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membrane proteins - genetics (15) 15
non-alcoholic fatty liver disease (15) 15
regional blood flow - drug effects (15) 15
alanine aminotransferase (14) 14
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1. Full Text Thiazolidinediones
by Yki-Järvinen, Hannele
The New England Journal of Medicine, ISSN 0028-4793, 09/2004, Volume 351, Issue 11, pp. 1106 - 1118
Despite a large need for new hypoglycemic therapies, given the epidemic of type 2 diabetes, very few agents have been introduced during the past 20 years. The... 
Hypoglycemic Agents - therapeutic use | Cardiovascular Diseases - physiopathology | Humans | Risk Factors | Gene Expression Regulation | Diabetes Mellitus, Type 2 - metabolism | Thiazolidinediones - adverse effects | Fatty Liver - drug therapy | Hypoglycemic Agents - pharmacology | Transcription Factors - metabolism | Adipose Tissue - metabolism | Thiazolidinediones - therapeutic use | Polycystic Ovary Syndrome - drug therapy | Insulin Resistance - physiology | Biomarkers | Female | Lipodystrophy - drug therapy | Diabetes Mellitus, Type 2 - drug therapy | Thiazolidinediones - pharmacology | Adipose Tissue - drug effects | Hypoglycemic Agents - adverse effects | Receptors, Cytoplasmic and Nuclear - metabolism | Thiazolidinediones | Hypoglycemic agents | Dosage and administration
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2. Full Text Fatty Liver: A Novel Component of the Metabolic Syndrome
by Kotronen, Anna and Yki-Järvinen, Hannele
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 01/2008, Volume 28, Issue 1, pp. 27 - 38
Although the epidemic of obesity has been accompanied by an increase in the prevalence of the metabolic syndrome, not all obese develop the syndrome and even... 
Nonalcoholic liver disease | Liver fat | Metabolic syndrome | HEPATIC INSULIN SENSITIVITY | DE-NOVO LIPOGENESIS | GAMMA-GLUTAMYL-TRANSFERASE | FOLLOW-UP | nonalcoholic liver disease | NONALCOHOLIC STEATOHEPATITIS | ALANINE AMINOTRANSFERASE | metabolic syndrome | APPARENTLY HEALTHY-MEN | MIDDLE-AGED MEN | liver fat | PERIPHERAL VASCULAR DISEASE | PLACEBO-CONTROLLED TRIAL | HEMATOLOGY | ADIPOSE-TISSUE | Diabetes Mellitus, Type 2 - physiopathology | Insulin Resistance - physiology | Fatty Liver - physiopathology | Humans | Fatty Liver - complications | Metabolic Syndrome - physiopathology | Waist-Hip Ratio - adverse effects | Female | Male | Metabolic Syndrome - complications
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3. Full Text Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome
by Yki-Järvinen, Hannele, Prof
Lancet Diabetes & Endocrinology, The, ISSN 2213-8587, 2014, Volume 2, Issue 11, pp. 901 - 910
Summary Metabolic syndrome is a cluster of metabolic abnormalities that identifies people at risk of diabetes and cardiovascular disease, whereas non-alcoholic... 
Endocrinology & Metabolism | Other | POLYCYSTIC-OVARY-SYNDROME | OBSTRUCTIVE SLEEP-APNEA | SWEETENED BEVERAGE CONSUMPTION | NUTRITION EXAMINATION SURVEY | INSULIN-RESISTANCE | ENDOCRINOLOGY & METABOLISM | 3RD NATIONAL-HEALTH | CORONARY-HEART-DISEASE | TYPE-2 DIABETES-MELLITUS | CARDIOVASCULAR RISK-FACTORS | ADIPOSE-TISSUE | Non-alcoholic Fatty Liver Disease - genetics | Membrane Proteins - genetics | Obesity - complications | Humans | Risk Factors | Fatty Liver - complications | Non-alcoholic Fatty Liver Disease - etiology | Male | Metabolic Syndrome - complications | Metabolic Syndrome - diagnosis | Non-alcoholic Fatty Liver Disease - diagnosis | Female | Diabetes Mellitus, Type 2 - complications | Lipase - genetics
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4. Full Text Out of the frying pan: Dietary saturated fat influences nonalcoholic fatty liver disease
by Parks, Elizabeth and Yki-Järvinen, Hannele and Hawkins, Meredith
Journal of Clinical Investigation, ISSN 0021-9738, 02/2017, Volume 127, Issue 2, pp. 454 - 456
Nonalcoholic fatty liver disease (NAFLD) is characterized by excess accumulation of fat in the liver. In some cases, NAFLD is also accompanied by insulin... 
MEDICINE, RESEARCH & EXPERIMENTAL | SKELETAL-MUSCLE | TRIGLYCERIDE | PLASMA | METABOLISM | DE-NOVO LIPOGENESIS | ACIDS | INSULIN-RESISTANCE | MEN | TRIACYLGLYCEROL | LIPOPROTEINS | Non-alcoholic Fatty Liver Disease - pathology | Dietary Fats - adverse effects | Liver - pathology | Gluconeogenesis - drug effects | Humans | Liver - metabolism | Insulin Resistance | Non-alcoholic Fatty Liver Disease - metabolism | Triglycerides - metabolism | Animals | Non-alcoholic Fatty Liver Disease - chemically induced | Dietary Fats - pharmacology | Mice | Development and progression | Care and treatment | Fatty liver | Lipid metabolism | Health aspects | Saturated fatty acids | Studies | Liver diseases | Rodents | Spectrum analysis | Insulin resistance | Lipids | Oils & fats | Oxidation | Glucose | Metabolism | Gene expression | Fatty acids | Index Medicus | Abridged Index Medicus
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5. Full Text Congruence between NOTCH3 mutations and GOM in 131 CADASIL patients
by Tikka, Saara and Mykkänen, Kati and Ruchoux, Marie-Magdeleine and Bergholm, Robert and Junna, Maija and Pöyhönen, Minna and Yki-Järvinen, Hannele and Joutel, Anne and Viitanen, Matti and Baumann, Marc and Kalimo, Hannu and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Institutionen för genetik och patologi and Uppsala universitet
Brain, ISSN 0006-8950, 4/2009, Volume 132, Issue 4, pp. 933 - 939
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common hereditary subcortical vascular... 
Skin biopsy | NOTCH3 | CADASIL | Genetic testing | GOM | SUBCORTICAL INFARCTS | DEMENTIA | MUSCLE | NEUROSCIENCES | skin biopsy | CLINICAL NEUROLOGY | STROKE | LEUKOENCEPHALOPATHY | DIAGNOSTIC STRATEGIES | genetic testing | ECTODOMAIN | DISEASE | AUTOSOMAL-DOMINANT ARTERIOPATHY | SPECTRUM | CADASIL - pathology | Cytoplasmic Granules | Venules - ultrastructure | Muscle, Smooth, Vascular - ultrastructure | Humans | Arterioles - ultrastructure | Receptors, Notch - genetics | Microscopy, Electron | CADASIL - genetics | Skin - blood supply | Biopsy | Skin - ultrastructure | Receptor, Notch3 | Retrospective Studies | Mutation | Original | Medical and Health Sciences | Medicin och hälsovetenskap | MEDICIN | MEDICINE
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6. Full Text New Insulin Glargine 300 Units/mL Versus Glargine 100 Units/mL in People With Type 2 Diabetes Using Oral Agents and Basal Insulin: Glucose Control and Hypoglycemia in a 6-Month Randomized Controlled Trial (EDITION 2)
by Yki-Jarvinen, H and Bergenstal, R and Ziemen, M and Wardecki, M and Muehlen-Bartmer, I and Boelle, E and Riddle, MC and EDITION 2 Study Investigators
DIABETES CARE, ISSN 0149-5992, 12/2014, Volume 37, Issue 12, pp. 3235 - 3243
OBJECTIVE To compare the efficacy and safety of new insulin glargine 300 units/mL (Gla-300) with glargine 100 units/mL (Gla-100) in people with type 2 diabetes... 
NAIVE PATIENTS | ENDOCRINOLOGY & METABOLISM | TO-TARGET TRIAL | Glycated Hemoglobin A - analysis | Hypoglycemia - epidemiology | Administration, Oral | Humans | Middle Aged | Male | Insulin Detemir | Diabetes Mellitus, Type 2 - epidemiology | Blood Glucose - drug effects | Dose-Response Relationship, Drug | Insulin, Long-Acting - adverse effects | Diabetes Mellitus, Type 2 - blood | Insulin, Long-Acting - administration & dosage | Hypoglycemic Agents - administration & dosage | Insulin Glargine | Adult | Female | Aged | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Hypoglycemia - chemically induced | Hypoglycemic Agents - adverse effects | Type 2 diabetes | Usage | Care and treatment | Insulin glargine | Blood sugar | Analysis | Clinical trials | Dosage and administration | Hypoglycemia | Risk factors
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7. Full Text Drug therapy: Thiazolidinediones
by Yki-Jarvinen, H
NEW ENGLAND JOURNAL OF MEDICINE, ISSN 0028-4793, 09/2004, Volume 351, Issue 11, pp. 1106 - 1118
  Despite a large need for new hypoglycemic therapies, given the epidemic of type 2 diabetes, very few agents have been introduced during the past 20 years.... 
POLYCYSTIC-OVARY-SYNDROME | MEDICINE, GENERAL & INTERNAL | ACTIVATED RECEPTOR-GAMMA | HAART-ASSOCIATED LIPODYSTROPHY | HEPATIC FAT-CONTENT | IMPROVES GLYCEMIC CONTROL | ADIPOSE-SPECIFIC PROTEIN | INSULIN-RESISTANCE | PPAR-GAMMA | TYPE-2 DIABETES-MELLITUS | CORONARY-ARTERY-DISEASE | Proteins | Insulin resistance | Diabetes | Insulin | Rodents
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8. Full Text Better glycaemic control and less hypoglycaemia with insulin glargine 300 U/mL vs glargine 100 U/mL: 1-year patient-level meta-analysis of the EDITION clinical studies in people with type 2 diabetes
by Ritzel, Robert and Roussel, Ronan and Giaccari, Andrea and Vora, Jiten and Brulle-Wohlhueter, Claire and Yki-Järvinen, Hannele
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 03/2018, Volume 20, Issue 3, pp. 541 - 548
AimsTo investigate the efficacy and safety of insulin glargine 300U/mL (Gla-300) vs insulin glargine 100U/mL (Gla-100) over 12months in a patient-level... 
meta-analysis | glycaemic control | type 2 diabetes | insulin analogues | hypoglycaemia | phase III study | INCLUDING 6-MONTH EXTENSION | GLUCOSE CONTROL | ADULTS | ADHERENCE | ORAL ANTIHYPERGLYCEMIC DRUGS | TRIAL | BASAL INSULIN | ENDOCRINOLOGY & METABOLISM | RESISTANCE | ASSOCIATION | UNITS/ML | Insulin Glargine - adverse effects | Glycated Hemoglobin A - metabolism | Humans | Diabetes Mellitus, Type 2 - prevention & control | Body Weight - drug effects | Treatment Outcome | Randomized Controlled Trials as Topic | Insulin Glargine - administration & dosage | Clinical Trials, Phase III as Topic | Diabetes Mellitus, Type 2 - blood | Multicenter Studies as Topic | Hypoglycemic Agents - administration & dosage | Hypoglycemia - chemically induced | Hypoglycemic Agents - adverse effects | Type 2 diabetes | Glycosylated hemoglobin | Medicine, Experimental | Medical research | Insulin | Diabetes therapy | Studies | Diabetes mellitus | Hemoglobin | Data processing | Diabetes | Hypoglycemia | Diabetes mellitus (non-insulin dependent) | meta‐analysis | Original
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9. Full Text Increased Liver Fat, Impaired Insulin Clearance, and Hepatic and Adipose Tissue Insulin Resistance in Type 2 Diabetes
by Kotronen, Anna and Juurinen, Leena and Tiikkainen, Mirja and Vehkavaara, Satu and Yki–Järvinen, Hannele
Gastroenterology, ISSN 0016-5085, 2008, Volume 135, Issue 1, pp. 122 - 130
Background & Aims: Liver fat is increased in type 2 diabetes. We determined whether it is associated with impaired insulin clearance and to what extent insulin... 
Gastroenterology and Hepatology | OBESITY | MAGNETIC-RESONANCE-SPECTROSCOPY | PIMA-INDIANS | SPLANCHNIC GLUCOSE-UPTAKE | ACID-METABOLISM | GAMMA-GLUTAMYL-TRANSFERASE | ALANINE AMINOTRANSFERASE | NONDIABETIC SUBJECTS | MELLITUS | GASTROENTEROLOGY & HEPATOLOGY | DOSE-RESPONSE CHARACTERISTICS | Body Mass Index | Hyperinsulinism - metabolism | Protons | Multivariate Analysis | Liver - pathology | Fatty Liver - metabolism | Fatty Liver - pathology | Humans | Liver - metabolism | Middle Aged | Insulin Resistance | Male | Diabetes Mellitus, Type 2 - metabolism | Insulin - blood | Adipose Tissue - metabolism | Magnetic Resonance Imaging | Regression Analysis | Adult | Fatty Acids, Nonesterified - blood | Female | Glucose Clamp Technique | Type 2 diabetes | Adipose tissues | Diabetics | Liver diseases | Low density lipoproteins | Liver | Insulin resistance | Aspartate aminotransferase | Glucose | Fatty acids | Dextrose
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10. Full Text Altered miRNA processing disrupts brown/white adipocyte determination and associates with lipodystrophy
by Mori, Marcelo A and Thomou, Thomas and Boucher, Jeremie and Lee, Kevin Y and Lallukka, Susanna and Kim, Jason K and Torriani, Martin and Yki-Järvinen, Hannele and Grinspoon, Steven K and Cypess, Aaron M and Kahn, C. Ronald
Journal of Clinical Investigation, ISSN 0021-9738, 08/2014, Volume 124, Issue 8, pp. 3339 - 3351
miRNAs are important regulators of biological processes in many tissues, including the differentiation and function of brown and white adipocytes. The... 
MEDICINE, RESEARCH & EXPERIMENTAL | MUSCULAR HYPERTROPHY | OBESITY | ENERGY-EXPENDITURE | BEIGE ADIPOCYTES | GLUCOSE-METABOLISM | GENE-EXPRESSION | BROWN ADIPOSE-TISSUE | INSULIN SENSITIVITY | FAT-CELL | WHITE ADIPOCYTES | Adipocytes, White - cytology | Adipocytes, Brown - metabolism | HIV-Associated Lipodystrophy Syndrome - genetics | Humans | Male | MicroRNAs - metabolism | Cell Differentiation - genetics | DEAD-box RNA Helicases - deficiency | Female | DEAD-box RNA Helicases - metabolism | Cell Differentiation - physiology | Disease Models, Animal | Ribonuclease III - genetics | Ribonuclease III - metabolism | RNA Processing, Post-Transcriptional | Down-Regulation | Insulin Resistance | Lipodystrophy - metabolism | Ribonuclease III - deficiency | Mice, Knockout | Lipodystrophy - genetics | DEAD-box RNA Helicases - genetics | HIV-Associated Lipodystrophy Syndrome - pathology | Animals | Energy Metabolism | Lipodystrophy - pathology | HIV-Associated Lipodystrophy Syndrome - metabolism | Mice | MicroRNAs - genetics | Adipocytes, Brown - cytology | Cohort Studies | Adipose tissues | Physiological aspects | Lipodystrophy | Genetic aspects | MicroRNA | Research | Body fat | Mortality | Adipocytes | Metabolism | Gene expression | Abdomen | Studies | Hospitals | Rodents | Insulin resistance | Diabetes | Metabolic disorders | Age
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11. Full Text Acquired obesity is associated with changes in the serum lipidomic profile independent of genetic effects - A monozygotic twin study
by Pietiläinen, Kirsi H and Sysi-Aho, Marko and Rissanen, Aila and Seppänen-Laakso, Tuulikki and Yki-Järvinen, Hannele and Kaprio, Jaakko and Orešič, Matej
PLoS ONE, ISSN 1932-6203, 02/2007, Volume 2, Issue 2, p. e218
Both genetic and environmental factors are involved in the etiology of obesity and the associated lipid disturbances. We determined whether acquired obesity is... 
BIOLOGY | Body Composition | Body Mass Index | Metabolomics | Abdominal Fat - pathology | Twins, Monozygotic - genetics | Humans | Insulin Resistance | Diet Records | Male | Obesity - blood | Obesity - genetics | Subcutaneous Fat - pathology | Obesity - pathology | Young Adult | Magnetic Resonance Imaging | Smoking - epidemiology | Lipids - blood | Obesity - epidemiology | Finland | Sphingomyelins - blood | Adult | Female | Lysophosphatidylcholines - blood | Insulin resistance | Lipids | Genetic aspects | Liquid chromatography | Twins | Health care | Plasma | Atherogenesis | Body fat | Alcohol | Population studies | Phospholipids | Family medical history | Body composition | Antioxidants | Genetic effects | Body mass index | Body composition (biology) | Etiology | Genetic factors | Lipid metabolism | Localization | Interviews | Public health | Dual energy X-ray absorptiometry | Obesity | Sensitivity analysis | Mass spectroscopy | Environmental factors | Inflammation | Metabolism | Insulin | Fatty acids | Studies | Nutrition research | Hospitals | Magnetic resonance imaging | Epigenetics | Diabetes | Females | Mass spectrometry
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12. Full Text Fat in the liver and insulin resistance
by Yki-Järvinen, Hannele
Annals of Medicine, ISSN 0785-3890, 2005, Volume 37, Issue 5, pp. 347 - 356
Insulin resistance in humans is not always accompanied by obesity, since severe insulin resistance also characterizes patients lacking subcutaneous fat such as... 
hypertriglyceridemia | magnetic resonance imaging | Glucose | proton spectroscopy | Proton spectroscopy | Magnetic resonance imaging | Hypertriglyceridemia | SUBCUTANEOUS ADIPOSE-TISSUE | GAMMA-GLUTAMYL-TRANSFERASE | ANTIRETROVIRAL THERAPY | NONALCOHOLIC STEATOHEPATITIS | ALANINE AMINOTRANSFERASE | BODY-COMPOSITION | MEDICINE, GENERAL & INTERNAL | TYPE-2 DIABETIC-PATIENTS | HAART-ASSOCIATED LIPODYSTROPHY | GLUCOSE-METABOLISM | THERAPY-ASSOCIATED LIPODYSTROPHY | Diabetes Mellitus, Type 2 - etiology | Insulin Resistance - physiology | Fatty Liver - physiopathology | Humans | Lipodystrophy - complications | Fatty Liver - complications
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