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1. Full Text Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance
by Rode, Baptiste and Shi, Jian and Endesh, Naima and Drinkhill, Mark J and Webster, Peter J and Lotteau, Sabine J and Bailey, Marc A and Yuldasheva, Nadira Y and Ludlow, Melanie J and Cubbon, Richard M and Li, Jing and Futers, T. Simon and Morley, Lara and Gaunt, Hannah J and Marszalek, Katarzyna and Viswambharan, Hema and Cuthbertson, Kevin and Baxter, Paul D and Foster, Richard and Sukumar, Piruthivi and Weightman, Andrew and Calaghan, Sarah C and Wheatcroft, Stephen B and Kearney, Mark T and Beech, David J
Nature communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 350 - 11
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Blood Pressure | Endothelial Cells - metabolism | Humans | Cells, Cultured | Ion Channels - genetics | Male | Ion Channels - physiology | Physical Conditioning, Animal - physiology | Vasoconstriction - physiology | Patch-Clamp Techniques | Animals | Ion Channels - metabolism | HEK293 Cells | Mice | Myocytes, Smooth Muscle - metabolism | Calcium Signaling | Homeostasis - genetics | Hypertension | Phenotypes | Calcium channels | Physical activity | Fluid dynamics | Calcium channels (voltage-gated) | Vasoconstriction | Fluid flow | Muscles | Inspection | Homeostasis | Smooth muscle | Body weight loss | Blood | Channels | Weight | Endothelium | Depolarization | Proteins | Molecular modelling | Blood pressure | Membrane potential | Calcium ions | Index Medicus
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2. Full Text Piezo1 integration of vascular architecture with physiological force
by Li, Jing and Li, Jing and Hou, Bing and Tumova, Sarka and Muraki, Katsuhiko and Bruns, Alexander and Ludlow, Melanie J and Sedo, Alicia and Hyman, Adam J and McKeown, Lynn and Young, Richard S and Yuldasheva, Nadira Y and Majeed, Yasser and Wilson, Lesley A and Rode, Baptiste and Bailey, Marc A and Kim, Hyejeong R and Fu, Zhaojun and Carter, Deborah A. L and Bilton, Jan and Imrie, Helen and Ajuh, Paul and Dear, T. Neil and Cubbon, Richard M and Kearney, Mark T and Prasad, K. Raj and Evans, Paul C and Ainscough, Justin F. X and Beech, David J
Nature (London), ISSN 0028-0836, 11/2014, Volume 515, Issue 7526, pp. 279 - 282
Animals | Friction | Ion Channels - metabolism | Endothelial Cells - cytology | Embryo, Mammalian - blood supply | Stress, Mechanical | Female | Male | Mice | Hemorheology | Embryo, Mammalian - metabolism | Endothelial Cells - physiology | Physiological aspects | Ion channels | Research | Shear stress | Cytoskeleton | Kinases | Cell adhesion & migration | Index Medicus
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3. Full Text Role of glutamine and interlinked asparagine metabolism in vessel formation
by Huang, Hongling and Vandekeere, Saar and Kalucka, Joanna and Bierhansl, Laura and Zecchin, Annalisa and Brüning, Ulrike and Visnagri, Asjad and Yuldasheva, Nadira and Goveia, Jermaine and Cruys, Bert and Brepoels, Katleen and Wyns, Sabine and Rayport, Stephen and Ghesquière, Bart and Vinckier, Stefan and Schoonjans, Luc and Cubbon, Richard and Dewerchin, Mieke and Eelen, Guy and Carmeliet, Peter
The EMBO journal, ISSN 0261-4189, 08/2017, Volume 36, Issue 16, pp. 2334 - 2352
asparagine | metabolism | glutamine | angiogenesis | endothelial cell | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Human Umbilical Vein Endothelial Cells | Neovascularization, Physiologic - drug effects | Endothelial Cells - metabolism | Humans | Neovascularization, Pathologic | Glutamine - metabolism | Glutaminase - metabolism | Cell Movement - drug effects | Metabolic Networks and Pathways | Asparagine - metabolism | Cell Proliferation - drug effects | Culture Media - chemistry | Endothelial Cells - physiology | Endothelial Cells - drug effects | TOR protein | Tricarboxylic acid cycle | Deprivation | Homeostasis | Protein biosynthesis | Metabolism | Glutaminase | Endothelial cells | Defects | Angiogenesis | Aspartate-ammonia ligase | Acids | Protein synthesis | Replenishment | Asparagine | Inhibition | Supplementation | Aberration | In vitro methods and tests | Glutamine | Index Medicus | Vascular Biology & Angiogenesis
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4. Full Text TRPC5 ion channel permeation promotes weight gain in hypercholesterolaemic mice
by Rode, Baptiste and Yuldasheva, Nadira Y and Baxter, Paul D and Sedo, Alicia and Ainscough, Justin F and Shires, Michael and Kearney, Mark T and Bailey, Marc A and Wheatcroft, Stephen B and Beech, David J
Scientific reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 773 - 773
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Adipose tissue | Transcription | Lipids | Inflammation | Gene expression | Body weight gain | Calcium permeability | Adiponectin | Steatosis | Interleukin 6 | Transient receptor potential proteins | Diet | Apolipoprotein E | Arteriosclerosis | Leptin | Coronary vessels | Interleukin 1 | Atherosclerosis | Aorta | Lipogenesis | Monocyte chemoattractant protein 1 | Index Medicus
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5. Full Text Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signalling Loop
by Viswambharan, Hema and Yuldasheva, Nadira and Sengupta, Anshuman and Imrie, Helen and Gage, Matthew and Haywood, Natalie and Walker, Andrew MN and Skromna, Anna and Makova, Natallia and Galloway, Stacey and Shah, Pooja and Sukumar, Piruthivi and Porter, Karen E and Grant, Peter J and Shah, Ajay M and Santos, Celio XC and Li, Jing and Beech, David J and Wheatcroft, Stephen B and Cubbon, Richard M and Kearney, Mark T
Circulation research, ISSN 0009-7330, 12/2016, Volume 120, Issue 5, pp. 784 - 798
diabetes mellitus | insulin | superoxide | insulin resistance | reactive oxygen species | Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Human Umbilical Vein Endothelial Cells | Atherosclerosis - pathology | Endothelial Cells - metabolism | Humans | Mice, Inbred C57BL | Cells, Cultured | Male | Mice, Transgenic | Mice, 129 Strain | Atherosclerosis - metabolism | Animals | Endothelium, Vascular - metabolism | Insulin Resistance - physiology | Endothelium, Vascular - pathology | Signal Transduction - physiology | Mice | Endothelial Cells - pathology | Organ Culture Techniques | Tyrosine | Phosphorylation | Proline-rich tyrosine kinase 2 | Diabetes mellitus | Proline | AKT protein | Superoxide | Kinases | Insulin | NAD(P)H oxidase | Vasodilation | Endothelial cells | Nitric-oxide synthase | Endothelium | Arteriosclerosis | CYBB protein | Acetylcholine | Mechanical stimuli | Diabetes mellitus (non-insulin dependent) | Protein-tyrosine kinase | Index Medicus
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6. Full Text 186 Reduced pericyte insulin signalling causes abnormal developmental angiogenesis
by Warmke, Nele and Griffin, Kathryn J and I Slater, Charles and MN Walker, Andrew and Yuldasheva, Nadira Y and Cubbon, Richard M
Heart (British Cardiac Society), ISSN 1355-6037, 06/2017, Volume 103, Issue Suppl 5, pp. A127 - A128
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7. Full Text P34 Changes in vesicular glutamate transporters in a murine model of global cerebral ischemia
by Khan, Sabah and Yuldasheva, Nadira and Saha, Sikha
Heart (British Cardiac Society), ISSN 1355-6037, 10/2016, Volume 102, Issue Suppl 8, p. A12
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8. Full Text A fibrin biofilm covers blood clots and protects from microbial invasion
by Macrae, Fraser L and Duval, Ceic and Papareddy, Praveen and Baker, Stephen R and Yuldasheva, Nadira and Kearney, Katherine J and McPherson, Helen R and Asquith, Nathan and Konings, Joke and Casini, Alessano and Degen, Jay L and Connell, Simon D and Philippou, Helen and Wolberg, Alisa S and Herwald, Heiko and Ariens, Robert A. S
The Journal of clinical investigation, ISSN 0021-9738, 08/2018, Volume 128, Issue 8, pp. 3356 - 3368
GAMMA | ELASTICITY | THROMBIN GENERATION | PLASMA | FACTOR-XIII | CROSS-LINKING | HOST-DEFENSE | COAGULATION | MECHANISMS | POLYMERIZATION | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Animals | Biofilms | Skin Diseases, Bacterial - microbiology | Humans | Blood Coagulation | Skin Diseases, Bacterial - metabolism | Bacterial Physiological Phenomena | Bacteria - pathogenicity | Mice | Fibrin - metabolism | Bacteria - genetics | Disease Models, Animal | Infection | Care and treatment | Hemostasis | Blood cells | Analysis | Fibrinogen | Research | Health aspects | Thrombosis | Blood clot | Blood coagulation | Scanning electron microscopy | Animal models | Bacterial infections | Infections | Plasmin | Clotting | Fibers | Blood clots | Fibrin | Blood platelets | Skin | Index Medicus | Abridged Index Medicus | Basic Medicine | Clinical Medicine | Medical and Health Sciences | Microbiology in the medical area | Hematologi | Hematology | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Mikrobiologi inom det medicinska området | Klinisk medicin
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9. Full Text Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
by Burton, Paul R and Clayton, David G and Cardon, Lon R and Craddock, Nick and Deloukas, Panos and Duncanson, Audrey and Kwiatkowski, Dominic P and McCarthy, Mark I and Ouwehand, Willem H and Samani, Nilesh J and Todd, John A and Donnelly, Peter and Barrett, Jeffrey C and Davison, Dan and Easton, Doug and Evans, David and Leung, Hin-Tak and Marchini, Jonathan L and Morris, Andrew P and Spencer, Chris C. A and Tobin, Martin D and Attwood, Antony P and Boorman, James P and Cant, Barbara and Everson, Ursula and Hussey, Judith M and Jolley, Jennifer D and Knight, Alexandra S and Koch, Kerstin and Meech, Elizabeth and Nutland, Sarah and Prowse, Christopher V and Stevens, Helen E and Taylor, Niall C and Walters, Graham R and Walker, Neil M and Watkins, Nicholas A and Winzer, Thilo and Jones, Richard W and McArdle, Wendy L and Ring, Susan M and Strachan, David P and Pembrey, Marcus and Breen, Gerome and St. Clair, David and Caesar, Sian and Gordon-Smith, Katherine and Jones, Lisa and Fraser, Christine and Green, Elaine K and Grozeva, Detelina and Hamshere, Marian L and Holmans, Peter A and Jones, Ian R and Kirov, George and Moskvina, Valentina and Nikolov, Ivan and O'Donovan, Michael C and Owen, Michael J and Collier, David A and Elkin, Amanda and Farmer, Anne and Williamson, Richard and McGuffin, Peter and Young, Allan H and Ferrier, I. Nicol and Ball, Stephen G and Balmforth, Anthony J and Barrett, Jennifer H and Bishop, D. Timothy and Iles, Mark M and Maqbool, Azhar and Yuldasheva, Nadira and Hall, Alistair S and Braund, Peter S and Dixon, Richard J and Mangino, Massimo and Stevens, Suzanne and Thompson, John R and Bredin, Francesca and Tremelling, Mark and Parkes, Miles and Drummond, Hazel and Lees, Charles W and Nimmo, Elaine R and Satsangi, Jack and Fisher, Sheila A and Forbes, Alastair and Lewis, Cathryn M and Onnie, Clive M and Prescott, Natalie J and Sanderson, Jeremy and Mathew, Christopher G and Barbour, Jamie and Mohiuddin, M. Khalid and Todhunter, Catherine E and Mansfield, John C and Ahmad, Tariq and Cummings, Fraser R and Jewell, Derek P and ... and Breast Canc Susceptib Collaborat and Wellcome Trust Case Control Cons and Biol RA Genet & Genom Study and Wellcome Trust Case Control Consortium and The Wellcome Trust Case Control Consortium
Nature (London), ISSN 0028-0836, 06/2007, Volume 447, Issue 7145, pp. 661 - 678
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Classical genetics, quantitative genetics, hybrids | Human | Biological and medical sciences | Genetics of eukaryotes. Biological and molecular evolution | Geography | Crohn Disease - genetics | Genetics, Population | Genetic Predisposition to Disease - genetics | Diabetes Mellitus - genetics | Chromosomes, Human - genetics | Gene Frequency | Humans | United Kingdom | Bipolar Disorder - genetics | Case-Control Studies | Genome, Human - genetics | Arthritis, Rheumatoid - genetics | Genetic Markers - genetics | Coronary Artery Disease - genetics | Hypertension - genetics | Data analysis | Disease | Genomics | Data collection | Gene loci | Epidemiology | Risk factors | Index Medicus
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