X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (61) 61
alzheimer's disease (57) 57
animals (40) 40
mice (38) 38
index medicus (34) 34
neurosciences (34) 34
alzheimer disease - genetics (33) 33
male (31) 31
brain (28) 28
female (26) 26
neurology (26) 26
alzheimers disease (23) 23
aged (22) 22
mice, transgenic (22) 22
mutation (20) 20
alzheimer disease - metabolism (19) 19
alzheimers-disease (19) 19
amyloid beta-protein precursor - genetics (19) 19
amyloid beta-peptides - metabolism (17) 17
clinical neurology (16) 16
gene expression (16) 16
in-vivo (16) 16
research (16) 16
article (15) 15
dementia (15) 15
transgenic mice (15) 15
aged, 80 and over (14) 14
amyloid beta-protein precursor - metabolism (14) 14
genetics (14) 14
presenilin-1 (14) 14
risk factors (14) 14
a-beta (13) 13
common variants (13) 13
genetic aspects (13) 13
genetic predisposition to disease (13) 13
genome-wide association study (13) 13
polymorphism, single nucleotide (13) 13
proteins (13) 13
risk (13) 13
amyloid beta-peptides - blood (12) 12
amyloid beta-peptides - genetics (12) 12
brain - metabolism (12) 12
case-control studies (12) 12
disease models, animal (12) 12
genes (12) 12
genetics & heredity (12) 12
mental disorders (12) 12
mice, inbred c57bl (12) 12
alzheimer disease (11) 11
amyloid precursor protein (11) 11
biochemistry & molecular biology (11) 11
genomics (11) 11
middle aged (11) 11
physiological aspects (11) 11
expression (10) 10
genomes (10) 10
multidisciplinary sciences (10) 10
neurodegenerative diseases (10) 10
protein (10) 10
alzheimer disease - pathology (9) 9
analysis (9) 9
biological sciences (9) 9
genome-wide association (9) 9
medical research (9) 9
memory (9) 9
peptide fragments - blood (9) 9
peptides (9) 9
alzheimer disease - physiopathology (8) 8
amyloid beta-protein (8) 8
amyloids (8) 8
brain - pathology (8) 8
metaanalysis (8) 8
molecular sequence data (8) 8
oxidative stress (8) 8
peptide fragments - metabolism (8) 8
rodents (8) 8
single nucleotide polymorphisms (8) 8
abridged index medicus (7) 7
adult (7) 7
age of onset (7) 7
aging (7) 7
biochemistry (7) 7
cerebral blood flow (7) 7
genetic variation (7) 7
genotype (7) 7
linkage disequilibrium (7) 7
membrane glycoproteins - genetics (7) 7
membrane proteins - genetics (7) 7
membrane proteins - metabolism (7) 7
mouse model (7) 7
plaques (7) 7
precursor protein (7) 7
amino acid sequence (6) 6
amyloid precursor protein secretases (6) 6
association (6) 6
hippocampus - metabolism (6) 6
identifies variants (6) 6
medicine (6) 6
medicine, experimental (6) 6
medicine, general & internal (6) 6
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal Article
by Sims, Rebecca and Van Der Lee, Sven J and Naj, Adam C and Bellenguez, Céline and Badarinarayan, Nandini and Jakobsdottir, Johanna and Kunkle, Brian W and Boland, Anne and Raybould, Rachel and Bis, Joshua C and Martin, Eden R and Grenier-Boley, Benjamin and Heilmann-Heimbach, Stefanie and Chouraki, Vincent and Kuzma, Amanda B and Sleegers, Kristel and Vronskaya, Maria and Ruiz, Agustin and Graham, Robert R and Olaso, Robert and Hoffmann, Per and Grove, Megan L and Vardarajan, Badri N and Hiltunen, Mikko and Nöthen, Markus M and White, Charles C and Hamilton-Nelson, Kara L and Epelbaum, Jacques and Maier, Wolfgang and Choi, Seung-Hoan and Beecham, Gary W and Dulary, Cécile and Herms, Stefan and Smith, Albert V and Funk, Cory C and Derbois, Céline and Forstner, Andreas J and Ahmad, Shahzad and Li, Hongdong and Bacq, Delphine and Harold, Denise and Satizabal, Claudia L and Valladares, Otto and Squassina, Alessio and Thomas, Rhodri and Brody, Jennifer A and Qu, Liming and Sánchez-Juan, Pascual and Morgan, Taniesha and Wolters, Frank J and Zhao, Yi and Garcia, Florentino Sanchez and Denning, Nicola and Fornage, Myriam and Malamon, John and Naranjo, Maria Candida Deniz and Majounie, Elisa and Mosley, Thomas H and Dombroski, Beth and Wallon, David and Lupton, Michelle K and Dupuis, Josée and Whitehead, Patrice and Fratiglioni, Laura and Medway, Christopher and Jian, Xueqiu and Mukherjee, Shubhabrata and Keller, Lina and Brown, Kristelle and Lin, Honghuang and Cantwell, Laura B and Panza, Francesco and McGuinness, Bernadette and Moreno-Grau, Sonia and Burgess, Jeremy D and Solfrizzi, Vincenzo and Proitsi, Petra and Adams, Hieab H and Allen, Mariet and Seripa, Davide and Pastor, Pau and Cupples, L Adrienne and Price, Nathan D and Hannequin, Didier and Frank-García, Ana and Levy, Daniel and Chakrabarty, Paramita and Caffarra, Paolo and Giegling, Ina and Beiser, Alexa S and Giedraitis, Vilmantas and Hampel, Harald and Garcia, Melissa E and Wang, Xue and Lannfelt, Lars and Mecocci, Patrizia and Eiriksdottir, Gudny and Crane, Paul K and Pasquier, Florence and Boccardi, Virginia and ... and EADI and GERAD PERADES and ARUKConsortium and CHARGE and ADGC and GERAD/PERADES, CHARGE, ADGC, EADI and ARUK Consortium and Stockholms universitet and Centrum för forskning om äldre och åldrande (ARC), (tills m KI) and Samhällsvetenskapliga fakulteten
Nature Genetics, ISSN 1061-4036, 09/2017, Volume 49, Issue 9, pp. 1373 - 1384
Journal Article
PLoS Medicine, ISSN 1549-1277, 12/2005, Volume 2, Issue 12, pp. 1318 - 1333
Background The proteases (secretases) that cleave amyloid-beta (A beta) peptide from the amyloid precursor protein (APP) have been the focus of considerable... 
NERVOUS-SYSTEM | MEDICINE, GENERAL & INTERNAL | GAMMA-SECRETASE INHIBITOR | PRECURSOR PROTEINS | MICROGLIAL ACTIVATION | MEMORY DEFICITS | DEPOSITION | MOUSE MODEL | IN-VIVO | GENE-EXPRESSION | MICE | Neurology | Pathology | Neuroscience | Neurosurgery | Other | Dementia
Journal Article
Circulation Research, ISSN 0009-7330, 07/2017, Volume 121, Issue 3, pp. 258 - 269
Rationale: Increasing evidence indicates that alterations of the cerebral microcirculation may play a role in Alzheimer disease, the leading cause of late-life... 
endothelium | cerebrovascular disease | brain | Alzheimer disease | oxidative stress | CEREBRAL AMYLOID ANGIOPATHY | CARDIAC & CARDIOVASCULAR SYSTEMS | CEREBROVASCULAR DYSFUNCTION | ENDOTHELIAL DYSFUNCTION | MEMORY DEFICITS | COGNITIVE IMPAIRMENT | PERIPHERAL VASCULAR DISEASE | CENTRAL-NERVOUS-SYSTEM | PRECURSOR PROTEIN | HEMATOLOGY | FUNCTIONAL HYPEREMIA | TRANSGENIC MICE | Reactive Oxygen Species - metabolism | Cerebrovascular Circulation - physiology | Macrophages - pathology | Male | Mice, Transgenic | Random Allocation | Alzheimer Disease - pathology | Brain - metabolism | Brain - blood supply | Macrophages - metabolism | Animals | Alzheimer Disease - metabolism | Amyloid beta-Peptides - metabolism | Brain - pathology | Somatosensory Cortex - blood supply | Mice | Somatosensory Cortex - metabolism | Oxidative stress | Reactive oxygen species | Oxygen | Neurodegenerative diseases | Cortex | Immune clearance | Transgenic mice | Innate immunity | CD36 antigen | Macrophages | Bisphosphonates | NAD(P)H oxidase | Amyloid precursor protein | Clodronic acid | Cerebrovascular system | Clonal deletion | Rodents | CYBB protein | Dementia disorders | Bone marrow | β-Amyloid | Chimeras | Species | Alzheimer's disease | perivascular macrophages | Oxidant Stress | Animal Models of Human Disease | Vascular Type | Nitric Oxide | Vascular biology | Basic Science Research
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2008, Volume 105, Issue 4, pp. 1347 - 1352
Alterations in cerebrovascular regulation related to vascular oxidative stress have been implicated in the mechanisms of Alzheimer's disease (AD), but their... 
Oxidases | Oxidative stress | Reactive oxygen species | Transcriptional regulatory elements | Transgenic animals | Protein precursors | Mice | Hyperemia | Amyloids | Alzheimers disease | tg2576 | Cerebral blood flow | Alzheimer's disease | MOUSE-BRAIN | ABNORMALITIES | REDUCES OXIDATIVE DAMAGE | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | BETA-PEPTIDE | MODEL | OXYGEN SPECIES MEDIATE | cerebral blood flow | CEREBRAL-BLOOD-FLOW | FUNCTIONAL HYPEREMIA | TRANSGENIC MICE | Hyperemia - metabolism | Membrane Glycoproteins - metabolism | Humans | Membrane Glycoproteins - biosynthesis | NADPH Oxidases - metabolism | Molecular Sequence Data | Male | Free Radicals - adverse effects | Cerebrovascular Circulation - genetics | Behavioral Symptoms - metabolism | Brain - metabolism | Brain - blood supply | Membrane Glycoproteins - antagonists & inhibitors | Free Radicals - metabolism | NADPH Oxidases - genetics | Female | NADPH Oxidases - biosynthesis | Behavioral Symptoms - physiopathology | Disease Models, Animal | Amino Acid Sequence | Maze Learning - physiology | Brain - physiopathology | Mice, Inbred C57BL | NADPH Oxidases - antagonists & inhibitors | Mice, Transgenic | NADPH Oxidase 2 | Membrane Glycoproteins - genetics | Mice, Knockout | Behavioral Symptoms - genetics | Amyloid beta-Protein Precursor - genetics | Animals | Hyperemia - physiopathology | Hyperemia - genetics | Amyloid beta-Protein Precursor - biosynthesis | Control | Radicals (Chemistry) | Cerebral circulation | Influence | Glycoproteins | Research | Neurovascular diseases | Properties | Index Medicus | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2013, Volume 110, Issue 8, pp. 3089 - 3094
Journal Article
PLoS Genetics, ISSN 1553-7390, 09/2014, Volume 10, Issue 9, p. e1004606
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2011, Volume 108, Issue 12, pp. 5063 - 5068
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 03/2002, Volume 22, Issue 5, pp. 1858 - 1867
Transgenic mice expressing mutant amyloid precursor proteins (APPs) have provided important new information about the pathogenesis of Alzheimer's disease (AD)... 
Learning | | Insoluble | Memory | SDS-soluble | Transgenic | Behavior | Alzheimer's disease | insoluble | memory | WATER-MAZE | COGNITIVE IMPAIRMENT | learning | AMYLOID PRECURSOR PROTEIN | PLAQUES | NEUROSCIENCES | A beta | DEPOSITS | transgenic | SPATIAL MEMORY | behavior | BRAIN | TRANSGENIC MICE | AGE | PRESENILIN-1
Journal Article