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Current Molecular Medicine, ISSN 1566-5240, 04/2010, Volume 10, Issue 3, p. 258
Journal Article
Current pharmaceutical design, ISSN 1381-6128, 04/2008, Volume 14, Issue 10, p. 939
¬† There is a growing body of evidence to show that AGEs, which form and accumulate at an accelerated rate under diabetes and normal aging, are implicated in... 
Journal Article
Circulation journal : official journal of the Japanese Circulation Society, ISSN 1347-4820, 2019, Volume 83, Issue 9, pp. 1822 - 1828
Journal Article
Current Pharmaceutical Design, ISSN 1381-6128, 2018, Volume 24, Issue 24, pp. 2802 - 2809
Journal Article
Current Drug Targets, ISSN 1389-4501, 12/2011, Volume 12, Issue 14, pp. 2096 - 2102
Recent meta-analyses have revealed that the risk of bone fracture is increased in both type 1 and type 2 diabetic patients. Low bone mineral density (BMD) can... 
Osteoporosis | Oxidative stress | AGEs | RAGE | BONE-MINERAL DENSITY | NITROGEN-CONTAINING BISPHOSPHONATE | I COLLAGEN | osteoporosis | CROSS-LINKS | FRACTURE RISK | PENTOSIDINE | NONENZYMATIC GLYCATION | SOLUBLE RAGE | PHARMACOLOGY & PHARMACY | ENDPRODUCTS | oxidative stress | BIOCHEMICAL BASIS
Journal Article
Cardiovascular diabetology, ISSN 1475-2840, 2019, Volume 18, Issue 1, pp. 12 - 4
...Author(s): Sho-ichi Yamagishi[sup.1] Background A number of papers have suggested that diabetes is one of the risk factors for development of atrial... 
Vascular calcification | Advanced glycation end products | Warfarin | Diabetes | Atrial fibrillation | Bone fracture | POPULATION | CARDIAC & CARDIOVASCULAR SYSTEMS | METAANALYSIS | RISK | ORAL ANTICOAGULANTS | ENDOCRINOLOGY & METABOLISM | COHORT | OUTCOMES | HEALTH | Diabetes Mellitus - blood | Age Factors | Anticoagulants - administration & dosage | Humans | Stroke - diagnosis | Warfarin - adverse effects | Male | Thromboembolism - epidemiology | Warfarin - administration & dosage | Thromboembolism - diagnosis | Thromboembolism - prevention & control | Clinical Decision-Making | Female | Stroke - epidemiology | Diabetes Mellitus - diagnosis | Osteoporotic Fractures - epidemiology | Atrial Fibrillation - diagnosis | Stroke - prevention & control | Risk Assessment | Administration, Oral | Atrial Fibrillation - drug therapy | Risk Factors | Treatment Outcome | Anticoagulants - adverse effects | Warfarin - pharmacokinetics | Atrial Fibrillation - blood | Stroke - blood | Osteoporotic Fractures - chemically induced | Thromboembolism - blood | Atrial Fibrillation - epidemiology | Blood Coagulation - drug effects | Diabetes Mellitus - epidemiology | Vascular Calcification - chemically induced | Vascular Calcification - epidemiology | Anticoagulants - pharmacokinetics | Calcification (ectopic) | Cardiac arrhythmia | Risk | Cardiovascular disease | Systematic review | Proteins | Osteoporosis | Biomedical materials | Fibrillation | Older people | Biocompatibility | Thromboembolism | Vitamin K | Hypertension | Anticoagulants | Stroke | Osteocalcin | Mortality | Diabetes mellitus | Health risks | Pharmacology | Patients | Morbidity | Quality of life | Meta-analysis | Fractures | Womens health | Coronary vessels | Calcification | Carboxylation | Pharmacokinetics | Health risk assessment | Geriatrics
Journal Article
Nutrition, ISSN 0899-9007, 2016, Volume 32, Issue 2, pp. 157 - 165
Abstract Reactive¬†derivatives from nonenzymatic glucose-protein condensation reactions, as well as lipids and nucleic acids exposed to reducing sugars, form a... 
Gastroenterology and Hepatology | Aging | Oxidative stress | AGEs | Diet | Cardiometabolic disorder | INTENSIVE DIABETES THERAPY | FOLLOW-UP | RECEPTOR-GAMMA ACTIVATION | ENDOTHELIAL FUNCTION | AGE-RAGE AXIS | COMMUNITY-DWELLING ADULTS | CARDIOVASCULAR-DISEASE MORTALITY | NUTRITION & DIETETICS | INSULIN-RESISTANCE | RENAL-FAILURE PATIENTS | EPSILON-CARBOXYMETHYL-LYSINE | Inflammation - pathology | Oxidative Stress | Humans | Insulin Resistance | Cardiovascular Diseases - pathology | Disease Progression | Alzheimer Disease - pathology | Renal Insufficiency, Chronic - pathology | Glycation End Products, Advanced - blood | Glycation End Products, Advanced - adverse effects | Diabetes Mellitus, Type 2 - pathology | Metabolic Syndrome - pathology | Proteins | Schiff bases | Chronic kidney failure | Insulin resistance | Glucose | Health aspects | Alzheimer's disease | Dextrose | Structural integrity | Intervention | Senescence | Cooking | Disorders | Cardiovascular disease | Lipids | Condensation | Disease resistance | Condensates | Physiology | Sugars | Age | Adducts | Advanced glycosylation end products | Neurodegenerative diseases | Mortality | Diabetes mellitus | Crosslinking | Inflammation | Glycosylation | Derivatives | Nucleic acids | Metabolism | Insulin | Covalence | Diabetes | Kidney diseases | Alzheimers disease | Cardiovascular diseases | Metabolic disorders
Journal Article
Journal of atherosclerosis and thrombosis, ISSN 1340-3478, 2016, Volume 23, Issue 11, pp. 1255 - 1256
See article vol. 23: 1261-1269 Changes in vascular function and structure of vessels are evaluated by flow-mediated vasodilation (FMD) and intima-media... 
ATHEROSCLEROSIS | RISK | PERIPHERAL VASCULAR DISEASE | FLOW-MEDIATED DILATION | CARDIOVASCULAR EVENTS | THICKNESS | Endothelium, Vascular - pathology | Vascular Diseases - physiopathology | Humans | Endothelium, Vascular - chemistry
Journal Article
Current Pharmaceutical Design, ISSN 1381-6128, 04/2008, Volume 14, Issue 10, pp. 973 - 978
Journal Article
Cardiovascular diabetology, ISSN 1475-2840, 2013, Volume 12, Issue 1, pp. 125 - 125
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 03/2017, Volume 25, Issue 13, pp. 1480 - 1500
Pigment epithelium-derived factor (PEDF) is a glycoprotein that belongs to the superfamily of serine protease inhibitors, serpins. It was first identified as a... 
Oxidative stress | Metabolic disorder | PEDF | Retinopathy | Cardiovascular disease | Diabetic nephropathy | Inflammation | C-REACTIVE PROTEIN | CHEMISTRY, MEDICINAL | ENDOTHELIAL-GROWTH-FACTOR | FATTY LIVER-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | IMPROVES CARDIAC-FUNCTION | FACTOR VEGF EXPRESSION | FACTOR PEDF BLOCKS | inflammation | retinopathy | HEPATIC INSULIN-RESISTANCE | metabolic disorder | SERUM-LEVELS | PHARMACOLOGY & PHARMACY | oxidative stress | diabetic nephropathy | GLYCATION END-PRODUCTS | RETINAL MULLER CELLS | Biomarkers - metabolism | Obesity - drug therapy | Serpins - metabolism | Obesity - complications | Cardiovascular Diseases - drug therapy | Humans | Diabetes Mellitus - drug therapy | Kidney Diseases - drug therapy | Metabolic Diseases - drug therapy | Nerve Growth Factors - metabolism | Cardiovascular Diseases - complications | Animals | Eye Proteins - metabolism | Metabolic Diseases - metabolism | Inflammation - drug therapy | Neovascularization, Pathologic - drug therapy | Liver Diseases - complications | Kidney Diseases - complications | Liver Diseases - drug therapy | Oxidative Stress - drug effects | Liver | Serine | Disorders | Serpins | Retina | Lymphocytes T | Adipocytes | Macrophages | Retinal pigment epithelium | Fatty liver | Lymphocytes | Atherosclerosis | Eye (anatomy) | Pigment epithelium-derived factor | Obesity | Reproductive systems | Liver diseases | Kidneys | Complications | Therapeutic applications | Diabetes mellitus | Proteinase inhibitors | Glycoproteins | Metabolism | Epithelium | Insulin | Protease inhibitors | Arteriosclerosis | Fibrosis | Biomarkers | Serine proteinase | Reproductive system | Angiogenesis inhibitors | Cardiovascular diseases | Metabolic disorders
Journal Article
Molecular medicine (Cambridge, Mass.), ISSN 1528-3658, 2015, Volume 21, Issue S1, pp. S32 - S40
A nonenzymatic reaction between reducing sugars and amino groups of proteins, lipids and nucleic acids contributes to the aging of macromolecules and... 
MEDICINE, RESEARCH & EXPERIMENTAL | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | PLASMINOGEN-ACTIVATOR INHIBITOR-1 | POSITIVE ASSOCIATION | CELL BIOLOGY | FACTOR PEDF | ASYMMETRIC DIMETHYLARGININE GENERATION | SOLUBLE FORM | SERUM-LEVELS | NEUTRALIZING RAGE-ANTIBODY | ENDOTHELIAL GROWTH-FACTOR | Dipeptidyl Peptidase 4 - metabolism | Alzheimer Disease - complications | Oxidative Stress | Cardiovascular Diseases - drug therapy | Diabetes Mellitus, Type 2 - genetics | Humans | Glycation End Products, Advanced - antagonists & inhibitors | Osteoporosis - drug therapy | Diabetes Mellitus, Type 1 - complications | Cardiovascular Diseases - pathology | Cardiovascular Diseases - genetics | Alzheimer Disease - pathology | Neoplasms - complications | Cardiovascular Diseases - complications | Diabetic Angiopathies - pathology | Neoplasms - genetics | Diabetic Angiopathies - complications | Osteoporosis - genetics | Receptor for Advanced Glycation End Products - genetics | Diabetic Angiopathies - genetics | Diabetes Mellitus, Type 2 - complications | Gene Expression | Receptor for Advanced Glycation End Products - metabolism | Diabetes Mellitus, Type 1 - pathology | Alzheimer Disease - drug therapy | Diabetes Mellitus, Type 1 - genetics | Aptamers, Nucleotide - therapeutic use | Dipeptidyl Peptidase 4 - genetics | Diabetic Angiopathies - drug therapy | Diabetes Mellitus, Type 1 - drug therapy | Neoplasms - drug therapy | Osteoporosis - pathology | Glycation End Products, Advanced - metabolism | Osteoporosis - complications | Diabetes Mellitus, Type 2 - pathology | Alzheimer Disease - genetics | Diabetes Mellitus, Type 2 - drug therapy | Neoplasms - pathology | Adenosine Deaminase Inhibitors - therapeutic use
Journal Article