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Journal Article
by Emile, Jean-François and Julié, Catherine and Le Malicot, Karine and Lepage, Come and Tabernero, Josep and Mini, Enrico and Folprecht, Gunnar and Van Laethem, Jean-Luc and Dimet, Stéphanie and Boulagnon-Rombi, Camille and Allard, Marc-Antoine and Penault-Llorca, Frédérique and Bennouna, Jaafar and Laurent-Puig, Pierre and Taieb, Julien and Thaler, Josef and Greil, Richard and Gaenzer, Johannes and Eisterer, Wolfgang and Tschmelitsch, Joerg and Keil, Felix and Samonigg, Hellmut and Zabernigg, August and Schmid, Franz and Steger, Günther and Steinacher, Robert and Andel, Johannes and Jagdt, Björn and Lang, Alois and Fridrik, Michael and Függer, Reinhold and Hofbauer, Friedrich and Woell, Ewald and Geissler, Michael and Geissler, Dietmar and Lenauer, Alfred and Prager, Manfred and D'Haens, Geert and Demolin, Gauthier and Kerger, Joseph and Deboever, Guido and Ghillebert, Gilbert and Polus, Marc and Van Cutsem, Eric and Kalantari, Hassan Rezaie and Delaunoit, Thierry and Goeminne, Jean Charles and Peeters, Marc and Vergauwe, Philippe and Houbiers, Ghislain and Humblet, Yves and Janssens, Jos and Schrijvers, Dirk and Vanderstraeten, Erik and Vermorken, Jan and Van Daele, Daniel and Ferrante, Michel and Forget, Frederic and Hendlisz, Alain and Yilmaz, Mette and Nielsen, Svend Erik and Vestermark, Lene and Larsen, Jim and Zawadi, Mohamed-Ayman and Bouche, Olivier and Mineur, Laurent and Bennouna-Louridi, Jaafar and Dourthe, Louis Marie and Ychou, Marc and Boucher, Eveline and Pezet, Denis and Desseigne, Francoise and Ducreux, Michel and Texereau, Patrick and Miglianico, Laurent and Rougier, Philippe and Fratte, Serge and Levache, Charles-Briac and Merrouche, Yacine and Ellis, Stephen and Locher, Christophe and Ramee, Jean-Francois and Garnier, Claire and Viret, Frederic and Chauffert, Bruno and Cojean-Zelek, Isabelle and Michel, Pierre and Lecaille, Cedric and Borel, Christian and Seitz, Jean-Francois and Smith, Denis and Lombard-Bohas, Catherine and Andre, Thierry and Gornet, Jean-Marc and Fein, Francine and Coulon-Sfairi, Marie-Aude and Kaminsky, Marie-Christine and Lagasse, Jean-Paul and Luet, Dominique and Etienne, Pierre-Luc and ... and PETACC8 Study Investigators and Istituto Oncologico Romagnolo (IOR) and Fédération Nationale des Centres de Lutte Contre le Cancer Association Européenne de Recherche en Oncologie (AERO) and Gruppo Cooperativo do Cancro Digestivo da Associação Portuguesa de Investigação Oncológica (GCCD, APIO) and Lone Nørgård Petersen and Gruppo Italiano per lo Studio dei Carcinomi dell'Apparato Digerente (GISCAD) and Austrian Breast and Colorectal cancer Study Group (ABCSG) and Belgian Group of Digestive Oncology (BGDO) and Gruppo Cooperativo Chirurgico Italiano (GOCCI) and John Allen Bridgewater and Gruppo Oncologico dell'Italia Meridionale (GOIM) and Fédération Francophone de Cancérologie Digestive (FFCD) and Gruppo Oncologico Nord Ovest (GONO) and Fédération Nationale des Centres de Lutte Contre le Cancer (UNICANCER) and Grupo Español para el Tratamiento de los Tumores Digestivos (TTD) and Arbeitsgemeinschaft Internistische Onkologie (AIO) and Gruppo Oncologico Italiano di Ricerca Clinica (GOIRC)
European Journal of Cancer, ISSN 0959-8049, 09/2017, Volume 82, pp. 16 - 24
Journal Article
Journal Article
Lancet Oncology, The, ISSN 1470-2045, 2015, Volume 16, Issue 8, pp. 937 - 948
Summary Background Tumour mutational status is an important determinant of the response of metastatic colorectal cancer to targeted treatments. However, the... 
Hematology, Oncology and Palliative Medicine | KRAS MUTATIONS | 1ST-LINE TREATMENT | LEUCOVORIN | PLUS IRINOTECAN | ONCOLOGY | RANDOMIZED PHASE-III | INHIBITS GROWTH | ACQUIRED-RESISTANCE | FLUOROURACIL | PLACEBO PLUS | TUMOR-GROWTH | Predictive Value of Tests | Proto-Oncogene Proteins p21(ras) | Colorectal Neoplasms - genetics | Humans | Middle Aged | Male | Antineoplastic Agents - therapeutic use | Clinical Trials, Phase III as Topic | Time Factors | DNA Mutational Analysis | Colorectal Neoplasms - drug therapy | Real-Time Polymerase Chain Reaction | Precision Medicine | Receptor, TIE-1 - blood | Phosphatidylinositol 3-Kinases - blood | Genetic Predisposition to Disease | Adenocarcinoma - blood | ras Proteins - blood | Adenocarcinoma - drug therapy | Adenocarcinoma - secondary | Disease Progression | Phenotype | Class I Phosphatidylinositol 3-Kinases | Biomarkers, Tumor - genetics | ras Proteins - genetics | Patient Selection | DNA, Neoplasm - blood | Female | Adenocarcinoma - genetics | Retrospective Studies | Pyridines - therapeutic use | Colorectal Neoplasms - mortality | Colorectal Neoplasms - blood | Kaplan-Meier Estimate | Proportional Hazards Models | Phenylurea Compounds - therapeutic use | Proto-Oncogene Proteins B-raf - blood | Proto-Oncogene Proteins - genetics | Treatment Outcome | Randomized Controlled Trials as Topic | Biomarkers, Tumor - blood | Phosphatidylinositol 3-Kinases - genetics | Disease-Free Survival | Proto-Oncogene Proteins B-raf - genetics | Aged | DNA, Neoplasm - genetics | Colorectal Neoplasms - pathology | Proto-Oncogene Proteins - blood | Adenocarcinoma - mortality | Medical colleges | Medical research | Cancer patients | Prognosis | Liver | DNA | Colorectal cancer | Genetic research | Medicine, Experimental | Metastasis | Index Medicus
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 09/2017, Volume 23, Issue 17, pp. 5267 - 5280
Purpose: Patients with metastatic colorectal cancer suffer from disease relapse mainly due to cancer stem cells (CSC). Interestingly, they have an increased... 
GASTRIN | ACTIVATION | INHIBITION | METASTASIS | ONCOGENIC RAS | ONCOLOGY | SIGNALING PATHWAY | GROWTH | RESISTANCE | THERAPIES | EXPRESSION | Protein Precursors - blood | Neoplastic Stem Cells - drug effects | Proto-Oncogene Proteins p21(ras) - genetics | Colorectal Neoplasms - genetics | Humans | Neoplasm Recurrence, Local - drug therapy | Neoplasm Recurrence, Local - pathology | Protein Precursors - antagonists & inhibitors | Antibodies, Anti-Idiotypic - administration & dosage | Antibodies, Monoclonal, Humanized - administration & dosage | Colorectal Neoplasms - drug therapy | Gene Expression Regulation, Neoplastic - drug effects | Gastrins - blood | Antibodies, Anti-Idiotypic - immunology | Gastrins - antagonists & inhibitors | Protein Precursors - immunology | Gastrins - immunology | HT29 Cells | Animals | Wnt Signaling Pathway - drug effects | Neoplasm Recurrence, Local - genetics | Cell Proliferation - drug effects | Mice | Mutation | Colorectal Neoplasms - pathology | Wnt protein | Colorectal carcinoma | Colorectal cancer | Medical services | Antibodies | Stem cell transplantation | Raf protein | Cancer therapies | K-Ras protein | Metastases | β-catenin | Allografts | Intestine | Colon | Immunoglobulins | Cell survival | Therapeutic applications | Transgenic mice | Tumor cell lines | Cell differentiation | Patients | Signaling | Chemotherapy | Lymphocytes B | Experimental design | Cell lines | Stem cells | Monoclonal antibodies | Cell migration | Tumors | Cancer | Index Medicus | Life Sciences
Journal Article
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 01/2013, Volume 31, Issue 1, pp. 23 - 29
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 05/2011, Volume 364, Issue 19, pp. 1817 - 1825
In this study, a four-drug combination chemotherapy regimen was associated with objective responses in more than 30% of patients and increased survival by more... 
PHASE-III TRIAL | 5-FLUOROURACIL | MEDICINE, GENERAL & INTERNAL | SOLID TUMORS | CLINICAL-TRIALS | IRINOTECAN | OXALIPLATIN | 1ST-LINE THERAPY | COMBINATION | CARCINOMA | COOPERATIVE-ONCOLOGY-GROUP | Leucovorin - administration & dosage | Follow-Up Studies | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Pancreatic Neoplasms - drug therapy | Deoxycytidine - therapeutic use | Organoplatinum Compounds - administration & dosage | Fluorouracil - administration & dosage | Neoplasm Metastasis - drug therapy | Adult | Camptothecin - administration & dosage | Deoxycytidine - adverse effects | Female | Pancreatic Neoplasms - mortality | Camptothecin - analogs & derivatives | Severity of Illness Index | Pancreatic Neoplasms - pathology | Proportional Hazards Models | Adenocarcinoma - drug therapy | Adenocarcinoma - secondary | Antimetabolites, Antineoplastic - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Antimetabolites, Antineoplastic - adverse effects | Survival Analysis | Quality of Life | Aged | Deoxycytidine - analogs & derivatives | Adenocarcinoma - mortality | Chemotherapy, Combination | Usage | Care and treatment | Gemcitabine | Pancreatic cancer | Leucovorin | Comparative analysis | Drug therapy | Fluorouracil | Clinical trials | Cytotoxicity | Pancreas | Patients | Index Medicus | Abridged Index Medicus
Journal Article