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Science, ISSN 0036-8075, 07/2017, Volume 357, Issue 6348, pp. 273 - 279
Journal Article
ELIFE, ISSN 2050-084X, 09/2019, Volume 8
Soluble guanylate cyclase (sGC) is the primary receptor for nitric oxide (NO) in mammalian nitric oxide signaling. We determined structures of full-length... 
CRYSTAL-STRUCTURE | ADENYLYL-CYCLASE | CATALYTIC DOMAINS | BIOLOGY | X-RAY-SCATTERING | HEME DOMAIN | SAXS | SUBUNIT | Enzymes | Biophysics | Electron microscopy | Guanylate cyclase | Proteins | Allosteric properties | X-ray scattering | Microscopy | Cyclic GMP | Nitric oxide | Heme | Ligands | Software | Sensors
Journal Article
Cell Reports, ISSN 2211-1247, 08/2019, Volume 28, Issue 8, pp. 2080 - 2095.e6
Hsp104 is an AAA+ protein disaggregase, which can be potentiated via diverse mutations in its autoregulatory middle domain (MD) to mitigate toxic misfolding of... 
aberrant phase separation | disaggregase | PD | Hsp104 | FUS | TDP-43 | FTD | ALS | engineering | alpha-synuclein | RNA-BINDING PROTEINS | OVEREXPRESSION | DOMAIN | VARIANTS | CLPB | ELIMINATION | GENE-THERAPY | HSP104 DISAGGREGASE | MODEL | AGGREGATION | CELL BIOLOGY
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 43, pp. 17617 - 17625
G-proteins regulate various processes ranging from DNA replication and protein synthesis to cytoskeletal dynamics and cofactor assimilation and serve as models... 
low molecular weight G-protein | adenosylcobalamin (AdoCbl) | allosteric regulation | Enzymology | GTPase | electron microscopy (EM)
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2017, Volume 292, Issue 43, pp. 17617 - 17625
Journal Article
Journal Article
SCIENCE, ISSN 0036-8075, 11/2019, Volume 366, Issue 6468, pp. 971 - 971
Journal Article
Nature structural & molecular biology, ISSN 1545-9993, 9/2016, Volume 23, Issue 9, pp. 830 - 837
ClpB and Hsp104 are conserved AAA+ protein disaggregases that promote survival during cellular stress. Hsp104 acts on amyloids, supporting prion propagation in... 
Journal Article
Science, ISSN 0036-8075, 07/2017, Volume 357, Issue 6348, p. 273
Hspl00 polypeptide translocases are conserved members of the AAA+ family (adenosine triphosphatases associated with diverse cellular activities) that maintain... 
Physiological aspects | Polypeptides | Translocation (Genetics) | Observations
Journal Article
Blood, ISSN 0006-4971, 12/2014, Volume 124, Issue 25, pp. 3730 - 3737
Journal Article
Cancer Research, ISSN 0008-5472, 10/2014, Volume 74, Issue 19 Supplement, pp. 3225 - 3225
Journal Article
Data in Brief, ISSN 2352-3409, 09/2015, Volume 4, Issue C, pp. 650 - 658
The data here consists of time-dependent experimental parameters from chemical and biophysical methods used to characterize Aβ monomeric reactants as well as... 
Journal Article
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