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2013, Zhongguo shi xue ji ben dian ji cong kan, ISBN 7101088759, 1 v.
Book
Lancet, The, ISSN 0140-6736, 2013, Volume 381, Issue 9881, pp. 1916 - 1925
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2014, Volume 9, Issue 5, pp. e98270 - e98270
DOT1L, the only known histone H3-lysine 79 (H3K79) methyltransferase, has been shown to be essential for the survival and proliferation of mixed-linkage... 
HISTONE METHYLTRANSFERASE DOT1L | RNA EXPRESSION LEVELS | METHYLATION | MULTIDISCIPLINARY SCIENCES | DNA-DAMAGE | LEUKEMOGENESIS | DOUBLE-STRAND BREAKS | H3K79 METHYLTRANSFERASE | MIXED-LINEAGE LEUKEMIA | MAMMALIAN-CELLS | CHILDRENS ONCOLOGY GROUP | Myeloid-Lymphoid Leukemia Protein - metabolism | Apoptosis - drug effects | Homeodomain Proteins - metabolism | Humans | Leukemia, Myeloid, Acute - metabolism | Methyltransferases - metabolism | Methyltransferases - genetics | Child, Preschool | Infant | Male | Leukemia, Myeloid, Acute - drug therapy | Female | Child | Histone-Lysine N-Methyltransferase | Enzyme Inhibitors - pharmacology | Homeodomain Proteins - genetics | Histones - genetics | Methyltransferases - antagonists & inhibitors | Gene Rearrangement | Adolescent | HL-60 Cells | DNA Damage | Histones - metabolism | Cell Cycle - drug effects | Leukemia, Myeloid, Acute - genetics | Chemotherapy | Methylation | Gene expression | Leukemia | Cancer | Cell proliferation | Pediatrics | Cell culture | Regulators | DNA damage | Methyltransferase | Kinases | CD14 antigen | Damage prevention | Cancer therapies | Proteins | Cytarabine | Cell cycle | DNA methylation | Inhibition | Mitoxantrone | Drug dosages | Deoxyribonucleic acid--DNA | Cell survival | Hematology | Etoposide | Tumor cell lines | Children & youth | Medicine | Signaling | Monocytes | Inhibitors | Lysine | Medical prognosis | Cell lines | Differentiation | Acute myeloid leukemia | Histone H3 | Apoptosis | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Science, ISSN 0036-8075, 3/2008, Volume 319, Issue 5868, pp. 1391 - 1394
Staphylococcus aureus produces hospital- and community-acquired infections, with methicillin-resistant S. aureus posing a serious public health threat. The... 
Carotenoids | Virulence | Pigments | Squalene | Ligands | Reports | Biosynthesis | Infections | Diphosphates | Cholesterols | Staphylococcus aureus | TARGET | SQUALENE SYNTHASE INHIBITOR | MULTIDISCIPLINARY SCIENCES | Organothiophosphorus Compounds - therapeutic use | Virulence - drug effects | Polyisoprenyl Phosphates - chemistry | Sesquiterpenes - metabolism | Humans | Bacterial Proteins - chemistry | Molecular Sequence Data | Crystallography, X-Ray | Enzyme Inhibitors - chemical synthesis | Organothiophosphorus Compounds - pharmacology | Farnesyl-Diphosphate Farnesyltransferase - chemistry | Anti-Bacterial Agents - therapeutic use | Anti-Bacterial Agents - chemistry | Staphylococcal Infections - microbiology | Organothiophosphorus Compounds - chemical synthesis | Staphylococcus aureus - metabolism | Amino Acid Sequence | Bacterial Proteins - antagonists & inhibitors | Cell Line | Staphylococcal Infections - drug therapy | Sesquiterpenes - chemistry | Enzyme Inhibitors - metabolism | Organothiophosphorus Compounds - metabolism | Protein Structure, Secondary | Farnesyl-Diphosphate Farnesyltransferase - isolation & purification | Enzyme Inhibitors - pharmacology | Polyisoprenyl Phosphates - metabolism | Staphylococcus aureus - pathogenicity | Farnesyl-Diphosphate Farnesyltransferase - metabolism | Anti-Bacterial Agents - chemical synthesis | Animals | Farnesyl-Diphosphate Farnesyltransferase - antagonists & inhibitors | Xanthophylls - biosynthesis | Bacterial Proteins - metabolism | Anti-Bacterial Agents - pharmacology | Cell Proliferation - drug effects | Mice | Cholesterol - biosynthesis | Staphylococcus aureus - drug effects | Staphylococcus aureus - growth & development | Bacterial Proteins - isolation & purification | Prevention | Physiological aspects | Staphylococcus aureus infections | Anticholesteremic agents | Enzymes | Inhibitor drugs | Rodents | Bacteria | Biochemistry | Drug resistance | Cholesterol | Index Medicus
Journal Article
细胞研究:英文版, ISSN 1001-0602, 2014, Volume 24, Issue 7, pp. 809 - 819
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 10/2011, Volume 133, Issue 42, pp. 16746 - 16749
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2007, Volume 104, Issue 24, pp. 10022 - 10027
Bisphosphonate drugs (e.g., Fosamax and Zometa) are thought to act primarily by inhibiting farnesyl diphosphate synthase (FPPS), resulting in decreased... 
Enzymes | Yeasts | Electronic structure | Molecular structure | Terpenoids | Diphosphonates | Ligands | Biosynthesis | Diphosphates | Binding sites | Undecaprenyl diphosphate synthase | Geranylgeranyl diphosphate synthase | X-ray structure | Cell wall | FARNESYL DIPHOSPHATE SYNTHASE | POTENTIAL ROUTE | INHIBITION | MECHANISM | ISOPRENOID BIOSYNTHESIS | STRUCTURAL BASIS | NITROGEN-CONTAINING BISPHOSPHONATES | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | GERANYLGERANYL PYROPHOSPHATE SYNTHASE | DRUGS | Diphosphates - metabolism | Polyisoprenyl Phosphates - chemistry | Sesquiterpenes - metabolism | Models, Chemical | Stereoisomerism | Alkyl and Aryl Transferases - antagonists & inhibitors | Substrate Specificity | Crystallography, X-Ray | Isoenzymes - chemistry | Isoenzymes - metabolism | Transferases - metabolism | Farnesyltranstransferase - antagonists & inhibitors | Molecular Structure | Transferases - antagonists & inhibitors | Diterpenes - metabolism | Binding Sites | Dimerization | Diterpenes - chemistry | Alkyl and Aryl Transferases - chemistry | Sesquiterpenes - chemistry | Protein Structure, Secondary | Models, Molecular | Transferases - chemistry | Diphosphonates - metabolism | Polyisoprenyl Phosphates - metabolism | Farnesyltranstransferase - chemistry | Diphosphates - chemistry | Diphosphonates - chemistry | Hydrophobic and Hydrophilic Interactions | Saccharomyces cerevisiae - enzymology | Isoenzymes - antagonists & inhibitors | Usage | Research | X-ray spectroscopy | Plant cell walls | Guanosine triphosphatase | Biochemistry | Inhibitor drugs | Drug therapy | Index Medicus | Biological Sciences | undecaprenyl diphosphate synthase | x-ray structure | geranylgeranyl diphosphate synthase | cell wall
Journal Article