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Journal Article
PLoS ONE, ISSN 1932-6203, 07/2014, Volume 9, Issue 7, pp. e99383 - e99383
The exact implication of innate immunity in granuloma formation and irreversible lung fibrosis remains to be determined. In this study, we examined the lung... 
FIBROSIS | TUMOR-NECROSIS-FACTOR | INDUCED PULMONARY INFLAMMATION | NMRI MICE | INDUCED LUNG INFLAMMATION | C57BL/6 MICE | MULTIDISCIPLINARY SCIENCES | RECEPTOR ANTAGONIST | MURINE SILICOSIS | T-LYMPHOCYTES | NALP3 INFLAMMASOME | Immunohistochemistry | Inflammation - chemically induced | T-Lymphocytes, Regulatory - metabolism | Granuloma - metabolism | Interleukin-1alpha - immunology | Receptors, Interleukin-1 - genetics | Immunity, Innate - genetics | Interleukin-1alpha - metabolism | Pulmonary Fibrosis - genetics | Interleukin-1beta - genetics | Silicosis - genetics | T-Lymphocytes, Regulatory - immunology | Signal Transduction - immunology | Flow Cytometry | Th17 Cells - metabolism | Interleukin-1beta - metabolism | Myeloid Differentiation Factor 88 - immunology | Interleukin-1alpha - genetics | Cytokines - genetics | Silicosis - immunology | Cytokines - immunology | Granuloma - genetics | Silicosis - etiology | Cytokines - metabolism | Receptors, Interleukin-1 - immunology | Silicon Dioxide - immunology | Mice, Inbred C57BL | Myeloid Differentiation Factor 88 - genetics | Pulmonary Fibrosis - immunology | Interleukin-1beta - immunology | Inflammation - immunology | Signal Transduction - genetics | Mice, Knockout | Receptors, Interleukin-1 - metabolism | Immunity, Innate - immunology | Animals | Silicon Dioxide - toxicity | Inflammation - genetics | Pulmonary Fibrosis - chemically induced | Th17 Cells - immunology | Granuloma - immunology | Myeloid Differentiation Factor 88 - metabolism | Platelet-derived growth factor | Collagen | Analysis | Inflammation | T cells | Transforming growth factors | Silica | Granuloma | Collagens | Parenchyma | Inflammatory response | Innate immunity | Lymphocytes T | Interleukin 1 receptors | Kinases | Immunity | Accumulation | Silicon dioxide | Toxicology | Lymphocytes | Rodents | Interleukin 1 | Toll-like receptors | Tumor necrosis factor-TNF | Cytokines | Sarcoidosis | Lung diseases | Pharmacology | Gene expression | Pulmonary fibrosis | Lungs | TLR2 protein | Interleukin 10 | Fibrosis | MyD88 protein | TNF inhibitors | Mice | Index Medicus
Journal Article
Journal Article
Journal Article
Archives of Toxicology, ISSN 0340-5761, 5/2018, Volume 92, Issue 5, pp. 1673 - 1684
Rechargeable Li-ion batteries (LIB) are increasingly produced and used worldwide. LIB electrodes are made of micrometric and low solubility particles,... 
Biomedicine, general | Biomedicine | Environmental Health | Occupational Medicine/Industrial Medicine | Ferruginous bodies | Lung | Fibrosis | Inflammation | HIF-1α | Pharmacology/Toxicology | Electric Power Supplies | Lithium - chemistry | Oxides - chemistry | Lithium - pharmacokinetics | Pneumonia - pathology | Titanium - chemistry | Air Pollutants - pharmacokinetics | Biological Availability | Pneumonia - chemically induced | Iron - pharmacokinetics | Female | Cobalt - pharmacokinetics | Lithium - toxicity | Lung - pathology | Microscopy, Electron, Scanning | Fibrosis - chemically induced | Iron - chemistry | Mice, Inbred C57BL | Administration, Inhalation | Oxides - toxicity | Oxides - pharmacokinetics | Particle Size | Titanium - toxicity | Cobalt - toxicity | Animals | Lung - drug effects | Titanium - pharmacokinetics | Bronchoalveolar Lavage Fluid - chemistry | Fibrosis - pathology | Air Pollutants - toxicity | Iron - toxicity | Toxicity Tests | Cobalt - chemistry | Air Pollutants - chemistry | Silica | Batteries | Toxicity | Cobalt oxides | Lithium | Iron | Cobalt | Lithium compounds | Silicon dioxide | Lithium-ion batteries | Alveoli | Crystal structure | Hypoxia-inducible factors | Bioassays | Particulates | Ions | Bioavailability | Crystallinity | Biological activity | Rechargeable batteries | Lungs | Health hazards | Hypoxia
Journal Article
Journal of Pathology, ISSN 0022-3417, 04/2015, Volume 235, Issue 5, p. 698
Macrophages play a central role in immune and tissue responses of granulomatous lung diseases induced by pathogens and foreign bodies. Circulating monocytes... 
Proteins | Fc receptors | Granuloma | Macrophages | Silica | Analysis
Journal Article
Journal Article
Particle and Fibre Toxicology, ISSN 1743-8977, 12/2014, Volume 11, Issue 1, pp. 67 - 67
Background: Ge-imogolites are short aluminogermanate tubular nanomaterials with attractive prospected industrial applications. In view of their nano-scale... 
High aspect ratio | Lung | Fibrosis | Genotoxicity | Fibre | Inflammation | Nanomaterial | Biopersistence | CELLS | PARTICLES | LENGTH | MECHANICAL-PROPERTIES | IN-VITRO | SUBACUTE INHALATION TOXICITY | MULTIWALL CARBON NANOTUBES | TOXICOLOGY | ASBESTOS | PLEURAL INFLAMMATION | Germanium - administration & dosage | Respiratory Mucosa - drug effects | Rats, Wistar | Pneumonia - pathology | Toxicity Tests, Acute | Alveolar Epithelial Cells - immunology | Dose-Response Relationship, Drug | Nanotubes - chemistry | Nanotubes - toxicity | Respiratory Mucosa - pathology | Tissue Distribution | Aluminum Silicates - chemistry | Alveolar Epithelial Cells - pathology | Pneumonia - chemically induced | Respiratory Mucosa - immunology | Aluminum Silicates - administration & dosage | Inhalation Exposure - adverse effects | Pneumonia - immunology | Female | Germanium - toxicity | Pulmonary Fibrosis - etiology | Germanium - chemistry | Lung - pathology | Metal Nanoparticles - chemistry | Cells, Cultured | Alveolar Epithelial Cells - metabolism | Alveolar Epithelial Cells - drug effects | Respiratory Tract Absorption | Particle Size | Toxicokinetics | Metal Nanoparticles - toxicity | Animals | Metal Nanoparticles - administration & dosage | Micronuclei, Chromosome-Defective - chemically induced | Lung - drug effects | Aluminum Silicates - toxicity | Air Pollutants - toxicity | Lung - immunology | Air Pollutants - chemistry | Asbestos | X-ray spectroscopy | Standard deviation | Regression analysis | Lungs | Experiments | Rodents | Rats | Biocompatibility | Nanostructure | Walls | Index Medicus | Material chemistry | Chemical Sciences
Journal Article
Particle and Fibre Technology, ISSN 1743-8977, 12/2014, Volume 11, Issue 1
Inflammasome-activated IL-1[beta] plays a major role in lung neutrophilic inflammation induced by inhaled silica. However, the exact mechanisms that contribute... 
Macrophages | Silica | Chromosomal proteins | Proteins | Toxicology | Cytokines | Metabolites | Rodents | Atoms & subatomic particles | Gene expression
Journal Article
Journal Article
Particle and Fibre Toxicology, ISSN 1743-8977, 12/2014, Volume 11, Issue 1, pp. 69 - 69
Background: Inflammasome-activated IL-1 beta plays a major role in lung neutrophilic inflammation induced by inhaled silica. However, the exact mechanisms that... 
Alarmins | Nanoparticles | Neutrophils | IL-1 family | Inflammasome | Inflammation | Silica | BRONCHOALVEOLAR LAVAGE FLUID | STERILE INFLAMMATION | PULMONARY INFLAMMATION | NLRP3 INFLAMMASOME | CRYSTALLINE SILICA | RECEPTOR ANTAGONIST | NALP3 INFLAMMASOME | WALLED-CARBON-NANOTUBES | IN-VITRO | EPITHELIAL-CELLS | TOXICOLOGY | Silicon Dioxide - administration & dosage | Respiratory Mucosa - drug effects | Nanoparticles - chemistry | Antibodies, Neutralizing - metabolism | Pneumonia - pathology | Interleukin-1alpha - metabolism | Toxicity Tests, Acute | Respiratory Mucosa - pathology | Microspheres | Interleukin-1beta - metabolism | Pneumonia - chemically induced | Respiratory Mucosa - immunology | Inhalation Exposure - adverse effects | Pneumonia - immunology | Female | Interleukin-1alpha - genetics | Lung - metabolism | Macrophages, Alveolar - immunology | Neutrophil Infiltration - drug effects | Interleukin-1beta - secretion | Cell Line | Lung - pathology | Mice, Inbred C57BL | Silicon Dioxide - chemistry | Cells, Cultured | Interleukin-1alpha - antagonists & inhibitors | Interleukin-1alpha - secretion | Macrophages, Alveolar - secretion | Nanoparticles - toxicity | Mice, Knockout | Particle Size | Animals | Silicon Dioxide - toxicity | Macrophages, Alveolar - drug effects | Lung - drug effects | Macrophages, Alveolar - cytology | Nanoparticles - administration & dosage | Respiratory Mucosa - metabolism | Air Pollutants - toxicity | Pneumonia - metabolism | Lung - immunology | Air Pollutants - chemistry | Lungs | Cytokines | In vitro testing | Exposure | Mice | Macrophages | Silicon dioxide | Index Medicus
Journal Article