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1. Full Text Prophylactic cranial irradiation versus observation in patients with extensive-disease small-cell lung cancer: a multicentre, randomised, open-label, phase 3 trial
by Takahashi, Toshiaki, MD and Yamanaka, Takeharu, Prof and Seto, Takashi, MD and Harada, Hideyuki, MD and Nokihara, Hiroshi, MD and Saka, Hideo, MD and Nishio, Makoto, MD and Kaneda, Hiroyasu, MD and Takayama, Koichi, MD and Ishimoto, Osamu, MD and Takeda, Koji, MD and Yoshioka, Hiroshige, MD and Tachihara, Motoko, MD and Sakai, Hiroshi, MD and Goto, Koichi, MD and Yamamoto, Nobuyuki, Prof
The lancet oncology, ISSN 1470-2045, 2017, Volume 18, Issue 5, pp. 663 - 671
Hematology, Oncology and Palliative Medicine | Life Sciences & Biomedicine | Oncology | Science & Technology | Lung Neoplasms - drug therapy | Brain Neoplasms - diagnostic imaging | Humans | Middle Aged | Lung Neoplasms - pathology | Male | Small Cell Lung Carcinoma - drug therapy | Small Cell Lung Carcinoma - secondary | Early Termination of Clinical Trials | Brain Neoplasms - secondary | Aged, 80 and over | Medical Futility | Adult | Female | Survival Rate | Cranial Irradiation - adverse effects | Brain Neoplasms - prevention & control | Small Cell Lung Carcinoma - prevention & control | Magnetic Resonance Imaging | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Intention to Treat Analysis | Small Cell Lung Carcinoma - diagnostic imaging | Watchful Waiting | Aged | Platinum Compounds - administration & dosage | Care and treatment | Chemotherapy | Lung cancer | Oncology, Experimental | Radiation | Clinical trials | Metastasis | Research | College teachers | Radiotherapy | Cancer | Analysis | Index Medicus
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2. Full Text Alectinib versus crizotinib in patients with ALK -positive non-small-cell lung cancer (J-ALEX): an open-label, randomised phase 3 trial
by Hida, Toyoaki, MD and Nokihara, Hiroshi, MD and Kondo, Masashi, MD and Kim, Young Hak, MD and Azuma, Koichi, MD and Seto, Takashi, MD and Takiguchi, Yuichi, Prof and Nishio, Makoto, MD and Yoshioka, Hiroshige, MD and Imamura, Fumio, MD and Hotta, Katsuyuki, Prof and Watanabe, Satoshi, MD and Goto, Koichi, MD and Satouchi, Miyako, MD and Kozuki, Toshiyuki, MD and Shukuya, Takehito, MD and Nakagawa, Kazuhiko, Prof and Mitsudomi, Tetsuya, Prof and Yamamoto, Nobuyuki, Prof and Asakawa, Takashi, PhD and Asabe, Ryoichi, MS and Tanaka, Tomohiro, MS and Tamura, Tomohide, Dr
The Lancet (British edition), ISSN 0140-6736, 2017, Volume 390, Issue 10089, pp. 29 - 39
Internal Medicine | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Single-Blind Method | Lung Neoplasms - drug therapy | Pyrazoles - therapeutic use | Humans | Middle Aged | Lung Neoplasms - pathology | Male | Antineoplastic Agents - therapeutic use | Protein Kinase Inhibitors - adverse effects | Piperidines - blood | Brain Neoplasms - secondary | Pyridines - adverse effects | Carcinoma, Non-Small-Cell Lung - secondary | Neoplasm Grading | Antineoplastic Agents - adverse effects | Pyrazoles - blood | Aged, 80 and over | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Adult | Female | Carbazoles - blood | Pyrazoles - adverse effects | Pyridines - therapeutic use | Carcinoma, Non-Small-Cell Lung - pathology | Carbazoles - adverse effects | Lung Neoplasms - enzymology | Kaplan-Meier Estimate | Receptor Protein-Tyrosine Kinases - metabolism | Protein Kinase Inhibitors - blood | Pyridines - blood | Piperidines - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Piperidines - adverse effects | Antineoplastic Agents - blood | Aged | Carbazoles - therapeutic use | Carcinoma, Non-Small-Cell Lung - drug therapy | Carcinoma, Non-Small-Cell Lung - enzymology | Medical colleges | Respiratory agents | Care and treatment | Lymphomas | Lung cancer, Non-small cell | Product development | Pharmaceutical industry | Analysis | Toxicity | Funding | Lung cancer | Central nervous system | Metastasis | Kinases | Evidence-based medicine | Recruitment | Motivation | Audio frequencies | Safety | Toxic diseases | Drug dosages | Protein-tyrosine kinase | Effectiveness | Data processing | Group dynamics | Patients | Survival | Lymphoma | Chemotherapy | Inhibitors | Interactive systems | Death | Mutation | Cancer | Pharmaceuticals | Index Medicus | Abridged Index Medicus
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3. Full Text Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial
by Mitsudomi, Tetsuya, Dr and Morita, Satoshi, Prof and Yatabe, Yasushi, MD and Negoro, Shunichi, MD and Okamoto, Isamu, MD and Tsurutani, Junji, MD and Seto, Takashi, MD and Satouchi, Miyako, MD and Tada, Hirohito, MD and Hirashima, Tomonori, MD and Asami, Kazuhiro, MD and Katakami, Nobuyuki, MD and Takada, Minoru, Prof and Yoshioka, Hiroshige, MD and Shibata, Kazuhiko, MD and Kudoh, Shinzoh, MD and Shimizu, Eiji, Prof and Saito, Hiroshi, MD and Toyooka, Shinichi, MD and Nakagawa, Kazuhiko, Prof and Fukuoka, Masahiro, Prof and for the West Japan Oncology Group and W Japan Oncology Grp and West Japan Oncology Group
The lancet oncology, ISSN 1470-2045, 2010, Volume 11, Issue 2, pp. 121 - 128
Hematology, Oncology and Palliative Medicine | Life Sciences & Biomedicine | Oncology | Science & Technology | Lung Neoplasms - genetics | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Humans | Middle Aged | Male | Antineoplastic Agents - administration & dosage | Cisplatin - administration & dosage | Taxoids - administration & dosage | Female | Quinazolines - administration & dosage | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Mutation | Tyrosine | Medical colleges | Care and treatment | Molecular genetics | Clinical trials | Respiratory agents | Lung cancer, Non-small cell | Chemotherapy | Cancer patients | Epidermal growth factor | Product development | Gefitinib | Cancer | Index Medicus | Liver diseases | Epidermal growth factor receptors | Exons | Toxicity | Hypersensitivity | Lung cancer | Diarrhea | Fatigue | Gene deletion | Survival | Cisplatin | Recruitment | Hospitals | Point mutation | Myelosuppression | Pharmaceuticals | Thyroid
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4. Full Text CH5424802 (RO5424802) for patients with ALK -rearranged advanced non-small-cell lung cancer (AF-001JP study): a single-arm, open-label, phase 1–2 study
by Seto, Takashi, MD and Kiura, Katsuyuki, Prof and Nishio, Makoto, MD and Nakagawa, Kazuhiko, Prof and Maemondo, Makoto, MD and Inoue, Akira, MD and Hida, Toyoaki, MD and Yamamoto, Nobuyuki, MD and Yoshioka, Hiroshige, MD and Harada, Masao, MD and Ohe, Yuichiro, MD and Nogami, Naoyuki, MD and Takeuchi, Kengo, MD and Shimada, Tadashi, MS and Tanaka, Tomohiro, MS and Tamura, Tomohide, Dr
The lancet oncology, ISSN 1470-2045, 2013, Volume 14, Issue 7, pp. 590 - 598
Hematology, Oncology and Palliative Medicine | Life Sciences & Biomedicine | Oncology | Science & Technology | Carcinoma, Large Cell - drug therapy | Lung Neoplasms - drug therapy | Prognosis | Follow-Up Studies | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Humans | Lung Neoplasms - metabolism | Middle Aged | Male | Immunoenzyme Techniques | Adenocarcinoma - metabolism | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Adult | Female | Piperidines - pharmacokinetics | Adenocarcinoma - genetics | Carcinoma, Large Cell - genetics | Lung Neoplasms - genetics | Protein Kinase Inhibitors - pharmacokinetics | Carcinoma, Large Cell - metabolism | Carcinoma, Non-Small-Cell Lung - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Receptor Protein-Tyrosine Kinases - metabolism | Adenocarcinoma - drug therapy | Maximum Tolerated Dose | Carcinoma, Squamous Cell - drug therapy | Receptor Protein-Tyrosine Kinases - genetics | Piperidines - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Gene Rearrangement | Carbazoles - pharmacokinetics | Aged | Carbazoles - therapeutic use | Carcinoma, Non-Small-Cell Lung - drug therapy | Neoplasm Staging | Care and treatment | Oncology, Experimental | Research | College teachers | Lung cancer, Non-small cell | Drug approval | Cancer | Index Medicus
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5. Full Text Reenlargement of radiation necrosis after stereotactic radiotherapy for brain metastasis from lung cancer during bevacizumab treatment
by Furuuchi, Koji, MD and Nishiyama, Akihiro, MD and Yoshioka, Hiroshige, MD, PhD and Yokoyama, Toshihide, MD and Ishida, Tadashi, MD, PhD
Respiratory investigation, ISSN 2212-5345, 2016, Volume 55, Issue 2, pp. 184 - 187
Internal Medicine | Pulmonary/Respiratory | Lung cancer | Brain metastasis | Stereotactic radiotherapy | Radiation necrosis | Bevacizumab | Necrosis - drug therapy | Brain - diagnostic imaging | Adenocarcinoma - pathology | Bevacizumab - therapeutic use | Humans | Middle Aged | Brain Neoplasms - pathology | Lung Neoplasms - pathology | Male | Necrosis - surgery | Radiosurgery - adverse effects | Adenocarcinoma - secondary | Necrosis - diagnostic imaging | Magnetic Resonance Imaging | Brain Neoplasms - secondary | Necrosis - etiology | Brain - pathology | Brain - surgery | Brain Neoplasms - radiotherapy | Adenocarcinoma - radiotherapy | Usage | Analysis | Radiosurgery | Metastasis | Drug therapy | Risk factors | Index Medicus
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6. Full Text Long-term survival outcome after lobectomy in patients with clinical T1 N0 lung cancer
by Ito, Hiroyuki and Suzuki, Kenji and Mizutani, Tomonori and Aokage, Keiju and Wakabayashi, Masashi and Fukuda, Haruhiko and Watanabe, Shun-ichi and Ito, Hiroyuki and Suzuki, Kenji and Mizutani, Tomonori and Aokage, Keiju and Wakabayashi, Masashi and Koike, Teruaki and Tsutani, Yasuhiro and Saji, Hisashi and Nakagawa, Kazuo and Zenke, Yoshitaka and Takamochi, Kazuya and Aoki, Tadashi and Okami, Jiro and Yoshioka, Hiroshige and Shiono, Satoshi and Okada, Morihito and Watanabe, Shun-ichi and Japan Clinical Oncology Group Lung Cancer Surgical Study Group
The Journal of thoracic and cardiovascular surgery, ISSN 0022-5223, 01/2021, Volume 161, Issue 1, pp. 281 - 290
lung cancer | lobectomy | 10-year follow-up | consolidation tumor ratio | Medicine, Experimental | Medical research | Care and treatment | Lung cancer | Patient outcomes | Tumors | Index Medicus | Abridged Index Medicus
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7. Full Text KEYNOTE‐025: Phase 1b study of pembrolizumab in Japanese patients with previously treated programmed death ligand 1–positive advanced non–small‐cell lung cancer
by Nishio, Makoto and Takahashi, Toshiaki and Yoshioka, Hiroshige and Nakagawa, Kazuhiko and Fukuhara, Tatsuro and Yamada, Kazuhiko and Ichiki, Masao and Tanaka, Hiroshi and Seto, Takashi and Sakai, Hiroshi and Kasahara, Kazuo and Satouchi, Miyako and Han, Shi Rong and Noguchi, Kazuo and Shimamoto, Takashi and Kato, Terufumi
Cancer science, ISSN 1347-9032, 03/2019, Volume 110, Issue 3, pp. 1012 - 1020
pembrolizumab | phase 1 | non–small‐cell lung cancer | immunotherapy | PD‐L1 | PD-L1 | non–small-cell lung cancer | Life Sciences & Biomedicine | Oncology | Science & Technology | Lung Neoplasms - drug therapy | Antibodies, Monoclonal, Humanized - therapeutic use | Humans | Lung Neoplasms - metabolism | Carcinoma, Non-Small-Cell Lung - metabolism | Male | Antineoplastic Agents - therapeutic use | Disease-Free Survival | Asian Continental Ancestry Group | B7-H1 Antigen - metabolism | Female | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Medical research | Care and treatment | Chemotherapy | Immunotherapy | Monoclonal antibodies | Medicine, Experimental | Lung cancer, Non-small cell | Cancer | Medical imaging | Cell survival | Toxicity | Mortality | Lung cancer | Non-small cell lung carcinoma | Cytotoxicity | Metastasis | Cancer therapies | Pembrolizumab | Pneumonitis | Platinum | Antitumor activity | Ligands | Death | Mutation | Apoptosis | Pharmaceuticals | Index Medicus | Original
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8. Full Text Recent advances and future perspectives in adjuvant and neoadjuvant immunotherapies for lung cancer
by Yotsukura, Masaya and Nakagawa, Kazuo and Suzuki, Kenji and Takamochi, Kazuya and Ito, Hiroyuki and Okami, Jiro and Aokage, Keiju and Shiono, Satoshi and Yoshioka, Hiroshige and Aoki, Tadashi and Tsutani, Yasuhiro and Okada, Morihito and Watanabe, Shun-ichi and Japan Clinical Oncology Grp JCOG and Lung Cancer Surgical Study Group (LCSSG) of the Japan Clinical Oncology Group (JCOG)
Japanese journal of clinical oncology, ISSN 0368-2811, 01/2021, Volume 51, Issue 1, pp. 28 - 36
Life Sciences & Biomedicine | Oncology | Science & Technology | Index Medicus
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9. Full Text Detection of epidermal growth factor receptor gene T790M mutation in cytology samples using the cobas® EGFR mutation test
by Satouchi, Miyako and Tanaka, Hiroshi and Yoshioka, Hiroshige and Shimokawaji, Tadasuke and Mizuno, Keiko and Takeda, Koji and Yoshino, Ichiro and Seto, Takashi and Kurata, Takayasu and Tashiro, Naoki and Hagiwara, Koichi
Lung cancer (Amsterdam, Netherlands), ISSN 0169-5002, 09/2017, Volume 111, pp. 190 - 194
non-small cell lung cancer | EGFR mutation-positive | progressive disease | TBLB | NSCLC | epidermal growth factor receptor | Eastern Cooperative Oncology Group | Cytology | formalin-fixed, paraffin-embedded | EGFR | EGFRm | trans-bronchial lung biopsy | TKI | FFPE | Biopsy | ECOG | performance status | tyrosine kinase inhibitor | Mutation | standard deviation | Epidermal growth factor receptor | Non-small cell lung cancer | Respiratory System | Oncology | Life Sciences & Biomedicine | Science & Technology | Lung Neoplasms - genetics | Receptor, Epidermal Growth Factor - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Exons | Humans | Middle Aged | Male | Mutation Rate | Carcinoma, Non-Small-Cell Lung - diagnosis | DNA Mutational Analysis - methods | Multicenter Studies as Topic | Neoplasm Grading | Alleles | Female | Aged | Lung Neoplasms - diagnosis | Neoplasm Staging | Amino Acid Substitution | Index Medicus
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10. Full Text Pharmacological aspects of anticancer drug-induced emesis with emphasis on serotonin release and vagal nerve activity
by Minami, Masaru and Endo, Toru and Hirafuji, Masahiko and Hamaue, Naoya and Liu, Yanxia and Hiroshige, Tsutomu and Nemoto, Masahiro and Saito, Hideya and Yoshioka, Mitsuhiro
Pharmacology & therapeutics (Oxford), ISSN 0163-7258, 08/2003, Volume 99, Issue 2, pp. 149 - 165
receptors | 5-HT | Intracellular calcium concentration | Vagal afferent nerve activity | 5-HT release | Anticancer drug-induced emesis | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Intestinal Mucosa - metabolism | Humans | Intestinal Mucosa - secretion | Vagus Nerve - drug effects | Serotonin - urine | Neurons, Afferent - physiology | Intestinal Mucosa - drug effects | Vagus Nerve - physiopathology | Serotonin - blood | Vomiting - chemically induced | Antineoplastic Agents - adverse effects | Enterochromaffin Cells - secretion | Neurons, Afferent - pathology | Serotonin - secretion | Neurons, Afferent - metabolism | Vomiting - physiopathology | Vomiting - prevention & control | Index Medicus
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