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1. Full Text Purine Pathway Implicated in Mechanism of Resistance to Aspirin Therapy: Pharmacometabolomics‐Informed Pharmacogenomics
by Yerges‐Armstrong, L M and Ellero‐Simatos, S and Georgiades, A and Zhu, H and Lewis, J p and Horenstein, R B and Beitelshees, A L and Dane, A and Reijmers, T and Hankemeier, T and Fiehn, O and Shuldiner, A R and Kaddurah‐Daouk, R and Pharmacometabol Res Network
Clinical pharmacology and therapeutics, ISSN 0009-9236, 10/2013, Volume 94, Issue 4, pp. 525 - 532
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Metabolomics | Purines - metabolism | Humans | Aspirin - pharmacokinetics | Male | Adenosine Kinase - genetics | Drug Resistance - genetics | Alleles | Platelet Aggregation Inhibitors - pharmacology | Adult | Female | Platelet Aggregation Inhibitors - pharmacokinetics | Aspirin - pharmacology | Purines | Aspirin | Usage | Care and treatment | Pharmacogenetics | Influence | Research | Cardiovascular diseases | Index Medicus | Abridged Index Medicus
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2. Full Text Association of Adiposity Genetic Variants With Menarche Timing in 92,105 Women of European Descent
by Fernández-Rhodes, L and Demerath, E.W and Cousminer, D.L and Tao, R and yfus, J.G and Esko, T and Smith, A.V and Gudnason, V and Harris, T.B and Launer, L and McArdle, P.F and Yerges-Armstrong, L.M and Elks, C.E and Strachan, D.P and Kutalik, Z and Vollenweider, P and Feenstra, B and Boyd, H.A and Metspalu, A and Mihailov, E and Broer, L and Zillikens, M.C and Oostra, B.A and van Duijn, C.M and Lunetta, K.L and Perry, J.R and Murray, A and Koller, D.L and Lai, D and Corre, T and Toniolo, D and Albrecht, E and Stöckl, D and Grallert, H and Gieger, C and Hayward, C and Polasek, O and Rudan, I and Wilson, J.F and He, C and Kraft, P and Hu, F.B and Hunter, D.J and Hottenga, J.J and Willemsen, G and Boomsma, D.I and Byrne, E.M and Martin, N.G and Montgomery, G.W and Warrington, N.M and Pennell, C.E and Stolk, L and Visser, J.A and Hofman, A and Uitterlinden, A.G and Rivadeneira, F and Lin, P and Fisher, S.L and Bierut, L.J and Crisponi, L and Porcu, E and Mangino, M and Zhai, G and Spector, T.D and Buring, J.E and Rose, L.M and Ridker, P.M and Poole, C and Hirschhorn, J.N and Murabito, J.M and Chasman, D.I and Widén, E and North, K.E and Ong, K.K and Franceschini, N
American journal of epidemiology, ISSN 0002-9262, 2013, Volume 178, Issue 3, pp. 451 - 460
adiposity | waist circumference | body mass index | women's health | waist:hip ratio | genetic association studies | obesity | menarche | Life Sciences & Biomedicine | Public, Environmental & Occupational Health | Science & Technology | Obesity | Public health. Hygiene-occupational medicine | Public health. Hygiene | General aspects | Miscellaneous | Biological and medical sciences | Metabolic diseases | Medical sciences | Epidemiology | Body Mass Index | European Continental Ancestry Group - genetics | Age Factors | Genetic Association Studies | Menarche - genetics | Humans | Adiposity - genetics | Obesity - genetics | Linkage Disequilibrium | Waist Circumference | Obesity - epidemiology | Adolescent | Women's Health - statistics & numerical data | Female | Polymorphism, Single Nucleotide | Child | Waist-Hip Ratio | Menarche | Genetic aspects | Health aspects | Studies | Body mass index | Genetics | Womens health | Index Medicus | Adipose tissue | Original Contributions
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3. Full Text FTO genotype is associated with phenotypic variability of body mass index
by Yang, J and Loos, R.J and Powell, J.E and Medland, S.E and Speliotes, E.K and Chasman, D.I and Rose, L.M and Thorleifsson, G and Steinthorsdottir, V and Magi, R and Waite, L and Smith, A.V and Yerges-Armstrong, L.M and Monda, K.L and Hadley, D and Mahajan, A and Li, G and Kapur, K and Vitart, V and Huffman, J.E and Wang, S.R and Palmer, C and Esko, T and Fischer, K and Zhao, J.H and Demirkan, A and Isaacs, A and Feitosa, M.F and Luan, J and Heard-Costa, N.L and White, C and Jackson, A.U and Preuss, M and Ziegler, A and Eriksson, J and Kutalik, Z and Frau, F and Nolte, I.M and Van Vliet-Ostaptchouk, J.V and Hottenga, J.J and Jacobs, K.B and Verweij, N and Goel, A and Medina-Gomez, C and Estrada, K and Bragg-Gresham, J.L and Sanna, S and Sidore, C and Tyrer, J and Teumer, A and Prokopenko, I and Mangino, M and Lindgren, C.M and Assimes, T.L and Shuldiner, A.R and Hui, J and Beilby, J.P and McArdle, W.L and Hall, P and Haritunians, T and Zgaga, L and Kolcic, I and Polasek, O and Zemunik, T and Oostra, B.A and Junttila, M.J and Gronberg, H and Schreiber, S and Peters, A and Hicks, A.A and Stephens, J and Foad, N.S and Laitinen, J and Pouta, A and Kaakinen, M and Willemsen, G and Vink, J and Wild, S.H and Navis, G and Asselbergs, F.W and Homuth, G and John, U and Iribarren, C and Harris, T and Launer, L and Gudnason, V and O'Connell, J.R and Boerwinkle, E and Cadby, G and Palmer, L.J and James, A.L and Musk, A.W and Ingelsson, E and Psaty, B.M and Beckmann, J.S and Waeber, G and Vollenweider, P and Hayward, C and Wright, A.F and Rudan, I and ... and Göteborgs universitet and Gothenburg University and Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition and Sahlgrenska Academy and Centre for Bone and Arthritis Research and Sahlgrenska akademin and Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Nature (London), ISSN 0028-0836, 2012, Volume 490, Issue 7419, pp. 267 - 272
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Analytical, structural and metabolic biochemistry | Molecular and cellular biology | Body Mass Index | Genome-Wide Association Study | Humans | Repressor Proteins - genetics | Alpha-Ketoglutarate-Dependent Dioxygenase FTO | Male | Nerve Tissue Proteins - genetics | Body Height - genetics | Genetic Variation | Proteins - genetics | Phenotype | Female | Polymorphism, Single Nucleotide | Co-Repressor Proteins | Body mass index | Physiological aspects | Phenotypic plasticity | Obesity gene | Genetic aspects | Single nucleotide polymorphisms | Methods | Studies | Genotype & phenotype | Genetics | Gene loci | Index Medicus | Clinical Medicine | Endokrinologi och diabetes | Klinisk medicin | Endocrinology and Diabetes
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4. Full Text Older men who sustain a hip fracture experience greater declines in bone mineral density at the contralateral hip than non-fractured comparators
by Rathbun, A M and Rathbun, A M and Magaziner, J and Magaziner, J and Shardell, M D and Shardell, M D and Yerges-Armstrong, L M and Yerges-Armstrong, L M and Orwig, D and Orwig, D and Hicks, G E and Hicks, G E and Hochberg, M C and Hochberg, M C
Osteoporosis international, ISSN 0937-941X, 2/2018, Volume 29, Issue 2, pp. 365 - 373
Osteoporosis | Hip fracture | Medicine & Public Health | Orthopedics | Rheumatology | Aging | Epidemiology | Endocrinology | Fracture prevention | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Recurrence | Bone Density - physiology | Follow-Up Studies | Humans | Osteoporotic Fractures - prevention & control | Male | Disease Progression | Hip Fractures - physiopathology | Hip Joint - physiopathology | Aged, 80 and over | Absorptiometry, Photon - methods | Femur Neck - physiopathology | Aged | Osteoporotic Fractures - physiopathology | Osteoporosis - physiopathology | Hip joint | Complications and side effects | Fractures | Prognosis | Physiological aspects | Bones | Research | Density | Dual energy X-ray absorptiometry | Femur | Statistical analysis | Bone mineral density | Bone density | Bone loss | Hip | Index Medicus
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5. Full Text Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study
by Haycock, Philip C and Burgess, Stephen and Nounu, Aayah and Zheng, Jie and Okoli, George N and Bowden, Jack and Wade, Kaitlin Hazel and Timpson, Nicholas J and Evans, David M and Willeit, Peter and Aviv, Abraham and Gaunt, Tom R and Hemani, Gibran and Mangino, Massimo and Ellis, Hayley Patricia and Kurian, Kathreena M and Pooley, Karen A and Eeles, Rosalind A and Lee, Jeffrey E and Fang, Shenying and Chen, Wei V and Law, Matthew H and Bowdler, Lisa M and Iles, Mark M and Yang, Qiong and Worrall, Bradford B and Markus, Hugh Stephen and Hung, Rayjean J and Amos, Chris I and Spurdle, Amanda B and Thompson, Deborah J and O’Mara, Tracy A and Wolpin, Brian and Amundadottir, Laufey and Stolzenberg-Solomon, Rachael and Trichopoulou, Antonia and Onland-Moret, N. Charlotte and Lund, Eiliv and Duell, Eric J and Canzian, Federico and Severi, Gianluca and Overvad, Kim and Gunter, Marc J and Tumino, Rosario and Svenson, Ulrika and van Rij, Andre and Baas, Annette F and Bown, Matthew J and Samani, Nilesh J and van t’Hof, Femke N.G and Tromp, Gerard and Jones, Gregory T and Kuivaniemi, Helena and Elmore, James R and Johansson, Mattias and Mckay, James and Scelo, Ghislaine and Carreras-Torres, Robert and Gaborieau, Valerie and Brennan, Paul and Bracci, Paige M and Neale, Rachel E and Olson, Sara H and Gallinger, Steven and Li, Donghui and Petersen, Gloria M and Risch, Harvey A and Klein, Alison P and Han, Jiali and Abnet, Christian C and Freedman, Neal D and Taylor, Philip R and Maris, John M and Aben, Katja K and Kiemeney, Lambertus A and Vermeulen, Sita H and Wiencke, John K and Walsh, Kyle M and Wrensch, Margaret and Rice, Terri and Turnbull, Clare and Litchfield, Kevin and Paternoster, Lavinia and Standl, Marie and Abecasis, Gonçalo R and SanGiovanni, John Paul and Li, Yong and Mijatovic, Vladan and Sapkota, Yadav and Low, Siew-Kee and Zondervan, Krina T and Montgomery, Grant W and Nyholt, Dale R and van Heel, David A and Hunt, Karen and Arking, Dan E and Ashar, Foram N and Sotoodehnia, Nona and Woo, Daniel and Rosand, Jonathan and ... and Telomeres Mendelian Randomization and Telomeres Mendelian Randomization Collaboration and The Telomeres Mendelian Randomization Collaboration
JAMA oncology, ISSN 2374-2437, 02/2017, Volume 3, Issue 5, pp. 636 - 651
Life Sciences & Biomedicine | Oncology | Science & Technology | Mendelian Randomization Analysis - methods | Risk Assessment - methods | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Humans | Middle Aged | Male | Telomere Homeostasis - genetics | Cardiovascular Diseases - genetics | Neoplasms - genetics | Aged, 80 and over | Germ-Line Mutation | Adult | Female | Aged | Polymorphism, Single Nucleotide | Telomere - genetics | Index Medicus
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6. Full Text Integration of Pharmacometabolomic and Pharmacogenomic Approaches Reveals Novel Insights Into Antiplatelet Therapy
by Lewis, J P and Yerges‐Armstrong, L M and Ellero‐Simatos, S and Georgiades, A and Kaddurah‐Daouk, R and Hankemeier, T
Clinical pharmacology and therapeutics, ISSN 0009-9236, 11/2013, Volume 94, Issue 5, pp. 570 - 573
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biological and medical sciences | Pharmacology. Drug treatments | Medical sciences | Pharmacogenetics - methods | Cardiovascular Diseases - metabolism | Aspirin - metabolism | Cardiovascular Diseases - drug therapy | Humans | Platelet Aggregation Inhibitors - pharmacology | Platelet Aggregation - drug effects | Aspirin - pharmacology | Platelet Aggregation Inhibitors - metabolism | Metabolomics - methods | Platelet Aggregation - genetics | Index Medicus | Abridged Index Medicus
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7. Full Text Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts
by Vimaleswaran, K.S and Berry, D.J and Lu, C and Tikkanen, E and Pilz, S and Hiraki, L.T and Cooper, J.D and Dastani, Z and Li, R and Houston, D.K and Wood, A.R and Michaelsson, K and Vandenput, L and Zgaga, L and Yerges-Armstrong, L.M and McCarthy, M.I and Dupuis, J and Kaakinen, M and Kleber, M.E and Jameson, K and Arden, N and Raitakari, O and Viikari, J and Lohman, K.K and Ferrucci, L and Melhus, H and Ingelsson, E and Byberg, L and Lind, L and Lorentzon, M and Salomaa, V and Campbell, H and Dunlop, M and Mitchell, B.D and Herzig, K.H and Pouta, A and Hartikainen, A.L and Streeten, E.A and Theodoratou, E and Jula, A and Wareham, N.J and Ohlsson, C and Frayling, T.M and Kritchevsky, S.B and Spector, T.D and Richards, J.B and Lehtimaki, T and Ouwehand, W.H and Kraft, P and Cooper, C and Marz, W and Power, C and Loos, R.J and Wang, T.J and Jarvelin, M.R and Whittaker, J.C and Hingorani, A.D and Hypponen, E and Kiemeney, L.A.L.M and et al and Genetic Invest Anthropometric Trai and Genetic Investigation of Anthropometric Traits-GIANT Consortium and the Genetic Investigation of Anthropometric Traits (GIANT) consortium and Göteborgs universitet and Gothenburg University and Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition and Sahlgrenska Academy and Centre for Bone and Arthritis Research and Sahlgrenska akademin and Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
PLoS medicine, ISSN 1549-1277, 2013, Volume 10, Issue 2, pp. e1001383 - e1001383
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Multivariate Analysis | Humans | Middle Aged | Male | North America | Obesity - genetics | Mendelian Randomization Analysis | Aged, 80 and over | Adult | Female | Obesity - diagnosis | Body Mass Index | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease | Vitamin D Deficiency - genetics | Risk Assessment | Europe | Risk Factors | Obesity - ethnology | Linear Models | Biomarkers - blood | Evidence-Based Medicine | Vitamin D - blood | Vitamin D Deficiency - ethnology | Vitamin D Deficiency - prevention & control | Phenotype | Vitamin D Deficiency - diagnosis | Obesity - therapy | Vitamin D - analogs & derivatives | Aged | Polymorphism, Single Nucleotide | Obesity | Vitamin D | Physiological aspects | Calcifediol | Social medicine | Alfacalcidol | Research | Health aspects | Studies | Body mass index | Index Medicus | Basic Medicine | cardiovascular-disease risk | 25-hydroxyvitamin d | common obesity | body-mass index | prevalence | instrumental variables | Endokrinologi och diabetes | d insufficiency | Medicinska grundvetenskaper | genome-wide association | genetic-variants | d deficiency | Endocrinology and Diabetes
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8. Full Text Pharmacometabolomics Reveals That Serotonin Is Implicated in Aspirin Response Variability
by Ellero‐Simatos, S and Lewis, JP and Georgiades, A and Yerges‐Armstrong, LM and Beitelshees, AL and Horenstein, RB and Dane, A and Harms, AC and Ramaker, R and Vreeken, RJ and Perry, CG and Zhu, H and Sànchez, CL and Kuhn, C and Ortel, TL and Shuldiner, AR and Hankemeier, T and Kaddurah‐Daouk, R
CPT: pharmacometrics and systems pharmacology, ISSN 2163-8306, 07/2014, Volume 3, Issue 7, pp. 1 - 9
Studies | Nutrition research | Aspirin | Metabolites | Serotonin | Collagen | American Recovery & Reinvestment Act 2009-US | Cardiovascular disease | Gender | Metabolism | Life Sciences | Original
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