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Nature Reviews Cancer, ISSN 1474-175X, 10/2019
Journal Article
Nature Reviews Clinical Oncology, ISSN 1759-4774, 05/2013, Volume 10, Issue 5, pp. 256 - 266
The promise of targeting epigenetic abnormalities for cancer therapy has not been realized for solid tumours, although increasing evidence is demonstrating its... 
CELL LUNG-CANCER | HISTONE DEACETYLASE INHIBITOR | PHASE-II TRIAL | POLYCYTHEMIA-VERA | DNA METHYLATION | ONCOLOGY | SUBEROYLANILIDE HYDROXAMIC ACID | GERMLINE EPIMUTATION | ESSENTIAL THROMBOCYTHEMIA | MYELODYSPLASTIC SYNDROMES | CHRONIC MYELOMONOCYTIC LEUKEMIA | Hematologic Neoplasms - therapy | Humans | Histone Deacetylase Inhibitors - administration & dosage | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | DNA (Cytosine-5-)-Methyltransferases - antagonists & inhibitors | Promoter Regions, Genetic - drug effects | Dose-Response Relationship, Drug | Enzyme Inhibitors - administration & dosage | Neoplasms - therapy | Molecular Targeted Therapy - trends | Multicenter Studies as Topic | Neoplasms - genetics | Antineoplastic Agents - pharmacology | Epigenesis, Genetic - drug effects | Drug Therapy, Combination | Molecular Targeted Therapy - methods | Myelodysplastic Syndromes - drug therapy | Drug Administration Schedule | Enzyme Inhibitors - pharmacology | Clinical Trials as Topic | Combined Modality Therapy | Genetic Therapy - trends | DNA, Neoplasm - drug effects | Enzyme Inhibitors - therapeutic use | Forecasting | Neoplasms - drug therapy | Animals | Hematologic Neoplasms - drug therapy | Histone Deacetylase Inhibitors - pharmacology | Hematologic Neoplasms - genetics | Histone Deacetylase Inhibitors - therapeutic use | Myelodysplastic Syndromes - genetics | DNA, Neoplasm - genetics | DNA Methylation - drug effects | Drug Screening Assays, Antitumor | Genetic Therapy - methods | Epigenetic inheritance | Care and treatment | Genetic aspects | Research | Gene expression | Tumors
Journal Article
Cancer Research, ISSN 0008-5472, 04/2016, Volume 76, Issue 7, pp. 1683 - 1689
The most exciting recent advance for achieving durable management of advanced human cancers is immunotherapy, especially the concept of immune checkpoint... 
CELL LUNG-CANCER | ENDOGENOUS RETROVIRUSES | CTLA-4 BLOCKADE | INTERFERON RESPONSE | DNA METHYLATION | ONCOLOGY | GENE-EXPRESSION | IMMUNOMODULATORY ACTION | OVARIAN-CANCER | HISTONE DEACETYLASE INHIBITORS | IMMUNE EVASION | Immunotherapy - methods | Neoplasms - therapy | Combined Modality Therapy - methods | Epigenomics - methods | Humans
Journal Article
Cancer Research, ISSN 0008-5472, 07/2017, Volume 77, Issue 13 Supplement, pp. 1002 - 1002
Journal Article
Cell, ISSN 0092-8674, 08/2015, Volume 162, Issue 5, pp. 974 - 986
Journal Article
Proceedings of the National Academy of Sciences of the United States, ISSN 0027-8424, 02/2018, Volume 115, Issue 6, p. E1239
Triple-negative breast cancer (TNBC) is treated with cytotoxic chemotherapy and is often characterized by early relapse and metastasis. To form a secondary... 
Chemotherapy | Genes | Oncology, Experimental | Breast cancer | Research | T cells | Cancer
Journal Article
Cancer Research, ISSN 0008-5472, 07/2017, Volume 77, Issue 13 Supplement, pp. 4045 - 4045
Journal Article
Cancer Research, ISSN 0008-5472, 07/2016, Volume 76, Issue 14 Supplement, pp. 4907 - 4907
Immunosuppression and relapse represent two major clinical challenges in managing patients with ovarian high-grade serous carcinoma (HGSC). Strategies to... 
Journal Article
Cancer Cell, ISSN 1535-6108, 03/2012, Volume 21, Issue 3, pp. 430 - 446
Journal Article
Cancer Research, ISSN 0008-5472, 07/2016, Volume 76, Issue 14 Supplement, pp. 2773 - 2773
Herein, we define a model for how cigarette smoke and chronic inflammation induce human lung cancer via evolution of a co-ordinated pattern of progressive... 
Journal Article
Cancer Research, ISSN 0008-5472, 08/2015, Volume 75, Issue 15 Supplement, pp. NG07 - NG07
Journal Article
Cancer Research, ISSN 0008-5472, 01/2016, Volume 76, Issue 2 Supplement, pp. B20 - B20
Journal Article
Cancer Discovery, ISSN 2159-8274, 03/2017, Volume 7, Issue 3, pp. 264 - 276
Immune checkpoint inhibitors have shown significant therapeutic responses against tumors containing increased mutation-associated neoantigen load. We have... 
METASTATIC MELANOMA | CTLA-4 BLOCKADE | ONCOLOGY | PD-1 BLOCKADE | COLORECTAL-CANCER | PANCREATIC-CANCER | COPY NUMBER | RESISTANCE | MUTATIONS | SEQUENCING DATA | TUMOR PURITY
Journal Article
Cancer Research, ISSN 0008-5472, 07/2016, Volume 76, Issue 14 Supplement, pp. 4019 - 4019
Therapies that activate the host immune system have shown tremendous promise for a wide variety of solid tumors, with patients exhibiting vigorous and durable... 
Journal Article
Genes & Development, ISSN 0890-9369, 03/2014, Volume 28, Issue 5, pp. 432 - 437
Despite recent progress, the physiological role of Hippo signaling in mammary gland development and tumorigenesis remains poorly understood. Here we show that... 
Journal Article
Oncotarget, ISSN 1949-2553, 04/2018, Volume 9, Issue 27, pp. 19379 - 19395
Leiomyosarcomas are rare mesenchymal neoplasms characterized by a smooth muscle differentiation pattern. Due to the extremely poor prognosis in patients, the... 
5-azacitidine | Guadecitabine | Leiomyosarcoma
Journal Article
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