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1. Full Text Heavy quark spin multiplet structure of P . (∗) Σq (∗) molecular states HEAVY QUARK SPIN MULTIPLET STRUCTURE of ⋯ YUKI SHIMIZU, YASUHIRO YAMAGUCHI, and MASAYASU HARADA
by Shimizu, Yuki and Yamaguchi, Yasuhiro and Harada, Masayasu
Physical Review D, ISSN 2470-0010, 07/2018, Volume 98, Issue 1
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2. Full Text The Truncated Isoform of the Receptor Tyrosine Kinase ALK Generated by Alternative Transcription Initiation (ALKATI) Induces Chromatin Structural Changes in the Nucleus in a Kinase Activity-Dependent Manner
by Takakura, Yuki and Yamaguchi, Noritaka and Honda, Takuya and Morii, Mariko and Yuki, Ryuzaburo and Nakayama, Yuji and Yamaguchi, Naoto
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2017, Volume 40, Issue 11, pp. 1968 - 1975
Anaplastic lymphoma kinase (ALK) is a receptor-type tyrosine kinase that promotes cell growth upon stimulation with ligands such as midkine and pleiotrophin.... 
alternative transcription initiation | A-kinase anchoring protein 8 | heterochromatinization | nuclear tyrosine kinase | chromatin structural change | anaplastic lymphoma kinase | Chromatin structural change | Nuclear tyrosine kinase | Alternative transcription initiation | Heterochromatinization | Anaplastic lymphoma kinase | LOCALIZATION | ACTIVATION | FUSION | PHOSPHORYLATION | IDENTIFICATION | CELL LUNG-CANCER | INHIBITION | PHARMACOLOGY & PHARMACY | GROWTH-FACTOR | EXPRESSION | Phosphorylation | Introns - genetics | Alternative Splicing | Isoenzymes - genetics | Humans | Receptor Protein-Tyrosine Kinases - metabolism | Protein Domains - genetics | A Kinase Anchor Proteins - genetics | Cell Nucleus - metabolism | Heterochromatin - genetics | Cell Nucleus - genetics | Heterochromatin - metabolism | Receptor Protein-Tyrosine Kinases - genetics | Isoenzymes - metabolism | Transcription Initiation Site | HeLa Cells | Histones - metabolism | A Kinase Anchor Proteins - metabolism
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3. Full Text Synthesis of benzo[d]imidazo[2,1-b]benzoselenoazoles: Cs2CO3-mediated cyclization of 1-(2-bromoaryl)benzimidazoles with selenium
by Matsumura, Mio and Kitamura, Yuki and Yamauchi, Arisa and Kanazawa, Yoshitaka and Murata, Yuki and Hyodo, Tadashi and Yamaguchi, Kentaro and Yasuike, Shuji
Beilstein Journal of Organic Chemistry, ISSN 1860-5397, 08/2019, Volume 15, Issue 1, pp. 2029 - 2035
The synthesis of benzimidazo[2,1-b]benzoselenoazoles is described. The novel ring-closure reaction of 1-(2-bromoaryl)benzimidazoles with Se powder is promoted... 
Absorption spectroscopy | Selenium | Spectrum analysis | Benzimidazole | Pharmaceutical sciences | selenoazole | benzimidazole | cesium carbonate | selenium | cyclization
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4. Full Text Synthesis of furanocoumarin, benzofuran and coumarin derivatives possessing an inhibitory effect on human CYP, and elucidation of the inhibitory mechanism
by Yamaguchi, Yuki
Yakugaku Zasshi, ISSN 0031-6903, 2017, Volume 137, Issue 10, pp. 1209 - 1214
Furanocoumarin | CYP3A4 | Grapefruit juice | Bergapten
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5. Full Text Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance
by Kabe, Yasuaki and Nakane, Takanori and Koike, Ikko and Yamamoto, Tatsuya and Sugiura, Yuki and Harada, Erisa and Sugase, Kenji and Shimamura, Tatsuro and Ohmura, Mitsuyo and Muraoka, Kazumi and Yamamoto, Ayumi and Uchida, Takeshi and Iwata, So and Yamaguchi, Yuki and Krayukhina, Elena and Noda, Masanori and Handa, Hiroshi and Ishimori, Koichiro and Uchiyama, Susumu and Kobayashi, Takuya and Suematsu, Makoto
Nature Communications, ISSN 2041-1723, 03/2016, Volume 7, Issue 1, p. 11030
Progesterone-receptor membrane component 1 (PGRMC1/Sigma-2 receptor) is a haem-containing protein that interacts with epidermal growth factor receptor (EGFR)... 
PGRMC1 | SIGMA-2 RECEPTOR | PROTEIN | CARBON-MONOXIDE | STRUCTURAL BASIS | MULTIDISCIPLINARY SCIENCES | MEMBRANE COMPONENT-1 | IRON | OXYGENASE | PROGESTERONE-RECEPTOR | BINDING | Neoplasms - metabolism | Cell Proliferation | Heme - metabolism | Humans | Protein Multimerization | Cytochrome P-450 Enzyme System - metabolism | Crystallography, X-Ray | Drug Resistance, Neoplasm | Carbon Monoxide - metabolism | Receptors, Progesterone - metabolism | Receptor, Epidermal Growth Factor - metabolism | Signal Transduction - drug effects | Solutions | Models, Biological | Protein Binding | Membrane Proteins - metabolism | Neoplasms - pathology | Receptors, sigma - metabolism
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6. Full Text Radiation Pneumonitis with Eosinophilic Alveolitis in a Lung Cancer Patient
by Hosono, Yuki and Sawa, Nobuhiko and Nakatsubo, Saeko and Ishijima, Mikako and Uenami, Takeshi and Kanazu, Masaki and Akazawa, Yuki and Yano, Yukihiro and Mori, Masahide and Yamaguchi, Toshihiko and Yokota, Soichiro
Internal Medicine, ISSN 0918-2918, 2018, Volume 57, Issue 9, pp. 1281 - 1285
A 59-year-old woman suffering from dry cough and dyspnea was admitted to our hospital. She had undergone concurrent chemo-radiotherapy five months earlier.... 
lung cancer | eosinophilia | bronchoalveolar lavage | radiation pneumonitis | steroid | Steroid | Bronchoalveolar lavage | Eosinophilia | Lung cancer | Radiation pneumonitis | MEDICINE, GENERAL & INTERNAL | THERAPY | Leukocytes (eosinophilic) | Radiation | Bronchus | Irradiated | Radiation therapy | Cough | Pneumonitis | Dyspnea | Computed tomography | Peripheral blood | Respiration | Alveoli | Alveolitis | Cancer | Case Report
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7. Full Text Functional Diversification of the Two C-Class MADS Box Genes OSMADS3 and OSMADS58 in Oryza sativa
by Takahiro Yamaguchi and Dong Yeon Lee and Akio Miyao and Hikohiko Hirochika and Gynheung An and Hiro-Yuki Hirano
The Plant Cell, ISSN 1040-4651, 1/2006, Volume 18, Issue 1, pp. 15 - 28
The C-class MADS box gene AGAMOUS (AG) plays crucial roles in Arabidopsis thaliana development by regulating the organ identity of stamens and carpels, the... 
Meristems | Carpels | Phenotypes | Determinacy | Flowering | Plants | Flowers | Stamens | Rice | Plant cells | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSGENIC RICE PLANTS | CONTROLLING FLOWER DEVELOPMENT | T-DNA | PLANT SCIENCES | CELL BIOLOGY | OVULE DEVELOPMENT | EVOLUTION | ECTOPIC EXPRESSION | DUPLICATION | ARABIDOPSIS | MAIZE | FLORAL ORGAN IDENTITY | Amino Acid Sequence | Gene Targeting | Oryza - metabolism | MADS Domain Proteins - genetics | Molecular Sequence Data | Phylogeny | MADS Domain Proteins - metabolism | Oryza - anatomy & histology | Plant Proteins - genetics | MADS Domain Proteins - classification | Phenotype | In Situ Hybridization | Plant Proteins - classification | Oryza - genetics | RNA Interference | Gene Expression Regulation, Plant | Flowers - anatomy & histology | Flowers - physiology | Plant Proteins - metabolism | Mutation | Evolution, Molecular | Arabidopsis thaliana | Development | Genetic aspects
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8. Full Text Copper-catalyzed [3 + 2] cycloaddition of (phenylethynyl)-di-p-tolylstibane with organic azides
by Yamada, Mizuki and Matsumura, Mio and Uchida, Yuki and Kawahat, Masatoshi and Murata, Yuki and Kakusawa, Naoki and Yamaguchi, Kentaro and Yasuike, Shuji
Beilstein Journal of Organic Chemistry, ISSN 1860-5397, 06/2016, Volume 12, Issue 1, pp. 1309 - 1313
Trisubstituted 5-stibano-1H-1,2,3-triazoles were synthesized in moderate to excellent yields by the Cu-catalyzed [3 + 2] cycloaddition of a ethynylstibane with... 
Ethynylstibane | Cycloaddition | 1 2 3-triazole | Copper catalyst | Organic azide | ethynylstibane | HALIDES | CROSS-COUPLING REACTION | organic azide | CLICK CHEMISTRY | CUAAC | CHEMISTRY, ORGANIC | TERMINAL ALKYNES | cycloaddition | COPPER(I)-CATALYZED CYCLOADDITION | 1,2,3-TRIAZOLES | copper catalyst | ARYL IODIDES | TRANSMETALLATING AGENT | 1,2,3-triazole | ALKYNE CYCLOADDITION
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9. Full Text Post-progression survival after cessation of treatment with nivolumab for advanced non-small cell lung cancer: A retrospective study
by Yano, Y and Kurebe, H and Edahiro, R and Hosono, Y and Nakatsubo, S and Nishida, K and Sawa, N and Ishijima, M and Uenami, T and Kanazu, M and Akazawa, Y and Yamaguchi, T and Mori, M
PLOS ONE, ISSN 1932-6203, 08/2018, Volume 13, Issue 8, p. e0203070
Objectives The effectiveness of treatment after cessation of nivolumab in patients with advanced non-small cell lung cancer (NSCLC) has not been well... 
RESPONSE RATES | PEMBROLIZUMAB | INHIBITORS | DOCETAXEL | MULTIDISCIPLINARY SCIENCES | CHEMOTHERAPY | Research | Lung cancer, Non-small cell | Drug therapy | Patient outcomes | Statistical analysis | Cell survival | Lung cancer | Medical treatment | Medical services | Non-small cell lung carcinoma | Oncology | Regression analysis | Cancer therapies | Disease control | Patients | Survival | Confidence intervals | Chemotherapy | Platinum | Correlation analysis | Immunotherapy | Response rates | Cancer
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10. Full Text Re-evaluating the Localization of Sperm-Retained Histones Revealed the Modification-Dependent Accumulation in Specific Genome Regions
by Yamaguchi, Kosuke and Hada, Masashi and Fukuda, Yuko and Inoue, Erina and Makino, Yoshinori and Katou, Yuki and Shirahige, Katsuhiko and Okada, Yuki
Cell Reports, ISSN 2211-1247, 06/2018, Volume 23, Issue 13, pp. 3920 - 3932
The question of whether retained histones in the sperm genome localize to gene-coding regions or gene deserts has been debated for years. Previous... 
ChIP-seq | sperm | NPM | histone | nucleoplasmin | DECONDENSATION | XENOPUS EGG EXTRACTS | NUCLEOSOMES | CHROMATIN | PROMOTERS | MOUSE SPERMATOZOA | NUCLEOPLASMIN | SPERMIOGENESIS | HETEROCHROMATIN | EMBRYOS | CELL BIOLOGY
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11. Full Text Piperlongumine rapidly induces the death of human pancreatic cancer cells mainly through the induction of ferroptosis
by Yamaguchi, Yuki and Kasukabe, Takashi and Kumakura, Shunichi
International Journal of Oncology, ISSN 1019-6439, 03/2018, Volume 52, Issue 3, pp. 1011 - 1022
Pancreatic cancer is one of the most lethal types of cancer with a mortality rate of almost 95%. Treatment with current chemotherapeutic drugs has limited... 
Piperlongumine | Ferroptosis | Sulfasalazine | Pancreatic cancer cells | Cotylenin A | RAPAMYCIN | ferroptosis | CARCINOMA CELLS | PHOSPHORYLATION | piperlongumine | IRON | ANTITUMOR-ACTIVITY | GEMCITABINE | BREAST-CANCER | THERAPY | ONCOLOGY | GROWTH | cotylenin A | sulfasalazine | COTYLENIN-A | pancreatic cancer cells | Antioxidants | Care and treatment | Chemotherapy | Usage | Cell death | Pancreatic cancer | Patient outcomes | Analysis | Health aspects | Risk factors | Cancer | Leukemia | Rodents | Cell cycle | Breast cancer | Cancer therapies | Apoptosis
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12. Full Text Identification of a Primary Target of Thalidomide Teratogenicity
by Takumi Ito and Hideki Ando and Yoshimasa Imamura and Yuki Yamaguchi and Hiroshi Handa and Takayuki Suzuki and Toshihiko Ogura and Kentaro Hotta
Science, ISSN 0036-8075, 3/2010, Volume 327, Issue 5971, pp. 1345 - 1350
Half a century ago, thalidomide was widely prescribed to pregnant women as a sedative but was found to be teratogenic, causing multiple birth defects. Today,... 
Receptors | Messenger RNA | Delta cells | Ubiquitins | Substrate specificity | Teratogenicity | HeLa cells | Pectorals | Cellular immunity | Embryos | Research Article | MULTIPLE-MYELOMA | CELLS | LIMB DEFECTS | ORIGIN | ZEBRAFISH | UBIQUITIN LIGASE | PATHWAY | MULTIDISCIPLINARY SCIENCES | DNA-DAMAGE | OUTGROWTH | EXPRESSION | Teratogens - toxicity | Thalidomide - metabolism | Peptide Hydrolases - genetics | Forelimb - embryology | Humans | Fibroblast Growth Factors - genetics | Ubiquitin-Protein Ligases - antagonists & inhibitors | Zebrafish - embryology | Embryo, Nonmammalian - drug effects | DNA-Binding Proteins - metabolism | Fibroblast Growth Factors - metabolism | Ubiquitination | Forelimb - abnormalities | Gene Expression Regulation, Developmental | Cullin Proteins - metabolism | Peptide Hydrolases - metabolism | Zebrafish Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Mutant Proteins - metabolism | Chick Embryo | Thalidomide - toxicity | Zebrafish - genetics | Animals | Carrier Proteins - metabolism | HeLa Cells | Zebrafish Proteins - genetics | Embryonic Development - drug effects | Teratogens - metabolism | Dosage and administration | Research | Teratogenic agents | Thalidomide | Protein binding | Pharmacology | Birth defects | Developmental biology | DNA damage | Binding sites | Index Medicus
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13. Full Text X-ray pumping of the 229Th nuclear clock isomer
by Masuda, Takahiko and Yoshimi, Akihiro and Fujieda, Akira and Fujimoto, Hiroyuki and Haba, Hiromitsu and Hara, Hideaki and Hiraki, Takahiro and Kaino, Hiroyuki and Kasamatsu, Yoshitaka and Kitao, Shinji and Konashi, Kenji and Miyamoto, Yuki and Okai, Koichi and Okubo, Sho and Sasao, Noboru and Seto, Makoto and Schumm, Thorsten and Shigekawa, Yudai and Suzuki, Kenta and Stellmer, Simon and Tamasaku, Kenji and Uetake, Satoshi and Watanabe, Makoto and Watanabe, Tsukasa and Yasuda, Yuki and Yamaguchi, Atsushi and Yoda, Yoshitaka and Yokokita, Takuya and Yoshimura, Motohiko and Yoshimura, Koji
Nature, ISSN 0028-0836, 09/2019, Volume 573, Issue 7773, pp. 238 - 242
The metastable first excited state of thorium-229, 229mTh, is just a few electronvolts above the nuclear ground state and is accessible by vacuum ultraviolet... 
Spectroscopy | Ultraviolet lasers | Nuclear structure | Atomic beam spectroscopy | Radiation | Ground state | Radioactive half-life | Optical pumping | Experiments | X rays | Vacuum | Energy | Lasers | Spectrum analysis | Laser spectroscopy | Silicon | Half-life | Excitation | Synchrotron radiation | Thorium | Half life
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14. Full Text Epigenetic modifications and reprogramming in paternal pronucleus: sperm, preimplantation embryo, and beyond
by Okada, Yuki and Yamaguchi, Kosuke
Cellular and Molecular Life Sciences, ISSN 1420-682X, 06/2017, Volume 74, Issue 11, pp. 1957 - 1967
Pronuclear/zygotic stage is the very first stage of life. In this period, paternal pronucleus undergoes massive chromatin remodeling called "paternal... 
Fertilization | Epigenetic modification | Protamine | Zygotic gene activation | Transgenerational epigenetic inheritance | Histone | Preimplantation development | Pronucleus | TRANSCRIPTIONAL ACTIVITY | DNA METHYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | HISTONE VARIANT H3.3 | MAMMALIAN SPERMATOZOA | PEDIATRIC GLIOBLASTOMA | CELL BIOLOGY | MOUSE OOCYTES | CHROMATIN MODIFICATIONS | TRANSGENERATIONAL INHERITANCE | HETEROCHROMATIN FORMATION | Animals | Gene Expression Regulation, Developmental | Epigenesis, Genetic | Humans | Blastocyst - metabolism | Zygote - metabolism | Male | Spermatozoa - metabolism | Cellular Reprogramming - genetics | Epigenetic inheritance | Embryonic development | Spermatozoa | Chromatin | Art schools | Genes | Genetic transcription | DNA binding proteins | Epigenetics | Sperm | Embryos
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15. Full Text Synthesis of Furanocoumarin, Benzofuran and Coumarin Derivatives Possessing an Inhibitory Effect on Human CYP, and Elucidation of the Inhibitory Mechanism
by Yamaguchi, Y
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, ISSN 0031-6903, 10/2017, Volume 137, Issue 10, pp. 1209 - 1214
Grapefruit juice (GFJ) consumption has been shown to increase the bioavailability of certain orally administered drugs. The furanocoumarin derivatives... 
grapefruit juice | GRAPEFRUIT | furanocoumarin | ETHERS | DRUG INTERACTION | bergapten | PHARMACOLOGY & PHARMACY | CYP3A4 | NATURAL PRODUCT CHEMISTRY | Furocoumarins - pharmacology | Cytochrome P-450 CYP3A Inhibitors - pharmacology | Citrus paradisi - chemistry | Humans | Benzofurans - chemical synthesis | Benzofurans - pharmacology | Coumarins - chemistry | Structure-Activity Relationship | Furocoumarins - chemical synthesis | Cytochrome P-450 CYP3A Inhibitors - chemical synthesis | Benzofurans - chemistry | Coumarins - pharmacology | Coumarins - chemical synthesis | Cytochrome P-450 CYP3A Inhibitors - chemistry | Fruit and Vegetable Juices - analysis | Furocoumarins - chemistry
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16. Full Text Desuppression of TGF-β signaling via nuclear c-Abl-mediated phosphorylation of TIF1γ/TRIM33 at Tyr-524, -610, and -1048
by Yuki, Ryuzaburo and Tatewaki, Takashi and Yamaguchi, Noritaka and Aoyama, Kazumasa and Honda, Takuya and Kubota, Sho and Morii, Mariko and Manabe, Ichiro and Kuga, Takahisa and Tomonaga, Takeshi and Yamaguchi, Naoto
Oncogene, ISSN 0950-9232, 01/2019, Volume 38, Issue 5, pp. 637 - 655
Protein-tyrosine kinases regulate a broad range of intracellular processes occurring primarily just beneath the plasma membrane. With the greatest care to... 
ACTIVATION | SMAD4 | PROTEIN | TYROSINE PHOSPHORYLATION | CHROMATIN | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | SRC-FAMILY KINASES | CANCER | CELL BIOLOGY | ONCOLOGY | GENETICS & HEREDITY | TGF-BETA-1 | Tyrosine | Phosphorylation | Chromatin | Epidermal growth factor | Mesenchyme | Phenylalanine | Smad2 protein | Transforming growth factor | Smad3 protein | Dephosphorylation | Protein-tyrosine kinase
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