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International Journal of Molecular Sciences, ISSN 1661-6596, 08/2016, Volume 17, Issue 8, pp. 1246 - 1246
In this research, we firstly demonstrated that physcion, an anthraquinone derivative, specifically increased the expression of the human alpha... 
Signal pathway | HST8Sia VI | Transcription factor Pax-5 | Physcion | SK-N-BE-C | PREPARATIVE ISOLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | VALPROIC ACID | hST8Sia VI | MEDIATED TRANSCRIPTIONAL REGULATION | PAX5 | IDENTIFICATION | CANCER | CHEMISTRY, MULTIDISCIPLINARY | SIALYLTRANSFERASES | COUNTER-CURRENT CHROMATOGRAPHY | ANTHRAQUINONES | SYNTHASE HST8SIA I | signal pathway | physcion | transcription factor Pax-5 | Gene Expression Regulation, Enzymologic - drug effects | Sequence Deletion | Transcriptional Activation - genetics | Apoptosis - drug effects | Emodin - analogs & derivatives | Humans | Neuroblastoma - enzymology | Transcriptional Activation - drug effects | Cell Survival - genetics | Apoptosis - genetics | Extracellular Signal-Regulated MAP Kinases - metabolism | RNA, Messenger - metabolism | 5' Flanking Region - genetics | Base Sequence | p38 Mitogen-Activated Protein Kinases - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Cell Survival - drug effects | Promoter Regions, Genetic | Brain Neoplasms - enzymology | Emodin - pharmacology | Emodin - isolation & purification | Neuroblastoma - genetics | RNA, Messenger - genetics | Sialyltransferases - genetics | Brain Neoplasms - genetics | Up-Regulation - genetics | Emodin - chemistry | Sialyltransferases - metabolism | Sequence Analysis, DNA | Up-Regulation - drug effects | Cell Line, Tumor | Cellular biology | Gene expression | Research
Journal Article
Apoptosis, ISSN 1360-8185, 9/2017, Volume 22, Issue 9, pp. 1079 - 1097
Fluoxetine (FLX) is an antidepressant drug that belongs to the class of selective serotonin reuptake inhibitors. FLX is known to induce apoptosis in multiple... 
Biochemistry, general | Biomedicine | Fluoxetine | Histone hyperacetylation | SK-N-BE-M17 cells | ER stress | Cancer Research | Oncology | Cell Biology | Virology | Apoptosis | MAPKs | ANTIDEPRESSANT | CANCER CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | DEATH | CELL BIOLOGY | NUCLEAR-FACTOR | SODIUM-BUTYRATE | DRUGS | MITOCHONDRIAL DYSFUNCTION | INHIBITORS | UP-REGULATION | Cell Survival - drug effects | Fluoxetine - pharmacology | Transcription Factor CHOP - genetics | Phosphorylation | Reactive Oxygen Species - metabolism | Endoplasmic Reticulum Stress - drug effects | MAP Kinase Kinase Kinase 5 - genetics | Apoptosis - drug effects | Humans | Transcription Factor CHOP - antagonists & inhibitors | Membrane Potential, Mitochondrial - drug effects | Gene Knockdown Techniques | Acetylation - drug effects | Animals | Caspases, Initiator - metabolism | Signal Transduction - drug effects | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Mice | Histones - metabolism | MAP Kinase Kinase Kinase 5 - metabolism | Neuroblastoma - pathology | Medical colleges | Histones | Research institutes | Neuroblastoma | Molecular biology | Mitogens | Protein kinases | Chromatin | Homology | Serotonin uptake inhibitors | Event-related potentials | Activation | CCAAT/enhancer-binding protein | Kinases | Caspase-4 | Neuroblastoma cells | Anticancer properties | Proteins | Mitochondria | Cell activation | Transfection | Membrane potential | Inhibition | Acetylation | Stresses | Serotonin | Mortality | Extracellular signal-regulated kinase | Caspase | MAP kinase | JNK protein | siRNA | Histone acetyltransferase | Stress | Molecular modelling | Inhibitors | Acids | Protein kinase | Cell death | Endoplasmic reticulum | Histone H3 | Phenylbutyric acid | Cancer
Journal Article
Journal Article
International Journal of Oncology, ISSN 1019-6439, 09/2012, Volume 41, Issue 3, pp. 1036 - 1042
Hepatocellular carcinoma (HCC) is one of the most aggressive malignant diseases and is highly resistant to conventional chemotherapy. Therefore, HCC requires... 
ER stress | Hepatocellular carcinoma | 5-Fluorouracil | Autophagy | Apoptosis | SURVIVAL | DEATH PROGRAM | LOCALIZATION | ACTIVATION | autophagy | PROTEIN | INDUCED APOPTOSIS | POLY(ADP-RIBOSE) PAR POLYMER | apoptosis | MECHANISMS | CANCER | 5-fluorouracil | ONCOLOGY | hepatocellular carcinoma
Journal Article
Toxicology in Vitro, ISSN 0887-2333, 09/2012, Volume 26, Issue 6, p. 783
a* An in vitro NASH model was created in SK-Hep-1 cells using palmitic acid and TNF-[alpha]. a* Palmitic acid promoted TNF-[alpha]-induced cytotoxicity by... 
Tumor necrosis factor | Analysis | Saturated fatty acids | Fatty acids
Journal Article
Toxicological Research, ISSN 1976-8257, 2011, Volume 27, Issue 4, pp. 211 - 216
Herbal medicines are widely used in many countries for the treatment of many diseases. Although the use of herb extracts as alternative medicine is growing,... 
Herbal medicine | Nile red | Srebp | Pparα | In vitro screening | Steatosis | SREBP | PPARα | 예방의학
Journal Article
약학회지, ISSN 0377-9556, 02/2012, Volume 56, Issue 1, pp. 14 - 19
Nonalcoholic steatohepatitis(NASH) is serious metabolic disease related to fatty acid. According to "two hit theory", fatty acid-induced oxidative stress is... 
약학
Journal Article
Toxicological research, ISSN 1226-8399, 2011, Volume 27, Issue 4, pp. 211 - 216
Herbal medicines are widely used in many countries for the treatment of many diseases. Although the use of herb extracts as alternative medicine is growing,... 
Journal Article
Environmental Health and Toxicology, ISSN 2233-6567, 03/2011, Volume 26, p. e2011017
Objectives Manganese chloride (MnCl 2 ) is one of heavy metals for causing neurogenerative dysfunction like Manganism. The purpose of this study was to... 
apoptosis | Manganese chloride (MnCl2) | Mitochondria dysfunction | Endoplasmic reticulum stress
Journal Article
JOURNAL OF CROHNS & COLITIS, ISSN 1873-9946, 11/2019, Volume 13, Issue 11, pp. 1410 - 1417
Background and Aims: Although the incidence of inflammatory bowel disease [IBD] is increasing in Asia, data on long-term epidemiological trends are limited. We... 
SK-IBD Study | POPULATION | CROHNS-DISEASE | ULCERATIVE-COLITIS | PHENOTYPE | Crohn's disease | MINNESOTA | DENMARK | prevalence | INCREASE | OLMSTED COUNTY | ulcerative colitis | COHORT | GASTROENTEROLOGY & HEPATOLOGY | incidence
Journal Article
by Park, H and Kim, H and Ha, E and Yoon, S and Kim, MJ and Hong, M and Yang, JS and Chung, JH
NEUROLOGICAL RESEARCH, ISSN 0161-6412, 2007, Volume 29, pp. S78 - S87
of various neurological disorders. To determine protective effect of Panax ginseng (PG) on hypoxia (0.1% O-2)-induced cell death in human neuroblastoma cells... 
hypoxia | OXYGEN RADICALS | PROTEIN | INJURY | cDNA microarray | ISCHEMIA | REPERFUSION | Panax ginseng | NEUROSCIENCES | DAMAGE | CLINICAL NEUROLOGY | cellular physiologic response | COMPONENT | CYTOCHROME-C RELEASE | BRAIN | EXTRACT
Journal Article
by Shen, JK and Tryon, DN and Myklak, KC and Alsyouf, MM and Peplinski, BS and Conceicao, C and Ruckle, HC and Baldwin, DD and Liu, LZQ and Johnson, LJ and Davenport, DL and Venkatesh, R and Soria, F and Morcillo, E and De la Cruz, J and Serrano, A and Rioja, J and Budia, A and Fernandez, T and Fernandez, I and Bachiller, J and Sanchez, FM and Lee, BR and Callaghan, C and Mandava, SH and Peralta, D and Bouljihad, M and Dash, SD and Liu, JL and Tarr, MT and Maddox, MM and Lai, WL and Jordão, RJ and Bandeira, RAST and Leite, KR and Miranda, EP and Srougi, M Miguel and Tefik, T and Seitz, C and Brehmer, M and Osther, P and Giusti, G and Rassweiler, JR and Grasso, MG and Preminger, GP and Pearle, MP and Traxer, OT and Lee, JW and Lee, MY and Oh, TH and Kwon, WA and Park, SC and Jeong, H J and Seo, I Y and Patankar, SBP and Smith, YS and Yallappa, S and Polson, P and Subramonian, K and Fukai, YF and Ishii, T and Igarashi, T and Lamb, BW and Lettin, J and Cook, J and Malik, S and Graham, S and Elhage, O and Sakellariou, C and Smith, Ra and Galustian, C and Dasgupta, P and Olweny, E and Zhang, Z and Haimovich, B and Kwon, YS and Lu, T and Fyfe-Kirschner, BFK and Kim, DSK and Choi, T and Yoo, KH and Jeon, S and Shahrour, K and Keck, R and Jankun, J and Ball, MW and Readal, NT and Gorin, MA and Pierorazio, PM and Allaf, ME and Kallidonis, P and Vasilas, M and Panagopoulos, VP and Amanatides, LA and Kyriazis, IK and Vrettos, T and Fligkou, F and Liatsikos, E and Lovegrove, CE and Novara, G and ...
Journal of Endourology, ISSN 0892-7790, 10/2015, Volume 29, Issue S1, pp. P1 - A457
Journal Article