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Expert Opinion on Investigational Drugs, ISSN 1354-3784, 10/2019, Volume 28, Issue 10, pp. 835 - 849
Introduction: The incidence of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) is increasing with the aging population. Prognosis and overall... 
myelodysplastic syndrome | guadecitabine | hypomethylating agent | Acute myeloid leukemia | SGI-110
Journal Article
The Lancet Oncology, ISSN 1470-2045, 10/2017, Volume 18, Issue 10, pp. 1317 - 1326
Journal Article
Journal Article
Blood, ISSN 0006-4971, 04/2007, Volume 109, Issue 8, pp. 3509 - 3512
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 04/2003, Volume 21, Issue 8, pp. 1618 - 1623
Journal Article
Journal Article
British Journal of Haematology, ISSN 0007-1048, 10/2017, Volume 179, Issue 1, pp. 83 - 97
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 09/2006, Volume 12, Issue 17, pp. 5165 - 5173
Purpose: Everolimus (RAD001, Novartis), an oral derivative of rapamycin, inhibits the mammalian target of rapamycin (mTOR), which regulates many aspects of... 
mTOR inhibitor | 4E-BP1 | hypoxia-inducible factor | chronic lymphocytic leukemia | p70S6K | myelodysplastic syndrome | WORKING GROUP | ONCOLOGY | CYCLIN D1 | OBLITERANS ORGANIZING PNEUMONIA | TEMSIROLIMUS CCI-779 | DOWN-REGULATION | ACUTE MYELOID-LEUKEMIA | TRANSPLANT RECIPIENTS | MTOR INHIBITORS | RENAL-CELL CARCINOMA | CANCER-THERAPY | Protein Kinases - metabolism | Recurrence | Phosphorylation | Humans | Leukemia, Prolymphocytic - drug therapy | Middle Aged | Leukemia, T-Cell - drug therapy | Vasculitis, Leukocytoclastic, Cutaneous - chemically induced | Male | Phosphoproteins - antagonists & inhibitors | Dose-Response Relationship, Drug | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Drug-Related Side Effects and Adverse Reactions | Killer Cells, Natural - immunology | Leukemia, Myeloid, Acute - drug therapy | Adult | Female | Everolimus | Myelodysplastic Syndromes - drug therapy | Sirolimus - adverse effects | Protein Kinases - drug effects | Sirolimus - analogs & derivatives | Sirolimus - therapeutic use | Drug Administration Schedule | Administration, Oral | Ribosomal Protein S6 Kinases, 70-kDa - antagonists & inhibitors | Lymphoma, Mantle-Cell - drug therapy | Treatment Outcome | Sirolimus - administration & dosage | Maximum Tolerated Dose | Signal Transduction - drug effects | Adolescent | T-Lymphocytes - immunology | Aged | TOR Serine-Threonine Kinases | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy
Journal Article
British Journal of Haematology, ISSN 0007-1048, 07/2009, Volume 146, Issue 1, pp. 76 - 85
Journal Article