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EMBO reports, ISSN 1469-221X, 05/2011, Volume 12, Issue 5, pp. 463 - 469
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2013, Volume 56, Issue 9, pp. 3680 - 3688
The fat mass and obesity associated protein (FTO) is a potential target for anti-obesity medicines. FTO is a 2-oxoglutarate (2OG)-dependent N-methyl nucleic... 
POSITION | DOMAIN | CHEMISTRY, MEDICINAL | GENE | RNA | SUBSTRATE | LEADS | HYPOXIA | Humans | Models, Molecular | Substrate Specificity | Alpha-Ketoglutarate-Dependent Dioxygenase FTO | Protein Conformation | Proteins - chemistry | Binding Sites | Drug Discovery | Proteins - antagonists & inhibitors
Journal Article
Journal Article
Molecular Biology Reports, ISSN 0301-4851, 4/2012, Volume 39, Issue 4, pp. 4857 - 4867
Infarction irreversibly damages the heart, with formation of an akinetic scar that may lead to heart failure. Endogenous cardiac stem cells (CSCs) are a... 
Life Sciences | Housekeeping genes | Animal Biochemistry | Prolyl-4-hydroxylase inhibitors | Hypoxia | Cardiosphere-derived cells | Animal Anatomy / Morphology / Histology | HIF | ANGIOGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | CARDIAC STEM-CELLS | HYDROXYLASES | REAL-TIME PCR | IN-VITRO | POLYMERASE-CHAIN-REACTION | NORMALIZATION | EXPRESSION | DNA, Complementary - genetics | Gene Expression Profiling | Stem Cells - cytology | Spheroids, Cellular - cytology | RNA, Messenger - metabolism | Procollagen-Proline Dioxygenase - metabolism | Reference Standards | Reverse Transcriptase Polymerase Chain Reaction - standards | Stem Cells - enzymology | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Reverse Transcriptase Polymerase Chain Reaction - methods | DNA Primers - metabolism | Procollagen-Proline Dioxygenase - antagonists & inhibitors | Spheroids, Cellular - drug effects | Genes, Essential - genetics | Animals, Newborn | Cell Hypoxia - drug effects | Reproducibility of Results | RNA, Messenger - genetics | Spheroids, Cellular - metabolism | Enzyme Inhibitors - pharmacology | Rats | Rats, Sprague-Dawley | Blotting, Western | Myocardium - cytology | Gene Expression Regulation - drug effects | Animals | Stem Cells - drug effects | Software | Cell Hypoxia - genetics | Phosphates | Infants (Newborn) | Heart failure | RNA | Genes | Genetic transcription | Cells | Monosaccharides | Purines | Anopheles | Stem cells | Genetic research | Sugars | Protein binding | Polymerase chain reaction | Enzymes | Cellular biology | Molecular biology
Journal Article
Journal Article
Journal Article
Chemical science, ISSN 2041-6520, 08/2013, Volume 4, Issue 8, pp. 3110 - 3117
2-Oxoglutarate and iron dependent oxygenases are therapeutic targets for human diseases. Using a representative 2OG oxygenase panel, we compare the inhibitory... 
Journal Article
Journal Article
Journal Article
Journal Article
Journal Article