Journal Article
NATURE, ISSN 0028-0836, 10/2014, Volume 514, Issue 7524, pp. 628 - 628
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers in western countries, with a median survival of 6 months and an extremely low...
STEM-CELLS | INHIBITION | MELANOMA | METABOLISM | GLUCOSE | MULTIDISCIPLINARY SCIENCES | IMATINIB | LEUKEMIA | AUTOPHAGY | INDUCTION | TUMOR-GROWTH | Recurrence | Pancreatic Neoplasms - metabolism | Neoplastic Stem Cells - drug effects | Proto-Oncogene Proteins p21(ras) - genetics | Carcinoma, Pancreatic Ductal - metabolism | Gene Expression Regulation, Neoplastic | Autophagy | Carcinoma, Pancreatic Ductal - genetics | Oxidative Phosphorylation - drug effects | Pancreatic Neoplasms - drug therapy | Lysosomes - metabolism | Neoplastic Stem Cells - metabolism | Cell Respiration - drug effects | Neoplastic Stem Cells - pathology | Female | Disease Models, Animal | Proto-Oncogene Proteins p21(ras) - metabolism | Cell Survival - drug effects | Neoplasm Recurrence, Local - prevention & control | Signal Transduction | Pancreatic Neoplasms - pathology | Pancreatic Neoplasms - genetics | Mitochondria - metabolism | Genes, p53 - genetics | Mitochondria - drug effects | Mutation - genetics | Carcinoma, Pancreatic Ductal - pathology | Carcinoma, Pancreatic Ductal - drug therapy | Animals | Glycolysis | Mice | Protein research | Ablation (Surgery) | Care and treatment | Pancreatic cancer | Oncology, Experimental | Genetic aspects | Research | Cancer | Mitochondria | Stem cells | Cell cycle | Lipids | Metabolism | Tumors | Apoptosis
STEM-CELLS | INHIBITION | MELANOMA | METABOLISM | GLUCOSE | MULTIDISCIPLINARY SCIENCES | IMATINIB | LEUKEMIA | AUTOPHAGY | INDUCTION | TUMOR-GROWTH | Recurrence | Pancreatic Neoplasms - metabolism | Neoplastic Stem Cells - drug effects | Proto-Oncogene Proteins p21(ras) - genetics | Carcinoma, Pancreatic Ductal - metabolism | Gene Expression Regulation, Neoplastic | Autophagy | Carcinoma, Pancreatic Ductal - genetics | Oxidative Phosphorylation - drug effects | Pancreatic Neoplasms - drug therapy | Lysosomes - metabolism | Neoplastic Stem Cells - metabolism | Cell Respiration - drug effects | Neoplastic Stem Cells - pathology | Female | Disease Models, Animal | Proto-Oncogene Proteins p21(ras) - metabolism | Cell Survival - drug effects | Neoplasm Recurrence, Local - prevention & control | Signal Transduction | Pancreatic Neoplasms - pathology | Pancreatic Neoplasms - genetics | Mitochondria - metabolism | Genes, p53 - genetics | Mitochondria - drug effects | Mutation - genetics | Carcinoma, Pancreatic Ductal - pathology | Carcinoma, Pancreatic Ductal - drug therapy | Animals | Glycolysis | Mice | Protein research | Ablation (Surgery) | Care and treatment | Pancreatic cancer | Oncology, Experimental | Genetic aspects | Research | Cancer | Mitochondria | Stem cells | Cell cycle | Lipids | Metabolism | Tumors | Apoptosis
Journal Article
Cancers, ISSN 2072-6694, 09/2019, Volume 11, Issue 10, p. 1460
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and lethal cancers, with a five-year survival rate of around 5% to 8%. To date, very few...
glucose metabolism | pancreatic cancer
glucose metabolism | pancreatic cancer
Journal Article
CELL, ISSN 0092-8674, 04/2019, Volume 177, Issue 3, pp. 516 - 518
In this issue of Cell, Lytle et al. (2019) integrate functional genomic approaches to identify molecular dependencies of pancreatic cancer stem cells that may...
BIOCHEMISTRY & MOLECULAR BIOLOGY | THERAPY | CELL BIOLOGY | T cells | Pancreatic cancer | Analysis | Stem cells
BIOCHEMISTRY & MOLECULAR BIOLOGY | THERAPY | CELL BIOLOGY | T cells | Pancreatic cancer | Analysis | Stem cells
Journal Article
Cancer Letters, ISSN 0304-3835, 2011, Volume 317, Issue 2, pp. 127 - 135
Abstract Pancreatic cancer is a devastating disease with a low overall survival rate. Chemotherapy is the most common treatment for patients presenting with...
Hematology, Oncology and Palliative Medicine | Molecular targeted therapy | Chemotherapy | Pancreatic cancer | Combinational therapy | GEMCITABINE PLUS CAPECITABINE | REGIONAL CHEMOTHERAPY | FOLINIC ACID | SMALL-MOLECULE INHIBITOR | INTRAARTERIAL CHEMOTHERAPY | PHASE-III TRIAL | ONCOLYTIC VIRUS THERAPY | ONCOLOGY | CLINICAL BENEFIT | CONTINUOUS-INFUSION | COOPERATIVE-ONCOLOGY-GROUP | Genetic Therapy | RNA Interference | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Humans | Clinical Trials as Topic | Combined Modality Therapy | Oncolytic Virotherapy | Pancreatic Neoplasms - therapy | Antimitotic agents | Metastasis | Antineoplastic agents | Health aspects | Cancer | Medical research | Pancreas | Pharmaceutical industry | Cancer therapies | Index Medicus
Hematology, Oncology and Palliative Medicine | Molecular targeted therapy | Chemotherapy | Pancreatic cancer | Combinational therapy | GEMCITABINE PLUS CAPECITABINE | REGIONAL CHEMOTHERAPY | FOLINIC ACID | SMALL-MOLECULE INHIBITOR | INTRAARTERIAL CHEMOTHERAPY | PHASE-III TRIAL | ONCOLYTIC VIRUS THERAPY | ONCOLOGY | CLINICAL BENEFIT | CONTINUOUS-INFUSION | COOPERATIVE-ONCOLOGY-GROUP | Genetic Therapy | RNA Interference | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Humans | Clinical Trials as Topic | Combined Modality Therapy | Oncolytic Virotherapy | Pancreatic Neoplasms - therapy | Antimitotic agents | Metastasis | Antineoplastic agents | Health aspects | Cancer | Medical research | Pancreas | Pharmaceutical industry | Cancer therapies | Index Medicus
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 12/2015, Volume 14, Issue 12 Supplement 2, pp. C157 - C157
Journal Article
Genes and Development, ISSN 0890-9369, 02/2016, Volume 30, Issue 4, pp. 355 - 385
With 5-year survival rates remaining constant at 6% and rising incidences associated with an epidemic in obesity and metabolic syndrome, pancreatic ductal...
KRAS | Cancer metabolism | Pancreatic cancer | Tumor immune modulation | COLONY-STIMULATING FACTOR | ONCOGENIC KRAS | TUMOR-INFILTRATING MACROPHAGES | PAPILLARY MUCINOUS NEOPLASM | tumor immune modulation | DEVELOPMENTAL BIOLOGY | INTRAEPITHELIAL NEOPLASIA | CELL BIOLOGY | cancer metabolism | MYELOID SUPPRESSOR-CELLS | pancreatic cancer | RAS-DRIVEN TUMORIGENESIS | K-RAS | GENETICS & HEREDITY | REGULATORY T-CELLS | NEOPLASTIC PRECURSOR LESIONS | Tumor Microenvironment - immunology | Signal Transduction | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Pancreatic Neoplasms - genetics | Carcinoma, Pancreatic Ductal - physiopathology | Carcinoma, Pancreatic Ductal - therapy | Pancreatic Neoplasms - physiopathology | Carcinoma, Pancreatic Ductal - genetics | Pancreatic Neoplasms - therapy | Carcinoma, Ductal | Epidemics | Control | Genetic aspects | Research | Patient outcomes | Review
KRAS | Cancer metabolism | Pancreatic cancer | Tumor immune modulation | COLONY-STIMULATING FACTOR | ONCOGENIC KRAS | TUMOR-INFILTRATING MACROPHAGES | PAPILLARY MUCINOUS NEOPLASM | tumor immune modulation | DEVELOPMENTAL BIOLOGY | INTRAEPITHELIAL NEOPLASIA | CELL BIOLOGY | cancer metabolism | MYELOID SUPPRESSOR-CELLS | pancreatic cancer | RAS-DRIVEN TUMORIGENESIS | K-RAS | GENETICS & HEREDITY | REGULATORY T-CELLS | NEOPLASTIC PRECURSOR LESIONS | Tumor Microenvironment - immunology | Signal Transduction | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Pancreatic Neoplasms - genetics | Carcinoma, Pancreatic Ductal - physiopathology | Carcinoma, Pancreatic Ductal - therapy | Pancreatic Neoplasms - physiopathology | Carcinoma, Pancreatic Ductal - genetics | Pancreatic Neoplasms - therapy | Carcinoma, Ductal | Epidemics | Control | Genetic aspects | Research | Patient outcomes | Review
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 07/2019, Volume 10, Issue 1, pp. 3144 - 10
Capitalizing on the inherent multiplexing capability of AsCpf1, we developed a multiplexed, high-throughput screening strategy that minimizes library size...
DESIGN | SPECIFICITIES | RNA | MULTIDISCIPLINARY SCIENCES | Multiplexing | CRISPR | Screening | Gene targeting | High-throughput screening | Libraries | Genomes
DESIGN | SPECIFICITIES | RNA | MULTIDISCIPLINARY SCIENCES | Multiplexing | CRISPR | Screening | Gene targeting | High-throughput screening | Libraries | Genomes
Journal Article
Diangong Jishu Xuebao = Transactions of China Electrotechnical Society, ISSN 1000-6753, 01/2019, Volume 34, Issue 5, p. 1068
The phenomenon of critical slowing down near the critical point of critical phase transformation was common in many complex systems. Currently the algorithms...
Algorithms | Computer simulation | Test procedures | Critical point | Complex systems | Phase transitions
Algorithms | Computer simulation | Test procedures | Critical point | Complex systems | Phase transitions
Journal Article
Cancer Biology & Therapy, ISSN 1538-4047, 02/2012, Volume 13, Issue 4, pp. 206 - 215
Integrin αvβ3 receptor is expressed on several types of cancer cells, including pancreatic cancer cells, and plays an important role in tumor growth and...
delivery | FITC | pancreatic cancer | nanoparticles | therapy | albumin | RGD | Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Nanoparticles | Therapy | Pancreatic cancer | Albumin | Delivery | CELLS | APOPTOSIS | ADENOCARCINOMA | ALPHA-V-BETA-3 INTEGRIN | GEMCITABINE | CASPASE-3 ACTIVATION | PEPTIDES | ONCOLOGY | NANOTUBES | EXPRESSION | LIPOSOMES | Pancreatic Neoplasms - drug therapy | Microscopy, Confocal | Animals | Cattle | Cell Line, Tumor | Albumins - administration & dosage | Nanoparticles - administration & dosage | Oligopeptides - administration & dosage | Microscopy, Fluorescence | Drug Delivery Systems
delivery | FITC | pancreatic cancer | nanoparticles | therapy | albumin | RGD | Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Nanoparticles | Therapy | Pancreatic cancer | Albumin | Delivery | CELLS | APOPTOSIS | ADENOCARCINOMA | ALPHA-V-BETA-3 INTEGRIN | GEMCITABINE | CASPASE-3 ACTIVATION | PEPTIDES | ONCOLOGY | NANOTUBES | EXPRESSION | LIPOSOMES | Pancreatic Neoplasms - drug therapy | Microscopy, Confocal | Animals | Cattle | Cell Line, Tumor | Albumins - administration & dosage | Nanoparticles - administration & dosage | Oligopeptides - administration & dosage | Microscopy, Fluorescence | Drug Delivery Systems
Journal Article
NATURE PHYSICS, ISSN 1745-2473, 09/2019, Volume 15, Issue 9, pp. 904 - 904
The interplay between disorder and superconductivity is a subtle and fascinating phenomenon in quantum many-body physics. Conventional superconductors are...
TRANSITION | LOCALIZATION | ORDER | DESTRUCTION | PHYSICS, MULTIDISCIPLINARY | FLUCTUATIONS | ENHANCEMENT | METAL | DIFFUSION | ABSENCE | T-C | Transition temperatures | Monolayers | Superconductivity | Wave functions | Entanglement | Niobium | Electrons
TRANSITION | LOCALIZATION | ORDER | DESTRUCTION | PHYSICS, MULTIDISCIPLINARY | FLUCTUATIONS | ENHANCEMENT | METAL | DIFFUSION | ABSENCE | T-C | Transition temperatures | Monolayers | Superconductivity | Wave functions | Entanglement | Niobium | Electrons
Journal Article
Nature, ISSN 0028-0836, 2019, Volume 568, Issue 7752, pp. 410 - 410
Pancreatic ductal adenocarcinoma (PDAC) remains recalcitrant to all forms of cancer treatment and carries a five-year survival rate of only 8%(1). Inhibition...
CELLS | KRAS | PROTEIN | MULTIDISCIPLINARY SCIENCES | FIBROBLASTS | ARF6 | Cellular proteins | Pancreatic cancer | Analysis | Pinocytosis | Genetic aspects | Research | Gene expression | Adenocarcinoma | Cell culture | Transformation | Animal models | Pathogenesis | Kinases | Cell surface | K-Ras protein | Proteins | Signal transduction | Cell growth | Annotations | Salvage | Fibroblasts | Localization | Genetic control | Extinction | Breast cancer | Signaling | Scientific imaging | Metabolic pathways | Mass spectrometry | Syndecan | Cancer | Tumors
CELLS | KRAS | PROTEIN | MULTIDISCIPLINARY SCIENCES | FIBROBLASTS | ARF6 | Cellular proteins | Pancreatic cancer | Analysis | Pinocytosis | Genetic aspects | Research | Gene expression | Adenocarcinoma | Cell culture | Transformation | Animal models | Pathogenesis | Kinases | Cell surface | K-Ras protein | Proteins | Signal transduction | Cell growth | Annotations | Salvage | Fibroblasts | Localization | Genetic control | Extinction | Breast cancer | Signaling | Scientific imaging | Metabolic pathways | Mass spectrometry | Syndecan | Cancer | Tumors
Journal Article
Cancer Research, ISSN 0008-5472, 07/2018, Volume 78, Issue 13 Supplement, pp. 392 - 392
Journal Article
Cell, ISSN 0092-8674, 07/2014, Volume 158, Issue 1, pp. 185 - 197
Activating mutations in are among the most frequent events in diverse human carcinomas and are particularly prominent in human pancreatic ductal adenocarcinoma...
INACTIVATION | TARGET | INHIBITION | ADENOCARCINOMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | HIPPO PATHWAY | RESISTANCE | PROLIFERATION | INDUCTION | CELL BIOLOGY | Proto-Oncogene Proteins - metabolism | Adenocarcinoma - pathology | Pancreatic Neoplasms - metabolism | Humans | Pancreatic Neoplasms - pathology | Carcinoma, Pancreatic Ductal - metabolism | ras Proteins - metabolism | DNA Replication | Phosphoproteins - metabolism | Carcinoma, Pancreatic Ductal - pathology | E2F Transcription Factors - metabolism | DNA-Binding Proteins - metabolism | Transcription Factors - metabolism | Adenocarcinoma - metabolism | Animals | Cell Cycle | Cell Line, Tumor | Mice | Adaptor Proteins, Signal Transducing - metabolism | Disease Models, Animal | Proto-Oncogene Proteins p21(ras) - metabolism | DNA replication | Pancreatic cancer | Analysis
INACTIVATION | TARGET | INHIBITION | ADENOCARCINOMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | HIPPO PATHWAY | RESISTANCE | PROLIFERATION | INDUCTION | CELL BIOLOGY | Proto-Oncogene Proteins - metabolism | Adenocarcinoma - pathology | Pancreatic Neoplasms - metabolism | Humans | Pancreatic Neoplasms - pathology | Carcinoma, Pancreatic Ductal - metabolism | ras Proteins - metabolism | DNA Replication | Phosphoproteins - metabolism | Carcinoma, Pancreatic Ductal - pathology | E2F Transcription Factors - metabolism | DNA-Binding Proteins - metabolism | Transcription Factors - metabolism | Adenocarcinoma - metabolism | Animals | Cell Cycle | Cell Line, Tumor | Mice | Adaptor Proteins, Signal Transducing - metabolism | Disease Models, Animal | Proto-Oncogene Proteins p21(ras) - metabolism | DNA replication | Pancreatic cancer | Analysis
Journal Article
The Lancet Infectious Diseases, ISSN 1473-3099, 10/2017, Volume 17, Issue 10, pp. 1053 - 1061
The management of latent infection is a new priority action for the WHO End Tuberculosis (TB) Strategy. However, national guidelines on latent tuberculosis...
UNITED-STATES | INFECTIOUS DISEASES | METAANALYSIS | COUNTRY | RISK | PREVALENCE | GAMMA RELEASE ASSAYS | Follow-Up Studies | Interferon-gamma Release Tests | Humans | Middle Aged | Latent Tuberculosis - epidemiology | Child, Preschool | Male | China - epidemiology | Tuberculin Test | Latent Tuberculosis - diagnosis | Incidence | Young Adult | Rural Population | Adolescent | Aged, 80 and over | Adult | Female | Aged | Latent Tuberculosis - pathology | Child | Cohort Studies | Health aspects | Analysis | Tuberculosis | Disease prevention | Pathogens | Medical research | Disease | Medical innovations | Innovations | Infections | Interferon | Cams | Epidemiology | Public health
UNITED-STATES | INFECTIOUS DISEASES | METAANALYSIS | COUNTRY | RISK | PREVALENCE | GAMMA RELEASE ASSAYS | Follow-Up Studies | Interferon-gamma Release Tests | Humans | Middle Aged | Latent Tuberculosis - epidemiology | Child, Preschool | Male | China - epidemiology | Tuberculin Test | Latent Tuberculosis - diagnosis | Incidence | Young Adult | Rural Population | Adolescent | Aged, 80 and over | Adult | Female | Aged | Latent Tuberculosis - pathology | Child | Cohort Studies | Health aspects | Analysis | Tuberculosis | Disease prevention | Pathogens | Medical research | Disease | Medical innovations | Innovations | Infections | Interferon | Cams | Epidemiology | Public health
Journal Article