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1. Full Text Administration of tolvaptan with reduction of loop diuretics ameliorates congestion with improving renal dysfunction in patients with congestive heart failure and renal dysfunction
by Hanatani, Akihisa and Shibata, Atsushi and Kitada, Ryouko and Iwata, Shinichi and Matsumura, Yoshiki and Doi, Atsushi and Sugioka, Kenichi and Takagi, Masahiko and Yoshiyama, Minoru
Heart and Vessels, ISSN 0910-8327, 3/2017, Volume 32, Issue 3, pp. 287 - 294
In patients with congestive heart failure and renal dysfunction, high dose of diuretics are necessary to improve congestion, which may progress to renal... 
Biomedical Engineering | Heart failure | Vasopressin V2-receptor antagonist | Renal function | Medicine & Public Health | Cardiac Surgery | Diuretics | Vascular Surgery | Cardiology | CARDIAC & CARDIOVASCULAR SYSTEMS | HEMODYNAMICS | TRIAL | IMPACT | FUROSEMIDE | PERIPHERAL VASCULAR DISEASE | OUTCOMES | ELDERLY-PATIENTS | REGISTRY | Body Weight | Kidney - drug effects | Prospective Studies | Sodium Potassium Chloride Symporter Inhibitors - therapeutic use | Humans | Japan | Middle Aged | Male | Sodium - blood | Heart Failure - drug therapy | Kidney Function Tests | Antidiuretic Hormone Receptor Antagonists - administration & dosage | Aged, 80 and over | Creatinine - blood | Female | Aged | Benzazepines - administration & dosage | Kidney - physiopathology | Kidney diseases | Pharmaceuticals
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2. Full Text Randomised controlled trial of long-term maintenance corticosteroid therapy in patients with autoimmune pancreatitis
by Masamune, Atsushi and Nishimori, Isao and Kikuta, Kazuhiro and Tsuji, Ichiro and Mizuno, Nobumasa and Iiyama, Tatsuo and Kanno, Atsushi and Tachibana, Yuichi and Ito, Tetsuhide and Kamisawa, Terumi and Uchida, Kazushige and Hamano, Hideaki and Yasuda, Hiroaki and Sakagami, Junichi and Mitoro, Akira and Taguchi, Masashi and Kihara, Yasuyuki and Sugimoto, Hiroyuki and Hirooka, Yoshiki and Yamamoto, Satoshi and Inui, Kazuo and Inatomi, Osamu and Andoh, Akira and Nakahara, Kazuyuki and Miyakawa, Hiroyuki and Hamada, Shin and Kawa, Shigeyuki and Okazaki, Kazuichi and Shimosegawa, Tooru and Res Comm Intractable Pancreas Dis and Research Committee of Intractable Pancreas Diseases in Japan
Gut, ISSN 0017-5749, 03/2017, Volume 66, Issue 3, pp. 487 - 494
ObjectiveCorticosteroid has been established as the standard therapy for autoimmune pancreatitis (AIP), but the requirement for maintenance corticosteroid... 
autoimmune disease | Pancreatic disease | RELAPSE | IGG4-RELATED DISEASE | MULTICENTER | MALIGNANCY | CLINICAL PROFILE | CHOLANGITIS | STEROID-THERAPY | OUTCOMES | DIAGNOSTIC-CRITERIA | TYPE-1 | GASTROENTEROLOGY & HEPATOLOGY | Prednisolone - adverse effects | Recurrence | Prednisolone - administration & dosage | Follow-Up Studies | Humans | Middle Aged | Male | Pancreatitis - drug therapy | Withholding Treatment | Disease-Free Survival | Anti-Inflammatory Agents - adverse effects | Time Factors | Anti-Inflammatory Agents - administration & dosage | Female | Aged | Maintenance Chemotherapy | Autoimmune Diseases - drug therapy | Usage | Care and treatment | Corticosteroids | Pancreatic diseases | Diagnosis | Patients | Health aspects | Studies | Disease | Pancreatic cancer
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3. Full Text Clinical course of type 1 autoimmune pancreatitis patients without steroid treatment: a Japanese multicenter study of 97 patients
by Kubota, Kensuke and Kamisawa, Terumi and Hirano, Kenji and Hirooka, Yoshiki and Uchida, Kazushige and Ikeura, Tsukasa and Shiomi, Hideyuki and Ohara, Hirotaka and Shimizu, Kyoko and Arakura, Norikazu and Kanno, Atsushi and Sakagami, Junichi and Itoi, Takao and Ito, Tetsuhide and Ueki, Toshiharu and Nishino, Takayoshi and Inui, Kazuo and Mizuno, Nobumasa and Yoshida, Hitoshi and Sugiyama, Masanori and Iwasaki, Eisuke and Irisawa, Atsushi and Okazaki, Kazuichi and Kawa, Shigeyuki and Shimosegawa, Toru and Takeyama, Yoshifumi and Chiba, Tsutomu
Journal of Hepato‐Biliary‐Pancreatic Sciences, ISSN 1868-6974, 04/2018, Volume 25, Issue 4, pp. 223 - 230
Background Sporadic autoimmune pancreatitis (AIP) cases showing remission without steroid treatment have been reported, however, the clinical course of these... 
Remission | Relapse | Autoimmune pancreatitis | Stent | Steroid treatment | SURGERY | CONSENSUS DIAGNOSTIC-CRITERIA | PROGNOSIS | LONG-TERM OUTCOMES | GUIDELINES | THERAPY | INTERNATIONAL CONSENSUS | DISEASE | SPONTANEOUS REMISSION | CHOLANGITIS | GASTROENTEROLOGY & HEPATOLOGY
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4. Full Text Highly Emissive Boron Ketoiminate Derivatives as a New Class of Aggregation‐Induced Emission Fluorophores
by Yoshii, Ryousuke and Nagai, Atsushi and Tanaka, Kazuo and Chujo, Yoshiki
Chemistry – A European Journal, ISSN 0947-6539, 04/2013, Volume 19, Issue 14, pp. 4506 - 4512
A series of boron ketoiminate derivatives that exhibited clear aggregation‐induced emission (AIE) characteristics (in THF: ΦPL≤0.01; in the solid state:... 
fluorophores | aggregation | luminescence | boron | ketoiminates | O-CARBORANE | COMPLEXES | CHEMISTRY, MULTIDISCIPLINARY | SOLID-STATE | CONJUGATED POLYMERS | FLUORESCENCE | RESTRICTED INTRAMOLECULAR ROTATION | ENAMINOKETONATOBORON DIFLUORIDES | DIFLUOROBORON | LIGHT-EMISSION | Boron Compounds - chemistry | Fluorescent Dyes - chemical synthesis | Fluorescent Dyes - chemistry | Boron Compounds - chemical synthesis | Ketones - chemical synthesis | Imines - chemistry | Ketones - chemistry | Molecular Structure | Imines - chemical synthesis | Nitrogen | Optical properties | Fluorides | Chemistry | Boron | Spectrum analysis | Solid state | Emission spectroscopy | Molecular structure | Photoluminescence | Derivatives | Bonding
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5. Full Text Unsteady peeling accompanied by oscillations of adhesive tape from a soft adherend
by Sugizaki, Yoshiki and Suzuki, Atsushi
SOFT MATTER, ISSN 1744-683X, 9/2019, Volume 15, Issue 35, pp. 78 - 788
Peel angle dependence of the peel force was investigated using cross-linked polydimethylsiloxane (PDMS) covered with a pressure-sensitive adhesive tape. In our... 
POLYMER SCIENCE | FILM | PHYSICS, MULTIDISCIPLINARY | SUBSTRATE | MATERIALS SCIENCE, MULTIDISCIPLINARY | CHEMISTRY, PHYSICAL | PRESSURE-SENSITIVE ADHESIVES | ANGLE | MODEL | SKIN | Pressure sensitive adhesives | Silicone resins | Oscillations | Elasticity | Crosslinking | Peeling | Polydimethyl siloxanes | Thickness | Shear forces | Adhesives | Dependence | Polydimethylsiloxane | Material properties
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6. Full Text Significance of perivascular tumour cells defined by CD109 expression in progression of glioma
by Shiraki, Yukihiro and Mii, Shinji and Enomoto, Atsushi and Momota, Hiroyuki and Han, Yi‐Peng and Kato, Takuya and Ushida, Kaori and Kato, Akira and Asai, Naoya and Murakumo, Yoshiki and Aoki, Kosuke and Suzuki, Hiromichi and Ohka, Fumiharu and Wakabayashi, Toshihiko and Todo, Tomoki and Ogawa, Seishi and Natsume, Atsushi and Takahashi, Masahide
The Journal of Pathology, ISSN 0022-3417, 12/2017, Volume 243, Issue 4, pp. 468 - 480
In the progression of glioma, tumour cells often exploit the perivascular microenvironment to promote their survival and resistance to conventional therapies.... 
glioma | tumour microenvironment | brain tumour stem cells | CD109 | STEM-CELLS | ACTIVATION | TGF-BETA | EGF | PROLIFERATION | PATHOLOGY | MOUSE MODELS | TEMOZOLOMIDE | HETEROGENEITY | GLIOBLASTOMA | ONCOLOGY | GROWTH | Neoplastic Stem Cells - drug effects | Humans | Brain Neoplasms - pathology | Gene Expression Regulation, Neoplastic | Tumor Microenvironment | Antineoplastic Agents, Alkylating - pharmacology | Neoplasm Proteins - metabolism | Antigens, CD - genetics | Brain Neoplasms - metabolism | Antigens, CD - metabolism | Glioma - metabolism | Glioma - genetics | Neoplastic Stem Cells - metabolism | Time Factors | Dacarbazine - pharmacology | Glioma - pathology | Dacarbazine - analogs & derivatives | Neoplastic Stem Cells - pathology | Tumor Cells, Cultured | Neoplasm Proteins - genetics | Signal Transduction | Brain Neoplasms - genetics | Brain Neoplasms - drug therapy | Disease Progression | GPI-Linked Proteins - metabolism | Mice, Knockout | Animals | Cell Proliferation - drug effects | Mice | Neoplasm Proteins - deficiency | Temozolomide | Glioma - drug therapy | GPI-Linked Proteins - genetics | Gliomas | Analysis | Brain tumors | Genomics | Stem cells | Development and progression | Transplantation | Brain | Cell survival | Brain stem | Brain cancer | Stem cell transplantation | Genomes | Tissue analysis | Tissues | Gene sequencing | Signal transduction | Signaling | Allografts | Glioma cells | Glycosylphosphatidylinositol
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7. Full Text Amendment of the Japanese Consensus Guidelines for Autoimmune Pancreatitis, 2013 III. Treatment and prognosis of autoimmune pancreatitis
by Kamisawa, Terumi and Okazaki, Kazuichi and Kawa, Shigeyuki and Ito, Tetsuhide and Inui, Kazuo and Irie, Hiroyuki and Nishino, Takayoshi and Notohara, Kenji and Nishimori, Isao and Tanaka, Shigeki and Nishiyama, Toshimasa and Suda, Koichi and Shiratori, Keiko and Tanaka, Masao and Shimosegawa, Tooru and Japan Pancreas Soc and Minist Hlth Labour Welf Japan and Working Committee of the Japan Pancreas Society and the Research Committee for Intractable Pancreatic Disease supported by the Ministry of Health, Labour and Welfare of Japan and The Working Committee of the Japan Pancreas Society and the Research Committee for Intractable Pancreatic Disease supported by the Ministry of Health, Labour and Welfare of Japan
Journal of Gastroenterology, ISSN 0944-1174, 6/2014, Volume 49, Issue 6, pp. 961 - 970
The standard treatment for autoimmune pancreatitis (AIP) is steroid therapy, although some patients improve spontaneously. Indications for steroid therapy in... 
Steroid | Treatment | Medicine & Public Health | Colorectal Surgery | Hepatology | Gastroenterology | Abdominal Surgery | Guideline | Surgical Oncology | Autoimmune pancreatitis | LONG-TERM PROGNOSIS | DUCTAL ADENOCARCINOMA | RITUXIMAB THERAPY | FOLLOW-UP | EXOCRINE FUNCTION | DIABETES-MELLITUS | IMMUNOGLOBULIN G4-ASSOCIATED CHOLANGITIS | EXTRAPANCREATIC LESIONS | STEROID-THERAPY | GASTROENTEROLOGY & HEPATOLOGY | CORTICOSTEROID TREATMENT | Recurrence | Asian Continental Ancestry Group | Glucocorticoids - administration & dosage | Glucocorticoids - therapeutic use | Prognosis | Humans | Pancreatitis - immunology | Treatment Outcome | Pancreatitis - drug therapy | Autoimmune Diseases - drug therapy | Consensus | Glucose metabolism | Enzymes | Medical examination | Blood sugar | Immunoglobulin G | Pancreatitis | Drug therapy | Blood
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8. Full Text Postoperative Visceral Tissue Edema Assessed by Computed Tomography Is a Predictor for Severe Complications After Pancreaticoduodenectomy
by Shimizu, Atsushi and Kawai, Manabu and Hirono, Seiko and Okada, Ken-ichi and Miyazawa, Motoki and Kitahata, Yuji and Ueno, Masaki and Hayami, Shinya and Miyamoto, Atsushi and Kimoto, Yoshiki and Shimokawa, Toshio and Yamaue, Hiroki
Journal of Gastrointestinal Surgery, ISSN 1091-255X, 1/2018, Volume 22, Issue 1, pp. 77 - 87
In pancreatoduodenectomy (PD), the adverse impact of tissue edema owing to intraoperative fluid overload remains unclear. This study aims to evaluate how... 
Visceral tissue edema | Medicine & Public Health | Goal-directed fluid therapy | Surgery | Fluid management | Gastroenterology | Complication | Pancreatoduodenectomy | DEFINITION | SURGERY | RANDOMIZED-CONTROLLED-TRIAL | CLINICAL-TRIAL | PANCREATIC SURGERY ISGPS | QUANTIFICATION | INTERNATIONAL STUDY-GROUP | SALT | THERAPY | ENHANCED RECOVERY | GASTROENTEROLOGY & HEPATOLOGY | Medical colleges | Dropsy | Complications and side effects | Edema | CT imaging | Analysis | Pancreaticoduodenectomy | Gastrointestinal surgery
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9. Full Text Langerhans cells are critical in epicutaneous sensitization with protein antigen via thymic stromal lymphopoietin receptor signaling
by Nakajima, Saeko, MD and Igyártó, Botond Z., PhD and Honda, Tetsuya, MD, PhD and Egawa, Gyohei, MD, PhD and Otsuka, Atsushi, MD, PhD and Hara-Chikuma, Mariko, PhD and Watanabe, Norihiko, MD, PhD and Ziegler, Steven F., PhD and Tomura, Michio, PhD and Inaba, Kayo, PhD and Miyachi, Yoshiki, MD, PhD and Kaplan, Daniel H., MD, PhD and Kabashima, Kenji, MD, PhD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2012, Volume 129, Issue 4, pp. 1048 - 1055.e6
Background The clarification of cutaneous dendritic cell subset and the role of thymic stromal lymphopoietin (TSLP) signaling in epicutaneous sensitization... 
Allergy and Immunology | epicutaneous sensitization | Langerhans cell | TSLP | protein antigen | TSLP receptor | ALLERGIC INFLAMMATION | OX40 LIGAND | IMMUNOLOGY | TH1 CHEMOKINES | ATOPIC-DERMATITIS | ALLERGY | IN-VIVO | STEADY-STATE | LANGERIN(+) DENDRITIC CELLS | SKIN | T-CELLS | Dermatitis, Allergic Contact - immunology | Ovalbumin - immunology | OX40 Ligand - metabolism | Dendritic Cells - immunology | Th2 Cells - immunology | Administration, Cutaneous | Dermatitis, Allergic Contact - metabolism | Immunoglobulin E - blood | Allergens - administration & dosage | Lymphocyte Activation - immunology | Immunoglobulin E - immunology | Allergens - immunology | Langerhans Cells - immunology | Female | Receptors, Cytokine - metabolism | Receptors, Cytokine - genetics | Dendritic Cells - metabolism | Disease Models, Animal | Chemokines - biosynthesis | Cytokines - metabolism | Signal Transduction | Mice, Inbred C57BL | Epitopes | Mice, Knockout | Animals | Ovalbumin - administration & dosage | Up-Regulation - immunology | Mice | Mice, Inbred BALB C | Chimerism | Langerhans Cells - metabolism | Bone Marrow Cells - metabolism | Medical colleges | Antigens | Dendritic cells | Atopic dermatitis | Fluorescein | Albumin | Fluorescence | Skin | Universities and colleges | Proteins | Skin diseases | Lymphocytes | Allergies | Chemokines | Ovalbumin | Animal models | Toxin A | Immune response | Helper cells | Transgenic mice | Immunoglobulin E | Lymphocytes T | Gene expression | Lymph nodes | Interleukin 4 | Thymic stromal lymphopoietin | Bone marrow | Langerhans cells
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10. Full Text Effect of Atorvastatin Therapy on Fibrous Cap Thickness in Coronary Atherosclerotic Plaque as Assessed by Optical Coherence Tomography
by Komukai, Kenichi, MD and Kubo, Takashi, MD, PhD and Kitabata, Hironori, MD, PhD and Matsuo, Yoshiki, MD, PhD and Ozaki, Yuichi, MD and Takarada, Shigeho, MD, PhD and Okumoto, Yasushi, MD and Shiono, Yasutsugu, MD and Orii, Makoto, MD and Shimamura, Kunihiro, MD and Ueno, Satoshi, MD and Yamano, Takashi, MD and Tanimoto, Takashi, MD, PhD and Ino, Yasushi, MD, PhD and Yamaguchi, Tomoyuki, MD and Kumiko, Hirata, MD, PhD and Tanaka, Atsushi, MD, PhD and Imanishi, Toshio, MD, PhD and Akagi, Hideharu, MD, PhD and Akasaka, Takashi, MD, PhD
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2014, Volume 64, Issue 21, pp. 2207 - 2217
Abstract Background The detailed mechanism of plaque stabilization by statin therapy is not fully understood. Objectives The aim of this study was to assess... 
Cardiovascular | Internal Medicine | atherosclerosis | macrophage | vulnerable plaque | statin therapy | CARDIAC & CARDIOVASCULAR SYSTEMS | RANDOMIZED CONTROLLED-TRIAL | LIPID-LOWERING THERAPY | ANGIOSCOPY | INFLAMMATION | DISEASE | ACUTE MYOCARDIAL-INFARCTION | INTRAVASCULAR ULTRASOUND | OUTCOMES | MORPHOLOGY | Cardiovascular agents | Antilipemic agents | Heart attacks | Angina pectoris | Drug therapy | Cholesterol | Statins
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11. Full Text The Janus kinase inhibitor JTE-052 improves skin barrier function through suppressing signal transducer and activator of transcription 3 signaling
by Amano, Wataru, DVM and Nakajima, Saeko, MD, PhD and Kunugi, Hayato, PhD and Numata, Yasuharu, MS and Kitoh, Akihiko, MD, PhD and Egawa, Gyohei, MD, PhD and Dainichi, Teruki, MD, PhD and Honda, Tetsuya, MD, PhD and Otsuka, Atsushi, MD, PhD and Kimoto, Yukari, MS and Yamamoto, Yasuo, MS and Tanimoto, Atsuo, MS and Matsushita, Mutsuyoshi, PhD and Miyachi, Yoshiki, MD, PhD and Kabashima, Kenji, MD, PhD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2015, Volume 136, Issue 3, pp. 667 - 677.e7
Background Barrier disruption and the resulting continuous exposure to allergens are presumed to be responsible for the development of atopic dermatitis (AD).... 
Allergy and Immunology | keratinocyte differentiation | signal transducer and activator of transcription 3 | Atopic dermatitis | filaggrin | Janus kinase inhibitor | JAK INHIBITOR | MODEL | IMMUNOLOGY | CORNIFIED ENVELOPE | NC/NGA MICE | ATOPIC-DERMATITIS | RESPONSES | ALLERGY | FILAGGRIN MUTATIONS | STAT6 | DIFFERENTIATION | TH2 | RNA, Small Interfering - genetics | Dermatitis, Atopic - genetics | Humans | Interleukin-13 - immunology | Transplantation, Heterologous | STAT6 Transcription Factor - genetics | Interleukin-13 - genetics | RNA, Small Interfering - immunology | Skin, Artificial | Dermatitis, Atopic - immunology | Intermediate Filament Proteins - genetics | Skin Transplantation | STAT6 Transcription Factor - antagonists & inhibitors | Interleukin-4 - genetics | STAT3 Transcription Factor - genetics | Disease Models, Animal | Intermediate Filament Proteins - immunology | Signal Transduction | Mice, Inbred C57BL | Gene Expression Regulation | Dermatitis, Atopic - pathology | STAT6 Transcription Factor - immunology | Keratinocytes - immunology | Interleukin-4 - immunology | Keratinocytes - pathology | Animals | Dermatitis, Atopic - drug therapy | Keratinocytes - drug effects | Cell Differentiation - drug effects | Mice, Nude | Mice | Protein Kinase Inhibitors - pharmacology | Immunocompromised Host | STAT3 Transcription Factor - immunology | STAT3 Transcription Factor - antagonists & inhibitors | Circuit components | Allergens | Mutual fund industry | Skin | Genetic transcription | Proteins | Cytokines | Genes | Skin & tissue grafts | Ligands | Kinases | Potassium | Chemokines
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12. Full Text Generation of a ciliary margin-like stem cell niche from self-organizing human retinal tissue
by Kuwahara, Atsushi and Ozone, Chikafumi and Nakano, Tokushige and Saito, Koichi and Eiraku, Mototsugu and Sasai, Yoshiki
Nature Communications, ISSN 2041-1723, 2015, Volume 6, Issue 1, p. 6286
In the developing neural retina (NR), multipotent stem cells within the ciliary margin (CM) contribute to de novo retinal tissue growth. We recently reported... 
PROGENITOR CELLS | OPTIC-CUP | PIGMENT EPITHELIUM | REGENERATION | MULTIDISCIPLINARY SCIENCES | MOUSE | NEURAL RETINA | INTERKINETIC NUCLEAR MIGRATION | DIFFERENTIATION | HOMEOBOX GENE | EXPRESSION | Immunohistochemistry | Embryonic Stem Cells - cytology | Humans | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Retina - embryology | Glycogen Synthase Kinase 3 - metabolism | Bone Morphogenetic Protein 4 - metabolism | Mice, Inbred ICR | Cell Lineage | Animals | Flow Cytometry | Retina - cytology | Multipotent Stem Cells - cytology | Female | Stem Cell Niche - physiology | Cell Differentiation | Mice | Cell Culture Techniques | Retinal Pigment Epithelium - cytology
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