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Nature Medicine, ISSN 1078-8956, 07/2018, Volume 24, Issue 7, pp. 939 - 946
Journal Article
한국식품영양과학회 학술대회발표집, 2010, Volume 2010, Issue 10, pp. 342 - 342
Journal Article
한국식품영양과학회 학술대회발표집, 2010, Volume 2010, Issue 10, pp. 343 - 344
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 09/2019, Volume 116, Issue 36, pp. 17970 - 17979
Journal Article
EMBO reports, ISSN 1469-221X, 09/2018, Volume 19, Issue 9, p. n/a
Journal Article
Journal Article
Cell Reports, ISSN 2211-1247, 04/2019, Volume 27, Issue 2, pp. 616 - 630.e6
Human pluripotent stem cells (hPSCs) generate a variety of disease-relevant cells that can be used to improve the translation of preclinical research. Despite... 
CRISPR genome-wide screening | DDR | iPSC | PAWR | PMAIP1 | human pluripotent stem cells | hESC | APOPTOSIS | CONTRACTILITY | PATHWAY | EMBRYONIC STEM-CELLS | COPY NUMBER | TRANSCRIPTION | PROLIFERATION | GENERATION | DIFFERENTIATION | PAR-4 | CELL BIOLOGY
Journal Article
Scientific Reports, ISSN 2045-2322, 02/2017, Volume 7, Issue 1, p. 42728
Chemogenomic profiling is a powerful and unbiased approach to elucidate pharmacological targets and the mechanism of bioactive compounds. Until recently,... 
TARGET | SCREENS | CANCER | MYC | MULTIDISCIPLINARY SCIENCES | NADPH | CRISPR | Clonal deletion | Bioactive compounds | Hypersensitivity | Nicotinamide phosphoribosyltransferase | Genomes | Mammalian cells
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2016, Volume 291, Issue 29, pp. 15256 - 15266
YAP signaling pathway plays critical roles in tissue homeostasis, and aberrant activation of YAP signaling has been implicated in cancers. To identify... 
BREAST-CANCER | TARGET | AXIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | TISSUE HOMEOSTASIS | HIPPO PATHWAY | ADP-RIBOSYLATION | TUMOR-SUPPRESSOR | DEGRADATION | KRAS | FAMILY PROTEINS | Lung Neoplasms - drug therapy | RNA, Small Interfering - genetics | Humans | Lung Neoplasms - metabolism | Intercellular Signaling Peptides and Proteins - chemistry | Phosphoproteins - antagonists & inhibitors | Phosphoproteins - metabolism | Tankyrases - antagonists & inhibitors | Intercellular Signaling Peptides and Proteins - metabolism | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | HEK293 Cells | Antineoplastic Agents - pharmacology | Membrane Proteins - metabolism | Protein Interaction Domains and Motifs | Tankyrases - genetics | Membrane Proteins - genetics | Down-Regulation | Carcinoma, Non-Small-Cell Lung - metabolism | Intercellular Signaling Peptides and Proteins - genetics | Ubiquitin-Protein Ligases - metabolism | Tankyrases - chemistry | Phosphoproteins - genetics | Gene Knockout Techniques | Membrane Proteins - chemistry | Signal Transduction - drug effects | Erlotinib Hydrochloride - pharmacology | Protein Stability - drug effects | Adaptor Proteins, Signal Transducing - genetics | CRISPR-Cas Systems | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - drug therapy | Adaptor Proteins, Signal Transducing - metabolism | CRISPR | Cas | yes-associated protein (YAP) | signal transduction | functional genomics | drug resistance | protein degradation | Cell Biology
Journal Article
Molecular Cell, ISSN 1097-2765, 10/2018, Volume 72, Issue 1, pp. 37 - 47.e4
Adenomatous polyposis coli (APC) and Axin are core components of the β-catenin destruction complex. How APC’s function is regulated and whether Wnt signaling... 
β-catenin | Axin | APC | Wnt | ICAT | ADENOMATOUS POLYPOSIS-COLI | MECHANISM | BETA-CATENIN DEGRADATION | DESTRUCTION COMPLEX | SIGNALING PATHWAY | PHOSPHORYLATION | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-SUPPRESSOR | BINDING | NEGATIVE REGULATOR | CELL BIOLOGY | Therapeutics | Homeopathy | Materia medica and therapeutics
Journal Article
Proceedings of the National Academy of Sciences of the United States, ISSN 0027-8424, 10/2018, Volume 115, Issue 44, p. E10362
Wnt/[beta]-catenin signaling plays pivotal roles in cell proliferation and tissue homeostasis by maintaining somatic stem cell functions. The mammalian target... 
Physiological aspects | Physiological research | Cell receptors | Cellular signal transduction | Research | Biological control systems
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2018, Volume 115, Issue 44, p. E10362
Wnt/β-catenin signaling plays pivotal roles in cell proliferation and tissue homeostasis by maintaining somatic stem cell functions. The mammalian target of... 
TOR protein | Cell proliferation | Clathrin | Regulators | Wnt protein | Frizzled protein | Liver | Homeostasis | Hamartin | Activation | Genomes | TSC1 protein | Cell surface | β-catenin | Signal transduction | Embryology | Organoids | Intestine | Dishevelled protein | CRISPR | Zonation | Tuberous sclerosis | Rapamycin | Gene expression | Signaling | Stem cells | Laboratory animals
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2019, Volume 294, Issue 10, pp. 3359 - 3366
Bile acids are critical metabolites in the gastrointestinal tract and contribute to maintaining intestinal immune homeostasis through cross-talk with the gut... 
microbiota | CRISPR | mucosal immunology | EPIMERIZATION | MECHANISM | bile acid | BIOCHEMISTRY & MOLECULAR BIOLOGY | gut homeostasis | NLRP3 INFLAMMASOME | microbiome | pyrin | autoimmune disease | DEOXYCHOLIC-ACID | biotransformation | Cas | GENE | COLITIS | immune response | CULTURE-SYSTEM | inflammasome | DISEASE | CRISPR screen | familial Mediterranean fever | Editors' Picks
Journal Article