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Chemistry – A European Journal, ISSN 0947-6539, 12/2013, Volume 19, Issue 52, pp. 17668 - 17672
Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 06/2015, Volume 21, Issue 25, pp. 9249 - 9255
The first solid‐phase parallel synthesis of macrocyclic peptides using three‐component coupling driven by aziridine aldehyde dimers is described. The method... 
peptides | drug discovery | solid‐phase synthesis | macrocycles | small ring systems | Small ring systems | Drug discovery | Peptides | Macrocycles | Solid-phase synthesis | solid-phase synthesis | MULTICOMPONENT REACTIONS | MACROCYCLIC PEPTIDES | PIPERAZINONES | LIBRARY | CHEMISTRY, MULTIDISCIPLINARY | STRATEGIES | Aldehydes | Joining | Dimers | Synthesis
Journal Article
Journal Article
ISBN 9781339926933
Cyclization is a technique often employed in the design of therapeutic agents and molecular probes to increase a molecule's affinity and selectivity towards... 
Organic chemistry | Chemistry | Biochemistry
eBook
ISSN 1477-0520, 7/2015, Volume 13, Issue 27, pp. 7384 - 7388
.../c5ob01050k www.rsc.org/obc Twisted amide electrophiles enable cyclic peptide sequencing† Serge Zaretsky, a Vishal Rai, a Gerald Gish, b Matthew W. Forbes, a Michael Kofl... 
Journal Article
ISSN 2041-6520, 9/2015, Volume 6, Issue 1, pp. 5446 - 5455
...Chemical Science EDGE ARTICLE Mechanistic investigation of aziridine aldehydedriven peptide macrocyclization: the imidoanhydride pathway† Serge Zaretsky... 
Journal Article
Chemical Science, ISSN 2041-6520, 10/2015, Volume 6, Issue 10, pp. 5446 - 5455
Aziridine aldehydes participate in a multicomponent reaction with α-amino amides and isocyanides to generate reactive imidoanhydride intermediates. Aziridine... 
Chemistry
Journal Article
Drug discovery today. Technologies, ISSN 1740-6749, 2017, Volume 26, pp. 3 - 10
Constrained peptides pose tremendous value in drug discovery. For example, owing to their large surface areas, they offer novel ways at inhibiting... 
Cysteine | Drug discovery
Journal Article
ISSN 2040-2503, 6/2013, Volume 4, Issue 7, pp. 1124 - 1128
...† Benjamin K. W. Chung, Jennifer L. Hickey, Conor C. G. Scully, Serge Zaretsky and Andrei K. Yudin * We present a method that can be applied to generate medium-sized... 
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 04/2017, Volume 82, Issue 8, pp. 4512 - 4512
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 08/2018, Volume 83, Issue 16, pp. 9119 - 9124
Aziridine aldehyde-driven macrocyclization of peptides is a powerful tool for the construction of biologically active macrocycles. While this process has been... 
CHEMISTRY, ORGANIC | DIMERS | CYCLIZATION | Thermodynamics | Cyclization | Models, Chemical | Peptides - chemistry | Molecular Conformation | Models, Molecular | Aziridines - chemistry | Aldehydes - chemistry
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2015, Volume 1248, pp. 67 - 80
Cyclic peptides have wide utility in the biological sciences. As conformationally locked analogs of the parent linear peptides, they possess greater stability... 
Chemical probe | Cyclic peptide | Bioconjugation | Azide | Peptide | Aziridine | Oligopeptides - chemical synthesis | Peptide Library | Peptides, Cyclic - chemical synthesis | Oligopeptides - chemistry | Peptides, Cyclic - chemistry
Journal Article
Journal of organic chemistry, ISSN 0022-3263, 07/2019, Volume 84, Issue 13, pp. 8360 - 8379
An intramolecular arene alkylation reaction has been developed using the organic photocatalyst 4CzIPN, visible light, and N-(acyloxy)­phthalimides as radical... 
FUNCTIONALIZATION | SUBSTITUTION | HIGH-THROUGHPUT EXPERIMENTATION | ELECTRON-TRANSFER | AZIDATION | RADICAL CYCLIZATION | CHEMISTRY, ORGANIC | PYRROLES | ALIPHATIC CARBOXYLIC-ACIDS | PHOTOREDOX CATALYSIS
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2016, Volume 59, Issue 11, pp. 5368 - 5376
We have developed a strategy for synthesizing passively permeable peptidomimetic macrocycles. The cyclization chemistry centers on using aziridine aldehydes in... 
CHEMISTRY, MEDICINAL | POOR SOLUBILITY | ASSAY | ORAL BIOAVAILABILITY | DRUG DISCOVERY | ABSORPTION | CONFORMATION | N-METHYLATION | CYCLIC-PEPTIDES | RA-V | PREDICTION | Amides - chemistry | Macrocyclic Compounds - chemistry | Amides - chemical synthesis | Macrocyclic Compounds - chemical synthesis | Molecular Conformation
Journal Article
Chemical Reviews, ISSN 0009-2665, 08/2014, Volume 114, Issue 16, pp. 8323 - 8359
Rotstein et al explore small heterocycles in multicomponent reactions, focusing on multicomponent reactions with heterocyclic substrates and multicomponent... 
Heterocyclic compounds | Chemical reactions
Journal Article
Chemical reviews, ISSN 0009-2665, 08/2014, Volume 114, Issue 16, p. 8323
  Rotstein et al explore small heterocycles in multicomponent reactions, focusing on multicomponent reactions with heterocyclic substrates and multicomponent... 
Chemistry | Chemical reactions | Chemical synthesis
Journal Article
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