPERIMENTAL | NADPH OXIDASE | ZEBRAFISH HEART | ENDOTHELIUM | IN-VIVO | CARDIOMYOCYTE PROLIFERATION | NOTCH | AUTOPHAGY | MESENCHYMAL TRANSITION | EXPRESSION | PROTECTS | Stress management | Technology application | Microscope and microscopy | Analysis | Methods | Heart | Morphogenesis | Microscopy | Cardiomyopathy | Rodents | Cardiomyocytes | Ligands | Shear stresses | Mutation | Kinases | Gene expression
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2016, Volume 59, Issue 10, pp. 4948 - 4964
In the treatment of echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase positive (ALK+) non-small-cell lung cancer (NSCLC),... 
CELL LUNG-CANCER | WILD-TYPE | CHEMISTRY, MEDICINAL | SRC TYROSINE KINASE | THERAPEUTIC TARGET | RESISTANCE | ATOMS-IN-MOLECULES | ALK INHIBITOR | IDENTIFICATION | ALK/ROS1 INHIBITOR | SMALL-MOLECULE INHIBITOR | Lung Neoplasms - drug therapy | Phosphines - pharmacology | Humans | Molecular Conformation | Lung Neoplasms - pathology | Structure-Activity Relationship | Antineoplastic Agents - administration & dosage | Pyrimidines - chemistry | Dose-Response Relationship, Drug | Neoplasms, Experimental - pathology | Protein Kinase Inhibitors - chemistry | Phosphines - chemistry | Organophosphorus Compounds - pharmacology | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Female | Antineoplastic Agents - pharmacology | Carcinoma, Non-Small-Cell Lung - pathology | Cell Survival - drug effects | Lung Neoplasms - enzymology | Administration, Oral | Pyrimidines - administration & dosage | Rats | Organophosphorus Compounds - chemistry | Pyrimidines - pharmacology | Antineoplastic Agents - chemistry | Mice, SCID | Receptor Protein-Tyrosine Kinases - metabolism | Drug Discovery | Protein Kinase Inhibitors - administration & dosage | Animals | Receptor Protein-Tyrosine Kinases - genetics | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Organophosphorus Compounds - administration & dosage | Protein Kinase Inhibitors - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy | Carcinoma, Non-Small-Cell Lung - enzymology | Neoplasms, Experimental - drug therapy | Drug Screening Assays, Antitumor
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 08/2016, Volume 126, Issue 8, p. 3158
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 09/2013, Volume 54, Issue 38, pp. 5214 - 5216
A novel synthesis of 1,4-benzothiazin-3-ones was developed from Cu-catalyzed coupling of readily available substituted 2-iodoanilines with 2-mercaptoacetate.... 
1,4-Benzothiazin-3-one | Heterocycle synthesis | Cu-catalysis | C–S bond formation | C-S bond formation | HALIDES | ONE-POT SYNTHESIS | CHEMISTRY, ORGANIC | THIOLS | AMINO-ACID | SMILES REARRANGEMENT | ARYL IODIDES | INHIBITORS | DERIVATIVES | EFFICIENT | Tetrahedrons | Synthesis (chemistry) | Joining | Copper
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 01/2014, Volume 55, Issue 2, pp. 441 - 444
Direct, chemo-specific arylation at C-2 or N-4 of 1,4-benzothiazin-3-one with aryl halides, based on Pd or Cu catalyst system, respectively, provided easy... 
1,4-Benzothiazin-3-one | Heterocycle synthesis | Pd-catalysis | Cu-catalysis | N-arylation | C-arylation | ALPHA-ARYLATION | OXINDOLES | CHEMISTRY, ORGANIC | CONVENIENT | CARBOXAMIDES | EQUIVALENTS | POTENT | ARYL HALIDES | INHIBITORS | DERIVATIVES | AMIDES | Palladium | Synthesis (chemistry) | Accessibility | Aromatic compounds | Tetrahedrons | Amides | Derivatives | Copper
Journal Article
by Lee, J and Fei, P and Packard, RRS and Kang, H and Xu, H and Baek, KI and Jen, N and Chen, JJ and Yen, H and Kuo, CCJ and Chi, NC and Ho, CM and Li, RS and Hsiai, TK
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 08/2016, Volume 126, Issue 8, pp. 3158 - 3158
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 04/2007, Volume 48, Issue 16, p. 2915
Journal Article
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 2007, Volume 48, Issue 16, pp. 2915 - 2918
Journal Article
01/2007, ISBN 0494318732
Innate immunity, one of two arms of the immune system, can provide more rapid defense mechanisms than adaptive immunity in human immune defense systems. The... 
Biochemistry | Pharmacology
Dissertation
10th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, 04/2015, pp. 243 - 247
Studies have shown emerging evidence that rupture of coronary plaque containing a lipid-rich core with subsequent thrombus formation is the most frequent... 
Electrodes | Sensitivity | Voltage measurement | Mice | Impedance | Lesions | Mathematical model
Conference Proceeding
ChemInform, ISSN 0931-7597, 06/2014, Volume 45, Issue 25, pp. no - no
Efficient reaction conditions for the regioselective N‐arylation as well as the regioselective C2‐arylation of 1,4‐benzothiazin‐3‐one are presented. 
catalysis, phase‐transfer catalysis | thiazine derivatives | amination, N‐alkylation, N‐arylation | C‐C bond formation | Palladium | Catalysis
Journal Article
ChemInform, ISSN 0931-7597, 01/2014, Volume 45, Issue 3, pp. no - no
The catalyst system consisting of copper iodide and a diamine ligand catalyzes the coupling between iodoanilines and mercaptoacetate, offering a new method... 
thiazine derivatives | ring closure reactions | catalysis, phase‐transfer catalysis
Journal Article
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