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Journal Article
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2016, Volume 113, Issue 41, pp. 11525 - 11530
The focal nature of atherosclerotic lesions suggests an important role of local hemodynamic environment. Recent studies have demonstrated significant roles of... 
Atherogenesis | Mechanotransduction | Endothelial cells | Disturbed flow | atherogenesis | endothelial cells | HIPPO-YAP PATHWAY | mechanotransduction | MULTIDISCIPLINARY SCIENCES | KINASE | TRANSCRIPTION | disturbed flow | CANCER | TISSUE GROWTH-FACTOR | INFLAMMATION | DYSFUNCTION | MEVALONATE | Inflammation - pathology | Apolipoproteins E - deficiency | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Phosphoproteins - metabolism | Cysteine-Rich Protein 61 - metabolism | Gene Knockdown Techniques | Cell Nucleus - metabolism | Muscle Proteins - metabolism | Repressor Proteins - metabolism | Atherosclerosis - pathology | Atherosclerosis - drug therapy | Rheology | Nuclear Proteins - metabolism | Atherosclerosis - metabolism | Phenotype | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Cell Cycle | Endothelium, Vascular - metabolism | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Carotid Artery, Common - pathology | Endothelium, Vascular - pathology | Cell Proliferation - drug effects | Mice | Adaptor Proteins, Signal Transducing - metabolism | Connective Tissue Growth Factor - metabolism | Genotype & phenotype | Genes | Rodents | Atherosclerosis | Homeostasis | Cells | Endothelium | Index Medicus | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2009, Volume 106, Issue 20, pp. 8326 - 8331
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2010, Volume 107, Issue 22, pp. 10268 - 10273
Shear stress imposed by blood flow is crucial for maintaining vascular homeostasis. We examined the role of shear stress in regulating SIRT1, an NAD⁺-dependent... 
Thoracic aorta | Statics | Phosphorylation | Laminar flow | Shear stress | Small interfering RNA | Physiological regulation | Acetylation | Bioavailability | Endothelial cells | Nad | Endothelial nitric oxide synthase | Endothelial homeostasis | NO bioavailability | AMP-activated protein kinase | dependent deacetylase | Sirtuin 1 - metabolism | RNA, Small Interfering - genetics | AMP-Activated Protein Kinases - metabolism | Pulsatile Flow | Humans | Homeostasis | Stress, Mechanical | Male | DNA Primers - genetics | Hemorheology | AMP-Activated Protein Kinases - deficiency | Base Sequence | Nitric Oxide Synthase Type III - metabolism | Endothelial Cells - physiology | Recombinant Proteins - metabolism | Mutagenesis, Site-Directed | Mice, Inbred C57BL | Cells, Cultured | Mitochondria - metabolism | Recombinant Proteins - genetics | Nitric Oxide Synthase Type III - genetics | Animals | Mice | Enzyme Activation | Blood Vessels - physiology | In Vitro Techniques | Nitric Oxide - metabolism | Aorta - physiology | AMP-Activated Protein Kinases - genetics | Amino Acid Substitution | Physiological aspects | Genetic aspects | Stress (Physiology) | Research | Protein kinases | Coronary vessels | Rodents | Biosynthesis | Shear stresses | Gene expression | Kinases | Blood | Index Medicus | Biological Sciences | endothelial nitric oxide synthase | endothelial homeostasis | NAD+-dependent deacetylase
Journal Article
Circulation Research, ISSN 0009-7330, 06/2013, Volume 113, Issue 1, pp. 40 - 51
RATIONALE:Endothelial microRNA-126 (miR-126) modulates vascular development and angiogenesis. However, its role in the regulation of smooth muscle cell (SMC)... 
Smooth muscle cell | Shear stress | Endothelial cell | Extracellular miR-126 | Atherosclerosis | atherosclerosis | CIRCULATING MICRORNAS | APOPTOSIS | extracellular miR-126 | CARDIAC & CARDIOVASCULAR SYSTEMS | smooth muscle cell | endothelial cell | NEOINTIMAL HYPERPLASIA | PROLIFERATION | MECHANISMS | shear stress | MIR-126 | PERIPHERAL VASCULAR DISEASE | CARDIOVASCULAR-DISEASES | HEMATOLOGY | INSULIN-RECEPTOR SUBSTRATE-1 | EXPRESSION | Human Umbilical Vein Endothelial Cells | MicroRNAs - therapeutic use | Coculture Techniques | Humans | Recombinant Fusion Proteins - physiology | Culture Media, Conditioned - pharmacology | Hemorheology | Ligation | Neointima | Insulin Receptor Substrate Proteins - biosynthesis | Argonaute Proteins - physiology | Insulin Receptor Substrate Proteins - genetics | Myocytes, Smooth Muscle - cytology | Cell Line | Forkhead Transcription Factors - biosynthesis | Argonaute Proteins - genetics | Cell Culture Techniques - instrumentation | Paracrine Communication | Gene Expression Regulation | Gene Silencing | Genes, bcl-2 | Forkhead Transcription Factors - genetics | Muscle, Smooth, Vascular - cytology | Proto-Oncogene Proteins c-bcl-2 - biosynthesis | Animals | Endothelial Cells - secretion | Umbilical Arteries - cytology | Carotid Artery, Common - pathology | Mice | MicroRNAs - genetics | MicroRNAs - physiology | Forkhead Box Protein O3 | Index Medicus
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2013, Volume 110, Issue 32, pp. 13174 - 13179
Endothelial cells (ECs) are constantly exposed to xenobiotics and endobiotics or their metabolites, which perturb EC function, as well as to shear stress,... 
Enzymes | Receptors | Genes | Cell lines | Shear stress | Pregnanes | Gene expression regulation | Xenobiotics | Endothelial cells | Apoptosis | Nuclear hormone receptor | Hemodynamics | Endothelial homeostasis | Gene regulation | NITRIC-OXIDE SYNTHASE | MULTIDISCIPLINARY SCIENCES | endothelial homeostasis | CELL APOPTOSIS | INDUCTION | PREGNANE-X-RECEPTOR | hemodynamics | FLOW | P-GLYCOPROTEIN | RESPONSE ELEMENT | IN-VITRO | gene regulation | nuclear hormone receptor | REGULATES DRUG-METABOLISM | EXPRESSION | Carotid Arteries - metabolism | Receptors, Steroid - metabolism | Human Umbilical Vein Endothelial Cells - metabolism | Oligonucleotide Array Sequence Analysis | Apoptosis - drug effects | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Aryl Hydrocarbon Hydroxylases - genetics | Stress, Mechanical | Male | Gene Expression Profiling | Xenobiotics - pharmacology | Glutathione Transferase - genetics | RNA Interference | Xenobiotics - metabolism | Mice, Inbred C57BL | Cells, Cultured | Glutathione Transferase - metabolism | Rats | Reverse Transcriptase Polymerase Chain Reaction | Rats, Sprague-Dawley | Blotting, Western | Aryl Hydrocarbon Hydroxylases - metabolism | Animals | Receptors, Steroid - genetics | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Cell Line, Tumor | Cytochrome P-450 CYP1B1 | Inactivation, Metabolic - genetics | Mice | Stress (Physiology) | Research | Homeostasis | T cell receptors | Gene expression | Rodents | Index Medicus | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2012, Volume 109, Issue 28, pp. 11110 - 11115
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2010, Volume 107, Issue 7, pp. 3234 - 3239
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 06/2019, Volume 116, Issue 26, pp. 12974 - 12979
Journal Article