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Materials Science & Engineering. C, Biomimetic Materials, Sensors and Systems, ISSN 0928-4931, 02/2017, Volume 71, p. 452
We developed a potential pH-responsive protein drug delivery system based on aldehyde-functionalized dendritic mesoporous silica nanoparticles (DMSNs-CHO) as... 
Drugs | Bovine serum albumin | Drug delivery systems | Amines | Toxicity | Cytotoxicity | Serum albumin | Drug delivery | Aldehydes | pH effects | Silica | Silicon dioxide | Nanoparticles | Hydrogen ions | Silicas | Chemical bonds | Bearing strength | Protein structure | Dendritic structure
Journal Article
Journal Article
Advanced Functional Materials, ISSN 1616-301X, 02/2016, Volume 26, Issue 8, pp. 1197 - 1208
Malignant bone tumor is one of the major bone diseases. The treatment of such a bone disease typically requires the removal of bone tumor and regeneration of... 
bone regeneration | bifunctional | scaffolds | 3D printing | photothermal therapy | Phosphates | Biological products | Gene expression | Graphene | Stem cells | Tumors | Surgical implants | Regeneration | Therapy | Biomedical materials | Bones | Scaffolds | Biomaterials
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2014, Volume 9, Issue 12, p. e113830
While significant progress has been made in understanding the anti-inflammatory and anti-proliferative effects of the natural diterpenoid component Oridonin on... 
BREAST-CANCER | CARCINOMA-CELLS | IN-VITRO | ADVANCED SOLID TUMORS | TRANSENDOTHELIAL MIGRATION | MULTIDISCIPLINARY SCIENCES | ENDOTHELIAL-CELLS | ACTIN DYNAMICS | MELANOMA-CELLS | DELTA-NOTCH | PHASE-I | Neoplasms - metabolism | Human Umbilical Vein Endothelial Cells - metabolism | Receptors, Notch - metabolism | Humans | Male | Intercellular Signaling Peptides and Proteins - metabolism | Neoplasm Metastasis | Serrate-Jagged Proteins | Antineoplastic Agents - pharmacology | Membrane Proteins - metabolism | Vascular Endothelial Growth Factor A - pharmacology | Disease Models, Animal | Calcium-Binding Proteins - metabolism | Diterpenes, Kaurane - pharmacology | Human Umbilical Vein Endothelial Cells - drug effects | Angiogenesis Inhibitors - pharmacology | Rats | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Cell Movement - drug effects | Animals | Signal Transduction - drug effects | Tumor Burden - drug effects | Neovascularization, Pathologic - drug therapy | Cell Communication - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Neovascularization, Pathologic - metabolism | Neoplasms - pathology | Immunohistochemistry | Antimitotic agents | Care and treatment | Analysis | Metastasis | Antineoplastic agents | Cancer | Cell proliferation | Cornea | Tumor cells | Xenotransplantation | Breast cancer | Inflammation | Gene expression | Molecular chains | Endothelial cells | Metastases | Angiogenesis | Molecular modelling | Xenografts | Aorta | Notch protein | Inhibition | Cell migration | Tumors
Journal Article
Breast Cancer Research and Treatment, ISSN 0167-6806, 9/2012, Volume 135, Issue 2, pp. 445 - 458
Journal Article
Nature Communications, ISSN 2041-1723, 12/2016, Volume 7, Issue 1, pp. 13122 - 13122
Journal Article
ACS Nano, ISSN 1936-0851, 03/2019, Volume 13, Issue 3, pp. 3740 - 3740
Journal Article
Journal Article
Chinese Journal of Cancer, ISSN 1000-467X, 2017, Volume 36, Issue 1, pp. 25 - 2
  Authors' contributions SP drafted the manuscript, and ZY and ML revised the manuscript. All authors read and approved the final manuscript. Acknowledgements... 
ONCOLOGY | ENZALUTAMIDE | Prostatic Neoplasms | Male | Quassins | Prostatic Neoplasms, Castration-Resistant | Humans | Phenylthiohydantoin - analogs & derivatives | Usage | Research | Gene expression | Drug therapy | Prostate cancer | Allelopathic agents | Manuscripts | Androgen Receptor | LNCaP Cell | Enzalutamide | Androgen Receptor Gene | Abiraterone
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 02/2012, Volume 165, Issue 4b, pp. 1084 - 1096
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2012, Volume 7, Issue 12, p. e52162
Activation of p53 effectively inhibits tumor angiogenesis that is necessary for tumor growth and metastasis. Reactivation of the p53 by small molecules has... 
P53-MDM2 INTERACTION | APOPTOSIS | PROTEIN | SIGNALING PATHWAY | PHOSPHORYLATION | VEGF | MULTIDISCIPLINARY SCIENCES | DNA-DAMAGE | COMPOUND | THROMBOSPONDIN-1 | CANCER-THERAPY | RNA, Small Interfering - genetics | Proto-Oncogene Proteins c-mdm2 - genetics | Immunoprecipitation | Human Umbilical Vein Endothelial Cells - metabolism | Tumor Suppressor Protein p53 - antagonists & inhibitors | Apoptosis - drug effects | Humans | Lung Neoplasms - pathology | Aorta - metabolism | Tumor Suppressor Protein p53 - genetics | Human Umbilical Vein Endothelial Cells - cytology | Phosphorylation - drug effects | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Proto-Oncogene Proteins c-mdm2 - metabolism | Real-Time Polymerase Chain Reaction | Lung Neoplasms - blood supply | Hallucinogens - pharmacology | Human Umbilical Vein Endothelial Cells - drug effects | Signal Transduction | Mice, Inbred C57BL | RNA, Messenger - genetics | Cells, Cultured | Harmine - pharmacology | Tumor Suppressor Protein p53 - metabolism | Angiogenesis Inhibitors - pharmacology | Rats | Reverse Transcriptase Polymerase Chain Reaction | Comet Assay | Blotting, Western | Aorta - pathology | Xenograft Model Antitumor Assays | Cell Movement - drug effects | Animals | Lung Neoplasms - prevention & control | Mice, Nude | Neovascularization, Pathologic - drug therapy | Fluorescent Antibody Technique | Cell Proliferation - drug effects | Mice | Cell Cycle - drug effects | Care and treatment | Growth | Tumor proteins | Health aspects | Tumors | Endothelium | Cancer | Phosphorylation | Cornea | Senescence | Transcription | p53 Protein | DNA damage | Activation | Biology | Kinases | Cancer therapies | Metastases | Proteins | Angiogenesis | Signal transduction | Cell cycle | Xenografts | Life sciences | Inhibition | Vascular endothelial growth factor | Deoxyribonucleic acid--DNA | MDM2 protein | Biological activity | Endothelial cells | Cycloheximide | Signaling | Laboratory animals | Cell migration | Apoptosis | Deoxyribonucleic acid | DNA
Journal Article
by Li, YQ and He, Y and Shao, T and Pei, HX and Guo, WK and Mi, DZ and Krimm, I and Zhang, YJ and Wang, PL and Wang, X and Liu, MY and Yi, ZF and Chen, YH
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 05/2019, Volume 62, Issue 10, pp. 4949 - 4966
Pancreatic cancer is one of the most common cancers with an extremely low survival rate. Metastasis, as one of the key reasons of cancer-related death, is... 
CYTOCHROME-P450 | CHEMISTRY, MEDICINAL | METABOLISM | IDENTIFICATION | EXPRESSION | GROWTH | Medicinal Chemistry | Chemical Sciences
Journal Article