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Journal of Clinical Investigation, ISSN 0021-9738, 12/2012, Volume 122, Issue 12, pp. 4505 - 4518
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2014, Volume 9, Issue 6, p. e100124
Cyclin G-associated kinase (GAK), a key player in clathrin-mediated membrane trafficking, is overexpressed in various cancer cells. Here, we report that GAK... 
MUTATION ANALYSIS | ANDROGEN RECEPTOR | LUNG-CANCER | REGULATOR | THERAPY | TYROSINE KINASE | MULTIDISCIPLINARY SCIENCES | TRAFFICKING | OSTEOSARCOMA | CELLULAR TARGETS | EXPRESSION | Prostatic Neoplasms - metabolism | Phosphorylation | Apoptosis - drug effects | Humans | Male | Intracellular Signaling Peptides and Proteins - metabolism | Antineoplastic Agents - administration & dosage | Receptor, Epidermal Growth Factor - metabolism | Neoplasm Grading | Prostatic Neoplasms - genetics | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Quinazolines - administration & dosage | Antineoplastic Agents - pharmacology | Active Transport, Cell Nucleus | Gene Expression Regulation, Neoplastic - drug effects | Luteolin - administration & dosage | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Cell Survival - drug effects | Prostatic Neoplasms - pathology | Gene Expression | Prostatic Neoplasms - surgery | Signal Transduction | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Protein-Serine-Threonine Kinases - genetics | Luteolin - pharmacology | Protein Transport | Protein Kinase Inhibitors - administration & dosage | Cell Cycle Checkpoints - drug effects | Models, Biological | Cell Line, Tumor | Cell Proliferation - drug effects | MicroRNAs - genetics | Protein Kinase Inhibitors - pharmacology | Quinazolines - pharmacology | Clathrin | Kinases | Biomedical materials | Cell growth | Epidermal growth factor | Osteosarcoma | Surgery | Down-regulation | Cyclin G | Fibroblasts | Biocompatibility | Gefitinib | Epidermal growth factor receptors | Dietary supplements | MiRNA | Embryo fibroblasts | Osteosarcoma cells | Embryos | Androgens | Diet | Ribonucleic acids | Cell death | Membrane trafficking | Protein-serine/threonine kinase | Mutation | Prostate cancer | Prostate | Viability | Cancer
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 4892 - 11
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 11334 - 12
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2016, Volume 11, Issue 7, p. e0158562
LATS2, a pivotal Ser/Thr kinase of the Hippo pathway, plays important roles in many biological processes. LATS2 also function in Hippo-independent pathway,... 
HISTONE METHYLTRANSFERASE ACTIVITY | SELECTIVE-INHIBITION | APOPTOSIS | STEM-CELLS | HUMAN GENOME | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | HIPPO PATHWAY | TUMOR-SUPPRESSOR | DIFFERENTIATION | EZH2 | Cell Cycle - genetics | Chromatin - metabolism | Protein-Serine-Threonine Kinases - deficiency | Phosphorylation | Polycomb Repressive Complex 2 - genetics | Humans | Genetic Complementation Test | MCF-7 Cells | Tumor Suppressor Proteins - deficiency | Base Sequence | Tumor Suppressor Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Chromatin - chemistry | Fibroblasts - metabolism | Cell Line | Epigenomics | Signal Transduction | Transcription Activator-Like Effector Nucleases - metabolism | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | Gene Knockout Techniques | Transcription Activator-Like Effector Nucleases - genetics | Plasmids - metabolism | Animals | Histones - genetics | Plasmids - chemistry | Protein Binding | Fibroblasts - cytology | Mice | HeLa Cells | Histones - metabolism | Polycomb Repressive Complex 2 - metabolism | Analysis | Physiological aspects | Research | Enzyme kinetics | Genetic regulation | Properties | Phosphotransferases | Chromatin | Mesenchyme | Mitosis | Genomics | DNA damage | Homology | Genomes | mRNA | Kinases | Proteins | Cell cycle | DNA methylation | Histone methyltransferase | Nuclease | Bioinformatics | Deoxyribonucleic acid--DNA | University graduates | Gene expression | Biological activity | Polycomb group proteins | Infectious diseases | Collaboration | Protein-serine/threonine kinase | Lymphomas | Mutation | Aberration | Deoxyribonucleic acid | DNA
Journal Article
Genes and Development, ISSN 0890-9369, 10/2006, Volume 20, Issue 19, pp. 2687 - 2700
Damage to the mitotic spindle and centrosome dysfunction can lead to cancer. To prevent this, cells trigger a succession of checkpoint responses, where an... 
Mdm2 | Lats2 | Tetraploidy checkpoint | p53 | PROTEIN-KINASE | DOWN-REGULATION | SPINDLE ASSEMBLY CHECKPOINT | DEVELOPMENTAL BIOLOGY | tetraploidy checkpoint | MAMMALIAN-CELLS | CANCER | CELL BIOLOGY | MITOTIC APPARATUS | GENETICS & HEREDITY | CYTOKINESIS FAILURE | GENOMIC INTEGRITY | HUMAN HOMOLOG | PROGRESSION | Flow Cytometry - methods | Proto-Oncogene Proteins c-mdm2 - genetics | Immunoprecipitation | Humans | Nocodazole - pharmacology | Tumor Suppressor Protein p53 - genetics | Polymerase Chain Reaction - methods | Tumor Suppressor Protein p53 - physiology | Microtubules - metabolism | Spindle Apparatus - metabolism | Protein Binding - drug effects | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Proto-Oncogene Proteins c-mdm2 - metabolism | Protein-Serine-Threonine Kinases - metabolism | Cell Line | Polyploidy | Tumor Suppressor Proteins - metabolism | Protein-Serine-Threonine Kinases - physiology | Cell Cycle Proteins - metabolism | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Tumor Suppressor Protein p53 - metabolism | Ubiquitin-Protein Ligases - metabolism | Centrosome - metabolism | Gene Expression Regulation - drug effects | Tumor Suppressor Proteins - physiology | Two-Hybrid System Techniques | Animals | Fluorescent Antibody Technique | Cell Cycle - physiology | Cell Line, Tumor | Mice | Cell Cycle - drug effects | Ubiquitin-Protein Ligases - genetics | Ubiquitin | Ploidy | Oncology, Experimental | Tumor suppressor genes | Genetic aspects | Research | Health aspects | Cancer | Research Paper
Journal Article
Journal Article
Developmental Cell, ISSN 1534-5807, 2009, Volume 16, Issue 3, pp. 398 - 410
Journal Article