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Journal of Bone and Mineral Research, ISSN 0884-0431, 11/2011, Volume 26, Issue 11, pp. 2682 - 2694
The aging process correlates with the accumulation of cellular and tissue damage caused by oxidative stress. Although previous studies have suggested that... 
Low‐turnover osteoporosis | Bone fragility | Senescent collagen cross‐links | Copper/zinc superoxide dismutase (CuZn‐SOD OR SOD1) | Reactive oxygen species (ROS) | Senescent collagen cross-links | Low-turnover osteoporosis | Copper/zinc superoxide dismutase (CuZn-SOD OR SOD1) | OSTEOBLAST | ANTIOXIDANTS | INCREASES | ACCELERATION | SKELETAL-MUSCLE | MINERAL DENSITY | REACTIVE OXYGEN SPECIES (ROS) | BONE FRAGILITY | DISMUTASE | ENDOCRINOLOGY & METABOLISM | COPPER/ZINC SUPEROXIDE DISMUTASE (CuZn-SOD OR SOD1) | ELEVATED OXIDATIVE STRESS | MICE | LOW-TURNOVER OSTEOPOROSIS | SENESCENT COLLAGEN CROSS-LINKS | EXPRESSION | Bone and Bones - pathology | RANK Ligand - metabolism | Cell Count | Aging - drug effects | Cytoplasm - metabolism | Bone and Bones - drug effects | Osteoporosis - metabolism | Bone and Bones - metabolism | Oxidation-Reduction - drug effects | Superoxides - metabolism | Osteoporosis - physiopathology | Superoxide Dismutase - metabolism | Cell Survival - drug effects | Bone Resorption - physiopathology | Osteoclasts - pathology | Osteoblasts - drug effects | Osteogenesis - drug effects | Ascorbic Acid - administration & dosage | Superoxide Dismutase - deficiency | Bone Resorption - complications | Macrophage Colony-Stimulating Factor - metabolism | Aging - pathology | Cross-Linking Reagents - metabolism | Collagen - metabolism | Osteoblasts - pathology | Bone and Bones - physiopathology | Organ Size - drug effects | Phenotype | Animals | Osteoporosis - pathology | Signal Transduction - drug effects | Osteoporosis - complications | Ascorbic Acid - pharmacology | Bone Resorption - pathology | Mice | Cytoplasm - drug effects | Osteoclasts - drug effects | Oxidative stress | Ascorbic acid | Spine | Intracellular signalling | Superoxide dismutase | Osteoblasts | Antioxidants | Cross-linking | Bones | Copper | TRANCE protein | Bone strength | Vertebrae | Therapeutic applications | Macrophage colony-stimulating factor | Mechanical properties | Stress | Vitamins | Connective tissue | Analysis | Collagen | Osteoclasts | Bone mineral density | Animal subjects | Osteogenesis
Journal Article
Nature Genetics, ISSN 1061-4036, 06/2013, Volume 45, Issue 6, pp. 676 - 679
Journal Article
Journal of Medical Genetics, ISSN 0022-2593, 09/2019, Volume 56, Issue 9, pp. 622 - 628
BackgroundCongenital scoliosis (CS) is a common vertebral malformation. Spondylocostal dysostosis (SCD) is a rare skeletal dysplasia characterised by multiple... 
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 08/2019, Volume 10, Issue 1, pp. 3685 - 9
Adolescent idiopathic scoliosis (AIS) is the most common pediatric spinal deformity. Several AIS susceptibility loci have been identified; however, they could... 
TBX1 | COMMON VARIANTS | BODY-MASS INDEX | GENE | CHILDHOOD | MULTIDISCIPLINARY SCIENCES | Pathogenesis | Phenotypic variations | Genomes | Uric acid | Gene expression | Loci | Quantitative trait loci | Heterogeneity | Body mass index | Body mass | Scoliosis | Etiology | Body size | Heritability | Gene mapping
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2013, Volume 8, Issue 9, p. e72802
Journal Article
by Ogura, Yoji and Takeda, Kazuki and Kou, Ikuyo and Khanshour, Anas and Grauers, Anna and Zhou, Hang and Liu, Gang and Fan, Yan-Hui and Zhou, Taifeng and Wu, Zhihong and Takahashi, Yohei and Matsumoto, Morio and Kawakami, Noriaki and Tsuji, Taichi and Uno, Koki and Suzuki, Teppei and Ito, Manabu and Minami, Shohei and Kotani, Toshiaki and Sakuma, Tsuyoshi and Yanagida, Haruhisa and Taneichi, Hiroshi and Yonezawa, Ikuho and Sudo, Hideki and Chiba, Kazuhiro and Hosogane, Naobumi and Nishida, Kotaro and Kakutani, Kenichiro and Akazawa, Tsutomu and Kaito, Takashi and Watanabe, Kei and Harimaya, Katsumi and Taniguchi, Yuki and Shigematsu, Hideki and Demura, Satoru and Iida, Takahiro and Kono, Katsuki and Okada, Eijiro and Fujita, Nobuyuki and Yagi, Mitsuru and Nakamura, Masaya and Karol, Lori A and Rathjen, Karl E and Sucato, Daniel J and Birch, John G and Johnston, Charles E and Richards, Benjamin S and Ramo, Brandon and McIntosh, Amy L and Herring, John A and Milbrandt, Todd A and Talwakar, Vishwas R and Iwinski, Henry J and Muchow, Ryan D and Tassone, J. Channing and Liu, X.-C and Shindell, Richard and Schrader, William and Eberson, Craig and Lapinsky, Anthony and Loder, Randall and Davey, Joseph and Einarsdottir, Elisabet and Kere, Juha and Huang, Dongsheng and Qiu, Guixing and Xu, Leilei and Qiu, Yong and Wise, Carol A and Song, You-Qiang and Wu, Nan and Su, Peiqiang and Gerdhem, Paul and Watanabe, Kota and Ikegawa, Shiro and Texas Scottish Rite Hosp Children and Japan Scoliosis Clinical Res Grp and Japan Scoliosis Clinical Research Group (JSCRG) and Texas Scottish Rite Hospital for Children Clinical Group (TSRHCCG)
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 4730 - 7
Adolescent idiopathic scoliosis (AIS) is a common spinal deformity with the prevalence of approximately 3%. We previously conducted a genome-wide association... 
VARIANTS | GENE | SNP | GENOTYPE IMPUTATION | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY | LBX1 | GENOME-WIDE ASSOCIATION | HISTORY | Population studies | Genomes | Scoliosis | Chromosome 9
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 11575 - 8
Adolescent idiopathic scoliosis (AIS) is the most common type of spinal deformity and has a significant genetic background. Genome-wide association studies... 
BONE-MINERAL DENSITY | RARE VARIANTS | GENE | MULTIDISCIPLINARY SCIENCES | MACULAR DEGENERATION | RISK | CHINESE | LBX1 | BODY | EPIDEMIOLOGY | GENOME-WIDE ASSOCIATION | Scoliosis | Chromosome 6 | Genomes
Journal Article
Journal Article
Journal of Orthopaedic Science, ISSN 0949-2658, 03/2017, Volume 22, Issue 2, pp. 237 - 242
Journal Article
Journal of Biomedical Science and Engineering, ISSN 1937-6871, 2018, Volume 11, Issue 4, pp. 45 - 59
Journal Article
Advanced Science Letters, ISSN 1936-6612, 11/2018, Volume 24, Issue 11, p. 8770
Vertebral subsequent fractures phenomenon following primary vertebral compression fractures (VCFs) at the adjacent vertebral level has becoming debatable... 
Stress concentration | Medical imaging | Deformation | Spine | Density | Finite element method | Biomechanics | Osteoporosis | Biomedical materials | Fractures | Strain distribution | Biocompatibility | Bone density
Journal Article