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by Costello, James C and Heiser, Laura M and Georgii, Elisabeth and Gönen, Mehmet and Menden, Michael P and Wang, Nicholas J and Bansal, Mukesh and Ammad-Ud-Din, Muhammad and Hintsanen, Petteri and Khan, Suleiman A and Mpindi, John-Patrick and Kallioniemi, Olli and Honkela, Antti and Aittokallio, Tero and Wennerberg, Krister and Collins, James J and Gallahan, Dan and Singer, Dinah and Saez-Rodriguez, Julio and Kaski, Samuel and Gray, Joe W and Stolovitzky, Gustavo and Abbuehl, Jean-Paul and Allen, Jeffrey and Altman, Russ B and Balcome, Shawn and Battle, Alexis and Bender, Andreas and Berger, Bonnie and Bernard, Jonathan and Bhattacharjee, Madhuchhanda and Bhuvaneshwar, Krithika and Bieberich, Andrew A and Boehm, Fred and Califano, Andrea and Chan, Christina and Chen, Beibei and Chen, Ting-Huei and Choi, Jaejoon and Coelho, Luis Pedro and Cokelaer, Thomas and Collins, James C and Creighton, Chad J and Cui, Jike and Dampier, Will and Davisson, V. Jo and De Baets, Bernard and Deshpande, Raamesh and DiCamillo, Barbara and Dundar, Murat and Duren, Zhana and Ertel, Adam and Fan, Haoyang and Fang, Hongbin and Gauba, Robinder and Gottlieb, Assaf and Grau, Michael and Gusev, Yuriy and Ha, Min Jin and Han, Leng and Harris, Michael and Henderson, Nicholas and Hejase, Hussein A and Homicsko, Krisztian and Hou, Jack P and Hwang, Woochang and IJzerman, Adriaan P and Karacali, Bilge and Keles, Sunduz and Kendziorski, Christina and Kim, Junho and Kim, Min and Kim, Youngchul and Knowles, David A and Koller, Daphne and Lee, Junehawk and Lee, Jae K and Lenselink, Eelke B and Li, Biao and Li, Bin and Li, Jun and Liang, Han and Ma, Jian and Madhavan, Subha and Mooney, Sean and Myers, Chad L and Newton, Michael A and Overington, John P and Pal, Ranadip and Peng, Jian and Pestell, Richard and Prill, Robert J and Qiu, Peng and Rajwa, Bartek and Sadanandam, Anguraj and Sambo, Francesco and Shin, Hyunjin and Song, Jiuzhou and Song, Lei and Sridhar, Arvind and ... and NCI DREAM Community
Nature Biotechnology, ISSN 1087-0156, 12/2014, Volume 32, Issue 12, pp. 1202 - 1212
Journal Article
Journal Article
by Bansal, Mukesh and Yang, Jichen and Karan, Charles and Menden, Michael P and Costello, James C and Tang, Hao and Xiao, Guanghua and Li, Yajuan and Allen, Jeffrey and Zhong, Rui and Chen, Beibei and Kim, Minsoo and Wang, Tao and Heiser, Laura M and Realubit, Ronald and Mattioli, Michela and Alvarez, Mariano J and Shen, Yao and Gallahan, Daniel and Singer, Dinah and Saez-Rodriguez, Julio and Xie, Yang and Stolovitzky, Gustavo and Califano, Andrea and Abbuehl, Jean-Paul and Altman, Russ B and Balcome, Shawn and Bell, Ana and Bender, Andreas and Berger, Bonnie and Bernard, Jonathan and Bieberich, Andrew A and Borboudakis, Giorgos and Chan, Christina and Chen, Ting-Huei and Choi, Jaejoon and Coelho, Luis Pedro and Creighton, Chad J and Dampier, Will and Davisson, V. Jo and Deshpande, Raamesh and Diao, Lixia and Di Camillo, Barbara and Dundar, Murat and Ertel, Adam and Goswami, Chirayu P and Gottlieb, Assaf and Gould, Michael N and Goya, Jonathan and Grau, Michael and Gray, Joe W and Hejase, Hussein A and Hoffmann, Michael F and Homicsko, Krisztian and Homilius, Max and Hwang, Woochang and Ijzerman, Adriaan P and Kallioniemi, Olli and Karacali, Bilge and Kaski, Samuel and Kim, Junho and Krishnan, Arjun and Lee, Junehawk and Lee, Young-Suk and Lenselink, Eelke B and Lenz, Peter and Li, Lang and Li, Jun and Liang, Han and Mpindi, John-Patrick and Myers, Chad L and Newton, Michael A and Overington, John P and Parkkinen, Juuso and Prill, Robert J and Peng, Jian and Pestell, Richard and Qiu, Peng and Rajwa, Bartek and Sadanandam, Anguraj and Sambo, Francesco and Sridhar, Arvind and Sun, Wei and Toffolo, Gianna M and Tozeren, Aydin and Troyanskaya, Olga G and Tsamardinos, Ioannis and Van Vlijmen, Herman W. T and Wang, Wen and Wegner, Joerg K and Wennerberg, Krister and Van Westen, Gerard J. P and Xia, Tian and Yang, Yang and Yao, Victoria and Yuan, Yuan and Zeng, Haoyang and Zhang, Shihua and Zhao, Junfei and Zhou, Jian and NCI-DREAM Community and Cellworks Group
Nature Biotechnology, ISSN 1087-0156, 12/2014, Volume 32, Issue 12, pp. 1213 - 1222
Recent therapeutic successes have renewed interest in drug combinations, but experimental screening approaches are costly and often identify only small numbers... 
DRUG-COMBINATIONS | NETWORK | THERAPY | INHIBITION | MODELS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | RESISTANCE | CANCER | EXPRESSION | CHEMOTHERAPY | SYSTEMS BIOLOGY | Drug Synergism | B-Lymphocytes - drug effects | Algorithms | Computer Simulation | Humans | Drug Combinations | Pharmaceutical research | Drug therapy, Combination | Research | Computers | Drug therapy | Predictions | Index Medicus
Journal Article
Gut, ISSN 0017-5749, 06/2017, Volume 66, Issue 6, pp. 1060 - 1073
ObjectivePatients with Niemann–Pick disease type C1 (NPC1), a lysosomal lipid storage disorder that causes neurodegeneration and liver damage, can present with... 
IBD-GENETICS | IBD CLINICAL | IMMUNODEFICIENCY | IBD BASIC RESEARCH | Crohn'S DISEASE | MIGLUSTAT THERAPY | PATHOGENESIS | APOPTOSIS | DENDRITIC CELLS | MACROPHAGES | SUSCEPTIBILITY | ILEAL MUCOSA | PHAGOSOME PROTEOME | GASTROENTEROLOGY & HEPATOLOGY | BOWEL-DISEASE | INNATE IMMUNITY | Tumor Necrosis Factor-alpha - metabolism | Crohn Disease - genetics | X-Linked Inhibitor of Apoptosis Protein - deficiency | Humans | Child, Preschool | Lysosomes | Male | Nod2 Signaling Adaptor Protein - genetics | Leukocytes, Mononuclear | Pyridazines - pharmacology | Niemann-Pick Disease, Type C - physiopathology | Autophagy - drug effects | Crohn Disease - complications | Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism | Young Adult | Gentamicins - pharmacology | Adult | Bacteria | Female | Genetic Diseases, X-Linked - genetics | Autophagy - genetics | Child | Receptor-Interacting Protein Serine-Threonine Kinase 2 - antagonists & inhibitors | Macrophages - physiology | Granuloma - genetics | Cells, Cultured | Chlorpromazine - pharmacology | Imidazoles - pharmacology | Acetylmuramyl-Alanyl-Isoglutamine - metabolism | X-Linked Inhibitor of Apoptosis Protein - genetics | Acetylmuramyl-Alanyl-Isoglutamine - pharmacology | Granuloma - pathology | Nod2 Signaling Adaptor Protein - metabolism | Crohn Disease - pathology | Dopamine Antagonists - pharmacology | Adolescent | X-Linked Inhibitor of Apoptosis Protein - metabolism | Macrophages - drug effects | Anti-Bacterial Agents - pharmacology | Protein Kinase Inhibitors - pharmacology | Mutation | Niemann-Pick Disease, Type C - complications | Niemann-Pick Disease, Type C - genetics | Autophagy (Cytology) | Inflammatory bowel diseases | Gastrointestinal diseases | Causes of | Colorectal diseases | Crohn's disease | Research | Niemann-Pick disease | Salmonella | Granuloma | Muramyl dipeptide | Liver | XIAP protein | Kinases | Macrophages | Autophagy | Defects | Genotype & phenotype | Cell activation | Intestine | Neurodegeneration | Npc1 protein | Age | NOD2 protein | Oligomerization | Dendritic cells | Cytokines | Blood & organ donations | Inflammation | Patients | Crohns disease | Studies | Inflammatory bowel disease | Monocytes | Proteomics | Colitis | Adapter proteins | Phagocytosis | Apoptosis | Index Medicus | Abridged Index Medicus | IBD - GENETICS | CROHN'S DISEASE | Inflammatory Bowel Disease | 1506
Journal Article
Cellular Signalling, ISSN 0898-6568, 2008, Volume 20, Issue 2, pp. 375 - 380
Epithelial cells represent the first line of defense against infection. Here we have studied the production of inflammatory mediators induced by IL–1β in the... 
Chemokine | MAP kinase | Inflammation | Epithelial cells | IL–1 receptor | IL-1 receptor | chemokine | PHOSPHORYLATION | P38 MAPK | epithelial cells | FACTOR-KAPPA-B | PROINFLAMMATORY CYTOKINES | CELL BIOLOGY | INTESTINAL INFLAMMATION | EPITHELIAL-CELLS | inflammation | PATHWAY | IN-VIVO | GENE-EXPRESSION | PROTEIN-KINASE INHIBITORS
Journal Article
Journal Article
Systems Biology in Reproductive Medicine, ISSN 1939-6368, 01/2016, Volume 62, Issue 1, pp. 49 - 56
Journal Article
by Mavaddat, Nasim and Michailidou, Kyriaki and Dennis, Joe and Lush, Michael and Fachal, Laura and Lee, Andrew and Lee, Eunjung and Tyrer, Jonathan P and Chen, Ting-Huei and Wang, Qin and Bolla, Manjeet K and Yang, Xin and Yang, Xiaohong R and Adank, Muriel A and Ahearn, Thomas and Aittomäki, Kristiina and Allen, Jamie and Andrulis, Irene L and Anton-Culver, Hoda and Antonenkova, Natalia N and Arndt, Volker and Aronson, Kristan J and Auer, Paul L and Auvinen, Päivi and Barrdahl, Myrto and Beane Freeman, Laura E and Beckmann, Matthias W and Behrens, Sabine and Benitez, Javier and Bermisheva, Marina and Bernstein, Leslie and Blomqvist, Carl and Bogdanova, Natalia V and Bojesen, Stig E and Bonanni, Bernardo and Børresen-Dale, Anne-Lise and Brauch, Hiltrud and Bremer, Michael and Brenner, Hermann and Brentnall, Adam and Brock, Ian W and Brooks-Wilson, Angela and Brucker, Sara Y and Brüning, Thomas and Burwinkel, Barbara and Campa, Daniele and Carter, Brian D and Castelao, Jose E and Chanock, Stephen J and Chlebowski, Rowan and Christiansen, Hans and Clarke, Christine L and Collée, J. Margriet and Cordina-Duverger, Emilie and Cornelissen, Sten and Couch, Fergus J and Cox, Angela and Cross, Simon S and Czene, Kamila and Daly, Mary B and Devilee, Peter and Dörk, Thilo and dos-Santos-Silva, Isabel and Dumont, Martine and Durcan, Lorraine and Dwek, Miriam and Eccles, Diana M and Ekici, Arif B and Eliassen, A. Heather and Ellberg, Carolina and Engel, Christoph and Eriksson, Mikael and Evans, D. Gareth and Fasching, Peter A and Figueroa, Jonine and Fletcher, Olivia and Flyger, Henrik and Försti, Asta and Fritschi, Lin and Gabrielson, Marike and Gago-Dominguez, Manuela and Gapstur, Susan M and García-Sáenz, José A and Gaudet, Mia M and Georgoulias, Vassilios and Giles, Graham G and Gilyazova, Irina R and Glendon, Gord and Goldberg, Mark S and Goldgar, David E and González-Neira, Anna and Grenaker Alnæs, Grethe I and Grip, Mervi and Gronwald, Jacek and Grundy, Anne and Guénel, Pascal and Haeberle, Lothar and Hahnen, Eric and Haiman, Christopher A and Håkansson, Niclas and ... and kConFab AOCS Investigators and ABCTB Investigators and NBCS Collaborators and kConFab/AOCS Investigators
The American Journal of Human Genetics, ISSN 0002-9297, 01/2019, Volume 104, Issue 1, pp. 21 - 34
Stratification of women according to their risk of breast cancer based on polygenic risk scores (PRSs) could improve screening and prevention strategies. Our... 
genetic | epidemiology | score | screening | stratification | polygenic | prediction | cancer | risk | breast | FUNCTIONAL VARIANTS | WOMEN | MODELS | SHRINKAGE | PROSTATE-CANCER | SUSCEPTIBILITY | GENETICS & HEREDITY | LOCUS | GENOME-WIDE ASSOCIATION | Prevention | Usage | Genetic susceptibility | Breast cancer | Genetic aspects | Research | Risk factors | Genetic screening
Journal Article