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Nature, ISSN 0028-0836, 03/2012, Volume 483, Issue 7387, pp. 100 - 104
Inhibition of the BRAF(V600E) oncoprotein by the small-molecule drug PLX4032 (vemurafenib) is highly effective in the treatment of melanoma(1). However, colon... 
PANITUMUMAB | TARGET | CETUXIMAB | MELANOMA | BRAF MUTATIONS | MULTIDISCIPLINARY SCIENCES | PAPILLARY THYROID-CARCINOMA | KRAS | METASTATIC COLORECTAL-CANCER | Erlotinib Hydrochloride | Receptor, Epidermal Growth Factor - agonists | Apoptosis - drug effects | Colorectal Neoplasms - genetics | Humans | Antineoplastic Agents - therapeutic use | Antibodies, Monoclonal, Humanized | Receptor, Epidermal Growth Factor - metabolism | RNA Interference | Colorectal Neoplasms - drug therapy | HEK293 Cells | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Cetuximab | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Melanoma - metabolism | Colorectal Neoplasms - enzymology | Antibodies, Monoclonal - pharmacology | Enzyme Activation - drug effects | Sulfonamides - pharmacology | Drug Synergism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | Sulfonamides - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Quinazolines - therapeutic use | Melanoma - drug therapy | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Feedback, Physiological - drug effects | Indoles - therapeutic use | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Colorectal Neoplasms - pathology | Quinazolines - pharmacology | Drug Resistance, Neoplasm - drug effects | Proteins | Library collections | Studies | Phosphorylation | Kinases | Tumors | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 1, pp. 118 - 122
Treatment of BRAF(V600E) mutant melanoma by small molecule drugs that target the BRAF or MEK kinases can be effective, but resistance develops invariably(1,2).... 
GROWTH-FACTOR RECEPTOR | BRAF INHIBITOR | RAF INHIBITION | CELLS | MULTIDISCIPLINARY SCIENCES | IMPROVED SURVIVAL | DIFFERENTIATION | C-JUN | CANCER | EXPRESSION | EGFR | Receptor, Epidermal Growth Factor - genetics | Humans | Receptor Protein-Tyrosine Kinases - biosynthesis | Cellular Senescence - drug effects | Melanoma - enzymology | Antineoplastic Agents - administration & dosage | Receptor, Platelet-Derived Growth Factor beta - genetics | Indoles - administration & dosage | Mitogen-Activated Protein Kinase Kinases - metabolism | Receptor, Epidermal Growth Factor - metabolism | Flow Cytometry | Melanoma - genetics | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | SOXE Transcription Factors - deficiency | Proto-Oncogene Proteins B-raf - metabolism | Receptor, Platelet-Derived Growth Factor beta - metabolism | Receptor, Epidermal Growth Factor - biosynthesis | Gene Library | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Melanoma - pathology | Receptor Protein-Tyrosine Kinases - metabolism | Sulfonamides - pharmacology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Protein Kinase Inhibitors - administration & dosage | Transforming Growth Factor beta - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Receptor Protein-Tyrosine Kinases - genetics | Signal Transduction - drug effects | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | RNA, Small Interfering | Transforming Growth Factor beta - metabolism | Receptor, Platelet-Derived Growth Factor beta - biosynthesis | Sulfonamides - administration & dosage | Drug Resistance, Neoplasm - drug effects | SOXE Transcription Factors - genetics | Proteins | Biopsy | Rodents | Genes | Melanoma | Mutation | Kinases | Drug resistance | Patients | Tumors | Index Medicus
Journal Article
Experimental Thermal and Fluid Science, ISSN 0894-1777, 04/2019, Volume 102, pp. 1 - 19
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 08/2010, Volume 120, Issue 8, pp. 2858 - 2866
Journal Article
Immunity, ISSN 1074-7613, 12/2017, Volume 47, Issue 6, pp. 1083 - 1099.e6
The immunosuppressive protein PD-L1 is upregulated in many cancers and contributes to evasion of the host immune system. The relative importance of the tumor... 
PD-L1 | TTP | KRAS | RAS | tristetraprolin | immunotherapy | CELL LUNG-CANCER | ACTIVATED PROTEIN-KINASE | EPITHELIAL-CELLS | TRISTETRAPROLIN | MELANOMA-CELLS | TNF-ALPHA | IMMUNOLOGY | EXPRESSION | CHECKPOINT BLOCKADE | Proto-Oncogene Proteins p21(ras) - immunology | Neoplasm Transplantation | RNA, Messenger - immunology | Tumor Escape | Proto-Oncogene Proteins p21(ras) - genetics | Tristetraprolin - immunology | Colorectal Neoplasms - genetics | Humans | Gene Expression Regulation, Neoplastic | Intracellular Signaling Peptides and Proteins - immunology | Lung Neoplasms - pathology | Male | Female | Intracellular Signaling Peptides and Proteins - genetics | Lung Neoplasms - genetics | Signal Transduction | MAP Kinase Kinase Kinases - genetics | Mice, Inbred C57BL | RNA, Messenger - genetics | Protein-Serine-Threonine Kinases - genetics | Epithelial Cells - pathology | RNA Cleavage | RNA Stability | B7-H1 Antigen - genetics | B7-H1 Antigen - immunology | MAP Kinase Kinase Kinases - immunology | Lung Neoplasms - immunology | Animals | Colorectal Neoplasms - immunology | Tristetraprolin - genetics | Epithelial Cells - immunology | Cell Line, Tumor | Protein Binding | Protein-Serine-Threonine Kinases - immunology | Mice | Mice, Inbred BALB C | Colorectal Neoplasms - pathology | Messenger RNA | Gastrointestinal diseases | Immunotherapy | Colorectal cancer | Cellular signal transduction | Cancer | Protein binding | Transcription factors | Cytokines | Lung cancer | Genomes | Ras protein | Kinases | Ribonucleic acid--RNA | Patients | Proteins | Signal transduction | Immunosuppression | DNA methylation | Tumor necrosis factor-TNF | Ligands | Protein expression | Mutation | Oncogenes | Tumors | Index Medicus
Journal Article
Cell Reports, ISSN 2211-1247, 10/2014, Volume 7, Issue 1, pp. 86 - 93
Journal Article
Journal of Sound and Vibration, ISSN 0022-460X, 08/2016, Volume 375, pp. 115 - 131
The tip leakage noise generated by a shrouded rotor of an axial-flow fan has been experimentally studied. The measurements have been taken at high flow rate... 
Tip-leakage noise | Spectral decomposition | Rotating shroud | Acoustic propagation function | Axial fan noise | Acoustic source distribution function | CLEARANCE | TONAL NOISE | VORTEX | ENGINEERING, MECHANICAL | BROAD-BAND | ACOUSTICS | MECHANICS | SOUND | GENERATION | TURBULENCE | Wave propagation | Acoustic properties | Leakage | Ramps | Broadband | Noise | Rotors | Upstream | Spectra | Rotational
Journal Article
The American Journal of Cardiology, ISSN 0002-9149, 06/2018, Volume 121, Issue 12, pp. 1601 - 1609
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 1321 - 10
We provide a model for the genesis of Holocene coralligenous buildups occurring in the northwestern Adriatic Sea offshore Venice at 17-24 m depth.... 
SEQUENCE STRATIGRAPHY | NORTHERN ADRIATIC SEA | LATE QUATERNARY | MULTIDISCIPLINARY SCIENCES | MARINE TERRACE | FACIES | CAPO COLONNA TERRACE | LATE PLEISTOCENE | EROSION | Diving | Nuclei | Lithification
Journal Article
Cancer Discovery, ISSN 2159-8274, 2013, Volume 3, Issue 6, pp. 658 - 673
Journal Article