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heart (7) 7
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heart defects, congenital - physiopathology (5) 5
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heart ventricles - abnormalities (5) 5
infant (5) 5
operation (5) 5
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treatment outcome (5) 5
adolescent (4) 4
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fontan procedure (4) 4
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angiotensin-converting enzyme inhibitors - therapeutic use (3) 3
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congenital heart-disease (3) 3
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infant, newborn (3) 3
mortality (3) 3
quality of life (3) 3
quality-of-life (3) 3
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somatic growth (3) 3
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generic core scales (2) 2
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heart defects, congenital - drug therapy (2) 2
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1. Full Text Longitudinal Outcomes of Patients With Single Ventricle After the Fontan Procedure
by Atz, Andrew M., MD and Zak, Victor, PhD and Mahony, Lynn, MD and Uzark, Karen, PhD and D’agincourt, Nicholas, MS and Goldberg, David J., MD and Williams, Richard V., MD and Breitbart, Roger E., MD and Colan, Steven D., MD and Burns, Kristin M., MD and Margossian, Renee, MD and Henderson, Heather T., MD and Korsin, Rosalind, RN and Marino, Bradley S., MD and Daniels, Kaitlyn, RN and McCrindle, Brian W., MD, MPH and Pediat Heart Network Investigators and Pediatric Heart Network Investigators
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2017, Volume 69, Issue 22, pp. 2735 - 2744
Abstract Background Multicenter longitudinal objective data for survival into adulthood of patients who have undergone Fontan procedures are lacking.... 
Cardiovascular | Internal Medicine | functional health status | exercise | adult congenital heart disease | Fontan procedure | single ventricle | SURVIVAL | MULTICENTER | CARDIAC & CARDIOVASCULAR SYSTEMS | NEW-ZEALAND | CHILDREN | IMPACT | AEROBIC EXERCISE CAPACITY | OPERATION | PREDICTORS | CONGENITAL HEART-DISEASE | QUALITY-OF-LIFE | United States - epidemiology | Echocardiography | Survival Rate - trends | Cross-Sectional Studies | Follow-Up Studies | Heart Defects, Congenital - surgery | Humans | Risk Factors | Male | Treatment Outcome | Fontan Procedure - methods | Forecasting | Heart Ventricles - diagnostic imaging | Young Adult | Heart Ventricles - abnormalities | Adolescent | Ontario - epidemiology | Quality of Life | Female | Heart Defects, Congenital - diagnosis | Heart Defects, Congenital - mortality | Retrospective Studies | Health Status | Child | Medical colleges | Children's hospitals | Research institutes | Heart | Medical research | Genetic disorders | Patient outcomes | Analysis | Medicine, Experimental | Congenital heart disease | Transplantation | Heart diseases | Natriuretic peptides | Pediatrics | Physical training | Syngeneic grafts | Heart surgery | Cardiovascular disease | Risk factors | Clinical outcomes | Exercise | Allografts | Functional anatomy | Risk assessment | Xenografts | Cross sections | Age | Brain natriuretic peptide | Oxygen | Congenital diseases | Health | Mortality | Heart transplantation | Test procedures | Time measurement | Regression analysis | Oxygen uptake | Risk analysis | Patients | Survival | Quality of life | Physical fitness | Morphology | Death | Ventricle | Ejection
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2. Full Text Assessment of Quality of Life in Young Patients with Single Ventricle after the Fontan Operation
by Uzark, Karen, PhD, CPNP and Zak, Victor, PhD and Shrader, Peter, MA and McCrindle, Brian W., MD, MPH and Radojewski, Elizabeth, RN and Varni, James W., PhD and Daniels, Kaitlyn, BSN, RN and Handisides, Jill, BSN and Hill, Kevin D., MD, MS and Lambert, Linda M., MSN, FNP and Margossian, Renee, MD and Pemberton, Victoria L., RNC, MS, CCRC and Lai, Wyman W., MD and Atz, Andrew M., MD and Pediat Heart Network Investigators and Pediatric Heart Network Investigators
Journal of Pediatrics, The, ISSN 0022-3476, 2015, Volume 170, pp. 166 - 172.e1
Objectives To assess self-reported quality of life (QOL) in a large multicenter cohort of adolescent and young adults surviving Fontan. Study design... 
Pediatrics | ADULT SURVIVORS | FUNCTIONAL HEALTH-STATUS | GENERIC CORE SCALES | FEASIBILITY | ADOLESCENTS | CONGENITAL HEART-DISEASE | PEDIATRICS | RELIABILITY | VALIDITY | EXERCISE | CHILDREN | United States - epidemiology | Age Factors | Cross-Sectional Studies | Follow-Up Studies | Humans | Survivors | Fontan Procedure - psychology | Male | Young Adult | Adolescent | Quality of Life | Adult | Female | Surveys and Questionnaires | Health aspects | Analysis | Children | congenital heart disease | psychosocial | quality of life | PedsQL
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3. Full Text Association of Impaired Linear Growth and Worse Neurodevelopmental Outcome in Infants with Single Ventricle Physiology: A Report from the Pediatric Heart Network Infant Single Ventricle Trial
by Ravishankar, Chitra, MD and Zak, Victor, PhD and Williams, Ismee A., MD, MS and Bellinger, David C., PhD, MSc and Gaynor, J. William, MD and Ghanayem, Nancy S., MD and Krawczeski, Catherine D., MD and Licht, Daniel J., MD and Mahony, Lynn, MD and Newburger, Jane W., MD, MPH and Pemberton, Victoria L., RNC, MS and Williams, Richard V., MD and Sananes, Renee, PhD and Cook, Amanda L., MD and Atz, Teresa, MSN and Khaikin, Svetlana, BSc, MPH and Hsu, Daphne T., MD and Pediat Heart Network Investigators and Pediatric Heart Network Investigators
Journal of Pediatrics, The, ISSN 0022-3476, 2013, Volume 162, Issue 2, pp. 250 - 256.e2
Objectives To describe neurodevelopmental outcomes in infants with single ventricle (SV) physiology and determine factors associated with worse outcomes. Study... 
Pediatrics | Extracorporeal membrane oxygenation | Hypoplastic left heart syndrome | BNP | MDI | Atrioventricular | PDI | PHN | Serious adverse event | Single ventricle | Mental developmental index | Superior cavopulmonary connection | Length of stay | ECMO | SCPC | Bayley Scale of Infant Development | Brain type natriuretic peptide | ISV | Congenital heart defects | HLHS | Psychomotor Developmental Index | LOS | BSID | Pediatric Heart Network | SAE | Infant single ventricle | CHD | FAILURE-TO-THRIVE | DEVELOPMENTAL TRAJECTORIES | GREAT-ARTERIES | CARDIAC-SURGERY | EARLY-CHILDHOOD | PEDIATRICS | NORWOOD PROCEDURE | NUTRITION | CIRCULATORY ARREST | TRANSPOSITION | CHILDREN | Developmental Disabilities - physiopathology | Developmental Disabilities - drug therapy | Prospective Studies | Double-Blind Method | Growth | Developmental Disabilities - etiology | Humans | Infant | Male | Treatment Outcome | Developmental Disabilities - epidemiology | Heart Ventricles - abnormalities | Female | Child Development | Physiological aspects | Medical colleges | Infants | Children's hospitals
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4. Full Text Factors Affecting Growth in Infants with Single Ventricle Physiology: A Report from the Pediatric Heart Network Infant Single Ventricle Trial
by Williams, Richard V., MD and Zak, Victor, PhD and Ravishankar, Chitra, MD and Altmann, Karen, MD and Anderson, Jeffrey, MD and Atz, Andrew M., MD and Dunbar-Masterson, Carolyn, RN and Ghanayem, Nancy, MD and Lambert, Linda, MSN and Lurito, Karen, MD and Medoff-Cooper, Barbara, PhD, RN, FAAN and Margossian, Renee, MD and Pemberton, Victoria L., RNC, MS and Russell, Jennifer, MD and Stylianou, Mario, PhD and Hsu, Daphne, MD and Pediat Heart Network Investigators and Pediatric Heart Network Investigators
Journal of Pediatrics, The, ISSN 0022-3476, 2011, Volume 159, Issue 6, pp. 1017 - 1022.e2
Objectives To describe growth patterns in infants with single ventricle physiology and determine factors influencing growth. Study design Data from 230... 
Pediatrics | MALNUTRITION | SOMATIC GROWTH | ENERGY-EXPENDITURE | NUTRITIONAL-STATUS | DISEASE | PEDIATRICS | FAILURE | CHILDREN | Heart Defects, Congenital - complications | Prospective Studies | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Humans | Growth Disorders - etiology | Female | Infant | Male | Enalapril - therapeutic use | Infant, Newborn | Physiological aspects | Infants | Child development | Growth | Children's hospitals | Heart
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5. Full Text Variation in Feeding Practices following the Norwood Procedure
by Lambert, Linda M., MSN-FNP and Pike, Nancy A., PhD, CPNP-AC and Medoff-Cooper, Barbara, RN, PhD, FAAN and Zak, Victor, PhD and Pemberton, Victoria L., RN, MS and Young-Borkowski, Lisa, MSN, RN and Clabby, Martha L., MD and Nelson, Kathryn N., DNP, CPNP and Ohye, Richard G., MD and Trainor, Bethany, RN, BSN and Uzark, Karen, PhD, CPNP and Rudd, Nancy, CPNP-AC/PC and Bannister, Louise, RD and Korsin, Rosalind, RN, BSN and Cooper, David S., MD, MPH and Pizarro, Christian, MD and Zyblewski, Sinai C., MD and Bartle, Bronwyn H., MSN-CPNP and Williams, Richard V., MD and Pediat Heart Network Investigators and Pediatric Heart Network Investigators
Journal of Pediatrics, The, ISSN 0022-3476, 2014, Volume 164, Issue 2, pp. 237 - 242.e1
Objectives To assess variation in feeding practice at hospital discharge after the Norwood procedure, factors associated with tube feeding, and associations... 
Pediatrics | Gastrostomy or gastrojejunostomy tube | WAZ | Weight-for-age z score | G-tube | Hypoplastic left heart syndrome | Nasojejunal or nasogastric tube | N-tube | Pediatric Heart Network Single Ventricle Reconstruction Trial | Principal investigator | HLHS | SVR | LARYNGOPHARYNGEAL DYSFUNCTION | SURGERY | INTERSTAGE MORTALITY | OPERATION | LEFT-HEART SYNDROME | INFANTS | GROWTH | DISEASE | PEDIATRICS | WEIGHT-GAIN | PALLIATION | Enteral Nutrition - methods | Follow-Up Studies | Humans | Hypoplastic Left Heart Syndrome - surgery | Male | Treatment Outcome | Norwood Procedures | Gastrostomy - methods | Length of Stay - trends | Female | Retrospective Studies | Patient Discharge - trends | Weight Gain | Infant, Newborn | Medical colleges | Children's hospitals | Genetic disorders | nutrition | growth | practice variation | hypoplastic left heart syndrome
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6. Full Text Relation off Post-Coronary Artery Bypass Graft Creatine Kinase-MB Elevations and New Q waves With Long-Term Cardiovascular Death in Patients with Diabetes Mellitus and Multivessel Coronary Artery Disease
by Domanski, Michael, MD and Farkouh, Michael E., MD, MSc and Zak, Victor, PhD and French, John, MBChB, PhD and Alexander, John H., MD, MHS and Bochenek, Andrzej, MD PhD and Hamon, Martial, MD and Mahaffey, Kenneth, MD and Puskas, John, MD and Smith, Peter, MD and Shrader, Peter, MA and Fuster, Valentin, MD, PhD
American Journal of Cardiology, The, ISSN 0002-9149, 2016
Abstract Associations of early creatine phosphokinase-MB (CK-MB) elevation and new Q waves and their association with cardiovascular death (CVD) post-coronary... 
Cardiovascular
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7. Full Text Predictors of Stroke Associated With Coronary Artery Bypass Grafting in Patients With Diabetes Mellitus and Multivessel Coronary Artery Disease
by Domanski, Michael J., MD and Farkouh, Michael E., MD and Zak, Victor, PhD and Feske, Steven, MD and Easton, Donald, MD and Weinberger, Jesse, MD and Hamon, Martial, MD and Escobedo, Jorge, MD, MSc and Shrader, Peter, MA and Siami, Flora S., MPH and Fuster, Valentin, MD, PhD
American Journal of Cardiology, The, ISSN 0002-9149, 2015, Volume 115, Issue 10, pp. 1382 - 1388
This study assesses demographic and clinical variables associated with perioperative and late stroke in diabetes mellitus patients after multivessel coronary... 
Cardiovascular | ON-PUMP | TRIAL | OFF-PUMP | REVASCULARIZATION | CARDIAC & CARDIOVASCULAR SYSTEMS | CARDIAC-SURGERY | RISK | OUTCOMES | PULSE PRESSURE | INTERVENTION | Risk Assessment - methods | Coronary Artery Disease - surgery | Prognosis | Survival Rate - trends | Follow-Up Studies | Global Health | Humans | Middle Aged | Stroke - diagnosis | Male | Diabetes Mellitus | Incidence | Coronary Artery Bypass - adverse effects | Stroke - etiology | Time Factors | Coronary Artery Disease - diagnosis | Coronary Artery Disease - complications | Aged, 80 and over | Adult | Female | Stroke - epidemiology | Aged | Retrospective Studies | Postoperative Complications | Diabetics | Medical colleges | Care and treatment | Low density lipoproteins | Anticoagulants (Medicine) | Plants | Coronary heart disease | Risk factors | Stroke (Disease) | Coronary artery bypass | Surgery | Analysis | Diabetes | Confidence intervals | Stroke | Heart attacks | Heart surgery | Coronary vessels | Mortality | Cardiovascular disease | Blood pressure | Family medical history | Multivariate analysis | Hemorrhage
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8. Full Text Growth Asymmetry, Head Circumference, and Neurodevelopmental Outcomes in Infants with Single Ventricles
by Miller, Thomas A., DO and Zak, Victor, PhD and Shrader, Peter, MA and Ravishankar, Chitra, MD and Pemberton, Victoria L., RNC, MS and Newburger, Jane W., MD and Shillingford, Amanda J., MD and Dagincourt, Nicholas, MS and Cnota, James F., MD and Lambert, Linda M., MSN and Sananes, Renee, PhD and Richmond, Marc E., MD, MS and Hsu, Daphne T., MD and Miller, Stephen G., MD and Zyblewski, Sinai C., MD and Williams, Richard V., MD and Pediat Heart Network Investigators and Pediatric Heart Network Investigators
Journal of Pediatrics, The, ISSN 0022-3476, 2016, Volume 168, pp. 220 - 225.e1
Objective To assess the variability in asymmetric growth and its association with neurodevelopment in infants with single ventricle (SV). Study design We... 
Pediatrics | IMPACT | PHYSIOLOGY | FETAL CEREBROVASCULAR RESISTANCE | DISEASE | PEDIATRICS | FETUSES | RESTRICTION | CEREBRAL-BLOOD-FLOW | INTRAUTERINE GROWTH | ASSOCIATION | AUTOREGULATION | Prospective Studies | Double-Blind Method | Humans | Growth Disorders - etiology | Heart Defects, Congenital - drug therapy | Infant | Male | Cephalometry | Enalapril - therapeutic use | Cardiovascular Abnormalities | Heart Ventricles - abnormalities | Heart Defects, Congenital - complications | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Female | Infant, Newborn | Neurodevelopmental Disorders - etiology | Infants | neurodevelopment | Congenital heart disease | somatic growth
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9. Full Text Anthropometric measures after Fontan procedure: Implications for suboptimal functional outcome
by Cohen, Meryl S., MD and Zak, Victor, PhD and Atz, Andrew M., MD and Printz, Beth F., MD, PhD and Pinto, Nelangi, MD and Lambert, Linda, RN and Pemberton, Victoria, MS and Li, Jennifer S., MD, MPH and Margossian, Renee, MD and Dunbar-Masterson, Carolyn, RN and McCrindle, Brian W., MD, MPH
American Heart Journal, ISSN 0002-8703, 2010, Volume 160, Issue 6, pp. 1092 - 1098.e1
Background Abnormal height and adiposity are observed after the Fontan operation. These abnormalities may be associated with worse functional outcome. Methods... 
Cardiovascular | HEART-DISEASE | SOMATIC GROWTH | OBESITY | IMPACT | CARDIAC & CARDIOVASCULAR SYSTEMS | RISK-FACTORS | OPERATION | QUALITY-OF-LIFE | SINGLE VENTRICLE | CHILDREN | Overweight - complications | Body Weight | Cross-Sectional Studies | Heart Defects, Congenital - surgery | Humans | Hypertrophy, Left Ventricular - etiology | Risk Factors | Hypertrophy, Left Ventricular - diagnosis | Postoperative Period | Male | Overweight - physiopathology | Fontan Procedure - methods | Disease Progression | Magnetic Resonance Imaging | Body Height | Female | Heart Defects, Congenital - diagnosis | Surveys and Questionnaires | Heart Defects, Congenital - physiopathology | Hypertrophy, Left Ventricular - physiopathology | Child | Heart | Pediatrics | Nuclear magnetic resonance--NMR | Cardiovascular disease | Anatomy & physiology | Regression analysis | Family medical history | Children & youth | Variables | Body mass index | Ultrasonic imaging | Population | Behavior
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10. Full Text The Effect of the Superior Cavopulmonary Anastomosis on Ventricular Remodeling in Infants with Single Ventricle
by Margossian, Renee, MD and Zak, Victor, PhD and Shillingford, Amanda J., MD and Hlavacek, Anthony M., MD and Cnota, James F., MD and Puchalski, Michael D., MD and Levine, Jami C., MD and McCrindle, Brian W., MD MPH and Cohen, Meryl S., MD and Altmann, Karen, MD and Barker, Piers C., MD and Hsu, Daphne T., MD and Colan, Steven D., MD and Pediat Heart Network Investigators and Pediatric Heart Network Investigators
Journal of the American Society of Echocardiography, ISSN 0894-7317, 2017, Volume 30, Issue 7, pp. 699 - 707.e1
Background Infants with single ventricular physiology have volume and pressure overload that adversely affect ventricular mechanics. The impact of superior... 
Cardiovascular | Single ventricle | Congenital heart disease | Ventricular remodeling | Diastolic ventricular function | Systolic ventricular function | Superior cavopulmonary anastomosis | SURGERY | CARDIAC & CARDIOVASCULAR SYSTEMS | DIASTOLIC FUNCTION | VOLUME | NATURAL-HISTORY | CHILDREN | IMPACT | REDUCTION | FONTAN OPERATION | ECHOCARDIOGRAPHY | GEOMETRY | Heart Defects, Congenital - surgery | Humans | Infant | Male | Ventricular Remodeling - physiology | Heart Ventricles - diagnostic imaging | North America | Heart Defects, Congenital - diagnostic imaging | Heart Ventricles - physiopathology | Heart Bypass, Right - methods | Heart Ventricles - surgery | Echocardiography, Doppler - methods | Female | Heart Defects, Congenital - physiopathology | Medical colleges | Infants | Research institutes | Children's hospitals | Heart | Genetic disorders | Analysis | Cardiology | Heart diseases | diastolic ventricular function | ventricular remodeling | congenital heart disease | systolic ventricular function | single ventricle | superior cavopulmonary anastomosis
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11. Full Text Design and rationale of the Fontan Udenafil Exercise Longitudinal (FUEL) trial
by Goldberg, David J and Zak, Victor and Goldstein, Bryan H and McCrindle, Brian W and Menon, Shaji C and Schumacher, Kurt R and Payne, R. Mark and Rhodes, Jonathan and McHugh, Kimberly E and Penny, Daniel J and Trachtenberg, Felicia and Hamstra, Michelle S and Richmond, Marc E and Frommelt, Peter C and Files, Matthew D and Yeager, James L and Pemberton, Victoria L and Stylianou, Mario P and Pearson, Gail D and Paridon, Stephen M and Pediat Heart Network Investigators and Pediatric Heart Network Investigators
American Heart Journal, ISSN 0002-8703, 07/2018, Volume 201, pp. 1 - 8
The Fontan operation creates a circulation characterized by elevated central venous pressure and low cardiac output. Over time, these characteristics result in... 
HEMODYNAMIC-RESPONSE | CARDIAC & CARDIOVASCULAR SYSTEMS | SILDENAFIL | CIRCULATION | TRICUSPID-ATRESIA | OPERATION | LEFT-HEART SYNDROME | PULMONARY VASCULAR-RESISTANCE | CARDIOPULMONARY EXERCISE | PEAK OXYGEN-CONSUMPTION | SINGLE VENTRICLE | Exercise Therapy - methods | Fontan Procedure | Sulfonamides - therapeutic use | Pyrimidines - therapeutic use | Randomized Controlled Trials as Topic - methods | Humans | Exercise - physiology | Heart Defects, Congenital - therapy | Phosphodiesterase 5 Inhibitors - therapeutic use | Postoperative Care - methods | Longitudinal Studies | Heart | Adolescence | Pediatrics | Clinical trials | Cardiovascular disease | Gender | Fuels | Safety engineering | Physiology | Blood pressure | Safety | Adolescents | Heart diseases | Age | Phosphodiesterase | Heart failure | Hypertension | Maximum oxygen consumption | Congenital diseases | Young adults | Pulmonary arteries | Abnormalities | Morbidity | Quality of life | Studies | Cardiac output | Pharmaceuticals
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12. Full Text Results of a Phase I/II Multi-Center Investigation of Udenafil in Adolescents after Fontan Palliation
by Goldberg, David J and Zak, Victor and Goldstein, Bryan H and Chen, Shan and Hamstra, Michelle S and Radojewski, Elizabeth A and Maunsell, Eileen and Mital, Seema and Menon, Shaji C and Schumacher, Kurt R and Payne, R. Mark and Stylianou, Mario and Kaltman, Jonathan R and deVries, Tina M and Yeager, James L and Paridon, Stephen M and Pediat Heart Network Investigators and Pediatric Heart Network Investigators
American Heart Journal, ISSN 0002-8703, 2017, Volume 188, pp. 42 - 52
Background The Fontan operation results in a circulation that is dependent on low pulmonary vascular resistance to maintain an adequate cardiac output. Medical... 
Cardiovascular | CONTROLLED-TRIAL | CARDIAC & CARDIOVASCULAR SYSTEMS | SILDENAFIL | CLINICAL-TRIAL | PULMONARY ARTERIAL-HYPERTENSION | TRICUSPID-ATRESIA | VASCULAR FUNCTION | HEART-FAILURE | DOUBLE-BLIND | EXERCISE CAPACITY | ERECTILE DYSFUNCTION | Follow-Up Studies | Humans | Male | Phosphodiesterase 5 Inhibitors - pharmacokinetics | Heart Ventricles - diagnostic imaging | Dose-Response Relationship, Drug | Time Factors | Vascular Resistance - drug effects | Female | Echocardiography | Drug Administration Schedule | Pyrimidines - administration & dosage | Cardiac Output - drug effects | Phosphodiesterase 5 Inhibitors - administration & dosage | Treatment Outcome | Postoperative Care - methods | Sulfonamides - pharmacokinetics | Fontan Procedure | Heart Ventricles - abnormalities | Heart Ventricles - physiopathology | Adolescent | Pyrimidines - pharmacokinetics | Heart Defects, Congenital - metabolism | Heart Defects, Congenital - physiopathology | Heart Defects, Congenital - therapy | Pulmonary Circulation - drug effects | Sulfonamides - administration & dosage | Therapeutics | Clinical trials | Youth | Product development | Teenagers | Homeopathy | Materia medica and therapeutics | Heart | Short term | Headache | Plasma | Adolescence | Physical training | Syngeneic grafts | Palliation | Cardiovascular disease | Males | Molecular weight | Mouth | Xenografts | Physiology | Safety | Adolescents | Drug therapy | Heart diseases | Drug dosages | Age | Heart failure | Dosing | Effectiveness | Pulmonary arteries | Pharmacology | Adults | Cardiac output | Pharmacokinetics | Circulation | pharmacokinetics | heart failure | Fontan procedure
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