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Cancer Research, ISSN 0008-5472, 07/2016, Volume 76, Issue 14 Supplement, pp. 1142 - 1142
Objective: All-trans retinoic acid (ATRA) is a widely-used differentiation drug that can effectively induce osteogenic differentiation of osteosarcoma cells,... 
Journal Article
Drug discovery today, 09/2019
Differentiation therapy involves the use of agents that can induce differentiation in cancer cells, with the irreversible loss of tumour phenotype. The... 
Index Medicus
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 12/2018, Volume 175, Issue 23, pp. 4285 - 4294
Journal Article
by You, JQ and Dong, R and Ying, MD and He, QJ and Cao, J and Yang, B
CURRENT DRUG TARGETS, ISSN 1389-4501, 2019, Volume 20, Issue 7, pp. 705 - 715
Background: Cellular senescence is generally understood as a permanent cell cycle arrest stemming from different causes. The mechanism of cellular... 
CELLS | APOPTOSIS | SECRETORY PHENOTYPE | biomarkers | Cellular senescence | DNA-DAMAGE | RADIATION | tumor suppression | BREAST-CANCER | cancer therapy | GROWTH ARREST | TUMOR-SUPPRESSOR | PHARMACOLOGY & PHARMACY | drug in combination | mechanism | CANCER PROGRESSION | TELOMERES | Therapy | Senescence | Cell cycle | Disease control | Growth disorders | Cancer | Tumors
Journal Article
International Journal of Cancer, ISSN 0020-7136, 09/2017, Volume 141, Issue 5, p. 1029
Journal Article
Stem Cell Reports, ISSN 2213-6711, 06/2017, Volume 8, Issue 6, pp. 1617 - 1629
Adriamycin-based combination chemotherapy is the standard first-line treatment for osteosarcoma, but tumor recurrence and metastasis occurs in most cases.... 
cancer stem cells | KLF4 | metastasis | Adriamycin | statins | osteosarcoma | METAANALYSIS | REDUCED RISK | GROWTH | SELF-RENEWAL | DEDIFFERENTIATION | DRUG-RESISTANCE | DIFFERENTIATION | CD133(+) CELLS | EXPRESSION | CHEMOTHERAPY | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Osteosarcoma - drug therapy | Doxorubicin - therapeutic use | Simvastatin - therapeutic use | Neoplastic Stem Cells - cytology | Antibiotics, Antineoplastic - pharmacology | Neoplastic Stem Cells - drug effects | Humans | Transplantation, Heterologous | Simvastatin - pharmacology | Bone Neoplasms - pathology | Bone Neoplasms - metabolism | Neoplastic Stem Cells - metabolism | RNA Interference | Kruppel-Like Transcription Factors - metabolism | Bone Neoplasms - drug therapy | Osteosarcoma - metabolism | Transcription Factors - genetics | Down-Regulation - drug effects | Transcription Factors - metabolism | Cell Movement - drug effects | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Antibiotics, Antineoplastic - therapeutic use | Mice, Nude | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Cell Line, Tumor | Mice, Inbred BALB C | Cell Transformation, Neoplastic - drug effects | Kruppel-Like Transcription Factors - antagonists & inhibitors | Kruppel-Like Transcription Factors - genetics | Doxorubicin - pharmacology | Microscopy, Fluorescence | Osteosarcoma - pathology | RNA, Small Interfering - metabolism | Index Medicus
Journal Article
Journal Article
Cancer Letters, ISSN 0304-3835, 2014, Volume 356, Issue 2, pp. 828 - 836
Highlights • SAHA triggers the activation of MET in HGF independent way. • The combination of SAHA and XL184 results in a synergistic inhibition of tumor... 
Hematology, Oncology and Palliative Medicine | SAHA | XL184 | Combination therapy | MET | HISTONE DEACETYLASE INHIBITOR | SUBEROYLANILIDE HYDROXAMIC ACID | TYROSINE KINASE | DOWN-REGULATION | LUNG-CANCER | PHASE-II TRIAL | ONCOLOGY | PROSTATE-CANCER | LEUKEMIA-CELLS | NF-KAPPA-B | UP-REGULATION | Proto-Oncogene Proteins c-met - metabolism | Lung Neoplasms - drug therapy | Prostatic Neoplasms - metabolism | RNA, Small Interfering - genetics | Apoptosis - drug effects | Humans | Lung Neoplasms - metabolism | Integrins - genetics | Drug Resistance, Neoplasm | Lung Neoplasms - pathology | Male | Integrins - metabolism | Immunoenzyme Techniques | Antineoplastic Agents - pharmacology | Tumor Cells, Cultured | Hydroxamic Acids - pharmacology | Real-Time Polymerase Chain Reaction | Prostatic Neoplasms - drug therapy | Prostatic Neoplasms - pathology | Proto-Oncogene Proteins c-met - antagonists & inhibitors | RNA, Messenger - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Proto-Oncogene Proteins c-met - genetics | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Cell Proliferation - drug effects | Mice | Integrins - antagonists & inhibitors | Cancer | Proteins | Phosphorylation | Acids | Cell cycle | Clinical trials | Kinases | Prostate cancer | Cancer therapies | Tumors | Apoptosis | Index Medicus
Journal Article
电影, ISSN 1671-2528, 2011, Issue 9, pp. 16 - 23
2002年,由西部电影集团策动,小说《白鹿原》的电影改编被提上日程。2011年,历时近10年之后,导演王全安完成电影《白鹿原》的拍摄。关于电影改编,这是一个最为典型的案例,其间的故事包括了导演的更迭,投资方的易手,甚至还有官司等等。2011年,张艺谋导演的《金陵十三钗》亦在紧锣密鼓地制作之中, 
电影改编 | 导演 | 张艺谋 | 王全安 | 投资方 | 西部电影 | 拍摄 | 白鹿原
Journal Article
Oncotarget, ISSN 1949-2553, 2014, Volume 5, Issue 20, pp. 9664 - 9677
Hypoxia is a common phenomenon occurring in the majority of human tumors and has been proved to play an important role in tumor progression. However, it... 
Polarization | Hypoxia | Metastasis | NSCLC | Macrophage | Index Medicus
Journal Article
Cancer Letters, ISSN 0304-3835, 12/2016, Volume 383, Issue 1, pp. 115 - 124
Acriflavine (ACF), a known antibacterial drug, has recently been recognized as a suitable candidate for cancer chemotherapy. However, the molecular target of... 
DNA-PKcs | Target identification | Acriflavine | Melphalan | p53 | MULTIPLE-MYELOMA | DEPENDENT PROTEIN-KINASE | DOUBLE-STRAND BREAKS | TUMOR-CELLS | Acrifiavine | MAMMALIAN-CELLS | REPLICATION FORKS | ONCOLOGY | COLORECTAL-CANCER | LEUKEMIA-CELLS | CELL-CYCLE | HOMOLOGOUS RECOMBINATION | DNA-Activated Protein Kinase - antagonists & inhibitors | Apoptosis - drug effects | Humans | Antineoplastic Agents, Alkylating - pharmacology | DNA Breaks, Double-Stranded | Tumor Suppressor Protein p53 - genetics | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Dose-Response Relationship, Drug | Neoplasms - genetics | Time Factors | DNA-Activated Protein Kinase - metabolism | Melphalan - pharmacology | Acriflavine - metabolism | Acriflavine - pharmacology | HCT116 Cells | Tumor Suppressor Protein p53 - metabolism | Neoplasms - enzymology | Nuclear Proteins - metabolism | Comet Assay | Neoplasms - drug therapy | Drug Synergism | Xenograft Model Antitumor Assays | Animals | Signal Transduction - drug effects | Tumor Burden - drug effects | Mice, Nude | Nuclear Proteins - antagonists & inhibitors | Protein Binding | Cell Proliferation - drug effects | Molecular Docking Simulation | Protein Kinase Inhibitors - pharmacology | HeLa Cells | Neoplasms - pathology | Protein Kinase Inhibitors - metabolism | Medical colleges | Chemotherapy | DNA | Drug therapy, Combination | Tumor proteins | Protein kinases | Cancer | DNA damage | Proteins | Immunoglobulins | Efficiency | Rodents | Kinases | Cancer therapies | Deoxyribonucleic acid--DNA | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2013, Volume 8, Issue 6, pp. e66915 - e66915
Dasatinib (BMS-354825) is a FDA-approved multitargeted kinase inhibitor of BCR/ABL and Src kinases. It is now used in the treatment of chronic myelogenous... 
PATHWAYS | CELLS | THERAPY | INTERFERON-GAMMA | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | GENE-EXPRESSION | TRANS-RETINOIC ACID | INHIBITORS | ACUTE PROMYELOCYTIC LEUKEMIA | Dasatinib | Leukemia, Myeloid, Acute - pathology | Humans | MAP Kinase Kinase Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Pyrimidines - pharmacology | Enzyme Activation - drug effects | Gene Knockdown Techniques | STAT1 Transcription Factor - metabolism | MAP Kinase Signaling System - drug effects | Cell Differentiation - drug effects | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Phosphorylation - drug effects | Drug approval | Phosphotransferases | Genetic transcription | BCR protein | Phosphorylation | Transcription | Leukemia | Abl gene | Activation | BCR gene | Kinases | Nuclei | Signal transduction | Toxicology | Cell growth | Cascades | Cell cycle | DNA methylation | Stat1 protein | Pharmaceutical sciences | Deoxyribonucleic acid--DNA | G1 phase | Imatinib | CD11b antigen | Myeloid leukemia | MEK inhibitors | Severe acute respiratory syndrome | Extracellular signal-regulated kinase | Pharmacology | Chronic myeloid leukemia | Gene expression | Intolerance | Differentiation | Acute myeloid leukemia | Cytoplasm | Apoptosis | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
by 林莹
中国广告, ISSN 1005-9156, 2014, Issue 5, pp. 48 - 49
Journal Article
Cell death and differentiation, ISSN 1350-9047, 05/2019
Insufficient pancreatic β-cell mass or insulin-producing β-cells are implicated in all forms of diabetes mellitus. However, the molecular mechanisms underlying... 
Journal Article
FEBS Journal, ISSN 1742-464X, 07/2014, Volume 281, Issue 13, p. 3032
  Small ubiquitin-related modifier-1 (SUMO-1) modification has been implicated in many important cellular processes, including cell cycle progression,... 
Ubiquitin | Cell differentiation | Leukemia | Proteins | Cellular biology
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 12/2015, Volume 14, Issue 12 Supplement 2, pp. B155 - B155
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 02/2013, Volume 12, Issue 2, pp. 195 - 206
Journal Article
Cancer Research, ISSN 0008-5472, 07/2016, Volume 76, Issue 14 Supplement, pp. 1638 - 1638
Intratumoral hypoxia occurs in many solid tumors, where it is associated with the development of metastatic character. However, the connections between these... 
Journal Article
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