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PLoS ONE, ISSN 1932-6203, 01/2013, Volume 8, Issue 1, pp. e54472 - e54472
Background: Toll like receptors (TLRs) sense the intestinal microbiota and regulate the innate immune response. A dysregulation of TLRs function participates... 
COLITIS | METABOLISM | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | LIVER | TOLL-LIKE RECEPTORS | PPAR-GAMMA | FARNESOID-X RECEPTOR | IRF-7 | NUCLEAR HORMONE-RECEPTORS | INNATE IMMUNITY | Monocytes - cytology | Colitis - genetics | Humans | Immunity, Innate - genetics | Toll-Like Receptor 9 - genetics | Male | Monocytes - metabolism | Interferon Regulatory Factor-7 - genetics | Trinitrobenzenesulfonic Acid | Intestines - immunology | Toll-Like Receptor 9 - immunology | Receptors, Cytoplasmic and Nuclear - immunology | Colitis - chemically induced | Myeloid Differentiation Factor 88 - immunology | Tumor Necrosis Factor-alpha - immunology | Signal Transduction - radiation effects | Colitis - immunology | Promoter Regions, Genetic | Toll-Like Receptor 9 - deficiency | Cells, Cultured | Myeloid Differentiation Factor 88 - genetics | Inflammation | Interferon Regulatory Factor-7 - immunology | Receptors, Cytoplasmic and Nuclear - genetics | Mice, Knockout | Gene Expression Regulation - drug effects | Animals | Myeloid Differentiation Factor 88 - deficiency | Signal Transduction - drug effects | Signal Transduction - physiology | Mice | Oligodeoxyribonucleotides - pharmacology | Receptors, Cytoplasmic and Nuclear - metabolism | Microbiota (Symbiotic organisms) | Genes | Genetic research | Physiological aspects | Interferon | Colitis | Deoxycholic acid | Transcription factors | Liver | Homeostasis | Lipids | Innate immunity | Activation | Immunity | Proteins | Receptors | Cell activation | Microbiota | Microorganisms | Intestine | Rodents | Animal tissues | Gastroenterology | Toll-like receptors | Lipid metabolism | Intestinal microflora | Localization | CpG islands | Immune response | Tumor necrosis factor-α | Metabolism | Gene expression | TLR9 protein | TLR3 protein | Immune systems | Inflammatory bowel disease | Interferon regulatory factor 7 | Probiotics | Signaling | Monocytes | Acids | TLR2 protein | MyD88 protein | Ligands | Bile | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2013, Volume 8, Issue 3, pp. e57801 - e57801
Here we have characterized perthamide C, a cyclopeptide from a Solomon Lithistid sponge Theonella swinhoei, which displays an... 
ACTIVATION | CARRAGEENAN-INDUCED EDEMA | NITRIC-OXIDE SYNTHASE | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | CYCLOPEPTIDES | THEONELLA-SWINHOEI | MICE | Gene Expression Regulation, Enzymologic - drug effects | Nitric Oxide Synthase Type II - biosynthesis | Nitric Oxide Synthase Type III - biosynthesis | Capillary Permeability - drug effects | Capillary Permeability - immunology | Male | Peptides, Cyclic - pharmacology | Cyclooxygenase 2 - biosynthesis | Lymphocytes - immunology | Nitric Oxide Synthase Type II - immunology | Cyclooxygenase 2 - immunology | Cyclooxygenase 1 - immunology | Neutrophil Infiltration - drug effects | Disease Models, Animal | Neutrophil Infiltration - immunology | Nitric Oxide - biosynthesis | Nitric Oxide - immunology | Nitric Oxide Synthase Type III - immunology | Cyclooxygenase 1 - biosynthesis | Edema - immunology | Edema - enzymology | Membrane Proteins - immunology | Edema - drug therapy | Lymphocytes - pathology | Membrane Proteins - biosynthesis | Animals | Lymphocytes - enzymology | Cell Proliferation - drug effects | Mice | Gene Expression Regulation, Enzymologic - immunology | Edema - pathology | Immunologic Factors - pharmacology | Metabolites | Nitric oxide | Endothelium | Metabolic rate | Inflammatory response | Activation | Selectivity | Prostaglandin endoperoxide synthase | Proteins | Cell activation | Immunology | Sterols | Lymphocytes | Rodents | Edema | Immunomodulation | Leukocytes (neutrophilic) | Pharmacology | Inflammation | Permeability | Nitric-oxide synthase | Cyclooxygenase-1 | Isoforms | Metabolic activation | Infiltration | Cyclooxygenase-2 | Laboratory animals | Index Medicus
Journal Article
Journal of Immunology, ISSN 0022-1767, 07/2017, Volume 199, Issue 2, pp. 718 - 733
GPBAR1 (TGR5 or M-BAR) is a G protein-coupled receptor for secondary bile acids that is highly expressed in monocytes/ macrophages. In this study, we aimed to... 
IMMUNITY | HOMEOSTASIS | DENDRITIC CELLS | INTEGRINS | FARNESOID X RECEPTOR | INFLAMMATION | CHEMOKINES | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | THERAPEUTIC TARGETS | MICROBIOTA | IMMUNOLOGY | Receptors, G-Protein-Coupled - metabolism | Chemokine CCL2 - immunology | Tumor Necrosis Factor-alpha - genetics | Antigens, Ly - genetics | Interleukin-1beta - genetics | Receptors, G-Protein-Coupled - agonists | T-Lymphocytes, Regulatory - immunology | Intestinal Mucosa - immunology | Colitis - chemically induced | Tumor Necrosis Factor-alpha - immunology | Colitis - immunology | Macrophages - immunology | Cell Line | Promoter Regions, Genetic | Interleukin-10 - deficiency | Interleukin-6 - genetics | Gene Expression Regulation - immunology | Trinitrobenzenesulfonic Acid - administration & dosage | Interleukin-1beta - immunology | Chemokine CCL2 - genetics | Inflammation - immunology | Macrophage Activation | Cholestanols - pharmacology | Phenotype | T-Lymphocytes, Regulatory - drug effects | Animals | Receptors, G-Protein-Coupled - deficiency | Antigens, Ly - immunology | Mucous Membrane - immunology | Interleukin-10 - genetics | Colitis - metabolism | Interleukin-6 - immunology | Macrophages - drug effects | Mice | Oxazolone - administration & dosage | Receptors, G-Protein-Coupled - genetics | Interleukin-10 - immunology | Cell Movement | Cholestanols - administration & dosage | CC chemokine receptors | Oxazolone | Animal models | Inflammatory bowel diseases | Trafficking | Mucosa | Activation | Regulatory sequences | Macrophages | Recruitment | Interleukin 6 | Genotype & phenotype | Cell activation | Intestine | Foxp3 protein | Colon | CD11b antigen | Bile acids | CCR7 protein | Lamina propria | Exposure | Cyclic AMP response element-binding protein | Gene expression | Ablation | CD4 antigen | Inflammatory bowel disease | White blood cells | Monocytes | Acids | Tumor necrosis factor | γ-Interferon | Interleukin 10 | Interferon | Colitis | Monocyte chemoattractant protein 1 | Bile | Index Medicus | Abridged Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2015, Volume 10, Issue 11, pp. e0141082 - e0141082
Background GPBAR1 is a bile acids activated receptor expressed in entero-hepatic tissues. In the liver expression of GPBAR1 is restricted to sinusoidal and... 
MOLECULAR TARGETS | HOMOCYSTEINE | HEPATIC STELLATE CELLS | CIRRHOSIS | MULTIDISCIPLINARY SCIENCES | NITRIC-OXIDE | FARNESOID-X-RECEPTOR | MICROCIRCULATION | HYDROGEN-SULFIDE | NORMAL RAT-LIVER | BILE-ACIDS | Hydrogen Sulfide - metabolism | Hypertension, Portal - physiopathology | Rats, Wistar | Ursodeoxycholic Acid - analogs & derivatives | Humans | Oncogene Protein v-akt - physiology | Endothelium, Vascular - drug effects | Male | Forkhead Transcription Factors - physiology | Receptors, G-Protein-Coupled - agonists | Endothelin-1 - physiology | Real-Time Polymerase Chain Reaction | Receptors, G-Protein-Coupled - physiology | Liver - metabolism | Mice, Inbred C57BL | Endothelium, Vascular - physiopathology | Rats | Bile Acids and Salts - metabolism | Hypertension, Portal - drug therapy | Cholestanols - pharmacology | Animals | Signal Transduction - drug effects | Signal Transduction - physiology | Forkhead Box Protein O1 | Mice | Sulfide | Animal models | Transcription | Liver | Carbon tetrachloride | AKT protein | Kinases | Vasodilation | Recruitment | Hydrogen sulfide | FOXO1 protein | Animal tissues | Hypertension | Bile acids | Liver diseases | Vasoconstriction | Methionine | Endothelin 1 | Cyclic AMP response element-binding protein | Gene expression | Cirrhosis | Acids | Hepatocytes | Perfusion | Nitric oxide | Norepinephrine | Bile | Index Medicus
Journal Article
Scientific Reports, ISSN 2045-2322, 02/2017, Volume 7, Issue 1, pp. 42801 - 42801
Journal Article
Handbook of experimental pharmacology, ISSN 0171-2004, 2019, Volume 256, p. 137
In the recent years, bile acid receptors FXR and GPBAR1 have attracted the interest of scientific community and companies, as they proved promising targets for... 
Bile Acids and Salts - pharmacology | Humans | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Bile Acids and Salts - chemistry | Receptors, G-Protein-Coupled - antagonists & inhibitors | Ligands | Receptors, Cytoplasmic and Nuclear - agonists | Receptors, G-Protein-Coupled - agonists
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 13689 - 13
Gpbar1 is a bile acid activated receptor for secondary bile acids. Here we have investigated the mechanistic role of Gpbar1 in the regulation of adipose... 
BEIGE ADIPOCYTES | STEATOSIS | FATTY LIVER-DISEASE | MULTIDISCIPLINARY SCIENCES | MOUSE | EXPRESSION | CELL | Animal models | Adipose tissue | Bile acids | Liver | Energy expenditure | Cyclic AMP response element-binding protein | Insulin | Fructose | Bile | High fat diet
Journal Article
Scientific Reports, ISSN 2045-2322, 01/2017, Volume 7, Issue 1, pp. 41055 - 41055
The small heterodimer partner (SHP) is an orphan nuclear receptor that lacks the DNA binding domain while conserves a putative ligand-binding site, thought... 
APOPTOSIS | PROTEIN | GENE | MULTIDISCIPLINARY SCIENCES | GROWTH | CHOLESTASIS | PROLIFERATION | IDENTIFICATION | DYSTROGLYCAN | EXPRESSION | SMALL-HETERODIMER-PARTNER | Stellate cells | Hepatocytes | Liver | Rodents | Collagen | Carbon tetrachloride | Fibrosis | Extracellular matrix | Isothiocyanate | Binding sites | Deoxyribonucleic acid--DNA | Index Medicus
Journal Article
Gastroenterology, ISSN 0016-5085, 05/2018, Volume 154, Issue 6, pp. S-1 - S-1
Journal Article
Gastroenterology, ISSN 0016-5085, 05/2018, Volume 154, Issue 6, pp. S-469 - S-469
Journal Article
Gastroenterology, ISSN 0016-5085, 05/2018, Volume 154, Issue 6, pp. S-1078 - S-1078
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2015, Volume 10, Issue 7, pp. e0129866 - e0129866
Background & Aims In cholestatic syndromes, body accumulation of bile acids is thought to cause itching. However, the mechanisms supporting this effect remain... 
TGR5 | FXR | DETOXIFICATION | LIVER-DISEASES | PRURITUS | MULTIDISCIPLINARY SCIENCES | FARNESOID-X RECEPTOR | BILE-ACID RECEPTOR | EXPRESSION | PRIMARY SCLEROSING CHOLANGITIS | AGONIST | Bile Acids and Salts - blood | Cholestasis - complications | Receptors, G-Protein-Coupled - metabolism | Male | Cholanes - metabolism | Estrogens - adverse effects | Cholestasis - physiopathology | Gene Deletion | Pruritus - complications | Isothiocyanates - adverse effects | Pruritus - chemically induced | Disease Models, Animal | Signal Transduction | Chemical and Drug Induced Liver Injury - genetics | Cholestasis - chemically induced | Bile Acids and Salts - adverse effects | Cholanes - pharmacology | Pruritus - metabolism | Animals | Cholestasis - prevention & control | Receptors, G-Protein-Coupled - deficiency | Chemical and Drug Induced Liver Injury - metabolism | Ligands | Mice | Receptors, G-Protein-Coupled - genetics | Pruritus - pathology | Receptors, Cytoplasmic and Nuclear - metabolism | Alkaline phosphatase | Animal models | G protein-coupled receptors | Liver | Disorders | Pruritus | Itching | MDR1 protein | Rodents | Scratching | Attenuation | Scratching behavior | Bile acids | Cell survival | Deactivation | Desensitization | Isothiocyanate | Gene expression | Signaling | Acids | Betulinic acid | Skin | Cholestasis | Bile | Index Medicus
Journal Article