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1. Full Text K2-287 b: An Eccentric Warm Saturn Transiting a G-dwarf
by Jordan, A and Brahm, R and Espinoza, N and Cortes, C and Diaz, M and Drass, H and Henning, T and Jenkins, JS and Jones, MI and Rabus, M and Rojas, F and Sarkis, P and Vuckovic, M and Zapata, A and Soto, MG and Bakos, GA and Bayliss, D and Bhatti, W and Csubry, Z and Lachaume, R and Moraga, V and Pantoja, B and Osip, D and Shporer, A and Suc, V and Vasquez, S
ASTRONOMICAL JOURNAL, ISSN 0004-6256, 03/2019, Volume 157, Issue 3, p. 100
We report the discovery of K2-287b, a Saturn mass planet orbiting a G-dwarf with a period of P approximate to 15 days. First uncovered as a candidate using K2... 
stars: individual (K2-287) | planets and satellites: gaseous planets | GIANT PLANET | SEARCH | PARAMETERS | JUPITERS | planetary systems | ORBIT | EXOPLANETS | ASTRONOMY & ASTROPHYSICS | RADII | MASS | STARS | planets and satellites: detection
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2. Full Text Cardiomyocyte-specific deletion of the G protein-coupled estrogen receptor (GPER) leads to left ventricular dysfunction and adverse remodeling: A sex-specific gene profiling analysis
by Wang, Hao and Sun, Xuming and Chou, Jeff and Lin, Marina and Ferrario, Carlos M and Zapata-Sudo, Gisele and Groban, Leanne
BBA - Molecular Basis of Disease, ISSN 0925-4439, 08/2017, Volume 1863, Issue 8, pp. 1870 - 1882
Activation of G protein-coupled estrogen receptor (GPER) by its agonist, G1, protects the heart from stressors such as pressure-overload, ischemia, a high-salt... 
Microarray | Cardiomyocyte | Knockout | GPER | ACTIVATION | HORMONE-THERAPY | BIOCHEMISTRY & MOLECULAR BIOLOGY | GPR30 | BETA | FEMALE | BREAST-CANCER | HEART-DISEASE | BIOPHYSICS | CARDIOVASCULAR-DISEASE | UPDATE | EXPRESSION | DNA microarrays | Analysis | Genes | Estrogen | Genetic research | Phenols | Genetic transcription | G proteins | Heart
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3. Full Text Molecular modeling of salsolinol, a full G i protein agonist of the μ-opioid receptor, within the receptor binding site
by Berríos-Cárcamo, Pablo and Rivera-Meza, Mario and Herrera-Marschitz, Mario and Zapata-Torres, Gerald
Chemical biology & drug design, ISSN 1747-0277, 03/2019
(R/S)-Salsolinol is a full agonist of the μ-opioid receptor (μOR) G protein pathway via its (S)-enantiomer and is functionally selective as it does not promote... 
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4. Full Text (5RS)‐5‐(4‐Methoxyphenyl)‐2‐(methylsulfanyl)benzo[g]pyrimido[4,5‐b]quinoline‐4,6,11(3H,5H,12H)‐trione, with Z′ = 3, forms a three‐dimensional hydrogen‐bonded framework containing five types of hydrogen bond
by Castillo, Yelder A and Zapata, Luis F and Trilleras, Jorge and Cobo, Justo and Glidewell, Christopher
Acta Crystallographica Section C, ISSN 2053-2296, 01/2014, Volume 70, Issue 1, pp. 50 - 54
The title compound, C 23 H 17 N 3 O 4 S, crystallizes with Z ′ = 3 in the space group P . Two of the three independent molecules are broadly similar in terms... 
crystal structure | six‐molecule aggregate | hydrogen bonding | supramolecular aggregation | six-mol-ecule aggregate | supra-molecular aggregation | six-molecule aggregate | PHENYLPHOSPHONIC ACID | VAN | 4,4'-SULFONYLDIPHENOL | ADDUCTS | CRYSTALLOGRAPHY | 4,4'-THIODIPHENOL | RADII | AGENTS | DERIVATIVES | Crystallography, X-Ray | Quinolones - chemistry | Hydrogen Bonding | Molecular Conformation | Pyrimidines - chemistry | Hydrogen bonds | Molecular biology | Index Medicus | Molecular conformation | Structural members | Molecular structure | Aggregates | Crystallization | Crystallography | Three dimensional
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5. Full Text Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes
by Zinman, Bernard and Wanner, Christoph and Lachin, John M and Fitchett, David and Bluhmki, Erich and Hantel, Stefan and Mattheus, Michaela and Devins, Theresa and Johansen, Odd Erik and Woerle, Hans J and Broedl, Uli C and Inzucchi, Silvio E and EMPA-REG OUTCOME Investigators
The New England Journal of Medicine, ISSN 0028-4793, 11/2015, Volume 373, Issue 22, pp. 2117 - 2128
In this study, the addition of empagliflozin, an inhibitor of sodium–glucose cotransporter 2, to standard care reduced cardiovascular morbidity and mortality... 
METFORMIN | MEDICINE, GENERAL & INTERNAL | ADD-ON | METAANALYSIS | GLUCOSE CONTROL | STIFFNESS | SITAGLIPTIN | DISEASE | DOUBLE-BLIND | RISK | 24-WEEK | Hypoglycemic Agents - therapeutic use | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Risk Factors | Kaplan-Meier Estimate | Hospitalization - statistics & numerical data | Male | Cause of Death | Benzhydryl Compounds - adverse effects | Diabetes Mellitus, Type 2 - mortality | Intention to Treat Analysis | Cardiovascular Diseases - epidemiology | Cardiovascular Diseases - mortality | Female | Glucosides - therapeutic use | Aged | Diabetes Mellitus, Type 2 - drug therapy | Benzhydryl Compounds - therapeutic use | Hypoglycemic Agents - adverse effects | Glucosides - adverse effects | Type 2 diabetes | Treatment outcome | Care and treatment | Patient outcomes | Analysis | Cardiovascular diseases | Risk factors | Myocardial infarction | Cerebral infarction | Inhibitor drugs | Mortality | Diabetes mellitus | Cardiovascular disease | Angina | Glucose | Morbidity | Sodium | Death | Diabetes | Health risk assessment | Drug therapy | Diabetes mellitus (non-insulin dependent) | Heart diseases
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6. Full Text Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes
by Wanner, Christoph and Inzucchi, Silvio E and Lachin, John M and Fitchett, David and von Eynatten, Maximilian and Mattheus, Michaela and Johansen, Odd Erik and Woerle, Hans J and Broedl, Uli C and Zinman, Bernard and EMPA-REG OUTCOME Investigators
The New England Journal of Medicine, ISSN 0028-4793, 07/2016, Volume 375, Issue 4, pp. 323 - 334
Among patients with type 2 diabetes at high cardiovascular risk, the rates of progression of kidney disease and clinically relevant renal events were lower... 
GLOMERULAR-FILTRATION-RATE | METFORMIN | MEDICINE, GENERAL & INTERNAL | ADD-ON | INHIBITION | ARTERIAL STIFFNESS | INTENSIVE GLUCOSE CONTROL | DOUBLE-BLIND | CARDIOVASCULAR-DISEASE | END-POINTS | BLOOD-PRESSURE | Hypoglycemic Agents - therapeutic use | Cardiovascular Diseases - etiology | Glomerular Filtration Rate | Kidney - blood supply | Humans | Middle Aged | Risk Factors | Kaplan-Meier Estimate | Proportional Hazards Models | Diabetic Nephropathies - drug therapy | Microvessels - drug effects | Male | Albuminuria | Disease Progression | Benzhydryl Compounds - adverse effects | Intention to Treat Analysis | Female | Glucosides - therapeutic use | Aged | Diabetes Mellitus, Type 2 - drug therapy | Benzhydryl Compounds - therapeutic use | Hypoglycemic Agents - adverse effects | Diabetes Mellitus, Type 2 - complications | Glucosides - adverse effects | Type 2 diabetes | Complications and side effects | Kidney diseases | Cardiovascular diseases | Risk factors | Creatinine | Kidneys | Mortality | Diabetes mellitus | Glomerular filtration rate | Side effects | Nephropathy | Sodium | Microvasculature | Diabetes | Health risk assessment | Drug therapy | Diabetes mellitus (non-insulin dependent)
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7. Full Text Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes
by Cannon, Christopher P and Blazing, Michael A and Giugliano, Robert P and McCagg, Amy and White, Jennifer A and Theroux, Pierre and Darius, Harald and Lewis, Basil S and Ophuis, Ton Oude and Jukema, J. Wouter and De Ferrari, Gaetano M and Ruzyllo, Witold and De Lucca, Paul and Im, KyungAh and Bohula, Erin A and Reist, Craig and Wiviott, Stephen D and Tershakovec, Andrew M and Musliner, Thomas A and Braunwald, Eugene and Califf, Robert M and IMPROVW-IT Investigators and IMPROVE-IT Investigators
The New England Journal of Medicine, ISSN 0028-4793, 06/2015, Volume 372, Issue 25, pp. 2387 - 2397
In this trial, patients with an acute coronary syndrome within the previous 10 days were randomly assigned to simvastatin plus either ezetimibe or placebo. At... 
CHOLESTEROL ABSORPTION | CARDIAC OUTCOMES | MEDICINE, GENERAL & INTERNAL | MYOCARDIAL-INFARCTION | EFFICACY | CARDIOVASCULAR OUTCOMES | CLINICAL-TRIALS | SIMVASTATIN | PRIMARY PREVENTION | IMPROVE-IT | ATORVASTATIN | Simvastatin - therapeutic use | Double-Blind Method | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Azetidines - adverse effects | Ezetimibe | Kaplan-Meier Estimate | Male | Anticholesteremic Agents - adverse effects | Acute Coronary Syndrome - drug therapy | Anticholesteremic Agents - therapeutic use | Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects | Azetidines - therapeutic use | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Triglycerides - blood | Cardiovascular Diseases - epidemiology | Cardiovascular Diseases - mortality | Cholesterol, LDL - blood | Female | Aged | Drug Therapy, Combination | Usage | Simvastatin | Analysis | Practice guidelines (Medicine) | Dosage and administration | Drug therapy, Combination | Acute coronary syndrome | Drug therapy | Myocardial infarction | Cerebral infarction | Lipoproteins (low density) | Stroke | Liver | Angina | Cholesterol | Intestine | Gallbladder | Acute coronary syndromes | Cardiovascular diseases | Statins | Pharmaceuticals | Cancer | Life Sciences | Human health and pathology | Cardiology and cardiovascular system
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