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Physiological Reviews, ISSN 0031-9333, 01/2013, Volume 93, Issue 1, p. 269
  Small GTPases use GDP/GTP alternation to actuate a variety of functional switches that are pivotal for cell dynamics. The GTPase switch is turned on by GEFs,... 
Enzymes | Signal transduction | Phosphorylation | Biochemistry | Cells
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 08/2011, Volume 7, Issue 8, pp. 493 - 495
Journal Article
Journal Article
Small GTPases, ISSN 2154-1248, 10/2016, Volume 7, Issue 4, pp. 283 - 296
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 04/2019, Volume 15, Issue 4, pp. 358 - 366
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2014, Volume 111, Issue 34, pp. 12378 - 12383
Guanine nucleotide exchange factors (GEFs) of the exchange factor for Arf6 (EFA6), brefeldin A-resistant Arf guanine nucleotide exchange factor (BRAG), and... 
Negative feedback | Guanine nucleotide exchange factors | Control loops | Nuclear membrane | Lipids | Cell membranes | Liposomes | Nucleotides | Kinetics | Positive feedback | Membrane traffic | Endocytosis | Autoinhibition | PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE | POSITIVE FEEDBACK | MEMBRANE | MULTIDISCIPLINARY SCIENCES | G-PROTEINS | PH DOMAIN | autoinhibition | membrane traffic | FAMILY | STRUCTURAL BASIS | NUCLEOTIDE EXCHANGE FACTOR | endocytosis | kinetics | BINDING | CONFORMATIONAL SWITCH | Cell Adhesion Molecules - chemistry | Cell Adhesion Molecules - genetics | Membrane Glycoproteins - metabolism | Humans | Membrane Glycoproteins - chemistry | Guanosine Triphosphate - metabolism | Nerve Tissue Proteins - chemistry | Guanine Nucleotide Exchange Factors - metabolism | ADP-Ribosylation Factor 1 - metabolism | Sulfotransferases - metabolism | Protein Interaction Domains and Motifs | ADP-Ribosylation Factor 1 - genetics | ADP-Ribosylation Factors - metabolism | Guanosine Diphosphate - metabolism | ADP-Ribosylation Factors - genetics | Recombinant Proteins - metabolism | Sulfotransferases - genetics | Cell Line | Cricetinae | Guanine Nucleotide Exchange Factors - genetics | Mutagenesis, Site-Directed | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Cell Adhesion Molecules - metabolism | Nerve Tissue Proteins - genetics | Membrane Glycoproteins - genetics | Nerve Tissue Proteins - metabolism | ADP-Ribosylation Factors - chemistry | Feedback, Physiological | Animals | Models, Biological | Enzyme Activation | ADP-Ribosylation Factor 1 - chemistry | Sulfotransferases - chemistry | Amino Acid Substitution | Guanine Nucleotide Exchange Factors - chemistry | Physiological aspects | Protein research | Research | Guanosine triphosphatase | Protein-protein interactions | Membrane proteins | Biological Sciences
Journal Article
Nature chemical biology, ISSN 1552-4450, 03/2019, Volume 15, Issue 5, pp. 549 - 549
In the version of this article originally published, several co-authors had incorrect affiliation footnote numbers listed in the author list. Tatiana Cañeque... 
Guanosinetriphosphatase | Life Sciences | Quantitative Methods
Journal Article
PLoS Pathogens, ISSN 1553-7366, 11/2013, Volume 9, Issue 11, p. e1003747
Journal Article
Biochemical Journal, ISSN 0264-6021, 04/2017, Volume 474, Issue 7, pp. 1259 - 1272
Active, GTP-bound small GTPases need to be attached to membranes by post-translational lipid modifications in order to process and propagate information in... 
MYRISTOYLATED ARF1 | REGULATOR | GUANINE-NUCLEOTIDE-EXCHANGE | STRUCTURAL BASIS | EFFICIENT ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | RAB7 GTPASE | RHO-GTPASES | PROTEINS | BINDING | FAMILY | Humans | cdc42 GTP-Binding Protein - metabolism | rhoA GTP-Binding Protein - metabolism | GTPase-Activating Proteins - metabolism | Histidine - metabolism | rhoA GTP-Binding Protein - genetics | DNA-Binding Proteins - metabolism | Protein Isoforms - metabolism | Guanine Nucleotide Exchange Factors - metabolism | ADP-Ribosylation Factor 1 - metabolism | Phosphatidylinositols - metabolism | ADP-Ribosylation Factor 1 - genetics | Legionella pneumophila - chemistry | Phosphatidylinositols - genetics | Recombinant Proteins - metabolism | Gene Expression | Guanine Nucleotide Exchange Factors - genetics | rho GTP-Binding Proteins - genetics | Oligopeptides - genetics | Bacterial Proteins - genetics | Histidine - genetics | Membranes, Artificial | Recombinant Proteins - genetics | Oligopeptides - metabolism | DNA-Binding Proteins - genetics | cdc42 GTP-Binding Protein - genetics | rho GTP-Binding Proteins - metabolism | Protein Binding | Bacterial Proteins - metabolism | Enzyme Activation | GTPase-Activating Proteins - genetics | rac1 GTP-Binding Protein - metabolism | Protein Isoforms - genetics | rac1 GTP-Binding Protein - genetics
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2007, Volume 104, Issue 25, pp. 10370 - 10375
Small molecules that produce nonfunctional protein-protein complexes are an alternative to competitive inhibitors for the inhibition of protein functions. Here... 
Molecules | Microscopy | Anisotropy | Fluorescence | Small interfering RNA | HeLa cells | Kinetics | Gross domestic product | Binding sites | Crystal structure | Guanine nucleotide exchage factor | Inhibition | Arf1 factor | GTPase | Protein-protein interactions | GUANINE-NUCLEOTIDE-EXCHANGE | MECHANISM | MULTIDISCIPLINARY SCIENCES | inhibition | ADP-RIBOSYLATION FACTOR-1 | protein-protein interactions | INTERFACE | SMALL-MOLECULE INHIBITORS | FACTOR ARNO | guanine nucleotide exchage factor | BREFELDIN-A | RAC1 | DOWNSTREAM ACTIVATION | BINDING | Humans | Brefeldin A - pharmacology | Structure-Activity Relationship | GTPase-Activating Proteins - metabolism | Dose-Response Relationship, Drug | Time Factors | Guanine Nucleotide Exchange Factors - metabolism | Computer Simulation | Sensitivity and Specificity | ADP-Ribosylation Factor 1 - metabolism | Guanosine Diphosphate - metabolism | Protein Synthesis Inhibitors - pharmacology | Protein Structure, Tertiary | Cell Line | Aniline Compounds - pharmacology | Models, Molecular | ADP-Ribosylation Factor 1 - antagonists & inhibitors | Cell Movement - drug effects | Animals | Dogs | Benzimidazoles - pharmacology | GTPase-Activating Proteins - genetics | HeLa Cells | Mutation | Proteins - antagonists & inhibitors | ADP-Ribosylation Factor 1 - chemistry | Guanine Nucleotide Exchange Factors - chemistry | RNA, Small Interfering - metabolism | Research | G proteins | Guanosine triphosphatase | Guanine | Benzimidazoles | Aniline Compounds | Brefeldin A | Guanosine Diphosphate | Cellular Biology | Proteins | Life Sciences | ADP-Ribosylation Factor 1 | Protein Synthesis Inhibitors | GTPase-Activating Proteins | Biochemistry, Molecular Biology | Guanine Nucleotide Exchange Factors | RNA, Small Interfering | Hela Cells | Cell Movement | protein–protein interactions | Biological Sciences
Journal Article